Quantitative target engagement of RIPK1 in human whole blood via the cellular thermal shift assay for potential pre-clinical and clinical applications by Shitalben Patel, Marie Karlsson, Joseph T. Klahn, Frank Gambino, Jr., Helena Costa, Kathleen A. McGuire, Christina K. Baumgartner, Jon Williams, Sarah Sandoz, James E. Kath

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells by Xuan Yang, Jeffery L. Smith, Michael T. Beck, Jennifer M. Wilkinson, Ani Michaud, James D. Vasta, Matthew B. Robers, Timothy M. Willson

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Assessing target engagement using proteome-wide solvent shift assays by Jonathan G Van Vranken, Jiaming Li, Dylan C Mitchell, José Navarrete-Perea, Steven P Gygi

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Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice by Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z. M. Homer, Rosana Leiva, Santiago Vázquez, Damian J. Mole, Christian Griñán-Ferré, Mercè Pallàs

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Creating a more strategic small molecule biophysical hit characterization workflow by Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder

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Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis by Boudewijn T. H. M. Sleutjes, Diederik J. L. Stikvoort García, Maria O. Kovalchuk, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Hessel Franssen, Leonard H. van denBerg

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The cellular thermal shift assay : a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies by Martinez Molina, Daniel, Nordlund, Pär

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Specificity and Durability of Changes in Auditory Processing Efficiency After Targeted Cognitive Training in Individuals With Recent-Onset Psychosis by Bruno Biagianti, Bruno Biagianti, Melissa Fisher, Rachel Loewy, Benjamin Brandrett, Catalina Ordorica, Kristin LaCross, Brandon Schermitzler, Michelle McDonald, Ian Ramsay, Sophia Vinogradov

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Current Advances in CETSA by Tuomas Aleksi Tolvanen, Tuomas Aleksi Tolvanen

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T-cell engagers: model interrogation as a tool to quantify the interplay of relative affinity and target expression on trimer formation by Massimo Lai, Cesar Pichardo-Almarza, Meghna Verma, Md Shahinuzzaman, Xu Zhu, Holly Kimko

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Quantification of Trastuzumab–HER2 Engagement In Vitro and In Vivo by Alena Rudkouskaya, Jason T. Smith, Xavier Intes, Margarida Barroso

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Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants by Jacob L. Capener, James D. Vasta, Vittorio L. Katis, Ani Michaud, Michael T. Beck, Sabrina C. D. Daglish, Sarit Cohen-Kedar, Sarit Cohen-Kedar, Efrat Shaham Barda, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Iris Dotan, Matthew B. Robers, Alison D. Axtman, Frances M. Bashore

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Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic by Maria Myzithras, Siqi Lin, Legairre Radden, Cynthia Hess Kenny, Zheng Cai, Angus MacDonald, Ralph Binetti, Michael Marlow, Paul Fracasso, Glenn Gibson, Christina Bartlett, Julie Hawkins, Steven Hansel

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When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement by Yasunori Aoki, Yasunori Aoki, Malcom Rowland, Yuichi Sugiyama, Yuichi Sugiyama

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Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance by Miguel Lemos, Serena Venezia, Violetta Refolo, Antonio Heras-Garvin, Sabine Schmidhuber, Armin Giese, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Gergana Galabova, Guenther Staffler, Gregor Karl Wenning, Nadia Stefanova

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Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody by Yan Wang, Donghui Pan, Chenrong Huang, Bingliang Chen, Mingzhu Li, Shuaixiang Zhou, Lizhen Wang, Min Wu, Xinyu Wang, Yicong Bian, Junjie Yan, Junjian Liu, Min Yang, Liyan Miao

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The timing of transcranial magnetic stimulation relative to the phase of prefrontal alpha EEG modulates downstream target engagement by Spiro P. Pantazatos, James R. Mclntosh, Golbarg T. Saber, Xiaoxiao Sun, Jayce Doose, Josef Faller, Yida Lin, Joshua B. Teves, Aidan Blankenship, Sarah Huffman, Robin I. Goldman, Mark S. George, Paul Sajda, Truman R. Brown

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Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2 by Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones

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Minimal Physiologically-Based Pharmacokinetic (mPBPK) Metamodeling of Target Engagement in Skin Informs Anti-IL17A Drug Development in Psoriasis by Vivaswath S. Ayyar, Jong Bong Lee, Weirong Wang, Meghan Pryor, Yanli Zhuang, Thomas Wilde, An Vermeulen, An Vermeulen

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Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinop... by Lone Fjord-Larsen, Annemette Thougaard, Karen Malene Wegener, Joan Christiansen, Frank Larsen, Lise Maj Schrøder-Hansen, Marianne Kaarde, Dorte Kornerup Ditlevsen

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