Sub-grouping of <it>Plasmodium falciparum </it>3D7 <it>var </it>genes based on sequence analysis of coding and non-coding regions by Arnot David E, Jensen Anja TR, Salanti Ali, Lavstsen Thomas, Theander Thor G

“…The best defined <it>var </it>group, group A, comprises telomeric genes transcribed towards the telomere encoding PfEMP1s with complex domain structures different from the 4-domain type dominant of groups B and C. …”
Get full text

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription. by Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Sayaka Aoki, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh

“…Telomerase is a ribonucleoprotein ribonucleic enzyme that is essential for cellular immortalization via elongation of telomere repeat sequences at the end of chromosomes. …”
Get full text

Karyotype diversity and patterns of chromosomal evolution in Eigenmannia (Teleostei, Gymnotiformes, Sternopygidae) by Viviane França Sene, José Carlos Pansonato-Alves, Ricardo Utsunomia, Claudio Oliveira, Fausto Foresti

“…Additionally, the presence of minor ribosomal gene sites on the sex chromosome pair of E. virescens represented a new type of the sex chromosomes in this group. The telomeric probe (TTAGGG)n hybridized to the terminal portion of all chromosomes in all species examined however, interstitial telomeric sites were found in the metacentric pair No. 2 in Eigenmannia sp.1. …”
Get full text

Chromosome-End Knockoff Strategy to Reshape Alkaloid Profiles of a Fungal Endophyte by Simona Florea, Timothy D. Phillips, Daniel G. Panaccione, Mark L. Farman, Christopher L. Schardl

“…We designed a vector with a fungal-active hygromycin phosphotransferase gene (hph), an lpsA1 gene fragment for homologous recombination at the telomere-distal end of EAS1, and a telomere repeat array positioned to drive spontaneous loss of hph and other vector sequences, and to stabilize the new chromosome end. …”
Get full text

Biogeographical karyotypic variation of Rhinophylla fischerae (Chiroptera: Phyllostomidae) suggests the occurrence of cryptic species by A Gomes, L Rodrigues, J Rissino, C Nagamachi, J Pieczarka

“…Fluorescence in situ hybridization using telomeric probes did not show any interstitial sequences. …”
Get full text

Reference Quality Genome Assemblies of Three Parastagonospora nodorum Isolates Differing in Virulence on Wheat by Jonathan K. Richards, Nathan A. Wyatt, Zhaohui Liu, Justin D. Faris, Timothy L. Friesen

“…These newly sequenced genomes, consisting of telomere-to-telomere assemblies of nearly all 23 P. nodorum chromosomes, provide a robust foundation for the further examination of effector biology and genome evolution.…”
Get full text

The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa by Lai, A, Pouchkina-Stantcheva, N, Di Donfrancesco, A, Kildisiute, G, Sahu, S, Aboobaker, A

“…BACKGROUND: Most animals employ telomerase, which consists of a catalytic subunit known as the telomerase reverse transcriptase (TERT) and an RNA template, to maintain telomere ends. Given the importance of TERT and telomere biology in core metazoan life history traits, like ageing and the control of somatic cell proliferation, we hypothesised that TERT would have patterns of sequence and regulatory evolution reflecting the diverse life histories across the Animal Kingdom. …”

A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2/B13 haplotype) derived from a monosomy 6 mutant cell line. by Ragoussis, J, Bloemer, K, Pohla, H, Messer, G, Weiss, E, Ziegler, A

“…The class I region contains a gap of about 500 kb, just telomeric of HLA-C, in which further class I genes could not be detected. …”

Cytoplasmic polyadenylation in S. pombe by Stevenson, A, Stevenson, Abigail Louise

“…Many RNAs affected by Cid1 in these circumstances were cell-cycle dependent and telomeric transcripts, including those encoding histones and a novel RecQ helicase, Rqh2. …”

ATR-16 syndrome: mechanisms linking monosomy to phenotype by Babbs, C, Brown, J, Horsley, S, Slater, J, Maifoshie, E, Kumar, S, Ooijevaar, P, Kreik, M, Dixon-Mciver, A, Harteveld, C, Traeger-Synodinos, J, Wilkie, A, Higgs, D, Buckle, V

“…We characterised deletion extents and screened for genetic background effects, telomere position effect and compensatory upregulation of hemizygous genes. …”

Telomerase and cells youth. by Alexander Benavides Couto, Osvaldo Morales Mondeja

“…Telomerase is an enzyme formed by a protein-ribonucleic acid complex that allows telomere enlargement, non codifying DNA structures. …”
Get full text

Telomerase and cells youth. by Alexander Benavides Couto, Osvaldo Morales Mondeja

“…Telomerase is an enzyme formed by a protein-ribonucleic acid complex that allows telomere enlargement, non codifying DNA structures. …”
Get full text

Avascular Peripheral Retina in Infants by Şengül Özdek, Ece Özdemir Zeydanlı, Caroline Baumal, Sandra Hoyek, Nimesh Patel, Audina Berrocal, Ashley Lopez-Cañizares, Hasenin Al-Khersan, Shunji Kusaka, Fukutaro Mano, Subhadra Jalali, Domenico Lepore, Solmaz Akar

“…In this review, key features of each disease in the differential diagnosis, from retinopathy of prematurity, familial exudative vitreoretinopathy, Coats disease, incontinentia pigmenti, Norrie disease, and persistent fetal vasculature, to other rare hematologic conditions and telomere disorders, will be discussed by expert ophthalmologists in the field.…”
Get full text

RTEL1 is upregulated in gastric cancer and promotes tumor growth by Chunyu Yang, Suzeng Wang, Ge Gao, Peiwen Xu, Mengyuan Qian, Yuan Yin, Surui Yao, Zhaohui Huang, Zehua Bian

“…Regulator of Telomerase Length 1 (RTEL1) has been found to maintain telomere stability through its helicase activity, facilitating telomere reconstruction and repair. …”
Get full text

Validation of whole genome sequencing from dried blood spots by Pooja Agrawal, Shanmukh Katragadda, Arun K. Hariharan, Vijayashree Gauribidanur Raghavendrachar, Arunika Agarwal, Rashmi Dayalu, Disha Awasthy, Sanjay C. Sharma, Yasodha Kannan Sivasamy, P. Lakshmana, Ashwini Shanmugam, Vamsi Veeramachaneni, Vaijayanti Gupta, B. P. Vani, Lekha Subaiya, T. S. Syamala, Ramesh Hariharan, Vijay Chandru, David E. Bloom

“…Telomere length estimates in most DBS samples were on par with those from venous blood. …”
Get full text

A high-quality chromosome-level genome assembly of the traditional Chinese medicinal herb Zanthoxylum nitidum by Yanxia Zhu, Guiyu Tan, Qingsong Dong, Baoyou Huang, Yude Peng, Jianping Jiang

“…Among these, 26 chromosomes achieved telomere-to-telomere assembly, and 11 chromosomes were gap-free. …”
Get full text

Assessment of in vitro aging of mesenchymal stem cell by M Mohyeddin Bonab, K Alimoghaddam, F Talebian, S.H Ghaffari, A Ghavamzadeh, B Nikbin

“…The average number of PD decreased from 7.7 to 1.2 in the 10th passage. The mean telomere length decreased from 9.19 Kbp to 8.7 kbp in the 9th passage. …”
Get full text

GWAS advancements to investigate disease associations and biological mechanisms by Oluwaferanmi Omidiran, Aashna Patel, Sarah Usman, Ishani Mhatre, Habiba Abdelhalim, William DeGroat, Rishabh Narayanan, Kritika Singh, Dinesh Mendhe, Zeeshan Ahmed

“…This review provides an overview of GWAS and highlights recent advances in genetics that employ a range of methodologies, including whole‐genome sequencing (WGS), Mendelian randomisation (MR), the Pangenome's high‐quality Telomere‐to‐Telomere (T2T)‐CHM13 panel and the Human BioMolecular Atlas Program (HuBMAP), as potential enablers of current and future GWAS research. …”
Get full text

Allium cytogenetics: a critical review on the Indian taxa by Biplab Kumar Bhowmick, Sayantika Sarkar, Dipasree Roychowdhury, Sayali D. Patil, Manoj M. Lekhak, Deepak Ohri, Satyawada Rama Rao, S. R. Yadav, R. C. Verma, Manoj K. Dhar, S. N. Raina, Sumita Jha

“…The presence of a unique telomere sequence and its conservation in Allium sets this genus apart from all other Amaryllids and supports monophyletic origin. …”
Get full text

Case report: Germline POT1 mutation in a patient with GIST and lung adenocarcinoma by Stefania Martino, Simona De Summa, Brunella Pilato, Maria Digennaro, Letizia Laera, Stefania Tommasi, Margherita Patruno

“…The gene protection of telomere 1 (POT1) is involved in telomere maintenance and stability and plays a crucial role in the preservation of genomic stability. …”
Get full text