Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. by Selina E R Bopp, Micah J Manary, A Taylor Bright, Geoffrey L Johnston, Neekesh V Dharia, Fabio L Luna, Susan McCormack, David Plouffe, Case W McNamara, John R Walker, David A Fidock, Eros Lazzerini Denchi, Elizabeth A Winzeler

“…We observed 18 large-scale (>1 kb on average) deletions of telomere-proximal regions encoding multigene families, involved in immune evasion (9.5×10(-6) structural variants per base pair per generation). …”
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Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis. by Gokhan Yildiz, Ayca Arslan-Ergul, Sevgi Bagislar, Ozlen Konu, Haluk Yuzugullu, Ozge Gursoy-Yuzugullu, Nuri Ozturk, Cigdem Ozen, Hilal Ozdag, Esra Erdal, Sedat Karademir, Ozgul Sagol, Dilsa Mizrak, Hakan Bozkaya, Hakki Gokhan Ilk, Ozlem Ilk, Biter Bilen, Rengul Cetin-Atalay, Nejat Akar, Mehmet Ozturk

“…In HCC tumors and immortal cells genes involved in DNA repair, cell cycle, telomere extension and branched chain amino acid metabolism were up-regulated, whereas genes involved in cell signaling, as well as in drug, lipid, retinoid and glycolytic metabolism were down-regulated. …”
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Household and social characteristics associated with COVID-19 vaccine intent among Latino families in the San Francisco Bay Area by Janet M. Wojcicki, Milagro Escobar, Andrea DeCastro Mendez, Suzanna M. Martinez

“…Results Three hundred and nineteen families were surveyed from the Telomere at Birth (TAB), Hispanic Eating and Nutrition (HEN) and Latino Eating and Diabetes Cohort (LEAD). …”
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Array comparative genomic hybridisation-based identification of two imbalances of chromosome 1p in a 9-year-old girl with a monosomy 1p36 related phenotype and a family history of... by Fitzgibbon Gregory J, Clayton-Smith Jill, Banka Siddharth, Hamilton Susan J, Needham Margaret M, Dore Jonathan K, Miller Jake T, Pawson Gareth D, Gaunt Lorraine

“…A further 7% have interstitial deletions and a proportion have a derivative chromosome 1 where the 1p telomere is replaced by material from another chromosome, either as a result of a de-novo rearrangement or as a consequence of malsegregation of a balanced parental translocation at meiosis.…”
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Characteristics and Functions of MYB (v-Myb avivan myoblastsis virus oncogene homolog)-Related Genes in <i>Arabidopsis thaliana</i> by Guofan Wu, Aohua Cao, Yuhan Wen, Wencheng Bao, Fawen She, Wangze Wu, Sheng Zheng, Ning Yang

“…The main functions of these <i>AtMYB</i>-related genes are light response and circadian rhythm regulation, root hair and trichome development, telomere DNA binding, and hormone response. From an analysis of cis-acting elements, it was found that the promoters of these genes contained light-responsive elements and plant hormone response elements. …”
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A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. by Christian Flueck, Richard Bartfai, Igor Niederwieser, Kathrin Witmer, Blaise T F Alako, Suzette Moes, Zbynek Bozdech, Paul Jenoe, Hendrik G Stunnenberg, Till S Voss

“…Genome-wide in silico mapping identified 777 putative binding sites, 94% of which cluster in heterochromatic domains upstream of subtelomeric var genes and in telomere-associated repeat elements. Immunofluorescence and chromatin immunoprecipitation (ChIP) assays revealed co-localization of PfSIP2-N with PfHP1 at chromosome ends. …”
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The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells by Liu AL, Wu JX, Li AJ, Bi WX, Liu T, Cao LZ, Liu YH, Dong L

“…Ailing Liu,1,2,* Jinxiang Wu,1,* Aijun Li,2 Wenxiang Bi,3 Tian Liu,1 Liuzhao Cao,1 Yahui Liu,1 Liang Dong1 1Department of Pulmonary Diseases, Qilu Hospital, Shandong University, Jinan, Shandong, People&rsquo;s Republic of China; 2Department of Pulmonary Diseases, Weihai Municipal Hospital, Weihai, Shandong, People&rsquo;s Republic of China; 3Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong, People&rsquo;s Republic of China *These authors contributed equally to this work Objectives: Cellular senescence is a state of irreversible growth arrest induced either by telomere shortening (replicative senescence) or stress. …”
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Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells by Joëlle El Hajj, Eric Nguyen, Qingyuan Liu, Claire Bouyer, Eric Adriaenssens, George Hilal, Evelyne Ségal-Bendirdjian

“…Telomerase activity was quantified by quantitative telomeric repeats amplification protocol (qTRAP). In vitro and in vivo assays were performed to investigate H19 function on telomerase expression and activity. …”
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Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence. by Fei Ye, Yibei Zhang, Yue Liu, Kazunari Yamada, Jonathan L Tso, Jimmy C Menjivar, Jane Y Tian, William H Yong, Dörthe Schaue, Paul S Mischel, Timothy F Cloughesy, Stanley F Nelson, Linda M Liau, William McBride, Cho-Lea Tso

“…Moreover, many upregulated genes highlighted maintenance and repair activities, including detoxifying lipid peroxidation products, activating lysosomal autophagy/ubiquitin-proteasome pathways, and enhancing telomere maintenance and DNA repair, closely resembling the anti-aging effects of caloric/glucose restriction (CR/GR), a nutritional intervention that is known to increase lifespan and stress resistance in model organisms. …”
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Karyotype Analysis of Diploid and Spontaneously Occurring Tetraploid Blood Orange [Citrus sinensis (L.) Osbeck] Using Multicolor FISH With Repetitive DNA Sequences as Probes by Honghong Deng, Zexi Cai, Suqiong Xiang, Qigao Guo, Wei Huang, Guolu Liang

“…In the present study, an integrated karyotype of blood orange was constructed using sequential multicolor fluorescence in situ hybridization (FISH) with four satellite repeats, two ribosomal DNAs (rDNAs), a centromere-like repeat and an oligonucleotide of telomere repeat (TTTAGGG)3 as probes. Satellite repeats were preferentially located at the terminal regions of the chromosomes of blood orange. …”
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Ultra-sensitive detection of Plasmodium falciparum by amplification of multi-copy subtelomeric targets. by Natalie Hofmann, Felista Mwingira, Seif Shekalaghe, Leanne J Robinson, Ivo Mueller, Ingrid Felger

“…<h4>Methods and findings</h4>Two quantitative PCR (qPCR) assays were developed for ultra-sensitive detection of Plasmodium falciparum, targeting the high-copy telomere-associated repetitive element 2 (TARE-2, ∼250 copies/genome) and the var gene acidic terminal sequence (varATS, 59 copies/genome). …”
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3548 De novo germline variants in Histone 3 Family 3A (H3F3A) and Histone 3 Family 3B (H3F3B) cause a severe neurodegenerative disorder and functional effects unique from their som... by Divya R Nair, Elizabeth Bhoj

“…Histone 3 Family 3 (H3F3) histones (H3.3), encoded by H3F3A and H3F3B, mark active genes, maintain epigenetic memory, and maintain heterochromatin and telomeric integrity. Specific somatic mutations in H3F3A and H3F3B have been strongly associated with pediatric glia and other tumors, but no germline mutations have been reported. …”
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A Clinical and Genetic Review of Aniridia by Reza Jafari, Ahmad Ahmadzadeh Amiri

“…Aniridia has been shown to be associated with mutations in the PAX6 gene, located on chromosome 11p13, telomeric to the Wilms’ tumor predisposition gene (WT1). …”
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Basic cytogenetics and physical mapping of ribosomal genes in four Astyanax species (Characiformes, Characidae) collected in Middle Paraná River, Iguassu National Park: considerati... by Leonardo Paiz, Lucas Baumgärtner, Weferson Júnio da Graça, Vladimir Margarido

“…Distinct distribution patterns of heterochromatin were observed for karyotypes of all species, with the exception of the first acrocentric chromosome pair characterized by centromeric, interstitial-proximal and telomeric blocks of heterochromatin on the long arm, which may represent homeology between karyotypes of A. abramis and A. asuncionensis. …”
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Exploring the G-quadruplex binding and unwinding activity of the bacterial FeS helicase DinG by Elisa De Piante, Federica D’Aria, Luisa M. R. Napolitano, Jussara Amato, Simone Pirrello, Silvia Onesti, Concetta Giancola

“…A series of G4-rich sequences from different genomic locations (promoter and telomeric regions), able to form unimolecular G4 structures with diverse topologies, were analyzed (c-KIT1, KRAS, c-MYC, BCL2, Tel23, T30695, Zic1). …”
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Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans. by Shanthi Duraimani, Robert H Schneider, Otelio S Randall, Sanford I Nidich, Shichen Xu, Muluemebet Ketete, Maxwell A Rainforth, Carolyn Gaylord-King, John W Salerno, John Fagan

“…Psychosocial stress, lifestyle and telomere dysfunction contribute to the pathogenesis of hypertension and cardiovascular disease. …”
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Immunohistochemical evaluation of salivary gland tumors differentiation and proliferation by using calponin and telomerase by Srwsht Saeed Abdulrahman, Dena Nadhim Mohammad, Marwa Abdul–Salam Hamied, Mardin Othman Abdulqadir

“…Telomerase is a ribonucleoprotein that adds telomere repeats at the end of chromosomes in order to prevent replicative senescence. …”
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Characterization of Stress Responses in a <em>Drosophila</em> Model of Werner Syndrome by Derek G. Epiney, Charlotte Salameh, Deirdre Cassidy, Luhan T. Zhou, Joshua Kruithof, Rolan Milutinović, Tomas S. Andreani, Aaron E. Schirmer, Elyse Bolterstein

“…Recent research has shown that <i>WRN</i> mutations contribute to multiple hallmarks of aging including genomic instability, telomere attrition, and mitochondrial dysfunction. …”
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Selective Binding and Redox-Activity on Parallel G-Quadruplexes by Pegylated Naphthalene Diimide-Copper Complexes by Valentina Pirota, Enrico Lunghi, Alessandra Benassi, Emmanuele Crespan, Mauro Freccero, Filippo Doria

“…In the present study, the presence of protonable moieties and the copper(II) cavity, increases the binding affinity and specificity of these two NDIs for a telomeric RNA-G4. Once defined the copper coordination relationship and binding constants by competition titrations, ability in G4 stabilization, and ROS-induced cleavage were analyzed. …”
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High-resolution genotyping and mapping of recombination and gene conversion in the protozoan <it>Theileria parva</it> using whole genome sequencing by Henson Sonal, Bishop Richard P, Morzaria Subhash, Spooner Paul R, Pelle Roger, Poveda Lucy, Ebeling Martin, Küng Erich, Certa Ulrich, Daubenberger Claudia A, Qi Weihong

“…Previously unrecognized COs in sub-telomeric regions were detected. About 50% of CO breakpoints were accompanied by gene conversion events. …”
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