Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei by Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover

“…Here, we have disrupted monoallelic VSG expression by stably expressing a second telomeric VSG from a ribosomal locus. We found that cells expressing two VSGs contained one VEX2 focus that was significantly larger in size than the wild-type cells; this therefore suggests the ectopic VSG is expressed from the same nuclear position as the active BES. …”
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The Role of microRNAs in Organismal and Skin Aging by Marta Gerasymchuk, Viktoriia Cherkasova, Olga Kovalchuk, Igor Kovalchuk

“…Dermal fibroblasts also expressed increased the levels of the biomarkers of aging that affect telomere maintenance and all phases of the cellular life cycle, such as let-7, miR-23a-3p, 34a-5p, miR-125a, miR-181a-5p, and miR-221/222-3p. …”
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Prolonged repeated inseminations trigger a local immune response and accelerate aging of the uterovaginal junction in turkey hens by Sunantha Kosonsiriluk, Kent M. Reed, Sally L. Noll, Ben W. Wileman, Marissa M. Studniski, Kahina S. Boukherroub

“…In the semen-inseminated group, the UVJ exhibited advanced aging at the late laying stage, evidenced by reduced telomere maintenance and translation processes. The results from this study provide valuable insights into the alteration of the UVJ function in response to the presence of sperm at different stages of production and throughout the production cycle. …”
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Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen <italic toggle="yes">Cryptococcus neoformans</ita... by Vikas Yadav, Kaustuv Sanyal

“…In ascomycetous yeast species, the role of the LINC complex in spindle pole body function and telomere clustering during meiosis has been determined. …”
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Multiple Loci within the major histocompatibility complex confer risk of psoriasis. by Bing-Jian Feng, Liang-Dan Sun, Razieh Soltani-Arabshahi, Anne M Bowcock, Rajan P Nair, Philip Stuart, James T Elder, Steven J Schrodi, Ann B Begovich, Gonçalo R Abecasis, Xue-Jun Zhang, Kristina P Callis-Duffin, Gerald G Krueger, David E Goldgar

“…Adjusting for HLA-Cw*0602, there were two remaining association signals: one demonstrated by rs2073048 (p = 2 x 10(-6), OR = 0.66), located within c6orf10, a potential downstream effecter of TNF-alpha, and one indicated by rs13437088 (p = 9 x 10(-6), OR = 1.3), located 30 kb centromeric of HLA-B and 16 kb telomeric of MICA. When HLA-Cw*0602, rs2073048, and rs13437088 were all included in a logistic regression model, each of them was significantly associated with disease (p = 3 x 10(-47), 6 x 10(-8), and 3 x 10(-7), respectively). …”
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Histone Methyltransferase Dot1L Contributes to RIPK1 Kinase‐Dependent Apoptosis in Cerebral Ischemia/Reperfusion by Jinghuan Wang, Wen Zhong, Haibi Su, Jie Xu, Di Yang, Xinhua Liu, Yi Zhun Zhu

“…Dot1L (disruptor of telomeric silencing 1‐like) is only known histone H3K79 methyltransferase. …”
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A linkage map of the Atlantic salmon (<it>Salmo salar</it>) based on EST-derived SNP markers by Kjøglum Sissel, Berg Paul R, Baranski Matthew, Hayes Ben, Moen Thomas, Koop Ben F, Davidson Willie S, Omholt Stig W, Lien Sigbjørn

“…The female map is likely to have close to full genome coverage, while the majority of male linkage groups probably lack markers in telomeric regions where male recombination events occur. …”
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Comparative expression profiling of <it>E. coli </it>and <it>S. aureus </it>inoculated primary mammary gland cells sampled from cows with different genetic predispositions for soma... by Ponsuksili Siriluck, Kühn Christa, Wellnitz Olga, Griesbeck-Zilch Bettina, Repsilber Dirk, Hartmann Anja, Brand Bodo, Meyer Heinrich HD, Schwerin Manfred

“…</p> <p>Methods</p> <p>Primary bovine mammary gland epithelial cells (pbMEC) were sampled from the udder parenchyma of cows selected for high and low mastitis susceptibility by applying a marker-assisted selection strategy considering QTL and molecular marker information of a confirmed QTL for SCS in the telomeric region of BTA18. The cells were cultured and subsequently inoculated with heat-inactivated mastitis pathogens <it>Escherichia coli </it>and <it>Staphylococcus aureus</it>, respectively. …”
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Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized by Jelinsky Scott A, Whitley Maryann Z, Garbe James C, Saraf Katie, Tunkey Chris, Lee Jee, Li Jian-Liang, Pan Jing, Li Yizheng, Stampfer Martha R, Haney Steven A

“…Finite lifespan HMEC overcome an Rb-mediated stress-associated senescence barrier (stasis), and a stringent, telomere-length dependent, barrier (agonescence or crisis, depending on p53 status). …”
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Genetic Diversity, Population Structure, and Linkage Disequilibrium of Pearl Millet by Desalegn D. Serba, Kebede T. Muleta, Paul St. Amand, Amy Bernardo, Guihua Bai, Ramasamy Perumal, Elfadil Bashir

“…By mapping the GBS reads to the reference genome sequence, 82,112 genome‐wide SNPs were discovered. The telomeric regions of the chromosomes have the higher SNP density than in pericentromeric regions. …”
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DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation by Thomas Liontis, Karisma Verma, Alla Grishok

“…Methylation of histone H3 at lysine 79 (H3K79) is conserved from yeast to humans and is accomplished by Dot1 (disruptor of telomeric silencing-1) methyltransferases. The C. elegans enzyme DOT-1.1 and its interacting partners are similar to the mammalian DOT1L (Dot1-like) complex. …”
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Stem cells, senescence, neosis and self-renewal in cancer by Rajaraman Murali M, Guernsey Duane L, Rajaraman Rengaswami, Rajaraman Selva R

“…Senescence phenotype can be induced by (1) telomere attrition-induced senescence at the end of the cellular mitotic life span (MLS*) and (2) also by replication history-independent, accelerated senescence due to inadvertent activation of oncogenes or by exposure of cells to genotoxins. …”
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Karyotype variability in neotropical catfishes of the family Pimelodidae (Teleostei: Siluriformes) by Américo Moraes Neto, Maelin da Silva, Daniele Aparecida Matoso, Marcelo Ricardo Vicari, Mara Cristina de Almeida, Maria João Collares-Pereira, Roberto Ferreira Artoni

“…The analyzed species showed little amount of heterochromatin located preferentially in the centromeric and telomeric regions of some chromosomes. The nucleolus organizer regions activity (Ag-NORs) and the chromosomal location of ribosomal genes by fluorescent in situ hybridization (FISH), with 18S and 5S probes, showing only one chromosome pair marked bearer of ribosomal genes, the only exception was Pimelodus britskii that presented multiple NORs and syntenic location of the 18S and 5S probes. …”
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Immunohistochemical localization of hTERT protein in oral carcinogenesis by Kumar, S., Ismail, S.M., Zain, R.B., Abraham, M.T., Cheong, S.C.

“…Introduction: Human telomerase reverse transcriptase (hTERT) the catalytic subunit of telomerase is associated with cellular immortalization and tumorigenesis .In situ detection of hTERT using immunohistochemistry (IHC) allows localizing the hTERT- positive cells and also overcomes the limitation of requirement of fresh tissues for molecular techniques such as Telomeric Repeat Amplification Protocol (TRAP) for telomerase/ hTERT detection. …”
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Co-delivery of paclitaxel and temozolomide by CD133-B19 aptamer conjugated polyamidoamine dendrimer to U87 stem cells by Barzegarbehrooz, Amir

“…Addedly, simultaneous shortened telomere length with down-regulation of DKC1 and TERT subunits of telomerase by drug-loaded Apt-NPs increased apoptosis. …”
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Subtelomeric Rearrangements in Patients with Recurrent Miscarriage by Amani Hajlaoui, Wafa Slimani, Molka Kammoun, Amira Sallem, Fathi El Amri, Anouar Chaieb, Mohamed Bibi, Ali Saad, Soumaya Mougou-Zerelli

“…Materials and Methods In this cross-sectional study, fluorescent in situ hybridization (FISH), based on ToTelVysion telomeric probes, was undertaken for 21 clinically normal couples exhibiting a “normal” karyotype with at least two abortions. …”
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Eotaxin-1/CCL11 promotes cellular senescence in human-derived fibroblasts through pro-oxidant and pro-inflammatory pathways by Patrícia Lavandoski, Vinícius Pierdoná, Rafael Moura Maurmann, Lucas Kich Grun, Fatima T. C. R. Guma, Florencia María Barbé-Tuana, Florencia María Barbé-Tuana

“…Recent studies also suggest that CCL11 is involved in the aging process, as it is upregulated in elderly, and correlated with shorter telomere length in leukocytes from asthmatic children. …”
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Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy by Satoshi Muraoka, Mark P. Jedrychowski, Harutsugu Tatebe, Annina M. DeLeo, Seiko Ikezu, Takahiko Tokuda, Steven P. Gygi, Robert A. Stern, Robert A. Stern, Tsuneya Ikezu, Tsuneya Ikezu

“…The identified protein molecules were significantly enriched for the extracellular exosome molecules, Alzheimer’s disease pathway and Age/Telomere Length ontology as determined by DAVID Gene Ontology analysis. …”
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Chromosome map of the Siamese cobra: did partial synteny of sex chromosomes in the amniote represent “a hypothetical ancestral super-sex chromosome” or random distribution? by Worapong Singchat, Rebecca E. O’Connor, Panupong Tawichasri, Aorarat Suntronpong, Siwapech Sillapaprayoon, Sunutcha Suntrarachun, Narongrit Muangmai, Sudarath Baicharoen, Surin Peyachoknagul, Lawan Chanhome, Darren Griffin, Kornsorn Srikulnath

“…In addition, hybridization signals of telomeric repeat (TTAGGG)n and six microsatellite repeat motifs ((AAGG)8, (AGAT)8, (AAAC)8, (ACAG)8, (AATC)8, and (AAAAT)6) were observed on NKAW, and most of these were also found on other amniote sex chromosomes. …”
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<i>In Vitro</i> Anticancer Properties of Novel Bis-Triazoles by Maysaa M. Saleh, Duaa A. Abuarqoub, Alaa M. Hammad, Md Shahadat Hossan, Najneen Ahmed, Nazneen Aslam, Abdallah Y. Naser, Christopher J. Moody, Charles A. Laughton, Tracey D. Bradshaw

“…Both ligands failed to induce senescence in the human melanoma cells after 72 h of treatment, corroborating their weak stabilization of the telomeric G4-DNA.…”
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