Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease by Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson

“…Steatosis-associated acetylation and γH2AX were enriched at gene clusters in telomere-proximal regions which contained HCC tumour suppressors in hepatocytes and human fatty livers. …”
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A cross strain Plasmodium falciparum microarray optimized for the transcriptome analysis of Plasmodium falciparum patient derived isolates by Amit Kumar Subudhi, P.A. Boopathi, Sheetal Middha, Jyoti Acharya, Sudha Narayana Rao, Raja C. Mugasimangalam, Paramendra Sirohi, Sanjay K. Kochar, Dhanpat K. Kochar, Ashis Das

“…The array contains probes representing genome sequences of two distinct geographical isolates (i.e. 3D7 and HB3) and sub-telomeric var gene sequences of a third isolate (IT4) known to adhere in culture condition. …”
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DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations by Yasmeen Niazi, Yasmeen Niazi, Yasmeen Niazi, Hauke Thomsen, Hauke Thomsen, Bozena Smolkova, Ludmila Vodickova, Ludmila Vodickova, Ludmila Vodickova, Sona Vodenkova, Michal Kroupa, Michal Kroupa, Veronika Vymetalkova, Veronika Vymetalkova, Veronika Vymetalkova, Alena Kazimirova, Magdalena Barancokova, Katarina Volkovova, Marta Staruchova, Per Hoffmann, Per Hoffmann, Markus M. Nöthen, Maria Dusinska, Ludovit Musak, Pavel Vodicka, Pavel Vodicka, Pavel Vodicka, Kari Hemminki, Kari Hemminki, Kari Hemminki, Asta Försti, Asta Försti, Asta Försti

“…DNA damage and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs). …”
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Integrating copy number data of 64 iAMP21 BCP-ALL patients narrows the common region of amplification to 1.57 Mb by Femke M. Hormann, Femke M. Hormann, Femke M. Hormann, Alex Q. Hoogkamer, Alex Q. Hoogkamer, Aurélie Boeree, Aurélie Boeree, Edwin Sonneveld, Edwin Sonneveld, Gabriele Escherich, Gabriele Escherich, Monique L. den Boer, Monique L. den Boer, Monique L. den Boer, Monique L. den Boer, Judith M. Boer, Judith M. Boer

“…This region is located telomeric from, but not including, RUNX1, which is the locus commonly used to diagnose iAMP21. …”
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Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress by Li Liu, Jiri Veis, Wolfgang Reiter, Edwin Motari, Catherine E. Costello, John C. Samuelson, Gustav Ammerer, David E. Levin

“…Pkc1 undergoes hyper-phosphorylation specifically in response to genotoxic stress; we have found that this requires the DNA damage checkpoint kinases Mec1 (Mitosis Entry Checkpoint) and Tel1 (TELomere maintenance), but not their effector kinases. …”
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A muscadine locus confers resistance to predominant species of grapevine root-knot nematodes (<i>Meloidogyne</i> spp.) including virulent populations by Daniel Esmenjaud, Mohamed Youssef Banora, Ulysse Julien-Portier, Maria-Das-Dores Lafargue, Jean-Pascal Tandonnet, Bernadette Rubio, Andrew Walker, Cyril Van Ghelder, Nathalie Ollat

“…This dominant gene, referred to as MsppR1, is linked to the telomeric QTL XiR4 for X. index resistance from the same source. …”
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KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors by Claudia Alicata, Elham Ashouri, Elham Ashouri, Elham Ashouri, Elham Ashouri, Neda Nemat-Gorgani, Neda Nemat-Gorgani, Neda Nemat-Gorgani, Lisbeth A. Guethlein, Lisbeth A. Guethlein, Wesley M. Marin, Sudan Tao, Sudan Tao, Lorenzo Moretta, Jill A. Hollenbach, John Trowsdale, James A. Traherne, Abbas Ghaderi, Peter Parham, Peter Parham, Paul J. Norman, Paul J. Norman, Paul J. Norman

“…We also identified 170 centromeric and 94 telomeric haplotypes, and 15 different KIR haplotypes carrying either a deletion or duplication encompassing one or more complete KIR genes. …”
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Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease by Eleonora Cianflone, Michele Torella, Flavia Biamonte, Antonella De Angelis, Konrad Urbanek, Francesco S. Costanzo, Marcello Rota, Georgina M. Ellison-Hughes, Daniele Torella

“…Replicative senescence is mainly executed by telomere shortening, the activation of the p53/p16^INK4/Rb molecular pathways, and chromatin remodeling. …”
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Review of Mendelian Randomization Studies on Endometrial Cancer by Jian-Zeng Guo, Jian-Zeng Guo, Qi-Jun Wu, Qi-Jun Wu, Qi-Jun Wu, Fang-Hua Liu, Fang-Hua Liu, Chang Gao, Chang Gao, Ting-Ting Gong, Gang Li

“…The results of MR studies on EC showed that type 2 diabetes, uterine fibroids, higher body mass index, higher plasminogen activator inhibitor-1 (PAI-1), higher fasting insulin, early insulin secretion, longer telomere length, higher testosterone and higher plasma cortisol levels are associated with increased risk of EC. …”
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The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study by Henrik Dobewall, Henrik Dobewall, Liisa Keltikangas-Järvinen, Saara Marttila, Saara Marttila, Pashupati P. Mishra, Pashupati P. Mishra, Aino Saarinen, C. Robert Cloninger, Igor Zwir, Igor Zwir, Mika Kähönen, Mikko Hurme, Olli Raitakari, Olli Raitakari, Olli Raitakari, Terho Lehtimäki, Terho Lehtimäki, Mirka Hintsanen

“…Epigenetic age acceleration and telomere length were measured with five DNA methylation (DNAm) indicators (DNAmAgeHorvath, IEAA_Hannum, EEAA_Hannum, DNAmPhenoAge, and DNAmTL) based on blood drawn in 2011. …”
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T-Cell Composition of the Lymph Node Is Associated with the Risk for Early Rejection after Renal Transplantation by Burç Dedeoglu, Nicolle H. R. Litjens, Annelies E. de Weerd, Frank JMF. Dor, Mariska Klepper, Derek Reijerkerk, Carla C. Baan, Michiel G. H. Betjes

“…However, to date no data are present on LN T-cell subsets and the risk for acute rejection after kidney transplantation.MethodsT cells from LNs of ESRD patients were analyzed for frequency of recent thymic emigrants, relative telomere length, expression of differentiation markers, and were related to the development of early acute rejection (EAR), occurring within 3 months after renal transplantation (RT). …”
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Molecular Characterization of Human Lymph Node Stromal Cells During the Earliest Phases of Rheumatoid Arthritis by Emmanuel Karouzakis, Janine Hähnlein, Janine Hähnlein, Cristoforo Grasso, Cristoforo Grasso, Johanna F. Semmelink, Johanna F. Semmelink, Paul P. Tak, Paul P. Tak, Paul P. Tak, Paul P. Tak, Danielle M. Gerlag, Danielle M. Gerlag, Steffen Gay, Caroline Ospelt, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen

“…In RA LNSCs a significant enrichment was observed for genes involved in cytokine signaling, hemostasis and packaging of telomere ends. In contrast, in RA-risk LNSCs pathways in cancer (cell cycle related genes) were differentially expressed compared with HC, which could be validated in vitro using a proliferation assay, which indicated a slower proliferation rate. …”
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Association of Functional Polymorphisms of KIR3DL1/DS1 With Behçet's Disease by Ángel Castaño-Núñez, Marco-Antonio Montes-Cano, José-Raúl García-Lozano, Norberto Ortego-Centeno, Francisco-José García-Hernández, Gerard Espinosa, Genaro Graña-Gil, Juan Sánchez-Bursón, María-Rosa Juliá, Roser Solans, Ricardo Blanco, Ana-Celia Barnosi-Marín, Ricardo Gómez de la Torre, Patricia Fanlo, Mónica Rodríguez-Carballeira, Luis Rodríguez-Rodríguez, Teresa Camps, Santos Castañeda, Juan-Jose Alegre-Sancho, Javier Martín, María-Francisca González-Escribano

“…KIR3DL1*004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. …”
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Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma by Juan Feng, Yang Lan, Feng Liu, Ye Yuan, Jia Ge, Sen Wei, Hu Luo, Jianjun Li, Tao Luo, Xiuwu Bian

“…Abstract The genomic instability (GI) /homologous recombination deficiency (HRD) score, calculated as the sum of the events of loss of heterozygosity (LOH), large-scale state transition (LST) and telomere allele imbalance (TAI), is used to guide the choice of treatment in several cancers, but its relationship with genomic features, clinicopathological characteristics and prognosis in lung cancer is poorly understood, which could lead to population bias in prospective studies. …”
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Rapid identification of Psathyrostachys huashanica Keng chromosomes in wheat background based on ND-FISH and SNP array methods by Jia-chuang LI, Jiao-jiao LI, Li ZHAO, Ji-xin ZHAO, Jun WU, Xin-hong CHEN, Li-yu ZHANG, Pu-hui DONG, Li-ming WANG, De-hui ZHAO, Chun-ping WANG, Yu-hui PANG

“…Among them, HS-TZ3 and HS-TZ4 could specifically hybridize with P. huashanica chromosomes, mainly in the telomere area, and HS-CHTZ5 could hybridize with the chromosomal centromere area. …”
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MAT2A as Key Regulator and Therapeutic Target in <i>MLL</i>r Leukemogenesis by Kathy-Ann Secker, Bianca Bloechl, Hildegard Keppeler, Silke Duerr-Stoerzer, Hannes Schmid, Dominik Schneidawind, Johan Jeong, Thomas Hentrich, Julia M. Schulze-Hentrich, Corina Schneidawind

“…Moreover, the combinational treatment of PF-9366 with chemotherapy or targeted therapies against the SAM-dependent methyltransferases, disruptor of telomeric silencing 1 like (DOT1L) and protein arginine methyltransferase 5 (PRMT5), revealed even more pronounced effects. …”
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Case report: atypical Silver-Russell syndrome patient with hand dystonia: the valuable support of the consensus statement to the wide syndromic spectrum by Alessandro Vimercati, Pierpaola Tannorella, Eleonora Orlandini, Luciano Calzari, Mirella Moro, Sara Guzzetti, Angelo Selicorni, Milena Crippa, Lidia Larizza, Maria Teresa Bonati, Silvia Russo

“…The IGF2 and adjacent H19 are the imprinted genes of the telomeric cluster in the 11p15 chromosomal region regulated by differentially methylated regions (DMRs) or imprinting centers (ICs): H19/IGF2:IG-DMR (IC1). …”
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A near complete genome for goat genetic and genomic research by Ran Li, Peng Yang, Xuelei Dai, Hojjat Asadollahpour Nanaei, Wenwen Fang, Zhirui Yang, Yudong Cai, Zhuqing Zheng, Xihong Wang, Yu Jiang

“…Saanen_v1 displays a high level of completeness thanks to the presence of centromeric and telomeric repeats at the proximal and distal ends of two-thirds of the autosomes, and a much reduced number of gaps (169 vs. 773). …”
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Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade by Chang Youp Ok, Sera Park, Hye-Ock Jang, Moon-Kyoung Bae, Soo-Kyung Bae

“…Moreover, visfatin-induced senescence was associated with excessive ROS production; NADPH consumption; telomere DNA damage induction; interleukin (IL)-1β, IL-6, IL-8, cyclooxygenase-2, and tumor necrosis factor-α upregulation; and nuclear factor-κB and mitogen-activated protein kinase activation. …”
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A pro-oxidant combination of resveratrol and copper down-regulates multiple biological hallmarks of ageing and neurodegeneration in mice by Kavita Pal, Gorantla V. Raghuram, Jenevieve Dsouza, Sushma Shinde, Vishalkumar Jadhav, Alfina Shaikh, Bhagyeshri Rane, Harshali Tandel, Dipali Kondhalkar, Shahid Chaudhary, Indraneel Mittra

“…R–Cu treatment led to reduction of several biological hallmarks of ageing in brain cells which included telomere attrition, amyloid deposition, DNA damage, apoptosis, inflammation, senescence, aneuploidy and mitochondrial dysfunction. …”
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