Inherited bone marrow failure syndromes: phenotype as a tool for early diagnostic suspicion at a major reference center in Mexico by Paula Leal-Anaya, Paula Leal-Anaya, Paula Leal-Anaya, Tamara N. Kimball, Ana Lucia Yanez-Felix, Moisés Ó. Fiesco-Roa, Moisés Ó. Fiesco-Roa, Benilde García-de Teresa, Benilde García-de Teresa, Angélica Monsiváis, Rocío Juárez-Velázquez, Esther Lieberman, Camilo Villarroel, Emiy Yokoyama, Liliana Fernández-Hernández, Anet Rivera-Osorio, David Sosa, Maria Magdalena Ortiz Sandoval, Norma López-Santiago, Sara Frías, Sara Frías, Victoria del Castillo, Alfredo Rodríguez, Alfredo Rodríguez

“…Implementation of NGS and telomere length measurement are forthcoming measures to improve IBMFS diagnosis in Mexico.…”
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The nature and organization of satellite DNAs in Petunia hybrida, related, and ancestral genomes by Osamah Alisawi, Osamah Alisawi, Katja R. Richert-Pöggeler, J.S. (Pat) Heslop-Harrison, J.S. (Pat) Heslop-Harrison, J.S. (Pat) Heslop-Harrison, Trude Schwarzacher, Trude Schwarzacher, Trude Schwarzacher

“…PSAT1 is located at the ends of all chromosomes except the 45S rDNA bearing short arms of chromosomes II and III, and we classify it as a telomere associated sequence (TAS). It is the most abundant satellite repeat with over 300,000 copies, 0.2% of the genomes. …”
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High-grade B-cell lymphoma with 11q aberration in the HIV setting: a clinicopathological study of 10 cases and literature review by Jing Chang, Ying Liang, Yuxue Gao, Menghua Wu, Fudong Lv, Hui Liu, Lin Sun, Zhujun Yue, Lingjia Meng, Yulin Zhang, Mulan Jin

“…It lacks MYC translocation but carries proximal gains and/or telomeric losses of chromosome 11q. This rare type of B-cell lymphoma is less frequently reported in people living with HIV (PLWH), and its exact frequency remains unclear. …”
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Clinical, radiological and histopathological features of patients with familial pulmonary fibrosis by Hanna Jaula, Lauri Mattila, Elisa Lappi-Blanco, Johanna Salonen, Hannu Vähänikkilä, Lauri Ahvenjärvi, Jukka S. Moilanen, Outi Kuismin, Terttu Harju, Riitta Kaarteenaho

“…Rare genetic variants were found in 9 patients; these included telomerase reverse transcriptase (TERT, n = 6), telomerase RNA component (TERC, n = 2) and regulator of telomere elongation helicase 1 (RTEL1, n = 1). Half of the patients died (n = 29) or underwent lung transplantation (n = 5), with a median survival of 39.9 months. …”
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC by Lane, Keara M

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Characterisation of a cluster of novel genes in the human major histocompatibility complex by Olavesen, M

“…</p> <p>The G7 gene is a novel gene located 58kb telomeric of the HSP70-Hom locus. G7 has been sequenced at the cDNA and genomic levels. …”

Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells by Takaaki Murakami, Nobuya Inagaki, Hiroshi Kondoh, Hiroshi Kondoh

“…Cellular senescence is defined as a state of irreversible cell cycle arrest with concomitant functional decline. It is caused by telomere shortening or senescence-inducing stress. …”
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PRECISION MEDICINE IN CLL: TREATMENT BASED ON MOLECULAR PROFILES by Esra Terzi Demirsoy

“…CK is linked to advanced disease, unmutated IGHV, TP53 mutations, adverse FISH abnormalities, and telomere dysfunction. Even within the CK subgroup, heterogeneity exists in the number and type of aberrations. …”
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The effect of high polycyclic aromatic hydrocarbon exposure on biological aging indicators by Manuela Campisi, Giuseppe Mastrangelo, Danuta Mielżyńska-Švach, Mirjam Hoxha, Valentina Bollati, Andrea A. Baccarelli, Angela Carta, Stefano Porru, Sofia Pavanello

“…We explored whether polycyclic aromatic hydrocarbons (PAHs), excellent fossil and wood burning tracers, accelerate biological aging detected by lymphocytes DNA methylation age (DNAmAge) and telomere length (TL), early nuclear DNA (nDNA) hallmarks of non-mitotic and mitotic cellular aging, and mitochondrial DNA copy number (mtDNAcn). …”
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Cellular senescence of the long term culture human amnion mesenchymal stem cells (hamcs) by Fiona Macniesia Thomas

“…Thus, the aim of the study are: i) to determine the level of senescence in HAMCs at passage 5, 10 and 15 (P5, P10 and P15) through morphology changes of cells and the use of senescent-associated β-galactosidase (SA-β-Gal) assay; ii) to determine the expression of senescent-associated gene (p53, pRB, p21, p16 and GADD45) via reverse transcription polymerase chain reaction (RT-qPCR) at P5, P10 and P15; and iii)to determine the DNA damage level in HAMCs during long-term culture using comet assay, telomeric repeat amplification protocol (TRAP) and p53 mutation detection assay. …”
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High-Throughput Sequencing And Analysis Of'chromosome 1 Of Eimerl4 Tenella by Ling, King Hwa

“…GC skews were found to be correlated with the repeats rich regions of the chromosome. Telomeric sequence at both ends of the chromosome is derived as 'ITTAGGG / CCCTAAA with undefined real length. …”
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Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight by Johannes Schetelig, Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Falk Heidenreich, Jorinde D. Hoogenboom, Stephen R. Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A. A. Miranda, Alina Tanase, Liesbeth C. de Wreede, Vinzenz Lange, Alexander H. Schmidt, Alexander H. Schmidt, Jürgen Sauter, Joshua A. Fein, Yung-Tsi Bolon, Meilun He, Steven G. E. Marsh, Shahinaz M. Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer

“…Exploratory analyses in 1,939 patients (39%) who were transplanted from donors with homozygous centromeric (cen) or telomeric (tel) A or B motifs, showed that the donor cen B/B-tel A/A diplotype was associated with a trend to better event-free survival (HR 0.84, p=.08) and reduced risk of non-relapse mortality (NRM) (HR 0.65, p=.01). …”
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Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients by Anna Grigorevna Sorokina, Yana Arturovna Orlova, Olga Aleksandrovna Grigorieva, Ekaterina Sergeevna Novoseletskaya, Nataliya Andreevna Basalova, Natalya Andreevna Alexandrushkina, Maksim Aleksandrovich Vigovskiy, Karina Igorevna Kirillova, Alexander Vladimirovich Balatsky, Larisa Mihailovna Samokhodskaya, Natalya Vladimirovna Danilova, Uliana Denisovna Dyachkova, Victor Victorovich Kakotkin, David Albertovich Asratyan, Zhanna Alekseevna Akopyan, Anastasia Yurievna Efimenko

“…Isolated cells were analyzed using several senescent cells biomarkers such as telomere length and telomerase activity, proliferation rate, cell cycle inhibitor expression (p16 and p21), b-galactosidase activity, gH2AX expression. …”
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Decreased but persistent epigenetic age acceleration is associated with changes in T-cell subsets after initiation of highly active antiretroviral therapy in persons living with HI... by Mary E. Sehl, Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Fengxue Li, Joshua Zhang, Peter Langfelder, Peter Langfelder, Steve Horvath, Steve Horvath, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson

“…HIV infection is associated with accelerated epigenetic aging as measured using DNA methylation (DNAm)-based estimates of biological age and of telomere length (TL).MethodsDNAm levels (Infinium MethylationEPIC BeadChip) from peripheral blood mononuclear cells from 200 PLWH and 199 HIV-seronegative (SN) participants matched on chronologic age, hepatitis C virus, and time intervals were used to calculate epigenetic age acceleration, expressed as age-adjusted acceleration residuals from 4 epigenetic clocks [Horvath’s pan-tissue age acceleration residual (AAR), extrinsic epigenetic age acceleration (EEAA), phenotypic epigenetic age acceleration (PEAA), and grim epigenetic age acceleration (GEAA)] plus age-adjusted DNAm-based TL (aaDNAmTL). …”
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Recognition of nucleosomes by protein factors that regulate chromatin structure and dynamics by Lee, Phoi Leng

“…The SIRT6 protein is also involved in multiple signalling pathways, including DNA repair, telomere maintenance, glycolysis and inflammation. …”
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Chromatin topology defines cell identity and phenotypic transition in human cancer and fungal pathogen by Chen, Yao

“…Similar to C. albicans, the genome-wide chromatin contact map of C. tropicalis revealed strong centromere-centromere interactions as well as telomere-telomere interactions. We also identified a balanced translocation between one homolog of chromosome 1 and 4 in the diploid genome. …”
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Telomerase activity in patients with stage 2â5D chronic kidney disease by Veysel Kidir, Ayse Aynali, Atila Altuntas, Salih Inal, Buket Aridogan, Mehmet Tugrul Sezer

“…Recent studies support the hypothesis that common factors responsible for this phenomenon are cellular aging and telomere dysfunction. Objectives: The purpose of this study was to investigate the relation between telomerase activity and CKD stages. …”
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Integrated Genome-Wide Analysis of Gene Expression and DNA Copy Number Variations Highlights Stem Cell-Related Pathways in Small Cell Esophageal Carcinoma by Di Liu, Xinyan Xu, Junmiao Wen, Liyi Xie, Junhua Zhang, Yuxin Shen, Guoliang Jiang, Jiayan Chen, Min Fan

“…Functional annotation showed that genes associated with DNA replication, mitosis, cell cycle, DNA repair, telomere maintenance, RB, and p53 pathways were significantly altered in SCEC compared to corresponding noncancerous tissues (Benjamini p<0.05). …”
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Robertsonian chromosome polymorphism of Akodon molinae (Rodentia: Sigmodontinae): analysis of trivalents in meiotic prophase Polimorfismo cromosómico Robertsoniano de Akodon molina... by RAÚL FERNÁNDEZ-DONOSO, SOLEDAD BERRÍOS, JESUS PAGE, MARÍA S MERANI, MARTA S LIZARRALDE, LIDIA VIDAL-RIOJA, NESTOR O BIANCHI

“…The trivalent SC showed three telomeric ends, corresponding to arms: q1 and q1a; p1 and q1b; and p1a and p1b, with attachment plates to the nuclear envelope of normal organisation. …”
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