Regulation of gene expression during DNA damage response in Plasmodium falciparum by Gupta, Devendra Kumar

“…Although few focused studies on sub-telomeric virulence gene families have indicated the role of chromatin in regulating the differential gene expression. …”
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Microsatellite characterization and physiological changes of cryopreserved spermatozoa supplemented with antioxidants in malaysian mahseer, Tor tambra (Valenciennes, 1842) by Chew, Poh Chiang

“…The level of LPO and oxidative DNA damages after sperm cryopreservation was assessed by measuring malondialdehyde (MDA) content, 8-hydroxy-2’-deoxyguanosine (8-OHdG) concentration, DNA lesion analysis, relative sperm telomere length (STL) measurement and DNA fragmentation. …”
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Building a Better Defense: Expanding and Improving Natural Killer Cells for Adoptive Cell Therapy by Andreia Maia, Mubin Tarannum, Joana R. Lérias, Sara Piccinelli, Luis Miguel Borrego, Markus Maeurer, Rizwan Romee, Mireia Castillo-Martin

“…In conclusion, this review presents insights into the diverse strategies available for NK cell expansion, including the roles played by various cytokines, feeder cells, and culture material in influencing the activation phenotype, telomere length, and cytotoxic potential of expanded NK cells. …”
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The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness by Vijayalakshmi Kari, Sanjay Kumar Raul, Jana Maria Henck, Julia Kitz, Frank Kramer, Robyn Laura Kosinsky, Nadine Übelmesser, Wael Yassin Mansour, Jessica Eggert, Melanie Spitzner, Zeynab Najafova, Holger Bastians, Marian Grade, Jochen Gaedcke, Florian Wegwitz, Steven A. Johnsen

“…Abstract Background Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). …”
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Detection of chromosomal imbalances using combined MLPA kits in patients with syndromic intellectual disability by Sireteanu Adriana, Popescu Roxana, Braha Elena Emanuela, Bujoran Cornel, Butnariu Lăcrămioara, Caba Lavinia, Graur Elena, Gorduza Eusebiu Vlad, Grămescu Mihaela, Ivanov Iuliu Cristian, Pânzaru Monica, Rusu Cristina

“…Rezultatele anormale detectate de aceste kituri au fost caracterizate folosind kiturile MLPA corespunzătoare de urmărire (Telomere Follow-up set, P029-A1, P250-B2, ME028-B1). …”
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Full-Length Genome of an Ogataea polymorpha Strain CBS4732 ura3Δ Reveals Large Duplicated Segments in Subtelomeric Regions by Jia Chang, Jinlong Bei, Jinlong Bei, Qi Shao, Hemu Wang, Huan Fan, Tung On Yau, Tung On Yau, Wenjun Bu, Jishou Ruan, Dongsheng Wei, Shan Gao

“…Long terminal repeat retrotransposons (LTR-rts), rDNA, 5′ and 3′ telomeric, subtelomeric, low complexity and other repeat regions were exactly determined to improve the genome quality. …”
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Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria by Olusola Ajibaye, Olusola Ajibaye, Yetunde Adeola Olukosi, Eniyou C. Oriero, Mary Aigbiremo Oboh, Bamidele Iwalokun, Ikechukwu Chidiebere Nwankwo, Chinaza Favour Nnam, Olawunmi Victoria Adaramoye, Somadina Chukwemeka, Judith Okanazu, Eniafe Gabriel, Emmanuel Oluwadare Balogun, Emmanuel Oluwadare Balogun, Emmanuel Oluwadare Balogun, Alfred Amambua-Ngwa

“…Parasite detection was done by microscopy and molecular diagnostic approaches involving PCR amplification of genes for Pf18S rRNA, varATS, telomere-associated repetitive elements-2 (TARE-2). …”
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Inherited bone marrow failure syndromes: phenotype as a tool for early diagnostic suspicion at a major reference center in Mexico by Paula Leal-Anaya, Paula Leal-Anaya, Paula Leal-Anaya, Tamara N. Kimball, Ana Lucia Yanez-Felix, Moisés Ó. Fiesco-Roa, Moisés Ó. Fiesco-Roa, Benilde García-de Teresa, Benilde García-de Teresa, Angélica Monsiváis, Rocío Juárez-Velázquez, Esther Lieberman, Camilo Villarroel, Emiy Yokoyama, Liliana Fernández-Hernández, Anet Rivera-Osorio, David Sosa, Maria Magdalena Ortiz Sandoval, Norma López-Santiago, Sara Frías, Sara Frías, Victoria del Castillo, Alfredo Rodríguez, Alfredo Rodríguez

“…Implementation of NGS and telomere length measurement are forthcoming measures to improve IBMFS diagnosis in Mexico.…”
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The nature and organization of satellite DNAs in Petunia hybrida, related, and ancestral genomes by Osamah Alisawi, Osamah Alisawi, Katja R. Richert-Pöggeler, J.S. (Pat) Heslop-Harrison, J.S. (Pat) Heslop-Harrison, J.S. (Pat) Heslop-Harrison, Trude Schwarzacher, Trude Schwarzacher, Trude Schwarzacher

“…PSAT1 is located at the ends of all chromosomes except the 45S rDNA bearing short arms of chromosomes II and III, and we classify it as a telomere associated sequence (TAS). It is the most abundant satellite repeat with over 300,000 copies, 0.2% of the genomes. …”
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Characterization of the aldo-keto reductase 1C gene cluster on pig chromosome 10: possible associations with reproductive traits by Nonneman Dan J, Wise Tommy H, Ford J Joe, Kuehn Larry A, Rohrer Gary A

“…Quantitative trait loci (QTL) for age of puberty, nipple number and ovulation rate have been identified in Meishan crosses on pig chromosome 10q (SSC10) near the telomere, which is homologous to human chromosome 10p15 and contains an aldo-keto reductase (AKR) gene cluster with at least six family members. …”
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC by Lane, Keara M

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Characterisation of a cluster of novel genes in the human major histocompatibility complex by Olavesen, M

“…</p> <p>The G7 gene is a novel gene located 58kb telomeric of the HSP70-Hom locus. G7 has been sequenced at the cDNA and genomic levels. …”

Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells by Takaaki Murakami, Nobuya Inagaki, Hiroshi Kondoh, Hiroshi Kondoh

“…Cellular senescence is defined as a state of irreversible cell cycle arrest with concomitant functional decline. It is caused by telomere shortening or senescence-inducing stress. …”
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The effect of high polycyclic aromatic hydrocarbon exposure on biological aging indicators by Manuela Campisi, Giuseppe Mastrangelo, Danuta Mielżyńska-Švach, Mirjam Hoxha, Valentina Bollati, Andrea A. Baccarelli, Angela Carta, Stefano Porru, Sofia Pavanello

“…We explored whether polycyclic aromatic hydrocarbons (PAHs), excellent fossil and wood burning tracers, accelerate biological aging detected by lymphocytes DNA methylation age (DNAmAge) and telomere length (TL), early nuclear DNA (nDNA) hallmarks of non-mitotic and mitotic cellular aging, and mitochondrial DNA copy number (mtDNAcn). …”
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Cellular senescence of the long term culture human amnion mesenchymal stem cells (hamcs) by Fiona Macniesia Thomas

“…Thus, the aim of the study are: i) to determine the level of senescence in HAMCs at passage 5, 10 and 15 (P5, P10 and P15) through morphology changes of cells and the use of senescent-associated β-galactosidase (SA-β-Gal) assay; ii) to determine the expression of senescent-associated gene (p53, pRB, p21, p16 and GADD45) via reverse transcription polymerase chain reaction (RT-qPCR) at P5, P10 and P15; and iii)to determine the DNA damage level in HAMCs during long-term culture using comet assay, telomeric repeat amplification protocol (TRAP) and p53 mutation detection assay. …”
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High-Throughput Sequencing And Analysis Of'chromosome 1 Of Eimerl4 Tenella by Ling, King Hwa

“…GC skews were found to be correlated with the repeats rich regions of the chromosome. Telomeric sequence at both ends of the chromosome is derived as 'ITTAGGG / CCCTAAA with undefined real length. …”
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Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight by Johannes Schetelig, Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Falk Heidenreich, Jorinde D. Hoogenboom, Stephen R. Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A. A. Miranda, Alina Tanase, Liesbeth C. de Wreede, Vinzenz Lange, Alexander H. Schmidt, Alexander H. Schmidt, Jürgen Sauter, Joshua A. Fein, Yung-Tsi Bolon, Meilun He, Steven G. E. Marsh, Shahinaz M. Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer

“…Exploratory analyses in 1,939 patients (39%) who were transplanted from donors with homozygous centromeric (cen) or telomeric (tel) A or B motifs, showed that the donor cen B/B-tel A/A diplotype was associated with a trend to better event-free survival (HR 0.84, p=.08) and reduced risk of non-relapse mortality (NRM) (HR 0.65, p=.01). …”
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Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients by Anna Grigorevna Sorokina, Yana Arturovna Orlova, Olga Aleksandrovna Grigorieva, Ekaterina Sergeevna Novoseletskaya, Nataliya Andreevna Basalova, Natalya Andreevna Alexandrushkina, Maksim Aleksandrovich Vigovskiy, Karina Igorevna Kirillova, Alexander Vladimirovich Balatsky, Larisa Mihailovna Samokhodskaya, Natalya Vladimirovna Danilova, Uliana Denisovna Dyachkova, Victor Victorovich Kakotkin, David Albertovich Asratyan, Zhanna Alekseevna Akopyan, Anastasia Yurievna Efimenko

“…Isolated cells were analyzed using several senescent cells biomarkers such as telomere length and telomerase activity, proliferation rate, cell cycle inhibitor expression (p16 and p21), b-galactosidase activity, gH2AX expression. …”
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Recognition of nucleosomes by protein factors that regulate chromatin structure and dynamics by Lee, Phoi Leng

“…The SIRT6 protein is also involved in multiple signalling pathways, including DNA repair, telomere maintenance, glycolysis and inflammation. …”
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Chromatin topology defines cell identity and phenotypic transition in human cancer and fungal pathogen by Chen, Yao

“…Similar to C. albicans, the genome-wide chromatin contact map of C. tropicalis revealed strong centromere-centromere interactions as well as telomere-telomere interactions. We also identified a balanced translocation between one homolog of chromosome 1 and 4 in the diploid genome. …”
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