2,4 Dinitrophenol as Medicine by John G. Geisler

“…The “thalidomide babies„ became the case-in-point for the need of strict guidelines by the U.S. …”
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Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland by Panagiotis Samaras, Mario Bargetzi, Daniel Betticher, Michel Duchosal, Dominik Heim, Urs Hess, Nicolas Ketterer, Erika Lerch, Thomas Matthes, Ulrich Mey, Thomas Pabst, Christian Taverna, Thilo Zander, Christoph Renner

“… The availability of drugs such as thalidomide, bortezomib and lenalidomide changed the landscape in myeloma treatment and has extended the median survival up to 10 years with a substantial improvement in quality of life. …”
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Studier av årsaker til medfødte misdannelser basert på Medisinsk fødselsregister by Rolf T. Lie

“…This has dramatic background in the fact that it was the international epidemic of birth defects caused by the apparently harmless drug Thalidomide that lead to the establishment of the registry in 1967. …”
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Stop Abusing the Unborn by Abd Razak, Dzulkifli

“…Thus, there is a set of very stringent regulations that must be complied with before a drug could be marketed for use, especially to pregnant mothers. During the Thalidomide tragedy, involving a purported 'safe' drug, many expectant mothers learned a very painful lesson because their babies were exposed to its toxic effects. …”
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Efficacy of maintenance treatment in patients with multiple myeloma: a systematic review and network meta-analysis by Yongjin Zhi, Shuojing Bao, Jingcheng Mao, Gufan Chai, Jianfeng Zhu, Chengjiang Liu, Xi Chen

“…Maintenance therapy comprising lenalidomide-carfilzomib (OR ranged from 3.19 to 6.95), lenalidomide-prednisone (OR ranged from 2.62 to 4.44), bortezomib-thalidomide (OR ranged from 2.48 to 3.64), daratumumab (OR ranged from 2.0 to 2.98), lenalidomide (OR ranged from 1.4 to 3.19), ixazomib (OR ranged from 1.36 to 2.05), thalidomide (OR ranged from 1.5 to 1.86) demonstrated significant effects in prolonging PFS compared with placebo; Among the efficient therapies, lenalidomide-carfilzomib was significantly superior to lenalidomide (OR ranged from 2.18 to 2.20), daratumumab (OR ranged from 1.49 to 2.66) and ixazomib (OR ranged from 2.75 to 3.57).Conclusion Considering OS and PFS, lenalidomide-carfilzomib should be recommended as the best therapy. …”
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Clinical profiles and outcomes of young versus elderly patients with multiple myeloma: A retrospective observational study from a tertiary cancer center in South India by Angadi Veerendra, Nitesh Anand, Sachet Saxena, Manjunath Nandennavar, Shashidhar Vishvesh Karpurmath

“…In the overall population, the chemotherapy regimen, bortezomib + thalidomide + dexamethasone (VTd), led to a better complete response rate compared to thalidomide + dexamethasone (Td) (15 [57.7%] versus 3 [37.5%], respectively; P, 0.022. …”
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Historical perspective and advances in the treatment of multiple myeloma by Amir Harandi, Damian A. Laber

“…In the last decade, the development of new agents has progressed significantly. Thalidomide and its newer derivatives lenalidomide, bortezomib, and pegylated liposomal doxorubicin have drastically revolutionized treatment approaches. …”
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Long-term hematologic response after azacitidine treatment in a lower-risk myelodysplastic syndrome patient: A case report by Konstantinos Loukidis, Marcel Tschopp

“…After failure of erythropoietin and thalidomide, the patient received azacitidine and achieved hematological remission for 95 months. …”
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UNCONVENTIONAL PATTERN OF RESPONSE IN A METASTATIC MELANOMA PATIENT TREATED WITH IPILIMUMAB. by Francesco Spagnolo

“…In October the patient became metastatic and he underwent three different lines of traditional chemotherapy (Fotemustine, Dacarbazin and Carboplatin with Thalidomide) but each time a progression of the disease was noted. …”
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Reproductive medicine: still more ART than science? by Wilkinson, J, Bhattacharya, S, Duffy, J, Kamath, M, Marjoribanks, J, Repping, S, Vail, A, Van Wely, M, Farquhar, C

“…As a specialty, we have relied on investigations including X‐ray pelvimetry and antenatal stress tests, subjected innumerable women to stilboestrol and thalidomide, and have performed routine episiotomy in all primigravid women 1,. …”

Microbiological Isolation of Sporothrix Schenckii in an Immunocompromised Patient. A Case Report by Ledys Pérez Morales, Midiala Iglesias López, Odette Quiñones Cherta, Idalmis Reyes Rodríguez

“…We present the case of 67-year-old white patient of rural origin with a history of myelofibrosis that had evolved for ten years and was treated with thalidomide and prednisone. He was admitted to the University General Hospital of Cienfuegos in August 2013 because of skin lesions on the left cheek, chest and forearms. …”
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Integrating novel agents into multiple myeloma treatment – current status in Switzerland and treatment recommendations by C Taverna, M Bargetzi, D Betticher, J Gmür, M Gregor, U Hess, N Ketterer, E Lerch, T Matthes, U Mey, T Pabst, C Renner

“…The arrival of novel agents, especially thalidomide, bortezomib and lenalidomide, has expanded treatment options and patient outcomes are improving significantly. …”
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Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders by Fatemeh Salari, Mohammad Shahjahani, Seyed Ahmad Hosseini, Ali Dehghani Fard, Kaveh Jaseb

“…HbF inducers including hydroxyurea, histone deacetylase (HDAC) inhibitor agents such as sodium butyrate, azacitidine, decitabine and new immunomodulator drugs like pomalidomide, lenalidomide and thalidomide can reduce α-globin chain production in erythroid progenitors and improve α: β chain imbalance, the most crucial complication of β-thalassemia.Materials and Methods: In this article, we reviewed more than 40 articles published from 1979 to 2012 in the field of fetal hemoglobin augmentation.Results: Recent studies suggest the synergistic effect of drug combinations in efficient induction of fetal hemoglobin and gene over-expression.Conclusion: It seems that drugs which act with different molecular and epigenetic mechanisms have proper synergistic effects in fetal hemoglobin induction and gene over-expression…”
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How I manage frontline transplant-eligible multiple myeloma in Italy by Vittorio Montefusco, Giovanni Martinelli, Claudio Cerchione

“…The treatment of transplant-eligible multiple myeloma patients in Italy consists in an induction phase based on bortezomib plus thalidomide plus dexamethasone (VTd), followed by a single or tandem autologous stem cell transplantation (ASCT), followed by lenalidomide maintenance. …”
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QSPR Study and Distance-Based New Topological Descriptors of Some Drugs Used in the COVID-19 Treatment by Vignesh Ravi, Natarajan Chidambaram, Özge Çolakoğlu, Hanan Ahmed, Subhasri Jaganathan, Jayasri Jaganathan

“…Antiviral drugs such as Arbidol, chloroquine, hydroxychloroquine, lopinavir, remdesivir, ritonavir, thalidomide, and theaflavin are used to treat COVID-19. …”
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Potential Mechanisms of Cancer-Related Hypercoagulability by Nicola J. Nasser, Jana Fox, Abed Agbarya

“…These include hormonal therapy (e.g., tamoxifen), chemotherapy (e.g., cisplatin, thalidomide and asparaginase), molecular targeted therapy (e.g., lenvatinib, osimertinib), and anti-angiogenesis monoclonal antibodies (e.g., bevacizumab and ramucirumab).…”
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POEMS syndrome: A rare cause of ascites and pelvic effusion by Jing Ma, Yi Chen, Xiaojin Qin, Xiaogang Liu, Ercui Li, Huijuan Fan, Yandong Xie, Xin Wang

“…The patient was treated with thalidomide and dexamethasone and showed a good clinical response.…”
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Ubiquitination and Ubiquitin-Like Modifications in Multiple Myeloma: Biology and Therapy by Matthias Wirth, Markus Schick, Ulrich Keller, Jan Krönke

“…Drugs modulating the ubiquitin–proteasome system, such as proteasome inhibitors and thalidomide analogs, are approved and highly effective drugs in multiple myeloma. …”
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Behçet's disease in Portugal. by P de Souza-Ramalho, M F D'Almeida, J P Freitas, J Pinto

“…Steroids, colchicine and thalidomide were the main form of treatment, for the patients in the Lisbon area, but in some cases chlorambucil, cyclophosphamide, azathioprine, cyclosporine-A, fibrinolytic therapy, plasmapheresis and isovolemic hemodilution were also used.…”
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Microbiological Isolation of Sporothrix Schenckii in an Immunocompromised Patient. A Case Report by Ledys Pérez Morales, Midiala Iglesias López, Odette Quiñones Cherta, Idalmis Reyes Rodríguez

“…We present the case of 67-year-old white patient of rural origin with a history of myelofibrosis that had evolved for ten years and was treated with thalidomide and prednisone. He was admitted to the University General Hospital of Cienfuegos in August 2013 because of skin lesions on the left cheek, chest and forearms. …”
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