A Look at the Importance of Chirality in Drug Activity: Some Significative Examples by Jessica Ceramella, Domenico Iacopetta, Angelica Franchini, Michele De Luca, Carmela Saturnino, Inmaculada Andreu, Maria Stefania Sinicropi, Alessia Catalano

“…The classical examples of spontaneous enantiomerization and severe toxicity related to chirality are represented by ibuprofen and thalidomide, respectively, but numerous other cases have been reported in the literature. …”
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Obat-Obat Dalam Kehamilan dan Persalinan by Perpustakaan UGM, i-lib

“…Based on the teratogenic property of drugs, they can be classified into three major divisions: 1. known teratogens such as thalidomide, anticancer drugs, certain hormones, sodium valproate and isotretionine, 2. probable teratogens such as anticonvulsant, tobacco, alcohol, lithium, warfarin, and 3. possible teratogens such as barbiturate, sulphonamide, certain an timalarials, oral an ndiabetics, LSD, certain antibiotics and some vaccines. …”

Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections. by Schütt, P, Brandhorst, D, Stellberg, W, Poser, M, Ebeling, P, Müller, S, Buttkereit, U, Opalka, B, Lindemann, M, Grosse-Wilde, H, Seeber, S, Moritz, T, Nowrousian, MR

“…Conventional-dose chemotherapy resulted in significantly reduced CD4+ and even further decline of CD4+/CD45RO+ and CD19+ cells, most notably in relapsed patients. Additional thalidomide treatment had no significant effects on these parameters. …”

Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma by Song, Y, Park, P, Wu, L, Ray, A, Picaud, S, Li, D, Wimalasena, V, Du, T, Filippakopoulos, P, Anderson, K, Qi, J, Chauhan, D

“…WL40 was synthesized by linking the Rpn13 covalent inhibitor RA190 with the cereblon (CRBN) binding ligand thalidomide. We show that WL40 binds to both Rpn13 and CRBN and triggers degradation of cellular Rpn13, and is therefore first-in-class in exploiting a covalent inhibitor for the development of degraders. …”

Everolimus therapy for progressive adrenocortical cancer by Fraenkel, M, Gueorguiev, M, Barak, D, Salmon, A, Grossman, AB, Gross, D

“…All had progressive disease (PD) despite treatment with mitotane and other treatment modalities (etoposide, doxorubicin, cis-platinum in 3/4 patients, further streptozotocin + 5-FU in 1/4 patients, further thalidomide therapy in 2/4 patients; 1 patient progressed on an IGF-R antagonist). …”

Everolimus therapy for progressive adrenocortical cancer. by Fraenkel, M, Gueorguiev, M, Barak, D, Salmon, A, Grossman, AB, Gross, D

“…All had progressive disease (PD) despite treatment with mitotane and other treatment modalities (etoposide, doxorubicin, cis-platinum in 3/4 patients, further streptozotocin + 5-FU in 1/4 patients, further thalidomide therapy in 2/4 patients; 1 patient progressed on an IGF-R antagonist). …”

Frequency of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients in Sari Imam Khomeini Hospital by Ramin Shekarriz, Javad Momenabadi, Reza Alizadeh-Navaei, Versa Omrani-Nava

“…Materials and methods: This longitudinal study was done in cancer patients receiving thalidomide derivatives, vinca alkaloids, taxanes, proteasome inhibitors, platinums, and microtubule destabilizers in Comprehensive Cancer Center at Sari Imam Khomeini Hospital (2021-2022). …”
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The Importance of Gender-Neutral Terminology in Risk Evaluation and Mitigation Strategy Programs: A Call to Action by Colin Burnette, William Smithy, Daniel Strock, Torunn E Sivesind, Robert Dellavalle

“…We propose that other REMS programs follow the standard set by the iPLEDGE system, including those for the medications thalidomide, acitretin, and mycophenolate mofetil, all of which currently have a similar taxonomy to that of the old iPLEDGE system. …”
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Isolated duodenal ischemia of unknown etiology: a case report by Elahe Meftah, Narjes Mohammadzadeh, Faeze Salahshour

“…He was diagnosed with myelodysplastic syndrome 7 years ago, for which he took thalidomide and erythropoietin as the main medications. …”
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Hereditary hemorrhagic telangiectasia associated with inherited thrombophilia by Roganović Branka, Obradović Slobodan, Micić Aleksandar, Petrović Stanko

“…Remission was achieved by thalidomide. The initial therapy for pulmonary thromboembolism included aspirin (that have an increased risk of bleeding), but aspirin had to be discontinued because of massive hematemesis. …”
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Systemic lupus erythematosus combined with Castleman disease and secondary paraneoplastic pemphigus: a case report by Xin Ma, Jiyuan Li, Linlin Fan, Hongwei Jiang, Gaishao Shi, Dongfeng Ge, Xiaofei Shi

“…She was treated with prednisone, hydroxychloroquine, leflunomide, thalidomide, and dressings. Pathological examination of the skin revealed PNP. …”
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UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader by Jaeyong Cho, Atsushi Miyagawa, Kazuki Yamaguchi, Wakana Abe, Yoji Tsugawa, Hatsuo Yamamura, Takeshi Imai

“…We identified that both glucose and UDP-glucose bind to glucokinase and that both uridine and UDP-glucose bind to cereblon in a similar way to thalidomide. From these results, UDP-glucose was identified as a molecular glue between cereblon and glucokinase. …”
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International Drug Safety Monitoring by A. S. Kazakov, E. V. Shubnikova, M. A. Darmostukova, I. I. Snegireva, G. V. Kutekhova, K. E. Zatolochina, N. Yu. Velts, D. A. Kaperko, Yu. V. Olefir

“…In the 1960s, following the Thalidomide Disaster, the World Health Organization (WHO) initiated the development of an international drug safety monitoring programme. …”
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GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes. by Kambis Sadeghi, Lukas Wisgrill, Isabelle Wessely, Susanne C Diesner, Simone Schüller, Celia Dürr, Armando Heinle, Monika Sachet, Arnold Pollak, Elisabeth Förster-Waldl, Andreas Spittler

“…We further analysed monocyte TLR and CD14 expression upon exposure to the IMID® immunomodulatory drug Pomalidomide (CC-4047), a Thalidomide analogue known to downregulate PU.1. Indeed, Pomalidomide in part reversed the GM-CSF-mediated effects. …”
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Interconnection between Cardiac Cachexia and Heart Failure—Protective Role of Cardiac Obesity by María Elena Soto, Israel Pérez-Torres, María Esther Rubio-Ruiz, Linaloe Manzano-Pech, Verónica Guarner-Lans

“…Several therapeutic procedures are discussed including exercise, nutritional proposals, myostatin antibodies, ghrelin, anabolic steroids, anti-inflammatory substances, beta-adrenergic agonists, medroxyprogesterone acetate, megestrol acetate, cannabinoids, statins, thalidomide, proteasome inhibitors and pentoxifylline. …”
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Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges by Alessandro Allegra, Giovanni Pioggia, Alessandro Tonacci, Caterina Musolino, Sebastiano Gangemi

“…This review also reports the rationale for a possible use of drugs commonly employed in neoplastic therapy, such as bevacizumab, ibrutinib, selinexor, thalidomide, carfilzomib, and PD-1 inhibitors, for the treatment of SARS-CoV-2 infection. …”
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Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients by Nicolette Tay, E-Liisa Laakso, Daniel Schweitzer, Raelene Endersby, Irina Vetter, Irina Vetter, Hana Starobova

“…Herein, we aim to provide an understanding of CIPN in the pediatric population and focus on the 6 main substance groups that frequently cause CIPN, namely the vinca alkaloids (vincristine), platinum-based antineoplastics (cisplatin, carboplatin and oxaliplatin), taxanes (paclitaxel and docetaxel), epothilones (ixabepilone), proteasome inhibitors (bortezomib) and immunomodulatory drugs (thalidomide). We discuss the clinical manifestations, assessments and diagnostic tools, as well as risk factors, pathophysiological processes and current pharmacological and non-pharmacological approaches for the prevention and treatment of CIPN.…”
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Refractory Hydroa Vacciniforme-Like Lymphoma: Biological Insights from Morphoproteomic Analysis by Rohit Goswamy, Helen Ajufo, Abhishek Maiti, Robert Brown, Harinder Juneja, Effrosyni Apostolidou

“…We report a case of a patient who developed hydroa vacciniforme-like lymphoma (HVLL, an EBV-peripheral T-cell lymphoma), refractory to multiple lines of systemic therapy including methotrexate, mycophenolate mofetil, dapsone, thalidomide, prednisone, and romidepsin. We conducted morphoproteomic analysis of the patient’s tumor which provided important biological insights. …”
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A method for human teratogen detection by geometrically confined cell differentiation and migration by Xing, Jiangwa, Toh, Yi-Chin, Xu, Shuoyu, Yu, Hanry

“…We not only could measure dose-dependent effects but also correctly classify species-specific drug (Thalidomide) and false negative drug (D-penicillamine) in the conventional mouse embryonic stem cell test. …”
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Presentation and survival of patients with severe acute kidney injury and multiple myeloma: a 20-year experience from a single centre. by Haynes, R, Read, S, Collins, G, Darby, S, Winearls, C

“…The advent of efficacious low toxicity chemotherapy (such as thalidomide and bortezomib) and new dialysis techniques to remove free light chains may radically alter the outcome of this group of patients.…”