Expansion of non-invasive prenatal screening to the screening of 10 types of chromosomal anomalies: a cost-effectiveness analysis by Julian Little, François Audibert, Sylvie Langlois, François Rousseau, Daniel Reinharz, Bounhome Soukkhaphone, Mohammad Baradaran, Ba Diep Nguyen, Leon Nshimyumukiza

“…Objectives To determine the cost-effectiveness of the addition of chromosomal anomalies detectable by non-invasive prenatal screening (NIPS), in a prenatal screening programme targeting common aneuploidies.Design, setting and participants A simulation study was conducted to study the addition of chromosomal anomalies detectable by NIPS (sex chromosome aneuploidies, 22q11.2 deletion syndrome, large deletion/duplication >7 Mb and rare autosomal trisomies) to five basic strategies currently aiming the common trisomies: three strategies currently offered by the public healthcare systems in Canada, whose first-tier test is performed with biochemical markers, and two programmes whose first-tier test consists of NIPS-based methods.Outcome measures The total number of cases of chromosomal anomalies detected and the costs related to the consumption of medical services.Results The most effective and the most cost-effective option in almost all prenatal screening strategies is the option that includes all targeted additional conditions. …”
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Recent changes to adult national immunization programs for pneumococcal vaccination in Europe and how they impact coverage: A systematic review of published and grey literature by Stuti Arya, Nicholas Norton, Puneet Kaushik, Agnes Brandtmüller, Eleana Tsoumani

“…Third, most health economic analyses assessing higher-valency PCVs for adults found its inclusion in NIPs cost-effective. Finally, higher coverage rates were seen in most cases where countries had expanded their NIPs to cover at-risk populations. …”
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Evaluation of procedural pain for neonates in a neonatal intensive care unit: a single-centre study by Yun Pan, Lingli Mei, Shuohui Chen, Xiaofei Chen, Feixiang Luo, Huaiyu Zhu, Qi Shu, Xiaoying Cheng, Yisheng Zhao

“…The clinical painful procedures experienced by 957 participants could be divided into three groups: severe pain (NIPS score 5–7: peripheral intravenous cannulation, arterial catheterisation, arterial blood sampling, peripherally inserted central catheter placement and nasopharyngeal suctioning), mild to moderate pain (NIPS score 3–4: finger prick, intramuscular injection, adhesive removal, endotracheal intubation suctioning, heel prick, lumbar puncture and subcutaneous injection) and no pain to mild pain (NIPS score 0–2: gastric tube insertion, enema and intravenous injection).Conclusions The neonatal pain response to clinical procedures in NICU had certain pattern and preintervention drug analgesia could be taken for painful procedures with clustered high NIPS pain scores. …”
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Long Term Survival after Cytoreductive Surgery Combined with Perioperative Chemotherapy in Gastric Cancer Patients with Peritoneal Metastasis by Yutaka Yonemura, Aruna Prabhu, Shouzou Sako, Haruaki Ishibashi, Akiyoshi Mizumoto, Nobuyuki Takao, Masumi Ichinose, Shunsuke Motoi, Yang Liu, Kazurou Nishihara, Andreas Brandl, Sachio Fushida

“…Both negative pre- and post-NIPS cytology was associated with significant favorable prognosis. …”
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Assessment of the comprehensiveness of paediatric national immunisation programmes in Europe: expert validation and future perspectives by Ugne Sabale, Janice Murtagh, James Cochrane, Danielle Riley, Richard Perry, Louise Heron, Paolo Bonanni, Jose Navarro Alonso, Juhani Eskola, Valerie Laigle

“…ABSTRACTBackground The breadth of protection of National Immunisation Programmes (NIPs) across Europe varies, however, this has not been assessed within published literature. …”
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Clinical Experience with Genome-Wide Noninvasive Prenatal Screening in a Large Cohort of Twin Pregnancies by Luigia De Falco, Giovanni Savarese, Pasquale Savarese, Nadia Petrillo, Monica Ianniello, Raffaella Ruggiero, Teresa Suero, Cosimo Barbato, Alessio Mori, Cristina Ramiro, Luigi Della Corte, Gabriele Saccone, Attilio Di Spiezio Sardo, Antonio Fico

“…All samples underwent an NIPS for common trisomies, with 61.5% of study participants choosing to undergo genome-wide NIPS for additional fetal anomalies (namely, rare autosomal aneuploidies and CNVs). …”
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Insights into non-informative results from non-invasive prenatal screening through gestational age, maternal BMI, and age analyses. by Juraj Gazdarica, Natalia Forgacova, Tomas Sladecek, Marcel Kucharik, Jaroslav Budis, Michaela Hyblova, Martina Sekelska, Andrej Gnip, Gabriel Minarik, Tomas Szemes

“…The discovery of cell-free fetal DNA fragments in the maternal plasma initiated a novel testing method in prenatal care, called non-invasive prenatal screening (NIPS). One of the limitations of NIPS is the necessity for a sufficient proportion of fetal fragments in the analyzed circulating DNA mixture (fetal fraction), otherwise, the sample is uninterpretable. …”
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Prenatal detection and molecular cytogenetic characterization of Xp deletion and Xq duplication: a case report and literature review by Qing Lin, Chunya Liang, Bole Du, Lijiao Li, Hong Li, Xiaolan Mai, Sheng Li, Wenyu Xu, Cunzhen Wu, Mi Zeng

“…In recent years, due to the high sensitivity and high specificity of NIPS, its application has gradually expanded from chromosome aneuploidy to CNV. …”
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Reanalysis of the Clinical and Economic Burden of Pneumococcal Disease Due to Serotypes Contained in Current and Investigational Pneumococcal Conjugate Vaccines in Children < 5 Age... by Xiuyan Li, Sophie Warren, Mark H. Rozenbaum, Johnna Perdrizet

“…The five countries with PCV10 NIPs bear a greater societal burden associated with PCV13 serotypes, whereas the residual societal burden in the eight countries with PCV13 NIPs was primarily attributable to non-PCV13 serotypes. …”
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Maternal and fetal factors influencing fetal fraction: A retrospective analysis of 153,306 pregnant women undergoing noninvasive prenatal screening by Cechuan Deng, Cechuan Deng, Jianlong Liu, Jianlong Liu, Sha Liu, Sha Liu, Hongqian Liu, Hongqian Liu, Ting Bai, Ting Bai, Xiaosha Jing, Xiaosha Jing, Tianyu Xia, Tianyu Xia, Yunyun Liu, Yunyun Liu, Jing Cheng, Jing Cheng, Xiang Wei, Xiang Wei, Lingling Xing, Lingling Xing, Yuan Luo, Yuan Luo, Quanfang Zhou, Quanfang Zhou, Qian Zhu, Qian Zhu, Shanling Liu, Shanling Liu

“…Fetal fraction refers to the proportion of cell-free fetal DNA in maternal plasma, which can influence the accuracy of NIPS. Elucidating the factors that influence fetal fraction can provide guidance for the interpretation of NIPS results and genetic counseling. …”
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Performance of Cell-Free DNA Screening for Fetal Common Aneuploidies and Sex Chromosomal Abnormalities: A Prospective Study from a Less Developed Autonomous Region in Mainland Chin... by Yunli Lai, Xiaofan Zhu, Sheng He, Zirui Dong, Yanqing Tang, Fuben Xu, Yun Chen, Lintao Meng, Yuli Tao, Shang Yi, Jiasun Su, Hongqian Huang, Jingsi Luo, Tak Yeung Leung, Hongwei Wei

“…To evaluate the performance of noninvasive prenatal screening (NIPS) in the detection of common aneuploidies in a population-based study, a total of 86,262 single pregnancies referred for NIPS were prospectively recruited. …”
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Timing for maximum anaesthetic effect of topical cream during early infant circumcision (EIC) in Rakai, Uganda by Stephen Kiboneka, Aggrey Anok, Regina Nakabuye, Silas Odiya, Julius Magembe, Rose Nazziwa, Charles Ddamulira, Andrew Mulooki, Ronald Moses Galiwango, Stephen Watya, Philip S. Li, Richard K. Lee, Ronald H. Gray, Godfrey Kigozi, Edward Nelson Kankaka

“…The response was measured using the Neonatal Infant Pain Scale (NIPS). We determined the onset and duration of anaesthesia (defined as <20% of infants with NIPS score >4) and maximum anaesthesia (defined as <20% of infants with NIPS score >2). …”
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The Annual Trends between Neurointerventional and Neurosurgical Procedures in Korea: Analysis using HIRA Data from 2010 to 2016 by Sang Hyun Suh

“…Especially, carotid artery stenting is rapidly increasing in secondary general hospitals, where more than 50% of these procedures were performed after 2014.ConclusionIn this study, we found that most of NIPs has increased annually over the past 7 years and that NIPs are rapidly replacing conventional surgical maneuvers in Korea.…”
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Preparation of Chemically Resistant Cellulose Benzoate Hollow Fiber Membrane via Thermally Induced Phase Separation Method by Shota Takao, Saeid Rajabzadeh, Masahide Shibata, Chihiro Otsubo, Toyozo Hamada, Noriaki Kato, Keizo Nakagawa, Tooru Kitagawa, Hideto Matsuyama, Tomohisa Yoshioka

“…Prepared CBzOH membrane by TIPS method showed high porosity, pore size around 100 nm or larger and high pure water permeability (PWP) with slightly low rection performance compared to that by NIPS. On the contrary, CBzOH membranes prepared with the NIPS method showed three times lower PWP with higher rejection. …”
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Input-to-State Stability and Stabilization of Nonlinear Impulsive Positive Systems by Yiqing Xue, Ping Zhao

“…This paper focuses on the problems of input-to-state stability (ISS) and stabilization for nonlinear impulsive positive systems (NIPS). Using the max-separable ISS Lyapunov function method, a sufficient condition on ISS is given for general NIPS. …”
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The Role of the Left Inferior Frontal Gyrus in Introspection during Verbal Communication by Ayumi Yoshioka, Hiroki C. Tanabe, Eri Nakagawa, Motofumi Sumiya, Takahiko Koike, Norihiro Sadato

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Recommendations and Health Technology Assessment (HTA) landscape evaluation for pediatric pneumococcal conjugate vaccines (PCV) in Europe: A systematic literature review by Goran Bencina, Hanna Fues Wahl, Eleana Tsoumani, Stina Salomonsson

“…Fifteen countries’ records included a recommendation concerning implementation of PCV NIP, switching from one PCV to another or a change in vaccination schedule within an existing NIP. …”
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Unraveling and leveraging in situ surface amorphization for enhanced hydrogen evolution reaction in alkaline media by Qiang Fu, Lok Wing Wong, Fangyuan Zheng, Xiaodong Zheng, Chi Shing Tsang, Ka Hei Lai, Wenqian Shen, Thuc Hue Ly, Qingming Deng, Jiong Zhao

“…Trace Ru (0.81 wt.%) is doped into NiPS3 nanosheets for alkaline hydrogen production. …”
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Association between cell-free DNA fetal fraction and pregnant character: a retrospective cohort study of 27,793 maternal plasmas by Yaping Hou, Jiexia Yang, Fuli Deng, Fanghua Wang, Haishan Peng, Fangfang Guo, Dongmei Wang, Aihua Yin

“…FF was close related to the result of NIPS and related maternal factors. Though NIPS has increased accuracy, the complexity still should be recognized especially in clinical practice.…”
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Patterns of Health Services Utilization During Pregnancy, Delivery, and Postpartum Period: Evidence from Pakistan Maternal Mortality Survey by Rabia Zafar, Ayesha Sheraz, Farid Midhet, Sidra Ishfaq

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