Osteoarthritis and other long-term health conditions in former elite cricketers. by Jones, M, Davies, M, Leyland, K, Delmestri, A, Porter, A, Ratcliffe, J, Peirce, N, Newton, J, Arden, N

“…Anxiety and depression were reported by 12.4% and 8.8% of former cricketers, respectively, SMRs 3.95 (2.34–6.67)and 2.22 (1.20–4.14). 97% of former cricketers reflected they would undertake their cricket career again, 98% agreed that cricket enriched their lives.…”

A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance by Eyre, D, Golubchik, T, Gordon, N, Bowden, R, Piazza, P, Batty, E, Ip, C, Wilson, D, Didelot, X, O'Connor, L, Lay, R, Buck, D, Kearns, A, Shaw, A, Paul, J, Wilcox, M, Donnelly, P, Peto, T, Walker, A, Crook, D

“…DESIGN: The authors used Illumina MiSeq benchtop sequencing to undertake case studies investigating potential outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile. …”

Measurement of particulate emissions from gasoline direct injection engines by Chen, L

“…</p><p>This thesis undertakes to investigate: a) the effects of the after-treatment (Three-Way Catalyst) and various engine operational parameters, such as injection and ignition timing, injection strategy and valve timing on the PM emissions; b) the characteristics of GDI PM emissions using a range of gasoline/ethanol blends; c) The compositional information for GDI-generated PM emissions, i.e. the PM mass fractions in different volatility ranges. …”

Assessing the complexity of interventions within systematic reviews: development, content and use of a new tool (iCAT_SR). by Lewin, S, Hendry, M, Chandler, J, Oxman, A, Michie, S, Shepperd, S, Reeves, B, Tugwell, P, Hannes, K, Rehfuess, E, Welch, V, Mckenzie, J, Burford, B, Petkovic, J, Anderson, L, Harris, J, Noyes, J

“…</p> <h4>Conclusions</h4> <p>The iCAT_SR tool facilitates more in-depth, systematic assessment of the complexity of interventions in systematic reviews and can assist in undertaking reviews and interpreting review findings. …”

Purifying selection determines the short-term time dependency of evolutionary rates in SARS-CoV-2 and pH1N1 influenza by Ghafari, M, du Plessis, L, Raghwani, J, Bhatt, S, Xu, B, Pybus, OG, Katzourakis, A

“…High throughput sequencing enables rapid genome sequencing during infectious disease outbreaks and provides an opportunity to quantify the evolutionary dynamics of pathogens in near real-time. One difficulty of undertaking evolutionary analyses over short timescales is the dependency of the inferred evolutionary parameters on the timespan of observation. …”

Bicruciate substituting total knee replacement: how effective are the added kinematic constraints in vivo? by van Duren, B, Pandit, H, Price, M, Tilley, S, Gill, H, Murray, D, Thomas, N

“…The aim of this study was to undertake a comprehensive study of the Journey BCS kinematics in vivo to assess the function of the cam-post mechanisms and their effect on functional kinematics and compared to the kinematics of a group of normal knees. …”

Practical Bayesian optimisation for hyperparameter tuning by Alvi, AS

“…</p> <p>The case of data with input noise is relevant when we are modelling (or finding extremal values of) a quantity defined on a spatial grid. We undertake a comparative study evaluating existing uncertain-input GP methods, and develop a novel approach based on the unscented transform that outperforms existing uncertain-input methods. …”

Pathogen identification in lower respiratory tract infection by Wrightson, JM

“…High sensitivity nested polymerase chain reaction (PCR) is a culture-independent technique which is used to undertake a systematic evaluation for these pathogens in pleural infection samples.…”

Soil-lubricant-structure interface mechanics for microtunnelling by Phillips, B

“…The installation process consists of a tunnel boring machine (TBM) undertaking controlled excavation at the front of a string of pipes, whilst thrust is applied from a jacking frame located at the rear of the string. …”

Efficacy and safety of carbon dioxide insufflation for brain protection for patients undergoing planned left-sided open heart valve surgery: protocol for a multicentre, placebo-con... by Todd, R, Rogers, CA, Pufulete, M, Culliford, L, Pretorius, P, Voets, N, Akowuah, E, Sayeed, R, Lazaroo, M, Kaur, S, Angelini, GD, Gibbison, B

“…All participants will provide written informed consent prior to undertaking any study assessments. Consent will be obtained by the principal investigator or a delegated member of the research team who has been trained in the study and undergone Good Clinical Practice training. …”

The Galactic center chimneys: the base of the multiphase outflow of the Milky Way by Ponti, G, Morris, MR, Churazov, E, Heywood, I, Fender, RP

“…<br> <strong>Aims.</strong> We undertake a detailed examination of the spatial relationships between the emission in the different bands in order to place constraints on the nature and history of the chimneys and to better understand their impact on the GC environment and their relation with Galactic scale outflows. …”

The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study by Wildenbeest, JG, Billard, M-N, Zuurbier, RP, Korsten, K, Langedijk, AC, van de Ven, PM, Snape, MD, Pollard, AJ, Drysdale, SB, Pollard, AJ, Robinson, H, Heikkinen, T, Cunningham, S, O'Neill, T, Rizkalla, B, Dacosta-Urbieta, A, Martinón-Torres, F, van Houten, MA, Bont, LJ

“…</p> <p><strong>Funding:</strong> Innovative Medicines Initiative 2 Joint Undertaking, with support from the EU's Horizon 2020 research and innovation programme and European Federation of Pharmaceutical Industries and Associations.…”

Digital technology interventions to reduce loneliness in adults: A systematic review by Shah, SGS, Nogueras, D, van Woerden, H, Kiparoglou, V

“…</p><br /> <p><strong>Aim:</strong><br /> To undertake a systematic review of published primary research on digital technology interventions to reduce loneliness in adults.…”

HOPE: Help fOr People with money, employment, benefit or housing problems: study protocol for a randomised controlled trial by Barnes, M, Haase, A, Bard, A, Donovan, J, Davies, R, Dursley, S, Potokar, J, Kapur, N, Hawton, K, O'Connor, R, Hollingworth, W, Metcalfe, C, Gunnell, D

“…</p> <h3>Method</h3> <p>A pilot study including randomisation will be employed to determine whether it is possible to undertake a full-scale trial. Twenty people presenting to the ED who have self-harmed, have suicidal thoughts and depression and/or are in crisis and where financial, employment or benefit problems are cited as contributory factors will be asked to consent to random allocation to the intervention or control arm on a 2:1 basis. …”

Experience of patients and physiotherapists within the AFTER pilot randomised trial of two rehabilitation interventions for people aged 50 years and over post ankle fracture: a qua... by Tutton, E, Gould, J, Lamb, SE, Costa, ML, Keene, DJ

“…Progressive exercise added value with a perceived increase in strength, motion, ability to undertake activities and continued use of the workbook. …”

Study protocol: developing, disseminating, and implementing a core outcome set for selective fetal growth restriction in monochorionic twin pregnancies by Khalil, A, Duffy, JMN, Perry, H, Ganzevoort, W, Reed, K, Baschat, AA, Deprest, J, Gratacos, E, Hecher, K, Lewi, L, Lopriore, E, Oepkes, D, Papageorghiou, AT, Gordijn, SJ, International Collaboration to Harmonise Outcomes for Selective Fetal Growth Restriction (CHOOSE-FGR)

“…</br> <br>Potential core outcomes will be developed by undertaking a systematic review of studies evaluating interventions for selective fetal growth restriction in monochorionic twin pregnancies. …”

The hidden harm of home-based care: pulmonary tuberculosis symptoms among children providing home medical care to HIV/AIDS-affected adults in South Africa. by Cluver, L, Orkin, M, Moshabela, M, Kuo, C, Boyes, M

“…Millions of children in sub-Saharan Africa undertake personal and medical care for family members who are unwell with AIDS. …”

Evidence-based indications for mobile-bearing unicompartmental knee replacement in a consecutive cohort of 1000 knees. by Hamilton, T, Pandit, H, Jenkins, C, Mellon, S, Dodd, C, Murray, D

“…Previously recommended contra-indications include: age under 60years, weight 180lb (82kg) or over, patients undertaking heavy labour, chondrocalcinosis, and exposed bone in the patellofemoral joint. …”

A world from nowhere: nineteenth-century expert politics and the technocratic international by Eijking, J

“…A technocratic worldview gave them the confidence to first undertake large-scale engineering works across borders, and then worry about implications, from extraterritoriality to dispossession and informal empire, later. …”

The future higher education workforce in locally and globally engaged higher education institutions: a review of literature on the topic of 'the academic workforce' by Locke, W, Whitchurch, C, Marini, G

“…Working Paper 43, authored by Dr Giulio Marini, Professor William Locke and Dr Celia Whitchurch, reviews the literature on the academic workforce, undertaking an in-depth review of journals dedicated to higher education studies, and other academic journals where contributions to the field occur. …”