The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial by Bernie Carter, Lucy Bray, Nadia al-Najjar, Agnès Tort Piella, Catrin Tudur-Smith, Catherine Spowart, Amber Collingwood, Holly Crudgington, Janet Currier, Dyfrig A. Hughes, Eifiona Wood, Rachael Martin, Christopher Morris, Deborah Roberts, Alison Rouncefield-Swales, Heather Sutherland, Victoria Watson, Georgia Cook, Luci Wiggs, Paul Gringras, Deb Pal

“…As with other paediatric clinical trials, researchers undertaking paediatric epilepsy clinical trials face a range of challenges that may compromise external validity Main body In this paper, we critically reflect upon the factors which impacted recruitment to the pilot phase of a phase IV unblinded, randomised controlled 3×2 factorial trial examining the effectiveness of two antiseizure medications (ASMs) and a sleep behaviour intervention in children with Rolandic epilepsy. …”
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Device-measured physical activity behaviours, and physical function, in people with type 2 diabetes mellitus and peripheral artery disease: A cross-sectional study by Jemma Perks, Francesco Zaccardi, Harjeet Rayt, Robert Sayers, Emer M. Brady, Melanie J. Davies, Alex V. Rowlands, Charlotte L. Edwardson, Andrew Hall, thomas yates, joseph henson

“…People with T2DM and PAD undertake less PA (MVPA1min: −9.2 min [95 % CI: −15.3 to −3.0; p = 0.004]) (light intensity PA: −18.7 min [−36.4 to −1.0; p = 0.039]), spend more time inactive (49.2 min [12.1 to 86.2; p = 0.009]), and have reduced PF (SPPB score: −1.6 [−2.5 to −0.8; p = 0.001]) (DASI score: −14.8 [−19.8 to −9.8; p = 0.001]) (STS-60 repetitions: −7.1 [−10.5 to −3.8; p = 0.001]) compared to people without; some differences in PA were attenuated by confounders. …”
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Multimodal learning for emergency department triage implementation: experiences from Papua New Guinea during the COVID-19 pandemicResearch in context by Rob Mitchell, Sarah Bornstein, Donna Piamnok, Wilma Sebby, Carl Kingston, Rayleen Tefatu, Mangu Kendino, Betty Josaiah, Jasper Pole, Sylvia Kuk, Sarah Körver, Jean-Philippe Miller, Travis Cole, Andrew Erbs, Gerard O'Reilly, Peter Cameron, Duncan Sengiromo, Colin Banks

“…There were statistically significant improvements in confidence for 13 of 15 clinical tasks, including undertaking a triage assessment and identifying an unwell patient.In an evaluation survey, 100% of 30 respondents agreed or strongly agreed the online learning platform was easy to access, use and navigate, and that the digital teaching methods were appropriate for their learning needs. …”
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Comparison of machine learning models to predict the risk of breast cancer-related lymphedema among breast cancer survivors: a cross-sectional study in China by Jiali Du, Jing Yang, Qing Yang, Xin Zhang, Ling Yuan, Bing Fu

“…Consequently, this precise identification equips nurses with the means to undertake timely and tailored interventions, thus averting the onset of BCRL.…”
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Triglyceride−glucose index in the prediction of major adverse cardiovascular events in patients with type 2 diabetes mellitus after coronary artery bypass surgery: A retrospective... by He Zhang, Hoshun Chong, Zeshi Li, Kai Li, Bomin Zhang, Yunxing Xue, Dongjin Wang, Dongjin Wang

“…A high TyG index may serve as an early warning signal for individuals to undertake lifestyle adjustments that can reduce the progression or incidence of MACEs.…”
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Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONYResearch in context by Thomas Chatzikonstantinou, Lydia Scarfò, Georgios Karakatsoulis, Eva Minga, Dimitra Chamou, Gloria Iacoboni, Jana Kotaskova, Christos Demosthenous, Lukas Smolej, Stephen Mulligan, Miguel Alcoceba, Salem Al-Shemari, Thérèse Aurran-Schleinitz, Francesca Bacchiarri, Mar Bellido, Fontanet Bijou, Anne Calleja, Angeles Medina, Mehreen Ali Khan, Ramona Cassin, Sofia Chatzileontiadou, Rosa Collado, Amy Christian, Zadie Davis, Maria Dimou, David Donaldson, Gimena Dos Santos, Barbara Dreta, Maria Efstathopoulou, Shaimaa El-Ashwah, Alicia Enrico, Alberto Fresa, Sara Galimberti, Andrea Galitzia, Rocío García-Serra, Eva Gimeno, Isabel González-Gascón-y-Marín, Alessandro Gozzetti, Valerio Guarente, Romain Guieze, Ajay Gogia, Ritu Gupta, Sean Harrop, Eleftheria Hatzimichael, Yair Herishanu, José-Ángel Hernández-Rivas, Luca Inchiappa, Ozren Jaksic, Susanne Janssen, Elżbieta Kalicińska, Laribi Kamel, Volkan Karakus, Arnon P. Kater, Bonnie Kho, Maria Kislova, Eliana Konstantinou, Maya Koren-Michowitz, Ioannis Kotsianidis, Robert J. Kreitman, Jorge Labrador, Deepesh Lad, Mark-David Levin, Ilana Levy, Thomas Longval, Alberto Lopez-Garcia, Juan Marquet, Lucia Martin-Rodríguez, Marc Maynadié, Stanislava Maslejova, Carlota Mayor-Bastida, Biljana Mihaljevic, Ivana Milosevic, Fatima Miras, Riccardo Moia, Marta Morawska, Roberta Murru, Uttam Kumar Nath, Almudena Navarro-Bailón, Ana C. Oliveira, Jacopo Olivieri, David Oscier, Irina Panovska-Stavridis, Maria Papaioannou, Tomas Papajík, Zuzana Kubova, Punyarat Phumphukhieo, Cheyenne Pierie, Anna Puiggros, Lata Rani, Gianluigi Reda, Gian Matteo Rigolin, Rosa Ruchlemer, Marcos Daniel de Deus Santos, Mattia Schipani, Annett Schiwitza, Yandong Shen, Martin Simkovic, Svetlana Smirnova, Dina Sameh Abdelrahman Soliman, Martin Spacek, Tamar Tadmor, Kristina Tomic, Eric Tse, Theodoros Vassilakopoulos, Andrea Visentin, Candida Vitale, Julia von Tresckow, George Vrachiolias, Vojin Vukovic, Renata Walewska, Ewa Wasik-Szczepanek, Zhenshu Xu, Munci Yagci, Lucrecia Yañez, Mohamed Yassin, Jana Zuchnicka, Maria Angelopoulou, Darko Antic, Bella Biderman, Mark Catherwood, Rainer Claus, Marta Coscia, Antonio Cuneo, Fatih Demirkan, Blanca Espinet, Gianluca Gaidano, Olga B. Kalashnikova, Luca Laurenti, Eugene Nikitin, Gerassimos A. Pangalis, Panagiotis Panagiotidis, Viola Maria Popov, Sarka Pospisilova, Paolo Sportoletti, Niki Stavroyianni, Constantine Tam, Livio Trentin, Anastasia Chatzidimitriou, Francesc Bosch, Michael Doubek, Paolo Ghia, Kostas Stamatopoulos

“…Funding: AbbVie, and EU/EFPIA Innovative Medicines Initiative Joint Undertaking HARMONY grant n° 116026.…”
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N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease by Florence E. Layburn, Adelie Y.S. Tan, Nasim F. Mehrabi, Maurice A. Curtis, Lynette J. Tippett, Clinton P. Turner, Nathan Riguet, Lorène Aeschbach, Hilal A. Lashuel, Mike Dragunow, Richard L.M. Faull, Malvindar K. Singh-Bains

“…Mutant Htt is a current target for novel therapeutic strategies for HD, however, the lack of translation from preclinical research to disease-modifying treatments highlights the need to improve our understanding of the role of Htt protein in the human brain. This study aims to undertake an immunohistochemical screen of 12 candidate antibodies against various sequences along the Htt protein to characterize Htt distribution and expression in post-mortem human brain tissue microarrays (TMAs).Immunohistochemistry was performed on middle temporal gyrus TMAs comprising of up to 28 HD and 27 age-matched control cases, using 12 antibodies specific to various sequences along the Htt protein. …”
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Adaptación de los servicios de una organización de salud pública a la disminución de los recursos by Joan R. Villalbí, Carme Borrell, Manel Macía, Teresa Subirana, María José López, Samuel Portaña, Xavier Llebaria, Conrad Casas

“…A working group reviewed the different business activities, taking into account their costs and generated revenue and their justification, assessing factors such as the existence of legal constraints, tied funding, explicit demands from the founding administrations and other actors that may be capable of undertaking particular activities. The changes and their consequences are described. …”
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A case control investigation of COVID-19 associated mucormycosis in India by Tanu Anand, Aparna Mukherjee, Aanchal Satija, Poonam Sharma Velamuri, Kh. Jitenkumar Singh, Madhuchhanda Das, Kripa Josten, Pragya D. Yadav, Rima R. Sahay, Archana Y. Keche, Nitin M. Nagarkar, Prashant Gupta, D. Himanshu, Sejal N. Mistry, Jimy D. Patel, Prajwal Rao, Shalesh Rohatgi, Soumitra Ghosh, Avijit Hazra, Anupma Jyoti Kindo, Radha Annamalai, Shivaprakash M. Rudramurthy, Mini P. Singh, Mohammad Shameem, Nazish Fatima, Janakkumar R. Khambholja, Sangita Parikh, Manisha Madkaikar, Vandana D. Pradhan, Sushila Kataria, Pooja Sharma, Samiran Panda, ICMR-Mucormycosis group

“…Abstract Background Increased occurrence of mucormycosis during the second wave of COVID-19 pandemic in early 2021 in India prompted us to undertake a multi-site case–control investigation. …”
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Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study by Kui Wang, Kui Wang, Xianzheng Qin, Taojing Ran, Yundi Pan, Yu Hong, Jiawei Wang, Xianda Zhang, XiaoNan Shen, Chenxiao Liu, Xinchen Lu, Yifei Chen, Yaya Bai, Yao Zhang, Chunhua Zhou, Duowu Zou

“…Therefore, our study aimed to investigate the causal relationship between gut microbiota and four types of pancreatitis.MethodsAn investigative undertaking encompassing a genome-wide association study (GWAS) comprising 18,340 participants was undertaken with the aim of discerning genetic instrumental variables that exhibit associations with gut microbiota, The aggregated statistical data pertaining to acute pancreatitis (AP), alcohol-induced AP (AAP), chronic pancreatitis (CP), and alcohol-induced CP (ACP) were acquired from the FinnGen Consortium. …”
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Development of a Quality-of-Life Instrument to Measure Current Health Outcomes: Health-Related Quality of Life with Six Domains (HRQ-6D) by Mohamad Adam Bujang, Wei Hong Lai, Selvasingam Ratnasingam, Xun Ting Tiong, Yoon Khee Hon, Eileen Pin Pin Yap, Yvonne Yih Huan Jee, Nurul Fatma Diyana Ahmad, Alex Ren Jye Kim, Masliyana Husin, Jamaiyah Haniff

“…This is a questionnaire development study involving five phases, which are (i) to explore the subject matter content for gaining a better understanding of the topic, (ii) to develop the questionnaire, (iii) to assess both its content validity and face validity, (iv) to conduct a pilot study, and finally, (v) to undertake a field testing of the questionnaire. For the field-testing phase, a cross-sectional study involving a self-administered survey for HRQ-6D items was conducted among healthcare workers with various health conditions. …”
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Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study by John R Hurst, Ann Blandford, William Henley, Elizabeth Murray, Katherine Bradbury, Sarah Walker, Manuel Gomes, Fiona A Stevenson, Fiona L Hamilton, Paul Pfeffer, William Ricketts, Henry Goodfellow, Julia Bindman, Hannah Hylton, Stuart Linke, Chris Robson, Belinda Cooper, Patra Pookarnjanamorakot, David Sunkersing, Jiunn Wang, Living With Covid Recovery Collaboration

“…To assess the impact of symptoms on health-related quality of life (HRQoL) and patients’ ability to work and undertake activities of daily living.Design Cross-sectional single-arm service evaluation of real-time user data.Setting 31 post-COVID-19 clinics in the UK.Participants 3754 adults diagnosed with PCS in primary or secondary care deemed suitable for rehabilitation.Intervention Patients using the Living With Covid Recovery digital health intervention registered between 30 November 2020 and 23 March 2022.Primary and secondary outcome measures The primary outcome was the baseline Work and Social Adjustment Scale (WSAS). …”
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An intervention to support stroke survivors and their carers in the longer term: results of a cluster randomised controlled feasibility trial (LoTS2Care) by Anne Forster, Seline Ozer, Richard Brindle, Lorna Barnard, Natasha Hardicre, Thomas F. Crocker, Marie Chenery, Lauren Moreau, Alan Wright, Louisa-Jane Burton, Suzanne Hartley, Claire Hulme, Bryony Dawkins, Ivana Holloway, Allan House, Jenny Hewison, Amanda Farrin, on behalf of the LoTS2Care Programme Team

“…Conclusions Stroke service recruitment and longer-term stroke survivor postal recruitment and outcome data collection are feasible; however, refinement of intervention targeting and delivery is required prior to undertaking a definitive trial. Trial registration ISRCTN38920246. …”
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Loggerhead turtle oceanic-neritic habitat shift reveals key foraging areas in the Western Indian Ocean by Jonathan R. Monsinjon, Antoine Laforge, Antoine Laforge, Philippe Gaspar, Anne Barat, Olivier Bousquet, Olivier Bousquet, Stéphane Ciccione, Claire Jean, Katia Ballorain, Mayeul Dalleau, Rui Coelho, Sylvain Bonhommeau, Jérôme Bourjea

“…Loggerhead sea turtles (Caretta caretta) use both oceanic and neritic habitats depending on their life stage, eventually undertaking an ontogenetic shift. Juveniles likely start foraging in a purely opportunistic manner and later seek resources more actively. …”
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Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel by Kang Zhang, Zhe Zhao, Liting Lan, Xiaoli Wei, Liyun Wang, Xiaoyan Liu, Haitao Yan, Jianquan Zheng

“…Considering both sigma-1 receptors and N-type Ca2+ channels are involved in intracellular calcium homeostasis and neurotransmission, we undertake studies to explore the possible interaction between these two proteins. …”
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Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii In Vivo by Satya D. Pandey, John D. Perpich, Kendall S. Stocke, Jillian M. Mansfield, Yuichiro Kikuchi, Lan Yakoumatos, Artur Muszyński, Parastoo Azadi, Hervé Tettelin, Marvin Whiteley, Silvia M. Uriarte, Juhi Bagaitkar, Margaret Vickerman, Richard J. Lamont

“…Furthermore, constituents of communities can undertake activities that relieve the burden of energetically costly biosynthetic reactions on partner species.…”
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Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) by Opeyemi O. Babatunde, Elizabeth Cottrell, Simon White, Adrian Chudyk, Emma L. Healey, John Edwards, Elaine Nicholls, Nicola O’Brien, Adam Todd, Christine Walker, Colin Stanford, Tania Cork, Angela Long, Joanna Simkins, Christian D. Mallen, Krysia Dziedzic, Melanie A. Holden

“…Methods Informed by the Theoretical Domains Framework, Normalisation Process Theory, and the Medical Research Council (MRC) framework for developing complex interventions, we will undertake a multi-methods study involving five phases: 1. …”
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miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells by Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li

“…ABSTRACT: miR-19b-3p is reported to undertake various biological role, while its function and action mechanism in chicken hepatic lipid metabolism is unclear. …”
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Mistyczne implikacje doktryny o miłości Aelreda z Rievaulx by Ryszard Groń

“…The initial visits make room for the next ones, and once their mission of inciting to greater love is complete they face the various trials and undertake, in the name of God, a number of mortifications, followed by practice of virtues. …”
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Individual-Level Evaluation of the Exposure Notification Cascade in the SwissCovid Digital Proximity Tracing App: Observational Study by Tala Ballouz, Dominik Menges, Hélène E Aschmann, Ruedi Jung, Anja Domenghino, Jan S Fehr, Milo A Puhan, Viktor von Wyl

“…However, the effect of DPT apps can only be exerted if code generation processes are efficient and exposed contacts are willing to undertake preventive actions. This highlights the need to focus efforts on keeping barriers to efficient code generation as low as possible and promoting not only app adoption but also compliance with the recommended measures upon an EN. …”
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