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11221
The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial
Published 2023-02-01“…As with other paediatric clinical trials, researchers undertaking paediatric epilepsy clinical trials face a range of challenges that may compromise external validity Main body In this paper, we critically reflect upon the factors which impacted recruitment to the pilot phase of a phase IV unblinded, randomised controlled 3×2 factorial trial examining the effectiveness of two antiseizure medications (ASMs) and a sleep behaviour intervention in children with Rolandic epilepsy. …”
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11222
Device-measured physical activity behaviours, and physical function, in people with type 2 diabetes mellitus and peripheral artery disease: A cross-sectional study
Published 2023-07-01“…People with T2DM and PAD undertake less PA (MVPA1min: −9.2 min [95 % CI: −15.3 to −3.0; p = 0.004]) (light intensity PA: −18.7 min [−36.4 to −1.0; p = 0.039]), spend more time inactive (49.2 min [12.1 to 86.2; p = 0.009]), and have reduced PF (SPPB score: −1.6 [−2.5 to −0.8; p = 0.001]) (DASI score: −14.8 [−19.8 to −9.8; p = 0.001]) (STS-60 repetitions: −7.1 [−10.5 to −3.8; p = 0.001]) compared to people without; some differences in PA were attenuated by confounders. …”
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11223
Multimodal learning for emergency department triage implementation: experiences from Papua New Guinea during the COVID-19 pandemicResearch in context
Published 2023-04-01“…There were statistically significant improvements in confidence for 13 of 15 clinical tasks, including undertaking a triage assessment and identifying an unwell patient.In an evaluation survey, 100% of 30 respondents agreed or strongly agreed the online learning platform was easy to access, use and navigate, and that the digital teaching methods were appropriate for their learning needs. …”
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11224
Comparison of machine learning models to predict the risk of breast cancer-related lymphedema among breast cancer survivors: a cross-sectional study in China
Published 2024-02-01“…Consequently, this precise identification equips nurses with the means to undertake timely and tailored interventions, thus averting the onset of BCRL.…”
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11225
Triglyceride−glucose index in the prediction of major adverse cardiovascular events in patients with type 2 diabetes mellitus after coronary artery bypass surgery: A retrospective...
Published 2022-10-01“…A high TyG index may serve as an early warning signal for individuals to undertake lifestyle adjustments that can reduce the progression or incidence of MACEs.…”
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11226
Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONYResearch in context
Published 2023-11-01“…Funding: AbbVie, and EU/EFPIA Innovative Medicines Initiative Joint Undertaking HARMONY grant n° 116026.…”
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11227
N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease
Published 2022-11-01“…Mutant Htt is a current target for novel therapeutic strategies for HD, however, the lack of translation from preclinical research to disease-modifying treatments highlights the need to improve our understanding of the role of Htt protein in the human brain. This study aims to undertake an immunohistochemical screen of 12 candidate antibodies against various sequences along the Htt protein to characterize Htt distribution and expression in post-mortem human brain tissue microarrays (TMAs).Immunohistochemistry was performed on middle temporal gyrus TMAs comprising of up to 28 HD and 27 age-matched control cases, using 12 antibodies specific to various sequences along the Htt protein. …”
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11228
Adaptación de los servicios de una organización de salud pública a la disminución de los recursos
Published 2017-05-01“…A working group reviewed the different business activities, taking into account their costs and generated revenue and their justification, assessing factors such as the existence of legal constraints, tied funding, explicit demands from the founding administrations and other actors that may be capable of undertaking particular activities. The changes and their consequences are described. …”
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11229
A case control investigation of COVID-19 associated mucormycosis in India
Published 2022-11-01“…Abstract Background Increased occurrence of mucormycosis during the second wave of COVID-19 pandemic in early 2021 in India prompted us to undertake a multi-site case–control investigation. …”
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11230
Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study
Published 2023-11-01“…Therefore, our study aimed to investigate the causal relationship between gut microbiota and four types of pancreatitis.MethodsAn investigative undertaking encompassing a genome-wide association study (GWAS) comprising 18,340 participants was undertaken with the aim of discerning genetic instrumental variables that exhibit associations with gut microbiota, The aggregated statistical data pertaining to acute pancreatitis (AP), alcohol-induced AP (AAP), chronic pancreatitis (CP), and alcohol-induced CP (ACP) were acquired from the FinnGen Consortium. …”
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11231
Development of a Quality-of-Life Instrument to Measure Current Health Outcomes: Health-Related Quality of Life with Six Domains (HRQ-6D)
Published 2023-04-01“…This is a questionnaire development study involving five phases, which are (i) to explore the subject matter content for gaining a better understanding of the topic, (ii) to develop the questionnaire, (iii) to assess both its content validity and face validity, (iv) to conduct a pilot study, and finally, (v) to undertake a field testing of the questionnaire. For the field-testing phase, a cross-sectional study involving a self-administered survey for HRQ-6D items was conducted among healthcare workers with various health conditions. …”
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11232
Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study
Published 2023-06-01“…To assess the impact of symptoms on health-related quality of life (HRQoL) and patients’ ability to work and undertake activities of daily living.Design Cross-sectional single-arm service evaluation of real-time user data.Setting 31 post-COVID-19 clinics in the UK.Participants 3754 adults diagnosed with PCS in primary or secondary care deemed suitable for rehabilitation.Intervention Patients using the Living With Covid Recovery digital health intervention registered between 30 November 2020 and 23 March 2022.Primary and secondary outcome measures The primary outcome was the baseline Work and Social Adjustment Scale (WSAS). …”
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11233
An intervention to support stroke survivors and their carers in the longer term: results of a cluster randomised controlled feasibility trial (LoTS2Care)
Published 2023-03-01“…Conclusions Stroke service recruitment and longer-term stroke survivor postal recruitment and outcome data collection are feasible; however, refinement of intervention targeting and delivery is required prior to undertaking a definitive trial. Trial registration ISRCTN38920246. …”
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11234
Loggerhead turtle oceanic-neritic habitat shift reveals key foraging areas in the Western Indian Ocean
Published 2023-08-01“…Loggerhead sea turtles (Caretta caretta) use both oceanic and neritic habitats depending on their life stage, eventually undertaking an ontogenetic shift. Juveniles likely start foraging in a purely opportunistic manner and later seek resources more actively. …”
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11235
Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel
Published 2017-05-01“…Considering both sigma-1 receptors and N-type Ca2+ channels are involved in intracellular calcium homeostasis and neurotransmission, we undertake studies to explore the possible interaction between these two proteins. …”
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11236
Impact of Polymicrobial Infection on Fitness of Streptococcus gordonii In Vivo
Published 2023-06-01“…Furthermore, constituents of communities can undertake activities that relieve the burden of energetically costly biosynthetic reactions on partner species.…”
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11237
Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA)
Published 2024-01-01“…Methods Informed by the Theoretical Domains Framework, Normalisation Process Theory, and the Medical Research Council (MRC) framework for developing complex interventions, we will undertake a multi-methods study involving five phases: 1. …”
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11238
miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells
Published 2024-01-01“…ABSTRACT: miR-19b-3p is reported to undertake various biological role, while its function and action mechanism in chicken hepatic lipid metabolism is unclear. …”
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11239
Mistyczne implikacje doktryny o miłości Aelreda z Rievaulx
Published 2010-07-01“…The initial visits make room for the next ones, and once their mission of inciting to greater love is complete they face the various trials and undertake, in the name of God, a number of mortifications, followed by practice of virtues. …”
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11240
Individual-Level Evaluation of the Exposure Notification Cascade in the SwissCovid Digital Proximity Tracing App: Observational Study
Published 2022-05-01“…However, the effect of DPT apps can only be exerted if code generation processes are efficient and exposed contacts are willing to undertake preventive actions. This highlights the need to focus efforts on keeping barriers to efficient code generation as low as possible and promoting not only app adoption but also compliance with the recommended measures upon an EN. …”
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