Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis by Rajasekhar, M, Simpson, JA, Ley, B, Edler, P, Chu, CS, Abreha, T, Awab, GR, Baird, JK, Bancone, G, Barber, BE, Grigg, MJ, Hwang, J, Karunajeewa, H, Lacerda, MVG, Ladeia-Andrade, S, Llanos-Cuentas, A, Pukrittayakamee, S, Rijal, KR, Saravu, K, Sutanto, I, Taylor, WRJ, Thriemer, K, Watson, JA, Guerin, PJ, White, NJ, Commons, RJ, Price, RN, WorldWide Antimalarial Resistance Network (WWARN) Vivax Primaquine Dosing Efficacy, Tolerability and Safety Study Group

“…We included studies if they had active follow-up of at least 28 days, if they included a treatment group with daily primaquine given over multiple days where primaquine was commenced within 3 days of schizontocidal treatment and was given alone or coadministered with chloroquine or one of four artemisinin-based combination therapies (ie, artemether–lumefantrine, artesunate–mefloquine, artesunate–amodiaquine, or dihydroartemisinin–piperaquine), and if they recorded haemoglobin or haematocrit concentrations on day 0. …”

Development, characterization and anti-diabetic properties of thymoquinone rich fraction nanoemulsion obtained from black cumin by Tubesha, Zaki A.H.

“…Therefore, discovering new therapies is vital for management of T2DM. Although TQ and thymoquinone rich fraction (TQRF) are known to be powerful antioxidants and have hypoglycemic properties, their administration in vivo remains problematic partly due to their low bioavailability. …”
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Development of quinone-rich fraction of Ardisia crispa (Thunb.) A.DC roots mitigates rheumatoid arthritis by suppressing angiogenesis, in vitro and in vivo by Blin, Joan

“…Limitations of current arthritis therapies have encouraged for rapid development of alternative adjuncts from natural sources. 2-methoxy-6-undecyl-1,4-benzoquinone (BQ) is a pbenzoquinone derivative of Ardisia crispa roots (Family: Primulaceae), with proven anti-angiogenic properties. …”
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Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular preventi... by Roberta Pastorino, Eloisa Arbustini, Andrea Faini, Gianfranco Parati, Grzegorz Bilo, Davide Soranna, Antonella Zambon, Sergio Leonardi, Alessandro Gialluisi, Lorenzo Giovanni Mantovani, Walter Ricciardi, Fabio Blandini, Giovanni Scambia, Catherine Klersy, Marialaura Bonaccio, Augusto Di Castelnuovo, Simona Costanzo, Amalia De Curtis, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Licia Iacoviello, Giuseppe Remuzzi, Camilla Torlasco, Giuseppe Ambrosio, Gabriele Zoppoli, Maria Chiara Grimaldi, Daniela Pedicino, Giovanna Liuzzo, Serena Pelusi, Daniele Prati, Luca Valenti, Francesca Gorini, Maurizio Sanguinetti, Giuseppe Ferrante, Gianluigi Condorelli, Giulio Pompilio, Stefania Boccia, Luigi Badano, Victor Savevski, Tiziana Bachetti, Gian Franco Gensini, Silvano Bosari, Alice Bonanni, Elena Tremoli, Angelo Santoliquido, Stefano Genovese, Sara Boveri, Gianfranco Gensini, Francesco Gianfagna, Italo Porto, Fabio Tuzzolino, Carolina Lombardi, Egidio Traversi, Fabrizio Veglia, Andrea Urbani, Domenico D’Amario, Gaetano Antonio Lanza, Antonio Uccelli, José Pablo Werba, Livio Luzi, Pietro Ameri, Davide Gentilini, Luisa Gilardini, Cecilia Invitti, Maurizio Volterrani, Maria Teresa La Rovere, Giovanni Gentile, Francesco Clemenza, Mario Urtis, Francesca Ieva, Maria Carla Roncaglioni, Valentina Milani, Paola Baiardi, Debora Rosa, Fabiana Madotto, Emilia Ruggiero, Teresa Panzera, Simona Esposito, Sara Magnacca, Fabrizia Noro, Roberta Parisi, Francesca Bracone, Irene Baroni, Damiano Baldassarre, Roberta Baetta, Luigi Frati, Pier Giulio Conaldi, Massimo Fini, Antonio Di Malta, Mauro Amato, Alice Bonomi, Francesca Colazzo, Martino Pengo, Luciana Auteri, Marta Baviera, Alberico Catapano, Alexis Elias Malavazos, Serenella Castelvecchio, Massimiliano Marco Corsi-Romanelli, Rosanna Cardani, Valentina Agnese, Bianca Pane, Laura Spinardi, Marco Visconti, Anna Di Blasio, Luisa Ojeda-Fernández, Andreana Foresta, Simonetta Scalvini, Antonia Pierobon, Alessandra Gorini, Annarosa Racca, Manuela Bandi, Lorenzo Menicanti, Gualtiero Colombo, Chiara Vavassori, Maria Luisa Biondi, Beatrice Frigerio, Alessio Ravani, Daniela Sansaro, Daniela Coggi, Alessandra Romandini, Monica Giroli, Mattia Giuliani, Maurizio Rondinelli, Catia Trudu, Carmen Cinieri, Massimo Monturano, Anna Di Blasio, Elisa Perger, Lucia Zanotti, Lidia Cova, Luca Grappiolo, Laura Papa, Ignazio Romano, Luisa Ojeda, Fiorenza Clerici, Angela Palumbo, Roberto Mattioli, Ermanno Longhi, Augusto Di Castelnuovo, Amalia De Curtis, Anwal Ghulam, Sabatino Orlandi, Sabrina Franciosa, Martina Morelli, Fiorella De Rita, Giovanni de Gaetano, Massimiliano MarcoCorsi Romanelli, Ambra Cerri, Carola Dubini, Manuel Bruno Trevisan, Laura Valentina Renna, Paola Giubbilini, Lucia Ramputi, Giada DeAngeli, Francesca Olmetti, Maurizio Bussotti, Carlo Gaetano, Martina Balbi, Laura Comini, Monica Lorenzoni, Adriana Olivares, Camilla Garrè, Riccardo Sideri, Giuseppe Caruana, Nicola Cuscino, Gabriele Di Gesaro, Alessio Greco, Italia Loddo, Domenico Palombo, Giovanni Spinella, Gaddiel Mozzetta, Alice Finotello, Giovanni Pratesi, Margherita Clerici, Cristiana Bianco, Rossana Carpani, Giulia Periti, Sara Margarita, Anna Severino, Alessia D’Aiello, Ramona Vinci, Mattia Brecciaroli, Simone Filomia, Luca Proto, Dalila Tarquini, Arianna Elia, Alessia Currao, Alessandro Di Toro, Lorenzo Giuliani, Giuseppe Caminiti, Federica Marcolongo, Barbara Sposato, Fiorella Guadagni, Valentina Morsella, Angelica Marziale, Antonio Di Malta, Giulia Protti

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Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adap... by Vinata Vedam-Mai, Karl Deisseroth, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Nanthia Suthana, Nanthia Suthana, Nanthia Suthana, Jean-Philippe Langevin, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan, Tricia N. Cunningham, Sameer A. Sheth, Nader Pouratian, Katherine W. Scangos, Helen S. Mayberg, Andreas Horn, Kara A. Johnson, Kara A. Johnson, Christopher R. Butson, Christopher R. Butson, Ro’ee Gilron, Coralie de Hemptinne, Coralie de Hemptinne, Robert Wilt, Maria Yaroshinsky, Simon Little, Philip Starr, Greg Worrell, Prasad Shirvalkar, Prasad Shirvalkar, Edward Chang, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa, Andrea A. Kühn, Luming Li, Matthew Johnson, Kevin J. Otto, Robert Raike, Steve Goetz, Chengyuan Wu, Peter Silburn, Binith Cheeran, Yagna J. Pathak, Mahsa Malekmohammadi, Aysegul Gunduz, Aysegul Gunduz, Joshua K. Wong, Stephanie Cernera, Stephanie Cernera, Wei Hu, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Wissam Deeb, Addie Patterson, Kelly D. Foote, Michael S. Okun

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Phenotypic and Genetic Characteristics in a Cohort of Patients with Usher Genes by Helena M. Feenstra, Saoud Al-Khuzaei, Mital Shah, Suzanne Broadgate, Morag Shanks, Archith Kamath, Jing Yu, Jasleen K. Jolly, Robert E. MacLaren, Penny Clouston, Stephanie Halford, Susan M. Downes

“…An accurate molecular diagnosis is important for diagnosis and prognosis and has become particularly relevant with the advent of potential therapies for Usher-related gene…”
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Effect of porosity of a functionally-graded scaffold for the treatment of corticosteroid-associated osteonecrosis of the femoral head in rabbits by Masahiro Maruyama, Chi-Chun Pan, Seyedsina Moeinzadeh, Hunter W. Storaci, Roberto Alfonso Guzman, Elaine Lui, Masaya Ueno, Takeshi Utsunomiya, Ning Zhang, Claire Rhee, Zhenyu Yao, Michiaki Takagi, Stuart B. Goodman, Yunzhi Peter Yang

“…Background/Objective: Core decompression (CD) with scaffold and cell-based therapies is a promising strategy for providing both mechanical support and regeneration of the osteonecrotic area for early stage osteonecrosis of the femoral head (ONFH). …”
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Particularities regarding Clinical-biological and Evolutive Parameters of Immune-mediated Rheumatic Diseases in Patients with COVID-19 – systematic literature review by Andreea Iulia Trandafir, Gelu Onose, Constantin Munteanu, Mihai Băila, Ali-Osman Saglam, Mihaela Mandu, Ioana Săulescu, Elena Grădinaru, Violeta-Claudia Bojincă

“…Risk factors associated with severe outcomes and death are: age, comorbidities, un-derlying disease activity, therapies used (“the good” being anti-tumor necrosis factor α, “the bad” – Methotrexate, Sulfasalazine, Azathioprine and “the ugly” – anti CD20 mono-clonal antibodies). …”
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Martial arts intervention decreases pain scores in children with malignancy by Bluth MH, Thomas R, Cohen C, Bluth AC, Goldberg E

“…Keywords: martial arts, karate, cancer, pain, intervention, therapy…”
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A first-in-human, open-label, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and antitumor activity of QL... by Zhiyu Huang, Yanjun Xu, Wei Hong, Lei Gong, Kaiyan Chen, Jing Qin, Fajun Xie, Feng Wang, Xin Tian, Xiangrui Meng, Wenlei Feng, Lingyan Li, Baihui Zhang, Xiaoyan Kang, Yun Fan

“…Pharmacokinetics/pharmacodynamics (PK/PD) and preliminary antitumor activity were also assessed.MethodsPatients with advanced or metastatic solid tumors who failed or had no standard therapies available were recruited. In the dose-escalation phase, patients were treated with QL1604 at 0.3 mg/kg, 1 mg/kg, 3 mg/kg, and 10 mg/kg intravenously once every 2 weeks (Q2W) in an accelerated titration with a traditional 3 + 3 design, followed by a dose-expansion phase at 3 mg/kg Q2W, 3 mg/kg once every 3 weeks (Q3W), 10 mg/kg Q2W and a fixed dose of 200 mg Q3W. …”
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Instruments de mesure en français pour la réadaptation : une étude descriptive des informations fournies par les répertoires en ligne by Anne Martine Bertrand, Julien Duinat, Sylvain Keller, Basilie Gurtner, Nicolas Kühne

“…Standardized assessment tools, online resources, occupational therapy…”
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Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target by Katharina Schimmel, Katharina Schimmel, Katharina Schimmel, Kenzo Ichimura, Kenzo Ichimura, Kenzo Ichimura, Sushma Reddy, Sushma Reddy, Francois Haddad, Francois Haddad, Francois Haddad, Edda Spiekerkoetter, Edda Spiekerkoetter, Edda Spiekerkoetter

“…We touch upon important considerations and knowledge gaps to be addressed for future clinical testing of anti-fibrotic cardiac therapies.…”
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Utilidad del cefadroxilo en leishmaniosis tegumentaria americana con infecciones piógenas sobreagregadas by Navarro Pedro, Silva, Sylvia, De la Parte María A, Colmenares Luis Alfonso, Coraspe Virginia, Garrido Elinor, Redondo, María C

“…Since leishmaniosis is considered an emerging disease, a search for appropriate, alternative therapies is required. Resumen: La leishmaniosis tegumentaria americana es un problema de salud en el medio rural venezolano. …”
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MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis by Parvez Khan, Jawed Akhtar Siddiqui, Prakash G. Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana Kumari Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. Talmon, Prakash Kulkarni, Apar K. Ganti, Maneesh Jain, Ravi Salgia, Surinder Kumar Batra, Mohd Wasim Nasser

“…It targets the CXCR4/FOXM1/RRM2 axis and has a high potential for the development of novel SCLC therapies. Graphical Abstract MicroRNA-1 (miR-1) downregulation in the tumor tissues and serum samples of SCLC patients is an important hallmark of tumor growth and metastasis. …”
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Economic impacts of the COVID-19 pandemic on families of children with autism and other developmental disabilities by Olivia M. Pokoski, Olivia M. Pokoski, Hayley Crain, Hayley Crain, Carolyn DiGuiseppi, Sarah M. Furnier, Sarah M. Furnier, Eric J. Moody, Cy Nadler, Karen Pazol, Jessica Sanders, Lisa D. Wiggins, Maureen S. Durkin, Maureen S. Durkin, Maureen S. Durkin

“…In emergency situations, families of children with developmental disabilities (DDs), including autism, may experience increased difficulty accessing therapies, economic hardship, and caregiver stress, with the potential to exacerbate autism symptoms. …”
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Prevalence and subtyping of biofilms present in bronchoalveolar lavage from children with protracted bacterial bronchitis or non-cystic fibrosis bronchiectasis: a cross-sectional s... by Robyn L Marsh, PhD, Michael J Binks, PhD, Heidi C Smith-Vaughan, PhD, Maxine Janka, BSc, Sharon Clark, BBioMedSc, Peter Richmond, ProfMD, Anne B Chang, ProfPhD, Ruth B Thornton, PhD

“…Interpretation: Lower airway biofilms are prevalent, but not ubiquitous, in bronchoalveolar lavage from children with PBB or bronchiectasis, suggesting anti-biofilm therapies might be beneficial for some children. Detection of upper airway biofilms in bronchoalveolar lavage that did not have signs of contamination suggests that microaspiration might be important in some children. …”
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Aging‐associated skeletal muscle defects in HER2/Neu transgenic mammary tumour model by Ruizhong Wang, Brijesh Kumar, Poornima Bhat‐Nakshatri, Mayuri S. Prasad, Max H. Jacobsen, Gabriela Ovalle, Calli Maguire, George Sandusky, Trupti Trivedi, Khalid S. Mohammad, Theresa Guise, Narsimha R. Penthala, Peter A. Crooks, Jianguo Liu, Teresa Zimmers, Harikrishna Nakshatri

“…Conclusions These results suggest that breast cancer subtype has a specific impact on the type of molecular and structural changes in skeletal muscle, which needs to be taken into consideration while designing therapies to reduce breast cancer‐induced skeletal muscle loss and functional limitations.…”
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Comparative Outcomes of Primary Versus Recurrent High-risk Non–muscle-invasive and Primary Versus Secondary Muscle-invasive Bladder Cancer After Radical Cystectomy: Results from a... by Nico C. Grossmann, Pawel Rajwa, Fahad Quhal, Frederik König, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Satoshi Katayama, Reza Sari Motlagh, Christian D. Fankhauser, Agostino Mattei, Marco Moschini, Piotr Chlosta, Bas W.G. van Rhijn, Jeremy Y.C. Teoh, Eva Compérat, Marek Babjuk, Mohammad Abufaraj, Pierre I. Karakiewicz, Shahrokh F. Shariat, Benjamin Pradere

“…Therefore, early radical intervention may be indicated in selected patients, and potentially neoadjuvant systemic therapies in some patients with recHR-NMIBC. Patient summary: We compared cancer outcomes in different bladder cancer scenarios in a large, multinational series of patients who underwent removal of the bladder with curative intent. …”
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IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis by Dong Wang, Yujun Zhang, Liangping Zhang, Du He, Lan Zhao, Zhimin Miao, Wei Cheng, Chengyue Zhu, Li Zhu, Wei Zhang, Hongting Jin, Hang Zhu, Hao Pan

“…These findings suggest that targeting the IRF1-SMARCC1 regulatory axis, as well as the associated epigenetic modifications, could potentially be a novel approach in the development of OA therapies, offering new opportunities for disease management and improved patient outcomes.…”
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Mutational Profile of Malignant Pleural Mesothelioma (MPM) in the Phase II RAMES Study by Maria Pagano, Luca Giovanni Ceresoli, Paolo Andrea Zucali, Giulia Pasello, Marina Garassino, Federica Grosso, Marcello Tiseo, Hector Soto Parra, Francesca Zanelli, Federico Cappuzzo, Francesco Grossi, Filippo De Marinis, Paolo Pedrazzoli, Roberta Gnoni, Candida Bonelli, Federica Torricelli, Alessia Ciarrocchi, Nicola Normanno, Carmine Pinto

“…Data are not available in prospective trials on correlations between genetic alterations and outcomes of therapies. In this study, we assessed the genetic profile of MPM patients (pts) in tissue samples. …”
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