Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines by Martins Rucins, Pavels Dimitrijevs, Klavs Pajuste, Oksana Petrichenko, Ludmila Jackevica, Anita Gulbe, Signe Kibilda, Krisjanis Smits, Mara Plotniece, Dace Tirzite, Karlis Pajuste, Arkadij Sobolev, Janis Liepins, Ilona Domracheva, Aiva Plotniece

“…The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives differing in alkyl chain length and propargyl moiety/ties number and position were selected for the study of their self-assembling properties, evaluation of their cytotoxicity in vitro and toxicity on microorganisms, and the characterisation of their interaction with phospholipids. …”
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Interventional cardiology in cancer patients: A position paper from the Portuguese Cardiovascular Intervention Association and the Portuguese Cardio-Oncology Study Group of the Por... by Miguel Nobre Menezes, Marta Tavares da Silva, Andreia Magalhães, Bruno Melica, Júlia Cristina Toste, Rita Calé, Manuel Almeida, Manuela Fiuza, Eduardo Infante de Oliveira

“…While awareness of cardiotoxicity due to cancer disease and/or therapies has greatly increased, much of the attention has focused on myocardial systolic disfunction and heart failure. …”
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S-1/temozolomide versus S-1/temozolomide plus thalidomide in advanced pancreatic and non-pancreatic neuroendocrine tumours (STEM): A randomised, open-label, multicentre phase 2 tri... by Yihebali Chi, Lijie Song, Weili Liu, Yuhong Zhou, Yadong Miao, Weijia Fang, Huangying Tan, Susheng Shi, Hai Jiang, Jianming Xu, Ru Jia, Bo Zheng, Liming Jiang, Jiuda Zhao, Rui Zhang, Huijing Tan, Yuehua Wang, Qichen Chen, Minjie Yang, Xi Guo, Zhou Tong, Zhirong Qi, Fuxing Zhao, Xiaofei Yan, Hong Zhao

“…Adults (≥18 years) with unresectable/metastatic, pancreatic or non-pancreatic NETS, with an Eastern Cooperative Oncology Group (ECOG) PS of 0–1, and progression on ≤2 previous therapies were randomised (1:1, using hierarchical block randomization with block length 4, stratified by pancreatic/non-pancreatic disease to receive S-1 40–60 mg orally twice daily on days 1–14 plus temozolomide 200 mg orally daily on days 10–14 in a 21-day cycle OR S-1 and temozolomide plus thalidomide orally nightly (100 mg on days 1–7, 200 mg on days 8–14, and 300 mg from day 15), until disease progression, death, intolerable toxicity, withdrawal of informed consent or at the investigator's discretion. …”
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A systematic review and meta-analysis of the serum lipid profile in prediction of diabetic neuropathy by Zixin Cai, Yan Yang, Jingjing Zhang

“…Lipid levels should be explored as routine laboratory markers for predicting the risk of DN, as they will help clinicians choose appropriate therapies, and thus optimize the use of available resources.…”
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Interventions for adults with a history of complex traumatic events: the INCiTE mixed-methods systematic review by Hollie Melton, Nick Meader, Holly Dale, Kath Wright, Julie Jones-Diette, Melanie Temple, Iram Shah, Karina Lovell, Dean McMillan, Rachel Churchill, Corrado Barbui, Simon Gilbody, Peter Coventry

“…Psychological interventions were superior to the control post treatment for reducing post-traumatic stress disorder symptoms (standardised mean difference –0.90, 95% confidence interval –1.14 to –0.66; number of trials = 39) and also for associated symptoms of depression, but not anxiety. Trauma-focused therapies were the most effective interventions across all populations for post-traumatic stress disorder and depression. …”
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A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures by Sarah Davis, Marrissa Martyn-St James, Jean Sanderson, John Stevens, Edward Goka, Andrew Rawdin, Susi Sadler, Ruth Wong, Fiona Campbell, Matt Stevenson, Mark Strong, Peter Selby, Neil Gittoes

“…We plan to extend the analysis to include non-bisphosphonate therapies. Study registration: This study is registered as PROSPERO CRD42013006883. …”
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Start2quit: a randomised clinical controlled trial to evaluate the effectiveness and cost-effectiveness of using personal tailored risk information and taster sessions to increase... by Hazel Gilbert, Stephen Sutton, Richard Morris, Irene Petersen, Qi Wu, Steve Parrott, Simon Galton, Dimitra Kale, Molly Sweeney Magee, Leanne Gardner, Irwin Nazareth

“…Control – standard generic letter from the general practice advertising the local SSS and the therapies available, and asking the smoker to contact the service to make an appointment. …”
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The Effect of Curcumex Supplement (Containing Turmeric, Ginger, and Black Pepper Extract) on Clinical Manifestations and Laboratory Findings of Patients with COVID-19 by Roya Ghasemian, Masoud Aliyali, Seyed Hossein Mehravaran, Iradj Maleki, Hossein Mohammadi, Ali Asghar Hemmati, Sara Bayat, Saber Palar, Gholamreza Houshmand

“…Thus far, numerous non-specific therapies have been employed for this viral infection, however, the majority of these medications have proven to be ineffective and have been correlated with a multitude of adverse effects for patients. …”
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Alternatives to Hospitalization: Adding the Patient Voice to Advanced Heart Failure Management by Hilary J. Bews, MD, Jana L. Pilkey, MD, Amrit A. Malik, MD, James W. Tam, MD

“…Such interventions include strategies to combat diuretic resistance, as well as nondiuretic treatments of dyspnea, and the continuation of guideline-directed medical therapies. Finally, to successfully care for advanced HF patients at home, care models, such as transitional care, telehealth, collaborative home-based palliative care programs, and home hospitals, must be robust. …”
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Diuretic dose is a strong prognostic factor in ambulatory patients awaiting heart transplantation by Guillaume Baudry, Guillaume Coutance, Richard Dorent, Fabrice Bauer, Katrien Blanchart, Aude Boignard, Céline Chabanne, Clément Delmas, Nicolas D'Ostrevy, Eric Epailly, Vlad Gariboldi, Philippe Gaudard, Céline Goéminne, Sandrine Grosjean, Julien Guihaire, Romain Guillemain, Mathieu Mattei, Karine Nubret, Sabine Pattier, Emmanuelle Vermes, Laurent Sebbag, Kevin Duarte, Nicolas Girerd

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In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlying Mycobacterium bovis infection by Aliakbar Hasankhani, Abolfazl Bahrami, Abolfazl Bahrami, Shayan Mackie, Sairan Maghsoodi, Heba Saed Kariem Alawamleh, Negin Sheybani, Farhad Safarpoor Dehkordi, Farhad Safarpoor Dehkordi, Fatemeh Rajabi, Ghazaleh Javanmard, Hosein Khadem, Herman W. Barkema, Marcos De Donato

“…Furthermore, several hub-central genes/TFs were identified that were significant in determining the fate of M. bovis infection and could be promising targets for developing novel anti-bTB therapies and diagnosis strategies.…”
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New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming by Leticia Colyn, Gloria Alvarez-Sola, M. Ujue Latasa, Iker Uriarte, Jose M. Herranz, Maria Arechederra, George Vlachogiannis, Colin Rae, Antonio Pineda-Lucena, Andrea Casadei-Gardini, Federica Pedica, Luca Aldrighetti, Angeles López-López, Angeles López-Gonzálvez, Coral Barbas, Sergio Ciordia, Sebastiaan M. Van Liempd, Juan M. Falcón-Pérez, Jesus Urman, Bruno Sangro, Silve Vicent, Maria J. Iraburu, Felipe Prosper, Leonard J. Nelson, Jesus M. Banales, Maria Luz Martinez-Chantar, Jose J. G. Marin, Chiara Braconi, Christian Trautwein, Fernando J. Corrales, F. Javier Cubero, Carmen Berasain, Maite G. Fernandez-Barrena, Matias A. Avila

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Hepatitis B immunization status and risk factors of people aged 1 to 69 in Huangpu District, Shanghai, China by Yijun Wang, Min Shu, Jun Chen, Fujie Shen, Hong Ren, Yongfu Yu

“…However, the existed HBV infected people were still needed to be discovered, evaluated whether to receive antiviral therapies and intervened with health education in order to reduce the incidence of viral hepatitis related hepatocellular carcinoma (HCC) and also reach the goal to eliminate public health hazards of viral hepatitis by 2030.ObjectiveTo know HepB immunization status among people aged 1 to 69 in Huangpu district of Shanghai, and find out risk factors changes of HBV infection.MethodsCross-sectional study was applied to analyze the HepB immunization status and related risk factors by carrying out survey among 706 participants aged 1 to 69 years old. …”
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Medium- and long-term outcome after a single second-generation cryoballoon ablation in patients with paroxysmal and persistent atrial fibrillation by Ginés Elvira Ruiz, Pablo Peñafiel Verdú, Juan Martínez Sánchez, Juan José Sánchez Muñoz, Francisco José García Almagro, Carmen Muñoz Esparza, Arcadi García Alberola

“…Of patients with recurrences, 11.1% did not require further therapies and an additional 16.7% had good control with antiarrhythmic drugs. …”
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Brief Research Report: Quantitative Analysis of Potential Coronary Microvascular Disease in Suspected Long-COVID Syndrome by Patrick Doeblin, Patrick Doeblin, Fridolin Steinbeis, Cian M. Scannell, Collin Goetze, Sarah Al-Tabatabaee, Jennifer Erley, Alessandro Faragli, Felix Pröpper, Martin Witzenrath, Thomas Zoller, Thomas Zoller, Christian Stehning, Holger Gerhardt, Holger Gerhardt, Javier Sánchez-González, Ebraham Alskaf, Titus Kühne, Titus Kühne, Burkert Pieske, Burkert Pieske, Burkert Pieske, Carsten Tschöpe, Carsten Tschöpe, Carsten Tschöpe, Amedeo Chiribiri, Sebastian Kelle, Sebastian Kelle, Sebastian Kelle

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Kidney Transplantation in Times of Covid-19: Decision Analysis in the Canadian Context by Ivan Yanev, Michael Gagnon, Matthew P. Cheng, Steven Paraskevas, Deepali Kumar, Alice Dragomir, Ruth Sapir-Pichhadze

“…While population-level herd immunity may decrease infection risk in transplant patients, more data are required on vaccine efficacy against SARS-CoV-2 and variants of concern in ESKD, and how efficacy may be modified by a third vaccine dose, maintenance immunosuppression and timing of induction and rejection therapies.…”
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Deep Learning-Based Prediction of Future Extrahepatic Metastasis and Macrovascular Invasion in Hepatocellular Carcinoma by Fu S, Pan M, Zhang J, Zhang H, Tang Z, Li Y, Mu W, Huang J, Dong D, Duan C, Li X, Wang S, Chen X, He X, Yan J, Lu L, Tian J

“…In the high-risk population, current guideline indicates that first-line treatments are insufficient to prevent extrahepatic metastasis and macrovascular invasion and ensure survival benefits, so more therapies may be explored for these patients.Keywords: aggressive disease progression, deep learning radiomics, clinical factors, high-risk, risk prediction…”
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Establecimiento de las condiciones para el trasplante de células de médula ósea en un modelo de enfermedad de Huntington y su efecto funcional a través de la conducta motora by Teresa Serrano Sánchez, Lisette Blanco Lezcano, Esteban Alberti Amador, Iván Díaz Armesto, Nancy Pavón Fuente, Lourdes Lorigados Pedre, María Elena González Fraguela, Jorge Felipe Montero León, Liliana Francis Turner, Ivette Fernández Verdecia

“…At the present time it is known that it is possible to reproduce, some characteristics of the disease in experimental models for to use possible therapies [example: estriatal lesion of  quinolínico acid; (QA)]. the restorative effect of the bone marrow cells (BMC) is not known in this model. …”
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Pancreatic endocrine tumors or apudomas Tumores endocrinos o apudomas pancreáticos by Modesto Varas, Joan Gornals, José María Ponseti, Antonio Alastruè, Cristina Durán, Carlos Llevaria, Carlos Ballesta, Alberto Díez Caballero, Vicente Artigas

“…A database was set up with ten parameters: age, sex, symptoms, imaging techniques, size and location in the pancreas, metastasis, surgery, complications, adjuvant therapies, definite diagnosis, and survival or death. …”
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Infecciones por virus respiratorio sincitial que requieren hospitalización en pacientes con inmunodeficiencias primarias by Luis Ignacio González-Granado, Andrea Martín-Nalda, Laia Alsina, Olaf Neth, Manuel Santamaría, Pere Soler-Palacín

“…Two of the 13 patients were receiving palivizumab for RSV prophylaxis, and 3 received potentially active therapies against RSV during the hospital stay. Viral coinfection was detected in 6 patients, 5 (39%) developed complications, and 4 (31%) required admission to the paediatric intensive care unit. …”
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