Substantiation of a clopidogrel metabolism-associated gene (CYP2C19) variation among healthy individuals by Anshu Kumar Yadav, Aparna Kodakkat Chakkumkollath, Aysha Helna, Siddharth Birla, Rajesh Kumar Thimmulappa, Sunil Kumar Shambu, Prashant Vishwanath, Akila Prashant

“…Methodology: The study involved 300 healthy subjects between the ages of 18 and 85 recruited by simple random sampling. Allele-specific touchdown PCR was employed to identify the various alleles. …”
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Enhancement Effects and Mechanism Studies of Two Bismuth-Based Materials Assisted by DMSO and Glycerol in GC-Rich PCR by Zhu Yang, Junlei Yang, Lihuan Yue, Bei Shen, Jing Wang, Yuqing Miao, Ruizhuo Ouyang, Yihong Hu

“…Further, there are many ways to enhance the reaction, for example, using different PCR strategies such as hot-start/touchdown PCR or adding some special modifications or additives such as organic solvents or compatible solutes, which can improve PCR yield. …”
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A Comparison of the Different Stages of Dust Events over Beijing in March 2021: The Effects of the Vertical Structure on Near-Surface Particle Concentration by Futing Wang, Ting Yang, Zifa Wang, Jie Cao, Benli Liu, Jianbao Liu, Shengqian Chen, Shulin Liu, Binghao Jia

“…There was a strong temporal consistency between the occurrence of the downdraft and the dust touchdown. In E1, the continuous strong downdraft caused the maximum dust concentration to be above 4000 μg/m³ at around 200 m. …”
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A Template Model Explains Jerboa Gait Transitions Across a Broad Range of Speeds by Jiayu Ding , Talia Y. Moore , Zhenyu Gan

“…This mechanism generates changes in gait features (e.g., touchdown leg angle and timings of gait events) that have previously been shown to induce gait transitions. …”
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Molecular Study of Nucleotide Changes of ATPase6 and MT-CYB Genes in the Mitochondrial Genome of Patients with Familial Adenomatous Polyposis (FAP) by Mohammad Mehdi Heidari, Fatemeh Ebrahimi, Zahra Shaker Ardakani, Mahsa Mirzaei, Shima Mirhosseini, Mehri Khatami

“…For this purpose, a fragment with the length of 558bp containing the ATPase6 gene and also a fragment containing the MT-CYB gene with a length of 853bp were studied using the Touchdown-PCR method and sequencing. Sequencing results were analyzed with several bioinformatics software and databases, including ExPASy, SIFT, PSIPRED, PolyPhen-2, I-Mutant, PROVEAN, PredictSNP, and PyMol. …”
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Cloning, expression and functional activity of deoxyhypusine synthase from <it>Plasmodium vivax</it> by Nassar Marwa, Njuguna James T, Hoerauf Achim, Kaiser Annette E

“…</p> <p>Results</p> <p>We describe the cloning of a 1368 bp putative deoxyhypusine synthase gene (<it>dhs</it>) sequence from genomic DNA of <it>P. vivax </it>PEST strain Salvador I (Accession number <ext-link ext-link-type="gen" ext-link-id="AJ549098">AJ549098</ext-link>) after touchdown PCR. The corresponding protein was expressed and functionally characterized as deoxyhypusine synthase by determination of its specific activity and cross-reactivity to human DHS on a Western blot.…”
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Standards of Helicopter Emergency Medical Service (HEMS) for Patient Transport in Urban Areas: Review article by M Bahrami, Z Pilehvari, E Alavi

“…Some other standards include: algorithms for patient screening, flight heights for different diseases and injuries, rooftop and parking garage helipad at hospital, approach of flight paths and the facility at the touchdown area. HEMS standard medical equipment includes those needed for telemedicine and basic and advanced life support. …”
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Evaluating human fecal contamination sources in Kranji Reservoir Catchment, Singapore by Nshimyimana, Jean Pierre

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Air traffic flow management at airports : a unified optimization approach by Frankovich, Michael Joseph

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Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells by Youping Zhou, Youlin Deng, Jing Wang, Zhengjian Yan, Qiang Wei, Jixing Ye, Junhui Zhang, Tong-Chuan He, Min Qiao

“…Gene expression was detected by touchdown-quantitative real-time PCR. Inhibition of IGF1R was tested by immunofluorescence staining. …”
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The Influence of Percentile Weight Bearing on Foot Radiographs by Trevor Shelton MD, MS, Sohni Singh BS, Christopher Kreulen MD, MS, Eric Giza MD

“…For each radiographic measurement, a single factor ANOVA determined whether measurements were different between non-weight bearing, touchdown weight bearing, 25% weight bearing, 50% weight bearing, and 100% weight bearing. …”
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Requiring Reconsideration of Differences of Aeromonas Infections Between Extra-Intestinal and Intestinal in Hospitalized Patients by Zhang D, Li W, Hu X, Huang H, Zhang X

“…The broth microdilution method was used to investigate the antimicrobial susceptibility profiles. Touchdown polymerase chain reaction (PCR) assays and DNA sequencing were employed to confirm virulence and the presence of drug resistance genes.Results: The housekeeping genes identified 188 strains into 7 species. …”
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Proximal Hamstring Repair With All-Suture Anchors and an Accelerated Rehabilitation and Bracing Protocol Demonstrates Good Outcomes at 1-Year Follow-Up by Stephanie E. Wong, M.D., Kaitlyn R. Julian, B.S., Jocelyn G. Carpio, B.S., Alan L. Zhang, M.D.

“…After surgery, all patients underwent an accelerated rehabilitation protocol, including 6 weeks touchdown weight-bearing in a hinged knee brace locked in extension for ambulation, allowing passive knee flexion to 90° while seated. …”
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Influence of Arch-Support Orthoses with Heel Lift Manipulation on Joint Moments and Forefoot Mechanics in Running by Jun-Xiang Pan, Wing-Kai Lam, Peter Lung-Wai Sze, Mohammad Farhan Tan, Aaron Kam-Lun Leung

“…For sagittal plane, D10 had larger rearfoot touchdown dorsiflexion than D2 (<i>p</i> = 0.027) and control (<i>p</i> = 0.007) and larger in D6 than control (<i>p</i> = 0.025). …”
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Effects of a 12-week gait retraining program combined with foot core exercise on morphology, muscle strength, and kinematics of the arch: A randomized controlled trial by Bin Shen, Shen Zhang, Shen Zhang, Shen Zhang, Kedong Cui, Xini Zhang, Weijie Fu, Weijie Fu, Weijie Fu

“…Before and after the intervention, the arch morphology, as well as the strength of hallux flexion, lesser toe flexion, and the metatarsophalangeal joint (MPJ) flexors were measured in a static position, and changes in the arch kinematics during RFS and FFS running were explored.Results: After a 12-week intervention, 1) the normalized navicular height increased significantly in the INT group by 5.1% (p = 0.027, Cohen’s d = 0.55); 2) the hallux absolute flexion and relative flexion of the INT group increased significantly by 20.5% and 21.7%, respectively (p = 0.001, Cohen’s d = 0.59; p = 0.001, Cohen’s d = 0.73), the absolute and relative strength of the MPJ flexors of the INT group were significantly improved by 30.7% and 32.5%, respectively (p = 0.006, Cohen’s d = 0.94; p = 0.006, Cohen’s d = 0.96); 3) and during RFS, the maximum arch angle of the INT group declined significantly by 5.1% (p &lt; 0.001, Cohen’s d = 1.49), the arch height at touchdown increased significantly in the INT group by 32.1% (p &lt; 0.001, Cohen’s d = 1.98).Conclusion: The 12-week gait retraining program combined with foot core exercise improved the arch in both static and dynamic positions with a moderate to large effect size, demonstrating the superiority of this combined intervention over the standalone interventions. …”
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Effect of the Innovative Running Shoes With the Special Midsole Structure on the Female Runners’ Lower Limb Biomechanics by Fengqin Fu, Fengqin Fu, Fengqin Fu, Lianming Guo, Xunfei Tang, Jiayu Wang, Zhihao Xie, Gusztáv Fekete, Yuhui Cai, Qiuli Hu, Yaodong Gu

“…Regarding 0D parameters, the ankle dorsiflexion angle of innovative running shoes at touchdown was higher, and the peak dorsiflexion angle, range of motion, peak dorsiflexion velocity, and plantarflexion moment on the metatarsophalangeal joint of innovative running shoes during running were significantly smaller than those of normal running shoes (all p &lt; 0.001). …”
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Third Annual Summer Research Summit on Health Equity Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030... by Hamisu M. Salihu, MD, PhD, Deepa Dongarwa, MS, Toi B. Harris, MD

“…First option was to cancel the summit in its entirety: this was the easiest and most obvious choice once the COVID-19 pandemic forced a near total lockdown all over the country with unprecedented disruptions of normal daily activities as the disease announced its thunderous touchdown on United States (US) soil. It was also the most-logical response faced with uncertainty regarding summit logistics and expected poor attendance due to the raging pandemic. …”
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Tarmac delay policies: A passenger-centric analysis by Vaze, Vikrant, Vanderboll, Allison Elizabeth, Yan, Chiwei, Barnhart, Cynthia

“…The Tarmac Delay Rule stipulates that aircraft lift-off, or an opportunity for passengers to deplane, must occur no later than 3 h after the cabin door closure at the gate of the departure airport; and that an opportunity for passengers to deplane must occur no later than 3 h after the touchdown at the arrival airport. The Tarmac Delay Rule aims to protect enplaned passengers on commercial aircraft from excessively long delays on the tarmac upon taxi-out or taxi-in, and monetarily penalizes airlines that violate the stipulated 3-h tarmac time limit. …”
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Performance, Stability and Control of Electric Short Takeoff and Landing Aircraft by Courtin, Christopher B.

“…The ability of the aircraft and pilot to reject gusts and track a target trajectory directly effects the ground footprint required, because the expected lateral and longitudinal offset from the touchdown aiming point must be included in any estimate the total required runway size. …”
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A Comparison of Double Poling Physiology and Kinematics Between Long-Distance and All-Round Cross-Country Skiers by Per-Øyvind Torvik, Øyvind Sandbakk, Roland van den Tillaar, Rune Kjøsen Talsnes, Rune Kjøsen Talsnes, Jørgen Danielsen

“…However, group × speed interaction effects (p &lt; 0.05) were found for pole angle and vertical fluctuation of body center of mass, with LDS maintaining a more upright body position and more vertical pole angles at touchdown and lift-off at faster speeds. ARS displayed slightly higher normalized EMG amplitude than LDS in the muscles rectus abdominis (p = 0.074) and biceps femoris (p = 0.027). …”
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