Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine by Rita Ghosh, Gretchen E. Garcia, Katherine Crosby, Hiroyasu Inoue, Ian M. Thompson, Dean A. Troyer, Addanki P. Kumar

“…We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Our data also indicate that the antiproliferative effects of NexrutineR are mediated in part by Akt and Cyclic AMP response element binding protein (CREB). …”
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The Ant Genus <i>Cardiocondyla</i> (Hymenoptera: Formicidae): The Species Groups with Oriental and Australasian Origin by Bernhard Seifert

“…Exploratory and hypothesis-driven data analyses of phenotypic characters support the separation of the cryptic species <i>Cardiocondyla minutior</i> Forel, 1899, <i>C. goa</i> Seifert, 2003 and <i>C. tjibodana</i> Karavajev, 1935, two of which have dispersed as tramp species to the New World. Missing development of postzygotic isolation due to very strong prezygotic barriers is indicated in the closely related species <i>Cardiocondyla latifrons</i> n.sp. and <i>C. micropila</i> n.sp. which produce fertile hybrids in laboratory rearings but apparently do not hybridize in a natural context even if nesting in close neighborhood. …”
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Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer by Maike Stentenbach, Judith A Ermer, Danielle L Rudler, Kara L Perks, Samuel A Raven, Richard G Lee, Tim McCubbin, Esteban Marcellin, Stefan J Siira, Oliver Rackham, Aleksandra Filipovska

“…The Elac2 variant or knockout mice on the background of the transgenic adenocarcinoma of the mouse prostate (TRAMP) model show that Elac2 mutation with a secondary genetic insult exacerbated the onset and progression of prostate cancer. …”
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Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases. by Olga Aprelikova, Christine C Tomlinson, Mark Hoenerhoff, Julie A Hixon, Scott K Durum, Ting-Hu Qiu, Siping He, Sandra Burkett, Zi-Yao Liu, Steven M Swanson, Jeffrey E Green

“…REAR mice are more immunologically tolerant to SV40 T-antigen driven tumors and cell lines in an FVB/N background (including prostate tumors from TRAMP mice), but are otherwise immunologically intact. …”
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Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer by Souhil Lebdai, Mathieu Gigoux, Ricardo Alvim, Alexander Somma, Karan Nagar, Abdel Rahmene Azzouzi, Olivier Cussenot, Taha Merghoub, Jedd D. Wolchok, Avigdor Scherz, Kwanghee Kim, Jonathan Coleman

“…In this study, we investigated the effects of VTP on the recruitment of tumor-infiltrating myeloid cells, specifically MDSCs and tumor-associated macrophages (TAMs), in the Myc-Cap and TRAMP C2 murine prostate cancer models. We report that VTP increased the infiltration of myeloid cells into the tumors, as well as their expression of CSF1R, a receptor required for myeloid differentiation, proliferation, and tumor migration. …”
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TRAM flap in reconstructive operations in patients with breast cancer by A. D. Zikiryakhodzhaev, E. A. Rasskazova

“…The paper presents some experience in treating 11 BC patients in whom a displaced TRAMP flap was employed for reconstruction. At this time, the displaced TRAM flap was applied for delayed reconstruction in 3 patients. …”
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The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance by Natascha Hermann-Kleiter, Victoria Klepsch, Stephanie Wallner, Kerstin Siegmund, Sebastian Klepsch, Selma Tuzlak, Andreas Villunger, Sandra Kaminski, Christa Pfeifhofer-Obermair, Thomas Gruber, Dominik Wolf, Gottfried Baier

“…Here, we show that genetic ablation of Nr2f6 significantly improves survival in the murine transgenic TRAMP prostate cancer model. Furthermore, Nr2f6−/− mice spontaneously reject implanted tumors and develop host-protective immunological memory against tumor rechallenge. …”
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Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species. by Monika Tasak, Eric M Phizicky

“…In contrast, S. cerevisiae trm6/gcd10 mutants with reduced 1-methyladenosine (m1A58) specifically target pre-tRNAiMet(CAU) to the nuclear surveillance pathway for 3'-5' exonucleolytic decay by the TRAMP complex and nuclear exosome. We show here that the RTD pathway has an unexpected major role in the biology of m1A58 and tRNAiMet(CAU) in both S. pombe and S. cerevisiae. …”
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Towards sustainable material usage : time-dependent evaluation of upgrading technologies for recycling by Gaustad, Gabrielle G

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Changing concentration ratios and geographical patterns of bulk ports : the case of the Korean west coast by Lee, Taehwee, Yeo, Gi-tae, Thai, Vinh V.

“…Contrary to liner shipping, common shipping network patterns are difficult to organize in tramp shipping as origin and destination ports are irregular and they may change based on shippers’ demands. …”
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YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression by Tianyu Shen, Yang Li, Shimiao Zhu, Jianpeng Yu, Boya Zhang, Xuanrong Chen, Zheng Zhang, Yuan Ma, Yuanjie Niu, Zhiqun Shang

“…Methods The effects of conditioned media from different fibroblasts on the proliferation and invasion of epithelial cells TrampC1 were examined. We then analysed the interaction between the YAP1/TEAD1 protein complex and SRC, as well as the regulatory function of the downstream cytoskeletal proteins and actins. …”
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Diversity and Distribution of Forest Ants (Hymenoptera: Formicidae) in Nepal: Implications for Sustainable Forest Management by Indra Prasad Subedi, Prem Bahadur Budha, Ripu Mardhan Kunwar, Shambhu Charmakar, Sunita Ulak, Dhirendra Kumar Pradhan, Yam Prasad Pokharel, Sajeev Thavalathadathil Velayudhan, Shiroma Sathyapala, Illias Animon

“…This includes five genera and nine species new for the country, as well as eight tramp species, four of which are major ecological, agricultural, and/or household pests. …”
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TLK1‐mediated MK5‐S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies by Md Imtiaz Khalil, Vibha Singh, Judy King, Arrigo De Benedetti

“…A pMK5‐S354 antiserum was used to establish this site as an authentic TLK1 target in androgen‐sensitive human prostate adenocarcinoma (LNCaP) cells, and was used in immunohistochemistry (IHC) studies of age‐related PCa sections from TRAMP (transgenic adenocarcinoma of the mouse prostate) mice and to probe a human tissue microarray (TMA), which revealed pMK5‐S354 level is correlated with disease progression (Gleason score and nodal metastases). …”
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Polyphenon E Effects on Gene Expression in PC-3 Prostate Cancer Cells by L. Michael Carastro, Ethan J. Vallebuona, Ricardo Cordova, Ashley N. Gannon, Seung Joon Kim, Corrine M. Costello, Ricardo A. Declet-Bauzo, Nagi Kumar, Jong Y. Park

“…Poly E is reported to confer chemoprotective activity against prostate cancer (PCa) progression in the TRAMP model of human PCa, and has shown limited activity against human PCa in human trials. …”
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Disruption in maritime chokepoints and their implications (maritime route) by Lim, Hoong Keat

“…Information contained in this report should interest maritime professionals from fleet ownership & management and commercial freight owners of tramp & liner shipping. As this report only focuses on sea routes, we only include factors that would immediately disrupt stakeholders’ operations or sales. …”
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Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunity by Elizabeth R. Sturgill, Annah S. Rolig, Stefanie N. Linch, Courtney Mick, Melissa J. Kasiewicz, Zhaoyu Sun, Peter G. Traber, Harold Shlevin, William L. Redmond

“…Tumor-bearing (MCA-205 sarcoma, 4T1 mammary carcinoma, TRAMP-C1 prostate adenocarcinoma) mice were treated with a Gal-3 inhibitor (belapectin; GR-MD-02), aOX40, or combination therapy and the extent of tumor growth was determined. …”
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Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors by Nicola E. Annels, Guy R. Simpson, Mick Denyer, Mehreen Arif, Matt Coffey, Alan Melcher, Kevin Harrington, Richard Vile, Hardev Pandha

“…Treatment of subcutaneous TRAMP-C2 prostate tumors with combined intratumoral reovirus and anti-PD-1 or anti-CD73 antibody significantly enhanced survival of mice compared with reovirus or either antibody therapy alone. …”
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Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression by Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang, Mengfei Yao, Yongqiang Huang, Leilei Du, Xingming Zhang, Dingwei Ye, Xiaojie Bian, Jianhua Wang

“…Moreover, using the TGF-β receptor I antagonist, galunisertib, significantly inhibited the tumor growth and progression of the TRAMP-C1 cell line-derived subcutaneous tumor model. …”
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Endurance training lowers ribosome density despite increasing ribosome biogenesis markers in rodent skeletal muscle by Matthew A. Romero, C. Brooks Mobley, Melissa A. Linden, Grace Margaret-Eleanor Meers, Jeffrey S. Martin, Kaelin C. Young, R. Scott Rector, Michael D. Roberts

“…Ribophagy (USP10 and G3BP1) and TRAMP-exosome rRNA degradation pathway (EXOSC10 and SKIV2L2) proteins were assayed to determine if these pathways were involved with lower ribosome density in O-WD/EX rats. …”
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Targeting Prostate Cancer Using Intratumoral Cytotopically Modified Interleukin-15 Immunotherapy in a Syngeneic Murine Model by Papaevangelou E, Smolarek D, Smith RA, Dasgupta P, Galustian C

“…The efficacy of these agents was investigated by intratumoral administration either alone (cyto-IL-15 or cyto-abs) or in combination (cyto-combo) in subcutaneous TRAMP-C2 prostate tumors in C57BL/6J mice and compared with their non-modified equivalents in vivo. …”
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