-
17361
-
17362
-
17363
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice
Published 2019“…We infected p53 −/− ;Myc;Cas9 hepatocytes with the mGeCKOa lentiviral library of 67,000 single-guide RNAs (sgRNAs), targeting 20,611 mouse genes, and transplanted the transduced cells subcutaneously into nude mice. Within 1 month, all the mice that received the sgRNA library developed subcutaneous tumors. …”
Get full text
Article -
17364
Isogeometric analysis-based phase-field modeling of brittle fracture in piezoelectric materials
Published 2024“…Piezoelectric materials find extensive applications as sensors, actuators, and transducers, however, most of the functional piezoelectric ceramics though possessing excellent electromechanical coupling characteristics are often limited by brittleness and low fracture toughness. …”
Get full text
Thesis-Doctor of Philosophy -
17365
Dexamethasone can attenuate the pulmonary inflammatory response via regulation of the lncH19/miR-324-3p cascade
Published 2021-01-01“…LncH19 expression was inhibited by shRNA transduced with lentivirus. Cell assays for cell proliferation and apoptosis as well as RT-PCR, western blot, and ELISA for inflammatory genes were conducted to confirm the functions of lncH19. …”
Get full text
Article -
17366
Evaluation of trabecular meshwork-specific promoters in vitro and in vivo using scAAV2 vectors expressing C3 transferase
Published 2023-08-01“…CONCLUSION: In scAAV2-transduced TM cells, the promoter-driven efficiency of Ch3L1 is close to that of cytomegalovirus, but obviously higher than that of MGP. …”
Get full text
Article -
17367
NK-SPECIFIC CAR DESIGN IMPROVES NK CYTOTOXICITY AGAINST TUMOR CELLS
Published 2021-10-01“…Then, NK92 cell line was transduced, CAR19+ cells were enriched using magnetic beads and CAR19+ expression on cell surface evaluated by flow cytometry. …”
Get full text
Article -
17368
ESTABLISHMENT OF A CRISPR/CAS9-BASED GENOME EDITING PLATFORM FOR THE GENERATION OF AN OFF-THE-SHELF ALLOGENEIC CAR-T CELL MODEL
Published 2021-10-01“…The gRNAs sequences were cloned individually into lentiviral vectors upstream the anti-CD19 CAR gene, and the corresponding lentiviral particles were used to transduce Jurkat cells. We used these cells as a model for TCR and HLA depletion after the electroporation of a plasmid for a high-fidelity Cas9 transient expression. …”
Get full text
Article -
17369
Effects of Vitamin A on Immune Responses and Vitamin A Metabolism in Broiler Chickens Challenged with Necrotic Enteritis
Published 2023-05-01“…VitA supplementation up-regulated jejunal <i>RAR-β</i> expression but down-regulated mRNA expression of <i>RXR-α</i>, <i>RXR-γ</i>, signal transducers and activators of transcription (<i>STAT</i>) 5 and <i>STAT6</i> in the spleen (<i>p</i> < 0.05). …”
Get full text
Article -
17370
Attention mechanism optimization for sub-symbolic-based and neural-symbolic-based natural language processing
Published 2023“…The capability for machines to transduce, understand, and reason with natural language lives at the heart of Artificial Intelligence not only because natural language is one of the main mediums for information delivery, residing in documents, daily chats, and databases of various languages, but also because it involves many key aspects of intelligence (e.g., logic, understanding, abstraction, etc.). …”
Get full text
Thesis-Doctor of Philosophy -
17371
Development of chemical sensors based on tapered optical fiber tip coated with nanostructured thin films
Published 2015“…One of the most suitable optical transducing platforms for sensing applications is tapered optical fiber. …”
Get full text
Thesis -
17372
Characterization of dentatin isolated from Clausena excavate and its potential use for treatment of human breast and prostate cancers
Published 2012“…Treatment of MCF-7 cells with DTN encouraged apoptosis with cell death-transducing signals that reduced the MMP by down-regulation of Bcl-2 and up-regulation of Bax, triggering the cytochrome c release from mitochondria to cytosol. …”
Get full text
Thesis -
17373
Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1
Published 2019-10-01“…To evaluate the role of newly developed CXCR4 antagonists (PCT/IB2011/000120/ EP2528936B1/US2013/0079292A1) in potentiating anti-PD-1 efficacy two syngeneic murine models, the MC38 colon cancer and the B16 melanoma-human CXCR4-transduced, were employed. Methods Mice were subcutaneously injected with MC38 (1 × 106) or B16-hCXCR4 (5 × 105). …”
Get full text
Article -
17374
-
17375
Groundwater quality and quantity, and irrigation requirement for oil palm plantations in peat swamp, south Selangor, Malaysia
Published 2016“…With soil moisture probe and soil temperature sensors buried into the soil at two different depths of 5 cm and 70 cm, and pressure transducers inserted through a tube well into the groundwater in 10 different locations, the daily soil moisture and temperature at both depths and daily water table depths were determined over the period of 6 months. …”
Get full text
Thesis -
17376
Directional hear-through techiques for acoustic transparency to deliver augmented/mixed reality audio experiences over hearables
Published 2023“…Comb-filtering artifacts are a major issue in the practical implementation of all HT systems, including dirHT systems, which occur when the passively attenuated real sound that leaks into the hearables acoustically adds to the delayed HT equalized signal played back through the hearable's transducers. Mitigating comb-filtering artifacts in HT systems usually involves reducing the processing delay or further attenuating the leaked real sound signal using techniques such as Active Noise Control (ANC). …”
Get full text
Thesis-Doctor of Philosophy -
17377
INVESTIGATION INTO THE EFFECT OF CARPET FIBER INCLUSION ON THE PORE WATER PRESSURE GENERATION POTENTIAL O...
Published 2015-03-01“…Pore water pressure was recorded at three different levels, at the bottom, middle and top of the models, utilizing three pore pressure transducers connected to a data logger. …”
Get full text
Article