ACUTE TACROLIMUS-INDUCED KIDNEY INSUFFICIENCY IN PATIENT AFTER HEART TRANSPLANTATION by D. V. Doronin, A. M. Chernyavskiy, A. V. Fomichev, M. N. Deryagin, V. N. Gorbatykh

“…These drugs despite their effectiveness in the prevention of transplant rejection have serious side effects. Nephrosclerosis due to chronic nephrotoxic effect is recognized as the most important of them. …”
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Suppression of allograft rejection by regulatory B cells induced via TLR signaling by Kang Mi Lee, Qiang Fu, Guoli Huai, Kevin Deng, Ji Lei, Lisa Kojima, Divyansh Agarwal, Peter van Galen, Shoko Kimura, Naoki Tanimine, Laura Washburn, Heidi Yeh, Ali Naji, Charles G. Rickert, Christian LeGuern, James F. Markmann

“…More recently appreciated is that B cells are also integral in securing self-tolerance; this has led to interest in their therapeutic application to downregulate unwanted immune responses, such as transplant rejection. In this study, we found that PMA- and ionomycin-activated mouse B cells acquire regulatory properties following stimulation through TLR4/TLR9 receptors (Bregs-TLR). …”
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Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo. by Olivier Morteau, Samkeliso Blundell, Aron Chakera, Sophia Bennett, Charita M Christou, Philip D Mason, Richard J Cornall, Christopher A O'Callaghan

“…Despite an increasing awareness of the importance of innate immunity, the roles of natural killer (NK) cells in transplant rejection and antiviral and cancer immunity during immunosuppression have not been clearly defined.To address this issue we have developed a quantitative assay of NK cell function that can be used on clinical samples and have studied the influence of immunosuppression on NK cell function. …”
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Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells. by Graca, L, Le Moine, A, Lin, C, Fairchild, P, Cobbold, S, Waldmann, H

“…To investigate the antigen specificity of regulatory T cells capable of preventing transplant rejection, we have developed two different strategies to achieve tolerance to fully mismatched skin grafts in euthymic mice. …”

The calcineurin inhibitor tacrolimus specifically suppresses human T follicular helper cells by Wallin, E, Hill, D, Linterman, M, Wood, K

“…Therapeutic strategies targeting Tfh cells are important where antibody formation is implicated in disease, such as transplant rejection and autoimmune diseases. We investigated the impact of the immunosuppressive agent tacrolimus on human Tfh cell differentiation and function in transplant recipients. …”

IL‐33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation by Kawai, K, Uchiyama, M, Hester, J, Issa, F

“…Regulatory T cells (Tregs) are crucial mediators of immune homeostasis with the ability to modulate allogeneic response and control transplant rejection. While Treg‐based cell therapies have shown immense promise, methods to optimize current strategies are critical for successful implementation within the clinic. …”

Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance. by Graca, L, Thompson, S, Lin, C, Adams, E, Cobbold, S, Waldmann, H

“…This suggests that a capacity to regulate transplant rejection pre-exists in naive mice, and may be amplified in "tolerized" mice. …”

Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo. by Morteau, O, Blundell, S, Chakera, A, Bennett, S, Christou, C, Mason, P, Cornall, R, O'Callaghan, C

“…BACKGROUND: Despite an increasing awareness of the importance of innate immunity, the roles of natural killer (NK) cells in transplant rejection and antiviral and cancer immunity during immunosuppression have not been clearly defined. …”

The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice by Aidan W. Porter, Diep N. Nguyen, Dennis R. Clayton, Wily G. Ruiz, Stephanie M. Mutchler, Evan C. Ray, Allison L. Marciszyn, Lubika J. Nkashama, Arohan R. Subramanya, Sebastien Gingras, Thomas R. Kleyman, Gerard Apodaca, Linda M. Hendershot, Jeffrey L. Brodsky, Teresa M. Buck

“…Notably, the UPR is also activated in AKI when originating from various other etiologies, including ischemia, sepsis, glomerulonephritis, nephrotic syndrome, and transplant rejection. Our work establishes the central role of GRP170 in kidney homeostasis and directly links molecular chaperone function to kidney injury.…”
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Non-cytotoxic functions of CD8 T cells: “repentance of a serial killer” by Mouhamad Al Moussawy, Mouhamad Al Moussawy, Hossam A. Abdelsamed, Hossam A. Abdelsamed, Hossam A. Abdelsamed

“…Ironically, they are critical drivers of transplant rejection and autoimmune diseases, a scenario very similar to the famous novel “The strange case of Dr. …”
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IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts by Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podestà, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage

“…We found that IL-21–producing effector Tfh cells were essential for transplant rejection by regulating donor-specific germinal center B cell clonal dynamics both systemically in the draining LN and locally within kidney grafts. …”
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Polymeric nanomedicines for the treatment of hepatic diseases by Feixiang Luo, Ying Yu, Mingqian Li, Yuguo Chen, Peng Zhang, Chunsheng Xiao, Guoyue Lv

“…Therefore, disorders of liver functions triggered by various hepatic diseases, including hepatitis B virus infection, nonalcoholic steatohepatitis, hepatic fibrosis, hepatocellular carcinoma, and transplant rejection, significantly threaten human health worldwide. …”
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Sublabial Autologous Ear Cartilage Grafting for Increasing the Nasolabial Angle by Rajko Toncic, Dinko Toncic

“…Results Of all the patients, three patients experienced transplant rejection. The period of follow-up observation was one to five years (mean, 27 months). …”
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Stability and Species Specificity of Renal VEGF-A Splicing Patterns in Kidney Disease. by R J Turner, M Eikmans, I M Bajema, J A Bruijn, H J Baelde

“…The pattern of renal VEGF-A splice variants was unchanged in diabetic nephropathy and lupus nephritis and was stable throughout disease progression in acute transplant rejection and diabetic nephropathy; these results suggest renal VEGF-A splicing stability during kidney disease. …”
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THE BALANCE OF EFFECTORY AND REGULATORY MEMORY CELL INTERACTIONS AS A BASE FOR PRODUCING OF STEADY IMMUNE TOLERANCE STATE AFTER ORGAN TRANSPLANTATION (ANALYSIS OF PROBLEM AT THE LI... by S. D. Artamonov, D. A. Velikiy, N. A. Onischenko, L. V. Bashkina, A. O. Nikolskaya, M. E. Krasheninnikov, I. M. Ivanov

“…But because of a high risk of transplant rejection at different methods of tolerance producing it is necessary to work out safe diagnostic and prognostic methods for controlling of an individual level and power tolerance stability.…”
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Worked to the bone: antibody-based conditioning as the future of transplant biology by James M. Griffin, Fiona M. Healy, Lekh N. Dahal, Yngvar Floisand, John F. Woolley

“…Abstract Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding transplant rejection via immunosuppression. Standard conditioning regimens, typically comprising chemotherapy and/or radiotherapy, have proven successful in bone marrow clearance but are also associated with severe toxicities and high incidence of treatment-related mortality. …”
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The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation. by Anna K Kraus, Jin Chen, Ilka Edenhofer, Inga Ravens, Ariana Gaspert, Pietro E Cippà, Steffen Mueller, Rudolf P Wuthrich, Stephan Segerer, Guenter Bernhardt, Thomas Fehr

“…Thus, DNAM-1 blockade is not effective in preventing transplant rejection. Despite of being highly expressed, CD112 and CD155 do not appear to play a major immunogenic role in kidney transplantation. …”
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GLUCOCORTICOIDS AND ARTERIAL HYPERTENSION IN INTERNAL ORGANS RECIPIENTS by E. D. Kosmacheva, S. M. Martirosyan, N. A. Zubareva, A. E. Babich

“…In a practical manipulation it is necessary to use non-steroid protocols or minimize doses in internal organs recipients, weighing risks of transplant rejection and possible undesirable side responses in cases with glucocorticoids administration.…”
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Fate of lymphocytes after withdrawal of tofacitinib treatment. by Elisa Piscianz, Erica Valencic, Eva Cuzzoni, Sara De Iudicibus, Elisa De Lorenzo, Giuliana Decorti, Alberto Tommasini

“…Tofacitinib (Tofa) is an inhibitor of Janus Kinase 3, developed for the treatment of autoimmune diseases and for the prevention of transplant rejection. Due to its selective action on proliferating cells, Tofa can offer a way to block T cell activation, without toxic effects on resting cells. …”
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SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation. by Joshua D Mezrich, Linh P Nguyen, Greg Kennedy, Manabu Nukaya, John H Fechner, Xiaoji Zhang, Yongna Xing, Christopher A Bradfield

“…These characteristics lead us to suggest that SU5416 may be an ideal clinical agent for treatment of autoimmune diseases and prevention of transplant rejection, two areas where regulatory ligands of the AHR have shown promise. …”
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