Chimeric Antigen Receptors and Regulatory T Cells: The Potential for HLA-Specific Immunosuppression in Transplantation by Sabrina Wright, Conor Hennessy, Joanna Hester, Fadi Issa

“…CAR expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases, graft-versus-host disease (GVHD), and organ transplant rejection. In the latter, they hold immense potential as mediators of immune tolerance for recipients of allotransplants. …”
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Multimodality Imaging to Detect Rejection, and Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients—An Illustrative Review by Bibhuti B. Das, Shriprasad Deshpande, Tarique Hussain

“…This review illustrates noninvasive and invasive imaging techniques currently used or could be considered for clinical use in detecting heart transplant rejection, dysfunction, and CAV in children.…”
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Molecular detection and genotyping of Human Cytomegalovirus in kidney transplant recipients under ganciclovir prophylaxis in Iran by Farzane Behnezhad, Najmeh Parhizgari, Nazanin Zahra Shafiei-Jandaghi, Jila Yavarian, Talat Mokhtari-Azad

“…Although there are effective treatments strategies for the HCMV infection, this infection is still one of the causes of kidney transplant rejection. Methods: A total of 246 kidney transplant recipients participated in this cross-sectional study. …”
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Inappropriate expression of blood group antigens in hepatic allografts. by Bloom, S, Fleming, K, Chapman, R, Neuberger, J, Hubscher, S

“…We examined the expression of blood group antigens of the ABO, Lewis and Kell antigen systems using monoclonal antibodies and immunohistochemical study on 42 liver allograft specimens from 33 patients who underwent liver transplantation between 1986 and 1991 to learn whether altered blood group antigen expression might have a bearing on the immunopathogenesis of transplant rejection. Specimens were obtained at intervals of 0 days to 3 yr after transplant; they yielded the following histological diagnoses; time zero (n = 4), acute rejection (n = 4), pure cholestasis (n = 4), biliary obstruction (n = 4), early chronic rejection (n = 4), end-stage chronic rejection (n = 15) and miscellaneous late posttransplant biopsies (n = 7). …”

1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen. by James, L, Hale, G, Waldmann, H, Bloomer, A, Waldman, H

“…CAMPATH-1 antibodies have a long and successful history in the treatment of leukaemia, autoimmune disease and transplant rejection. The first antibody to undergo "humanisation", CAMPATH-1H, permits treatment with limited patient anti-globulin response. …”

Purine nucleotide metabolism regulates expression of the human immune ligand MICA by McCarthy, MT, Moncayo, G, Hiron, TK, Jakobsen, NA, Vali, A, Soga, T, Adam, J, O'Callaghan, CA

“…Immune recognition through NKG2D is implicated in cancer, atherosclerosis, transplant rejection, and inflammatory diseases, such as rheumatoid arthritis. …”

Low Immunogenicity of Keratinocytes Derived from Human Embryonic Stem Cells by Jiayi Shen, Xuanhao Zeng, Haozhen Lv, Yiting Jin, Yating Liu, Weiling Lian, Shiyi Huang, Qing Zang, Qi Zhang, Jinhua Xu

“…In humanized immune mouse models, ESKCs elicited weak transplant rejection responses in the host. Overall, we found that ESKCs have low immunogenicity and may have potential applications in the field of regenerative medicine.…”
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Do cells contribute to tendon and ligament biomechanics? by Niels Hammer, Daniel Huster, Sebastian Fritsch, Carsten Hädrich, Holger Koch, Peter Schmidt, Freddy Sichting, Martin Franz-Xaver Wagner, Andreas Boldt

“…This may increase the potential for transplant rejection when acellular tract scaffolds are used in soft tissue repair. …”
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The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits by Razavy Haide, Perez-Diez Ainhoa, Chan William FN, Anderson Colin C

“…<p>Abstract</p> <p>Background</p> <p>Transplant rejection has been considered to occur primarily because donor antigens are not present during the development of the recipient's immune system to induce tolerance. …”
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Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c. by Emily A Rowell, Liqing Wang, Neelanjana Chunder, Wayne W Hancock, Andrew D Wells

“…While both p18ink4c and p27kip1 act to restrict T cell proliferation, p18ink4c exerts an opposite effect from p27kip1 on alloimmunity and organ transplant rejection, most likely by sustaining T cell survival and the development of effector function. …”
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Degeneration of Bioprosthetic Heart Valves: Update 2020 by Alexander E. Kostyunin, Arseniy E. Yuzhalin, Maria A. Rezvova, Evgeniy A. Ovcharenko, Tatiana V. Glushkova, Anton G. Kutikhin

“…Recent studies implicate the host immune response as a major modality of SVD pathogenesis, manifested by a combination of processes phenocopying the long‐term transplant rejection, atherosclerosis, and calcification of native aortic valves. …”
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Polyelectrolyte Coating of Ferumoxytol Differentially Impacts the Labeling of Inflammatory and Steady-State Dendritic Cell Subtypes by Nehar Celikkin, John E. Wong, Martin Zenke, Thomas Hieronymus

“…Functionally distinct DC subsets exist, either under steady-state or inflammatory conditions, which are explored for the specific treatment of various diseases, such as cancer, autoimmunity, and transplant rejection. Here, the impact of the PE coating of ferumoxytol for uptake into both inflammatory and steady-state DCs and the cellular responses to MNP labeling is addressed. …”
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Regulation of Treg cells by cytokine signaling and co-stimulatory molecules by Yuan Zong, Yuan Zong, Kaihang Deng, Wai Po Chong, Wai Po Chong

“…This review delves into the potential of employing Treg-based immunotherapy for the treatment of autoimmune diseases, transplant rejection, and cancer. By shedding light on these topics, this article aims to enhance our understanding of the regulation of Tregs by cytokines and their therapeutic potential for various pathological conditions.…”
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Pretransplantation assessment of BK virus seropositivity in kidney donors and recipients by Aswathi M. Nair, B. Arun, Feroz Aziz, Vipin Vishwanath, K. S. Deepak, K. Anagha, S. Santheep, S. Gladies Kamalam

“…Conclusion: BKV can cause kidney transplant rejection. Routine screening of transplant recipients and donors for BKV IgG seropositivity is recommended before renal transplantation. …”
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Highly Reusable Electrochemical Immunosensor for Ultrasensitive Protein Detection by Kavya L. Singampalli, Camille Neal – Harris, Cassian Yee, Jamie S. Lin, Peter B. Lillehoj

“…As proof of concept, this platform is used to detect C‐X‐C motif chemokine ligand 9 (CXCL9), a biomarker associated with kidney transplant rejection, immune nephritis from checkpoint inhibitor therapy, and drug‐associated acute interstitial nephritis, in human urine. …”
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The Reasons for Refusing Kidney Transplantation Among Iranian Patients Undergoing Peritoneal Dialysis by Fateme Biabani, Gholamhossein Mahmudirad, Hadi Hassankhani, Azad Rahmani

“…According to patients, kidney transplantation is a long-term procedure that causes financial stress and physical and social problems and there is a risk of transplant rejection. On the other hand, patients were accustomed to performing PD and considered it a part of their life. …”
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Ocular surface complications following biological therapy for cancer by Kevin Sheng-Kai Ma, Kevin Sheng-Kai Ma, Kevin Sheng-Kai Ma, Ping-Feng Tsai, Tina Yi-Jin Hsieh, Tina Yi-Jin Hsieh, James Chodosh

“…Dry eye, Stevens-Johnson syndrome, and corneal transplant rejection have all been reported following the use of immune checkpoint inhibitors. …”
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SODIUM REABSORPTION ESTIMATION FOR EVALUATION OF FUNCTIONAL STATE OF TRANSPLANTED KIDNEY by I. E. Borodoulin, I. A. Pronchenko, I. P. Ermakova

“…In the group of recipients with chronic transplant rejection a free member of regression equation was significantly higher, than in health volunteers (р &lt; 0,01). …”
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The challenges of managing psychiatric disorders in children with kidney transplant and end-stage renal disease: A case report by O. Fodor, A.-M. Ciubotariu, I. Mihailescu

“…Moreover, his medical history includes CRS (congenital renal disease), kidney transplant at the age of 2 followed with transplant rejection in 2019. Currently he is under haemodialysis and multiple drug prescriptions associated with his severe medical condition which interferes with the psychotropic treatment. …”
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Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies by Michael Eikmans, Els M. Gielis, Kristien J. Ledeganck, Jianxin Yang, Daniel Abramowicz, Frans F. J. Claas

“…Here, we provide an overview of the current status on research of biomarkers of acute kidney transplant rejection in blood and urine. We specifically discuss relatively novel research strategies in biomarker research, including transcriptomics and proteomics, and elaborate on donor-derived cell-free DNA as a potential biomarker.…”
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