THE BALANCE OF EFFECTORY AND REGULATORY MEMORY CELL INTERACTIONS AS A BASE FOR PRODUCING OF STEADY IMMUNE TOLERANCE STATE AFTER ORGAN TRANSPLANTATION (ANALYSIS OF PROBLEM AT THE LI... by S. D. Artamonov, D. A. Velikiy, N. A. Onischenko, L. V. Bashkina, A. O. Nikolskaya, M. E. Krasheninnikov, I. M. Ivanov

“…But because of a high risk of transplant rejection at different methods of tolerance producing it is necessary to work out safe diagnostic and prognostic methods for controlling of an individual level and power tolerance stability.…”
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Worked to the bone: antibody-based conditioning as the future of transplant biology by James M. Griffin, Fiona M. Healy, Lekh N. Dahal, Yngvar Floisand, John F. Woolley

“…Abstract Conditioning of the bone marrow prior to haematopoietic stem cell transplant is essential in eradicating the primary cause of disease, facilitating donor cell engraftment and avoiding transplant rejection via immunosuppression. Standard conditioning regimens, typically comprising chemotherapy and/or radiotherapy, have proven successful in bone marrow clearance but are also associated with severe toxicities and high incidence of treatment-related mortality. …”
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The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation. by Anna K Kraus, Jin Chen, Ilka Edenhofer, Inga Ravens, Ariana Gaspert, Pietro E Cippà, Steffen Mueller, Rudolf P Wuthrich, Stephan Segerer, Guenter Bernhardt, Thomas Fehr

“…Thus, DNAM-1 blockade is not effective in preventing transplant rejection. Despite of being highly expressed, CD112 and CD155 do not appear to play a major immunogenic role in kidney transplantation. …”
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GLUCOCORTICOIDS AND ARTERIAL HYPERTENSION IN INTERNAL ORGANS RECIPIENTS by E. D. Kosmacheva, S. M. Martirosyan, N. A. Zubareva, A. E. Babich

“…In a practical manipulation it is necessary to use non-steroid protocols or minimize doses in internal organs recipients, weighing risks of transplant rejection and possible undesirable side responses in cases with glucocorticoids administration.…”
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Fate of lymphocytes after withdrawal of tofacitinib treatment. by Elisa Piscianz, Erica Valencic, Eva Cuzzoni, Sara De Iudicibus, Elisa De Lorenzo, Giuliana Decorti, Alberto Tommasini

“…Tofacitinib (Tofa) is an inhibitor of Janus Kinase 3, developed for the treatment of autoimmune diseases and for the prevention of transplant rejection. Due to its selective action on proliferating cells, Tofa can offer a way to block T cell activation, without toxic effects on resting cells. …”
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SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation. by Joshua D Mezrich, Linh P Nguyen, Greg Kennedy, Manabu Nukaya, John H Fechner, Xiaoji Zhang, Yongna Xing, Christopher A Bradfield

“…These characteristics lead us to suggest that SU5416 may be an ideal clinical agent for treatment of autoimmune diseases and prevention of transplant rejection, two areas where regulatory ligands of the AHR have shown promise. …”
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ACTH treatment promotes murine cardiac allograft acceptance by Jing Zhao, Liwei Jiang, Mayuko Uehara, Naima Banouni, Basmah S. Al Dulaijan, Jamil Azzi, Takaharu Ichimura, Xiaofei Li, Petr Jarolim, Paolo Fiorina, Stefan G. Tullius, Joren C. Madsen, Vivek Kasinath, Reza Abdi

“…Recent studies have highlighted the importance of the melanocortin receptors (MCRs) in inflammation, but how MCRs regulate the balance between alloreactive T cells and Tregs, and whether they impact chronic heart transplant rejection, is unknown. Here, we found that Tregs express MC2R, and MC2R expression was highest among all MCRs by Tregs. …”
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ULTRASOUND MONITORING IN THE EVALUATION OF THE FUNCTIONAL STATE OF A KIDNEY TRANSPLANT AT DIFFERENT IMMUNOSUPPRESSION THERAPIES by L.E. Belyaeva, V.A. Sandrikov, M.M. Kaabak, V.I. Sadovnikov, E.N. Platova, N.N. Babenko

“…Moreover, the authors have defined ultrasound signs of transplant rejection depending on the type (interstitial or vascular).Key words: kidney transplantation, transplant dysfunction, evaluation of the transplant function, immunosuppression.…”
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Post-traumatic stress symptoms in pediatric heart transplant recipients by Elana E. Evan, Payal A. Patel, Alison Amegatcher, Nancy Halnon

“…Nineteen subjects of the total sample had rejection in the first year following transplant. Rejection rates in the first year was 41% for those with PTSS (7 of 17 patients) and 36% for those without (12 of 33 patients) (P=n.s). …”
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Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function by Murali, TM, Gu, Y, Minhat, RA, Yap, J, Wood, KJ, Wang, C, Gascoigne, NRJ, Anantharaman, V, MacAry, PA

“…In this study, we employ hydrogen–deuterium exchange–mass spectrometry (HDX–MS), molecular dynamics (MD) simulations, and advanced biochemical and biophysical methodologies to thoroughly characterize a panel of human monoclonal alloantibodies and define the influence of Fc-region biology, antibody binding kinetics, target antigen density, and structural characteristics on their ability to potentiate the forms of immune effector mechanisms that are strongly implicated in transplant rejection. Our findings have significant implications for our understanding of the key biological determinants that underlie the pathogenicity or lack thereof of human alloantibodies.…”

Enhancing human regulatory T cells in vitro for cell therapy applications by Milward, K, Wood, K, Hester, J

“…Regulatory T cells (Tregs) are currently undergoing clinical trials in various immune-mediated pathologies, including transplant rejection and autoimmune conditions. In general, cell therapy relies upon ex vivo expansion of the cell product, in order to administer more cells than can be isolated from one person. …”

Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells. by Francis, R, Feng, G, Tha-In, T, Lyons, I, Wood, K, Bushell, A

“…The ability to generate similar populations against alloantigens offers the possibility of preventing transplant rejection without indefinite global immunosuppression. …”

Induced regulatory T cells in transplantation tolerance by Chen, Y

“…Harnessing their suppressive potential has therapeutic implications for the treatment of autoimmune conditions and transplant rejection. Although the role of TGFβ-conditioned iTreg in natural and therapeutic tolerance is indisputable, their mechanism of action as well as factors that influence their function and stability <em>in vivo</em> remain unclear. …”

K121Q polymorphism in the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 gene is associated with acute kidney rejection. by Denise A Sortica, Daisy Crispim, Andrea C Bauer, Pamela S Nique, Bruna B Nicoletto, Ricieli P Crestani, Jennifer T Staehler, Roberto C Manfro, Luis H Canani

“…Some members of the Ectonucleotidase family have been linked to transplant rejection processes. However, the association of Ectonucleotide Pyrophosphatase / Phosphodiesterase 1 (ENPP1) with AR has not yet been evaluated. …”
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Successful Venous Angioplasty of Superior Vena Cava Syndrome after Heart Transplantation by Thomas Strecker, Iris Zimmermann, Marco Heinz, Johannes Rösch, Abbas Agaimy, Michael Weyand

“…After transplantation, endomyocardial biopsy (EMB) is recommended for routine surveillance of heart transplant rejection again through the SVC. Case Presentation. …”
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ULTRASOUND MONITORING IN THE EVALUATION OF THE FUNCTIONAL STATE OF A KIDNEY TRANSPLANT AT DIFFERENT IMMUNOSUPPRESSION THERAPIES by L.E. Belyaeva, V.A. Sandrikov, M.M. Kaabak, V.I. Sadovnikov, E.N. Platova, N.N. Babenko

“…Moreover, the authors have defined ultrasound signs of transplant rejection depending on the type (interstitial or vascular).Key words: kidney transplantation, transplant dysfunction, evaluation of the transplant function, immunosuppression.…”
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Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection. by Mithun Khattar, Caitlin E Baum, Paul Schroder, Joshua D Breidenbach, Steven T Haller, Wenhao Chen, Stanislaw Stepkowski

“…However, the therapeutic potential of inhibiting the IL-21-BATF signaling axis, particularly in transplant rejection, remains unclear. We used heart transplant models to examine the effects of IL-21 blockade in prevention of chronic cardiac allograft vasculopathy (CAV) using genetic knock-out and therapeutic approaches. …”
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Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection by Christine M. McIntosh, Jennifer B. Allocco, Peter Wang, Michelle L. McKeague, Alexandra Cassano, Ying Wang, Stephen Z. Xie, Grace Hynes, Ricardo Mora-Cartín, Domenic Abbondanza, Luqiu Chen, Husain Sattar, Dengping Yin, Zheng J. Zhang, Anita S. Chong, Maria-Luisa Alegre

“…Paradoxically, infection-induced transplant rejection was not associated with transcriptional or functional reinvigoration of TCR75 cells. …”
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Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody. by Hirokazu Shiheido, Chen Chen, Masaki Hikida, Takeshi Watanabe, Jun Shimizu

“…The agonistic anti-human CD3ε antibody (Ab), OKT3, has been used to control acute transplant rejection. The in vivo administration of OKT3 was previously shown to induce the partial depletion of T cells and unresponsiveness (anergy) in the remaining CD4+ T cells. …”
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Regulation of Alloantibody Responses by Anita S. Chong, Peter T. Sage, Maria-Luisa Alegre

“…Here, we review new findings on the control of B cells and alloantibody production in the context of transplant rejection and tolerance.…”
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