C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates by Robin Schmitz, Zachary W. Fitch, Paul M. Schroder, Ashley Y. Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, John S. Yi, Sanjay Khandelwal, Gowthami M. Arepally, Alton B. Farris, Edimara S. Reis, John D. Lambris, Jean Kwun, Stuart J. Knechtle

“…Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.…”
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Differentiation of adult human mesenchymal stem cells into dopaminergic neurons by Marjan Khademizadeh, Manoochehr Messripour, Nazem Ghasemi, Fariborz Momen beik, Ahmad Movahedian Attar

“…It is concluded that hADSCs can be easily taken from the patient’s own body and differentiated into dopaminergic cells having a lower risk of transplant rejection.…”
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The Reasons for Refusing Kidney Transplantation Among Iranian Patients Undergoing Peritoneal Dialysis by Fateme Biabani, Gholamhossein Mahmudirad, Hadi Hassankhani, Azad Rahmani

“…According to patients, kidney transplantation is a long-term procedure that causes financial stress and physical and social problems and there is a risk of transplant rejection. On the other hand, patients were accustomed to performing PD and considered it a part of their life. …”
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Ocular surface complications following biological therapy for cancer by Kevin Sheng-Kai Ma, Kevin Sheng-Kai Ma, Kevin Sheng-Kai Ma, Ping-Feng Tsai, Tina Yi-Jin Hsieh, Tina Yi-Jin Hsieh, James Chodosh

“…Dry eye, Stevens-Johnson syndrome, and corneal transplant rejection have all been reported following the use of immune checkpoint inhibitors. …”
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Role of dendritic cells in the induction of lymphocyte tolerance by Fabiola eOsorio, Camila eFuentes, Mercedes N Lopez, Flavio eSalazar-Onfray, Fermín eGonzález

“…Importantly, these findings are now being applied to human research in the contexts of autoimmune diseases, allergies, and transplant rejection. Indeed, DC-based immunotherapy research has made important progress in the area of human health, particularly in regards to cancer. …”
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SODIUM REABSORPTION ESTIMATION FOR EVALUATION OF FUNCTIONAL STATE OF TRANSPLANTED KIDNEY by I. E. Borodoulin, I. A. Pronchenko, I. P. Ermakova

“…In the group of recipients with chronic transplant rejection a free member of regression equation was significantly higher, than in health volunteers (р < 0,01). …”
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The challenges of managing psychiatric disorders in children with kidney transplant and end-stage renal disease: A case report by O. Fodor, A.-M. Ciubotariu, I. Mihailescu

“…Moreover, his medical history includes CRS (congenital renal disease), kidney transplant at the age of 2 followed with transplant rejection in 2019. Currently he is under haemodialysis and multiple drug prescriptions associated with his severe medical condition which interferes with the psychotropic treatment. …”
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Non-invasive Biomarkers of Acute Rejection in Kidney Transplantation: Novel Targets and Strategies by Michael Eikmans, Els M. Gielis, Kristien J. Ledeganck, Jianxin Yang, Daniel Abramowicz, Frans F. J. Claas

“…Here, we provide an overview of the current status on research of biomarkers of acute kidney transplant rejection in blood and urine. We specifically discuss relatively novel research strategies in biomarker research, including transcriptomics and proteomics, and elaborate on donor-derived cell-free DNA as a potential biomarker.…”
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Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. by Cursiefen, C, Schlötzer-Schrehardt, U, Küchle, M, Sorokin, L, Breiteneder-Geleff, S, Alitalo, K, Jackson, D

“…METHODS: Human corneas exhibiting neovascularization secondary to keratitis, transplant rejection, trauma, and limbal insufficiency (n = 21) were assessed for lymphatic vessel content by conventional transmission electron microscopy and by immunostaining and immunoelectron microscopy with antibodies specific for the lymphatic endothelial markers, lymphatic vessel endothelial hyaluronan receptor (LYVE-1) and the 38-kDa integral membrane glycoprotein podoplanin. …”

Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection. by Oliveira, V, Sawitzki, B, Chapman, S, Appelt, C, Gebuhr, I, Wieckiewicz, J, Long, E, Wood, K

“…Regulatory T cells (Treg) have been shown to play a role in the prevention of autoimmune diseases and transplant rejection. Based on an established protocol known to generate alloantigen reactive Treg in vivo, we have developed a strategy for the in vitro selection of Treg. …”

Characterising the immune response to combined skin and solid organ transplants by Stark, H

“…Finally in Chapter 6 a human transgenic mouse model is used to explore the role of Langerhans cell related pathways in skin transplant rejection.</p> <p>This is the first study to characterise both the systemic and local immune response in a combined skin and solid organ transplant, offering unique insights into the dynamic changes in immune phenotype post-transplantation and during rejection. …”

Does Lymphovenous Anastomosis Effect Mammalian Target of Rapamycin Inhibitor-associated Lymphedema Patients? by Inah Yoon, Hyung Bae Kim, Jeongmok Cho, Changsik John Pak, Hyunsuk Peter Suh, Jae Yong Jeon, Joon Pio Hong

“…The mammalian target of rapamycin (mTOR) inhibitors are used to prevent organ transplant rejection and are preferred over other immunosuppressants due to its low nephrotoxicity. …”
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Efectos pleiotrópicos de las estatinas: Características farmacológicas útiles en la prevención, tratamiento y regresión de la enfermedad cardiovascular Pleiotropic effect of statin... by Darío Echeverri, Lorena Buitrago, Félix R Montes

“…The potent hypolipemic and pleiotropic effects could explain the benefit in atherosclerosis, arterial hypertension, diabetes mellitus, aortic stenosis, psoriasis, multiple sclerosis and post-transplant rejection, among other pathologies. Nevertheless, the amount of experimental information in favour of these effects should stimulate the initiation of better studies in order to clarify in an accurate way its clinical significance.…”
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Optimal Use of Ganciclovir and Valganciclovir in Transplanted Patients: How Does It Relate to the Outcome? by Maryam Mozaffar, Shahrzad Shahidi, Marjan Mansourian, Shirinsadat Badri

“…Organ transplant recipients receive immunosuppressive regimens to prevent transplant rejection, which put them at increased risk for opportunistic infections like cytomegalovirus (CMV). …”
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Prospects of the Use of Cell Therapy to Induce Immune Tolerance by Zhenkun Wang, Xiaolong Liu, Xiaolong Liu, Fenglin Cao, Joseph A. Bellanti, Jin Zhou, Song Guo Zheng

“…Conditions in which abnormal or excessive immune responses exist, such as autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being. …”
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Abacavir-reactive memory T cells are present in drug naïve individuals. by Andrew Lucas, Michaela Lucas, Anette Strhyn, Niamh M Keane, Elizabeth McKinnon, Rebecca Pavlos, Ellen M Moran, Viola Meyer-Pannwitt, Silvana Gaudieri, Lloyd D'Orsogna, Spyros Kalams, David A Ostrov, Søren Buus, Bjoern Peters, Simon Mallal, Elizabeth Phillips

“…CONCLUSIONS:We propose that these pre-existing abacavir-reactive memory CD8+ T-cell responses must have been primed by earlier exposure to another foreign antigen and that these T cells cross-react with an abacavir-HLA-B*57:01-endogenous peptide ligand complex, in keeping with the model of heterologous immunity proposed in transplant rejection.…”
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Mapping stain distribution in pathology slides using whole slide imaging by Fang-Cheng Yeh, Qing Ye, T Kevin Hitchens, Yijen L Wu, Anil V Parwani, Chien Ho

“…It also provides a way to validate/correlate cellular MRI data used for tracking immune-cell infiltration in cardiac transplant rejection and cardiac ischemic injury.…”
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Opportunities for Engaging Patients in Kidney Research by Maryam N. Demian, Ngan N. Lam, Fabrice Mac-Way, Ruth Sapir-Pichhadze, Nicolas Fernandez

“…The 4 research programs span the spectrum of kidney disease and focus on enhancing bone health, increasing living donor kidney transplants, improving medication adherence, and preventing kidney transplant rejection. Sources of Information: The sources of information for this review include published studies on the topics of patient engagement and the 4 research programs of the new investigators. …”
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The Immunosuppressant Tacrolimus (FK506) Facing the 21st Century: Past Findings, Present Applications and Future Trends by Carlos Barreiro, Ana Ibañez, Sonia Garrido-Chamorro, José Luis Barredo

“…Some of these events are reviewed, paying special attention to immunosuppressant drugs, which are one of the most relevant milestones in the prevention of organ transplant rejection. The discovery, industrial exploitation, mechanisms of action and side effects of several drugs exhibiting immunosuppressive effects (e.g., corticosteroids, nitrogen mustards, mycophenolic acid, rapamycin) are deeply detailed. …”
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Anti-CD45RC antibody immunotherapy prevents and treats experimental autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy syndrome by Marine Besnard, Céline Sérazin, Jason Ossart, Anne Moreau, Nadège Vimond, Léa Flippe, Hanna Sein, Grace A. Smith, Stefania Pittaluga, Elise M.N. Ferré, Claire Usal, Ignacio Anegon, Annamari Ranki, Michail S. Lionakis, Pärt Peterson, Carole Guillonneau

“…Targeted monoclonal antibody (mAb) therapies show great promise for the treatment of transplant rejection and autoimmune diseases by inducing more specific immunomodulatory effects than broadly immunosuppressive drugs routinely used. …”
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