Tranylcypromine ('Parnate') overdose: measurement of tranylcypromine concentrations and MAO inhibitory activity and identification of amphetamines in plasma. by Youdim, M, Aronson, J, Blau, K, Green, A, Grahame-Smith, D

“…A case of tranylcypromine overdose is reported. Tranylcypromine, amphetamine methamphetamine and phenylethylamine were detected in the plasma by gas chromatography and their identity confirmed by mass spectrometry. …”

Effect of Tranylcypromine on Spermatogenesis in Adult Male Rats by Mahboobeh Gholamzadeh, Mehrdad Shariati*, Davood Moghadamnia

“…Background: Tranylcypromine is a monoamine oxidase inhibitor. It inhibits the breakdown of dopamine, serotonin, epinephrine and other monoamines. …”
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Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts by Melek Akinci, Cetin Hakan Karadag, Serhat Huseyin, Cagatay Oltulu, Suat Canbaz, Ozgur Gunduz, Ruhan Deniz Topuz

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Safety of concomitant tranylcypromine treatment during electroconvulsive therapy (ECT) series by E. Kavakbasi, G.M. Ciftci, M. Tonkul, B. Baune

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Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity by Rossella Fioravanti, Veronica Rodriguez, Jonatan Caroli, Ugo Chianese, Rosaria Benedetti, Elisabetta Di Bello, Beatrice Noce, Clemens Zwergel, Davide Corinti, Dolores Viña, Lucia Altucci, Andrea Mattevi, Sergio Valente, Antonello Mai

“…As regioisomers/bioisosteres of 1a, a 4-phenylbenzamide tranylcypromine (TCP) derivative previously disclosed by us, we report here the synthesis and biological evaluation of some (hetero)arylbenzoylamino TCP derivatives 1b-6, in which the 4-phenyl moiety of 1a was shifted at the benzamide C3 position or replaced by 2- or 3-furyl, 2- or 3-thienyl, or 4-pyridyl group, all at the benzamide C4 or C3 position. …”
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Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality by Maryam Akhgari, Farzaneh Jokar, Afshar Etemadi-Aleagha, Ali Ghasemi

Subjects: “…tranylcypromine…”
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Serotonin syndrome masquerading as status epilepticus following ingestion of tranylcypromine and clomipramine and L-tryptophan: A case report by Swetha Ambarapu, Kedar Tilwe, Rahul A Pandit, Bhagyashri V Gaikwad, Haresh M Meshram, Jitendra Choudhary, Rima Chaudhari

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Title not available by Mahboobeh Gholamzadeh, Mehrdad Shareati

Subjects: “…tranylcypromine…”
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The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD by HyunHee Park, Kyung-Min Han, Hyongjun Jeon, Ji-Soo Lee, Hyunju Lee, Seong Gak Jeon, Jin-Hee Park, Yu Gyung Kim, Yuxi Lin, Young-Ho Lee, Yun Ha Jeong, Hyang-Sook Hoe

“…The small-molecule drug tranylcypromine, an inhibitor of MAO, is currently used as an antidepressant and in the treatment of cancer. …”
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Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model by Jing Huang, Jing Huang, Fangkun Liu, Hui Tang, Hui Tang, Haishan Wu, Haishan Wu, Lehua Li, Lehua Li, Renrong Wu, Renrong Wu, Jingping Zhao, Jingping Zhao, Ying Wu, Zhixiong Liu, Jindong Chen, Jindong Chen

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Beyond the Brain: Perinatal Exposure of Rats to Serotonin Enhancers Induces Long-Term Changes in the Jejunum and Liver by Romana Gračan, Sofia Ana Blažević, Matea Brižić, Dubravka Hranilovic

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Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration by Keri Callegari, Shinji Maegawa, Javiera Bravo-Alegria, Vidya Gopalakrishnan

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Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome by Ilaria Favicchia, Gemma Flore, Sara Cioffi, Gabriella Lania, Antonio Baldini, Antonio Baldini, Elizabeth Illingworth

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LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response by Fatemeh Mardani, Wael Saad, Nehme El-Hachem, Jean-Pierre Bikorimana, Mazen Kurdi, Riam Shammaa, Sebastien Talbot, Moutih Rafei

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Evolution of ideas about the risk of tyramine syndrome developing during therapy with irreversible non-selective monoamine oxidase inhibitors (to the 70th anniversary of the first... by D. S. Danilov, M. Yu. Brovko

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The History of Irreversible Non-Selective MAOI Antidepressants in Russia (for their 70th Anniversary) by D. S. Danilov

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Neurochemical effects of the monoamine oxidase inhibitor phenelzine on brain GABA and alanine: A comparison with vigabatrin by Kathryn G. Todd, Glen B. Baker

“…Pretreatment of rats with the MAO inhibitor tranylcypromine prevented the increase in brain GABA and ALA levels with PLZ, but did not block the effect of VIG on GABA. …”
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Neuropharmacological studies of antidepressant action on brain dopamine systems by Ainsworth, K, Ainsworth, Kerri

“…Subsequent receptor autoradiography experiments revealed that fluoxetine, sertraline and desipramine (but not tranylcypromine) also increased D2-like (most probably D₂) binding site density in this region.…”

Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain. by Sartori, S, Burnet, P, Sharp, T, Singewald, N

“…To test this hypothesis, rats were treated with desipramine, paroxetine, venlafaxine, tranylcypromine or vehicle for 14-42 days. NK1R binding sites and mRNA were determined in a wide variety of brain areas using in situ hybridization and quantitative receptor autoradiography. …”

New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Evaluation Anti-proliferative Activity by Sara Silva, Joana Marto, Lídia M. Gonçalves, Diana Duarte, O. Salomé G. P. Soares, Francisco Vasques-Nóvoa, António J. Almeida, Nuno Vale

“…In this paper, we described the synthesis of a new conjugated of tranylcypromine with MAP. In addition, taking into consideration our previous results, this study developed different NLCs loaded with three central nervous system (CNS) drugs (tacrine (TAC), rasagiline (RAS), and tranylcypromine (TCP)) functionalized with model amphipathic peptide (MAP) and evaluated their activity against cancer cells. …”
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