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Targeting the anaphase-promoting complex/cyclosome (APC/C) enhanced antiproliferative and apoptotic response in bladder cancer
Published 2023-03-01“…Cdc-20 expression in proTAME combined treatment groups were found to be decreased compared to their control groups. Low-dose triple-agent combination induced cytotoxicity and apoptosis in RT-4 cells effectively. …”
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The European External Action Service: Torn Apart Between Several Principals or Acting as a Smart ‘Double-agent’?
Published 2014-12-01“…This article tests the notion of 'double-agent' – or in fact “triple-agent” – as a way of characterizing the position of the EEAS, and in particular of the EU Delegations (as the ‘EU field-level bureaucracies’) vis-à-vis the MS, the Commission and the EP, as an expression of complex and interrelated chains of delegation, where the EU ‘embassies‘ have to interact with and to answer to (but not in a clear line of delegation) different (sets of) principals, namely the MS, the Commission and the EP. …”
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Detection rate and clinical significance of latent infective endocarditis in patients with aortic stenosis
Published 2019-11-01“…Single-agent antibiotic therapy (ABT) was carried out in 40,5% of patients, dual-agent ABT — in 50,0%, triple-agent — in 9,5%. The median duration of ABT was 14 days (7 to 42). …”
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Internal medicine, complexity, evidence based medicine, almost ‘‘without evidences’’
Published 2013-04-01“…<br />Discussion: Habitually the internist takes decisions in these situations: a) certainty (the ideal decision is adopted and the corresponding strategy follows), b) risk (the more suitable alternative selected can be the determination of the probable value or mathematical hope) and c) uncertainty, in which decisions linked to triple agents: beliefs and personal values of the doctors (I) for their patients (II) in the society (III). …”
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