Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation by Hellen Daghero, Flora Doffe, Belén Varela, Victoria Yozzi, José Manuel Verdes, Martina Crispo, Mariela Bollati-Fogolín, Romina Pagotto

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Cannabigerol Prevents Quorum Sensing and Biofilm Formation of Vibrio harveyi by Muna Aqawi, Ruth Gallily, Ronit Vogt Sionov, Batya Zaks, Michael Friedman, Doron Steinberg

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Tumor Microenvironment in Hepatocellular Carcinoma: Key Players for Immunotherapy by Feng H, Zhuo Y, Zhang X, Li Y, Li Y, Duan X, Shi J, Xu C, Gao Y, Yu Z

“…Immunotherapy achieves clinical progress in the treatment of this prevalent malignant disease by virtue of the development of tumor immunology; however, most patients have experienced minimal or no clinical benefit in terms of overall survival. …”
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Rituximab Plus Chemotherapy Provides No Clinical Benefit in a Peripheral T-Cell Lymphoma not Otherwise Specified with Aberrant Expression of CD20 and CD79a: A Case Report and Revie... by Alessandro Mangogna, Maria Christina Cox, Luigi Ruco, Gianluca Lopez, Beatrice Belmonte, Arianna Di Napoli

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Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy by Anja Feldmann, Anja Hoffmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Claudia Arndt, Liliana Rodrigues Loureiro, Enrico Kittel-Boselli, Nicola Mitwasi, Alexandra Kegler, Chris Lamprecht, Karla Elizabeth González Soto, Michael Bachmann

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Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets by Bai X, Pei Q, Pu C, Chen Y, He S, Wang B

“…Xue Bai1,2 *,* Qilin Pei3 *,* Chunyi Pu,1,2 Yi Chen,1,2 Sirong He,1,2 Bin Wang3 1Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 2Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 3Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sirong He; Bin Wang Email hesirong@cqmu.edu.cn; bwang@cqmu.edu.cnAbstract: Islet transplantation is regarded as the most promising treatment for type 1 diabetes (T1D). …”
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The Role of V-Set Ig Domain-Containing 4 in Chronic Kidney Disease Models by Sang Youb Han, Jung Yeon Ghee, Jin Joo Cha, Young Sun Kang, Han Seong Kim, Dae Young Hur, Dae Ryong Cha

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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

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Tumor‐infiltrating FoxP3+ T cells are associated with poor prognosis in oral squamous cell carcinoma by Tomio Hayashi, Kazuhiro Yoshikawa, Susumu Suzuki, Masahiko Gosho, Ryuzo Ueda, Yoshiaki Kazaoka

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Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways by Aurelia Rughetti, Shreya Bharti, Rajkumar Savai, Spyridoula Barmpoutsi, Andreas Weigert, Rajat Atre, Faaiza Siddiqi, Rahul Sharma, Rakhi Khabiya, Nik Hirani, Mirza S Baig

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Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint by Jörg Wischhusen, Ignacio Melero, Ignacio Melero, Ignacio Melero, Wolf Herman Fridman

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ATPase copper transporter A, negatively regulated by miR‐148a‐3p, contributes to cisplatin resistance in breast cancer cells by Ze Yu, Weifan Cao, Yuan Ren, Qijia Zhang, Jia Liu

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Aberrant HSP90 Expression in Lymphocytes and HSP90 Response to Anti-PD-1 Therapy in Lymphoma Patients by Zarema Albakova, Yana Mangasarova, Akhmet Albakov, Elena Nikulina, Sergey Kravchenko, Alexander Sapozhnikov, Alexander Sapozhnikov

“…Recent studies have highlighted the role of extracellular HSP90 in tumor immunology, however, the role that HSP90 plays in the regulation of immune responses and the impact of cancer immunotherapy, including immune checkpoint blockade, on HSP90 is still unclear. …”
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Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening by Antonella Sistigu, Antonella Sistigu, Martina Musella, Claudia Galassi, Ilio Vitale, Ilio Vitale, Ruggero De Maria, Ruggero De Maria

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Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment by Etienne D. Foucher, Clément Ghigo, Salem Chouaib, Salem Chouaib, Jérôme Galon, Juan Iovanna, Daniel Olive

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Prognostic biomarker IL17A correlated with immune infiltrates in head and neck cancer by Meng Yu, Xing Xing Qian, Guang Li, Zexing Cheng, Zhijie Lin

“…Abstract Background The underlying functions and mechanisms of the Th17 pathway in Head and neck squamous cell carcinoma (HNSCC) progression and tumor immunology are still unclear. We investigated the correlation between IL17A expression and certain clinical parameters, tumor-infiltrating immune cells (TIICs) in TCGA HNSCC samples. …”
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The clinical significance and oncogenic function of LRRFIP1 in pancreatic cancer by Jinping Li, Dayun Tuo, Gunan Guo, Yan Gao, Jinfeng Gan

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Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics by Ondondo, B, Jones, E, Hindley, J, Cutting, S, Smart, K, Bridgeman, H, Matthews, K, Ladell, K, Price, D, Godkin, A, Ager, A, Gallimore, A, Jackson, D

“…A consideration of this aspect of tumor immunology may be critical to the success of solid cancer immunotherapies. …”

Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts by David Carbone, Michael Sharpnack, Kai He, Lisa H. Butterfield, Alexander M. M. Eggermont, Maria Gonzalez-Cao, Niki Karachaliou, Guillermo Crespo, Erika Aldeguer, Ana Drozdowskyj, Ana Giménez-Capitán, Cristina Teixidó, Miguel Angel Molina-Vila, Santiago Viteri Ramírez, Salvador Martin Algarra, Elisabeth Pérez-Ruiz, Iván Márquez-Rodas, Delvys Rodriguez-Abreu, Remei Blanco, Teresa Puértolas, Maria Angeles Royo, Rafael Rosell, Maria Libera Ascierto, Svetlana Hamm, Tanja Wulff, Kerstin Kronthaler, Sabine Schrepfer, Ulrike Parnitzke, Anne Catherine Bretz, Roland Baumgartner, Veronica Ferrucci, Francesco Paolo Pennino, Luisa Dassi, Fatemeh Asadzadeh, Roberto Siciliano, Marianeve Carotenuto, Daniela Spano, Cristina Maria Chiarolla, Adelaide Greco, Monica Cantile, Maurizio Di Bonito, Gerardo Botti, Vandenbussche Jonathan, Gevaert Kris, Massimo Zollo, Teresa Amaral, Ioanna Tampouri, Ulrike Keim, Thomas Eigentler, Claus Garbe, Andrea Forschner, Alessandra Cesano, Sarah Warren, Duane Moogk, Kaitao Li, Zhou Yuan, Shi Zhong, Zhiya Yu, Ivan Liadi, William Rittase, Victoria Fang, Janna Dougherty, Arianne Perez-Garcia, Iman Osman, Navin Varadarajan, Nicholas P. Restifo, Alan Frey, Cheng Zhu, Michelle Krogsgaard, Claire Vanpouille-Box, Silvia C. Formenti, Sandra Demaria, Cristiana Lo Nigro, Alexander Renziehausen, Andreas G. Tzakos, Hexiao Wang, Bhavya Rao, Rubeta Matin, Catherine Harwood, Daniela Vivenza, Federica Tonissi, Marcella Occelli, Lynda Weir, Su Li, Van Ren Sim, Kevin O’Neill, Alan Evans, Alastair Thompson, Peter Szlosarek, Colin Fleming, Charlotte Proby, Nelofer Syed, Marco Merlano, Tim Crook, Robert Ferguson, Danny Simpson, Carlos Martinez, Matjaz Vogelsang, Esther Kazlow, Melissa Wilson, Anna Pavlick, Jeffrey Weber, Ryan Sullivan, Keith Flaherty, Antoni Ribas, Tomas Kirchhoff, Antonio D’Avino, Licia Guida, Augusto Cosacco, Roberta D’Aniello, Piera Maiolino, Teresa Tramontano, Maria R. Sarno, Ida Palazzo, Angela Di Napoli, Gianclaudio Acunzo, Mariarosanna De Fina, Antonia Silvestri, Monica Specchia, Michela Musacchio, Gianfranco Giglio, Francesco Carrozza, Liberato Di Lullo, Gian Marco De Maddi, Adele Venturelli, Elisabetta Gambale, Alessia Gatta, Davide Brocco, Consiglia Carella, Michele De Tursi, Thomas F. Gajewski, Costanza M. Cristiani, Rossana Tallerico, Valeria Ventura, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Eliska Selinger, Cinzia Garofalo, Elina Staaf, Ester Simeone, Antonio M. Grimaldi, Genny del Zotto, Elio Gulletta, Gennaro Ciliberto, Alessandro Moretta, Paolo A. Ascierto, Ennio Carbone, Susan Costantini, Angela Sorice, Francesca Capone, Gennaro Ciliberto, Alfredo Budillon, Carolina Cauchi, Grazia Sciancalepore, Cristiana Lo Nigro, Michela Rovera, Chiara Varamo, Zelda Seia, Stefania Palazzini, Fabiana Errico, Davide Basso, Laura Quaranta, Giuseppe Forte, Fulvio Lavagna, Silvia Violante, Paolo Bosio, Laura Lattanzio, Marco C Merlano, Mike Gowen, Jeremy Tchack, Hua Zhou, Keith Giles, Scott Paschke, Una Moran, David Fenyo, Aris Tsirigos, Michael Pacold, Silvana Morello, Claudia Sorrentino, Diana Giannarelli, Aldo Pinto, Federica Fratangelo, Rosaria Falcone, Vito Vanella, Dirk Schadendorf, Karl Lewis, Michele Maio, Lev Demidov, Mario Mandalà, Igor Bondarenko, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant Goodman, Brian Simmons, Chenglin Ye, Gregory Hooper, Matthew J. Wongchenko, Yibing Yan, Frank Hermann, Astrid Ammendola, Svetlana Hamm, René Bartz, Bulotta Alessandra, Colombo Letizia, Mirabile Aurora, Lazzari Chiara, Mercuri Santo Raffaele, Parolini Danilo, Rizzo Nathalie, Martella Stefano, Modorati Giulio, Brianti Pina, Cestone Enza, Bellinzona Federica, Miserocchi Elisabetta, Gianni Luca, Gregorc Vanesa, Sanjiv Agarwala, B. Mark Smithers, Axel Haushild, Eric Watcher, Luigi Fattore, Ciro Francesco Ruggiero, Domenico Liguoro, Andrea Cerri, Maria Elena Pisanu, Rita Mancini

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The CD64/CD28/CD3ζ chimeric receptor reprograms T-cell metabolism and promotes T-cell persistence and immune functions while triggering antibody-independent and antibody-dependent... by Sara Caratelli, Francesca De Paolis, Domenico Alessandro Silvestris, Silvia Baldari, Illari Salvatori, Apollonia Tullo, Giulia Lanzilli, Aymone Gurtner, Alberto Ferri, Cristiana Valle, Simona Padovani, Valeriana Cesarini, Tommaso Sconocchia, Loredana Cifaldi, Roberto Arriga, Giulio Cesare Spagnoli, Soldano Ferrone, Adriano Venditti, Piero Rossi, Graziano Pesole, Gabriele Toietta, Giuseppe Sconocchia

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