Comprehensive analysis of stearoyl-coenzyme A desaturase in prostate adenocarcinoma: insights into gene expression, immune microenvironment and tumor progression by Jie Wang, Liang Ying, He Xiong, Duan-Rui Zhou, Yi-Xuan Wang, Hui-Lian Che, Zhang-Feng Zhong, Guo-Sheng Wu, Yun-Jun Ge

“…Integration of comprehensive tumor immunological and genomic data revealed a robust positive correlation between SCD expression levels and the abundance of CD8+ T cells and macrophages. …”
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The immune landscape of solid pediatric tumors by Shimaa Sherif, Jessica Roelands, William Mifsud, Eiman I. Ahmed, Christophe M. Raynaud, Darawan Rinchai, Abbirami Sathappan, Ata Maaz, Ayman Saleh, Erdener Ozer, Khalid A. Fakhro, Borbala Mifsud, Vésteinn Thorsson, Davide Bedognetti, Wouter R. L. Hendrickx

“…Conclusions We demonstrated that extracranial pediatric tumors could be classified according to their immune disposition, unveiling similarities with adults’ tumors. Immunological parameters might be explored to refine diagnostic and prognostic biomarkers and to identify potential immune-responsive tumors.…”
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Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort by Stine Grønseth, Tormod Rogne, Lars Heggelund, Bjørn Olav Åsvold, Jan Egil Afset, Jan Kristian Damås

“…Comorbid cardiovascular disease, solid tumors, immunological disorders, premorbid corticosteroids, hypoxemia, abnormal leukocyte counts, low serum albumin, and C-reactive protein ≥100 were also independently associated with 30-day mortality. …”
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Macrophages promote pre-metastatic niche formation of breast cancer through aryl hydrocarbon receptor activity by Xu Jiang, Jiaqi Wang, Liangyu Lin, Liming Du, Yayun Ding, Fanjun Zheng, Hongzhen Xie, Yu Wang, Mingyuan Hu, Benming Liu, Muhan Xu, Jingjie Zhai, Xuefeng Wang, Jiayin Ye, Wei Cao, Chao Feng, Jingyi Feng, Zongliu Hou, Mingyao Meng, Ju Qiu, Qing Li, Yufang Shi, Ying Wang

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Dissecting the immune environment in glioblastoma by Ma, R

Self-delivery photothermal-boosted-nanobike multi-overcoming immune escape by photothermal/chemical/immune synergistic therapy against HCC by Huizhen Yang, Weiwei Mu, Shijun Yuan, Han Yang, Lili Chang, Xiao Sang, Tong Gao, Shuang Liang, Xiaoqing Liu, Shunli Fu, Zipeng Zhang, Yongjun Liu, Na Zhang

“…Nevertheless, therapeutic efficacy and wide clinical applicability remain a challenge due to “cold” tumors’ immunological characteristics. Tumor immunosuppressive microenvironment (TIME) continuously natural force for immune escape by extracellular matrix (ECM) infiltration, tumor angiogenesis, and tumor cell proliferation. …”
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ONCOS-102 plus pemetrexed and platinum chemotherapy in malignant pleural mesothelioma: a randomized phase 2 study investigating clinical outcomes and the tumor microenvironment by Magnus Jaderberg, Victor Levitsky, Luis Paz-Ares, Nicolas Isambert, Susana Cedres, Xavier Serres, Charles Ricordel, Sylvia Vetrhus, Alex Martinez-Marti, Santiago Viteri, Alejandro Navarro, Jon Zugazagoitia, Santiago Ponce, Mercedes Herrera-Juarez, Mathieu Lederlin, Thomas Birkballe Hansen

“…Overall survival (OS), progression-free survival, objective response rate, and tumor immunologic activation (baseline and day 36 biopsies) were also assessed.Results In total, 31 patients (safety lead-in: n=6, randomized: n=25) were enrolled. …”
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A SURVIVAL ANALYSIS ON THE IMMUNE LANDSCAPE OF PAEDIATRIC SOLID TUMOURS. by Khushboo Shrivastava, Tongbram Soni Devi, Saket Verma, P. Jaiswal, Tirumala Kanakadurga Sripati

“…To find diagnostic and prognostic biomarkers and to find potential immune-responsive tumors, immunological factors may be investigated. Recommendations: Close disease surveillance and genetic evaluation are recommended for patients with certain solid tumors or particular predisposing conditions. …”
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Characteristic and fate determination of adipose precursors during adipose tissue remodeling by Jiayin Ye, Cheng Gao, Yong Liang, Zongliu Hou, Yufang Shi, Ying Wang

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Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial. by Weidong Xiong, Marianela Candolfi, Chunyan Liu, A K M Ghulam Muhammad, Kader Yagiz, Mariana Puntel, Peter F Moore, Julie Avalos, John D Young, Dorothy Khan, Randy Donelson, G Elizabeth Pluhar, John R Ohlfest, Kolja Wawrowsky, Pedro R Lowenstein, Maria G Castro

“…This therapy triggers an anti-tumor immune response that leads to tumor regression and anti-tumor immunological memory in intracranial rodent cancer models. …”
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Chinese expert consensus on clinical application of recombinant oncolytic adenovirus in the treatment of malignant tumors by Expert Committee on Immunotherapy of Chinese Society of Clinical Oncology , Professional Committee on Cancer Biotherapy of Shanghai Anticancer Association

“…Treatment using oncolytic virus as a new tumor immunologic agent has made continuous breakthroughs in basic and clinical research of tumor in recent years, and it is expected to play an important role in cancer immunotherapy in the future. …”
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RGN as a prognostic biomarker with immune infiltration and ceRNA in lung squamous cell carcinoma by Yang Liao, Wen Cheng, Ruiyu Mou, Xiaojiang Li, Yingjie Jia

“…However, the role of RGN in the tumor immunological microenvironment in lung squamous cell carcinoma (LUSC) remains unclear. …”
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Case Report: Rare cardiovascular characteristics of tuberous sclerosis complex with novel TSC2 variant by Zhiqin Du, Xiao Ma, Xiao Ma, Xiao Ma, Jianhua Li, Fang Yang, Yangfan Guo, Yangfan Guo

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Glutamine metabolism-related genes predict prognosis and reshape tumor microenvironment immune characteristics in diffuse gliomas by Huanhuan Fan, Huanhuan Fan, Shuxin Zhang, Yunbo Yuan, Siliang Chen, Wenhao Li, Zhihao Wang, Yufan Xiang, Junhong Li, Xiaohong Ma, Xiaohong Ma, Yanhui Liu

“…ESTIMATE and CIBERSORTx were applied to depict the TME immune landscape. The tumor immunological phenotype analysis and TIDE were utilized for predicting the therapeutic response of immunotherapy.ResultsA total of 106 GMRGs were retrieved. …”
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Ubiquitin-Specific Protease 43 Impacts Pancreatic Ductal Adenocarcinoma Prognosis by Altering Its Proliferation and Infiltration of Surrounding Immune Cells by Ziqi Zhao, Zhikun Lin, Xin Guo, Abdullah Al-danakh, Hui He, Henan Qin, Chi Ma, Ningning Zhang, Guang Tan

“…The distinctive tumor immunological microenvironment (TIME) of PDAC, comprising a high number of stromal cells and a limited infiltration of cytotoxic T lymphocytes (CTLs), rendered immunotherapy ineffective. …”
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A radiogenomics biomarker based on immunological heterogeneity for non-invasive prognosis of renal clear cell carcinoma by Jiahao Gao, Fangdie Ye, Fangdie Ye, Fang Han, Haowen Jiang, Haowen Jiang, Haowen Jiang, Jiawen Zhang

“…BackgroundTumor immunological heterogeneity potentially influences the prognostic disparities among patients with clear cell renal cell carcinoma (ccRCC); however, there is a lack of macroscopic imaging tools that can be used to predict immune-related gene expression in ccRCC.MethodsA novel non-invasive radiogenomics biomarker was constructed for immune-related gene expression in ccRCC. …”
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Pan-cancer analysis of the prognostic and immunological roles of DEAD-box helicase 5 (DDX5) in human tumors by Shixuan Liu, Shixuan Liu, Yanbin Liu, Xi Zhang, Xuanlin Song, Boxiang Zhang, Yong Zhang

“…This study is the first to conduct a pan-cancer analysis of DDX5 for aiding the diagnosis and treatment of cancer.Methods: The gene expression, genetic alterations, protein phosphorylation, promoter methylation, immune infiltration, and enrichment analyses of DDX5 were performed using data retrieved from The Cancer Genome Atlas (TCGA), Genotype-tissue Expression (GTEx), Human Protein Atlas (HPA), Tumor Immunological Estimation Resource 2.0 (TIMER2.0), Gene Expression Profiling Interactive Analysis (GEPIA), DNA methylation interactive visualization database (DNMIVD), and Search Tool for the Retrieval of Interaction Genes/Proteins (STRING). …”
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Elevated CTSL Gene Expression Correlated with Proinflammatory Cytokines in Omental Adipose Tissue of Patients with Obesity by Zhou Q, Zhu Y, Li C, Li Z, Tang Z, Yuan B, Wang X, Zhang S, Wu X

“…Qiong Zhou,1,2 Yankun Zhu,3 Chun Li,2 Zhiqiang Li,1 Zhe Tang,2 Baohong Yuan,3 Xiaodan Wang,4 Shengqingyu Zhang,1 Xinan Wu1 1School of Public Health, Kunming Medical University, Kunming, People’s Republic of China; 2Department of Endocrinology, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, People’s Republic of China; 3Department of General Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, People’s Republic of China; 4Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, People’s Republic of ChinaCorrespondence: Xinan Wu, School of Public Health, Kunming Medical University, Kunming, 650500, People’s Republic of China, Tel +85-13888984762, Fax +86-871-65933614, Email wuxina@kmmu.edu.cnPurpose: Cathepsin L (CTSL) and B (CTSB) were lysosomal proteases, and their expression and activity contribute to the progression of inflammation in obese rodents. …”
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The correlation between neutrophil-to-lymphocyte ratio, carcinoembryonic antigen, and carbohydrate antigen 153 levels with chemotherapy-related cognitive impairment in early-stage... by Sheng Yu, Jingjing Zhao, Menglian Wang, Guo Cheng, Wen Li, Lingxue Tang, Senbang Yao, Lulian Pang, Xiangxiang Yin, Yanyan Jing, Huaidong Cheng

“…BackgroundThe changes in inflammation and tumor biomarkers are associated with the anti-tumor immunological processes. Early detection and intervention are of great significance to the clinical management of cancer-related diseases. …”
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Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy by Hena Khalique, Richard Baugh, Arthur Dyer, Eleanor M. Scott, Sally Frost, Sarah Larkin, Janet Lei-Rossmann, Leonard W. Seymour

“…This approach represents an immunological ‘volte-face’ whereby a tumor immunological defense mechanism can be instantly transformed into an Achilles’ heel for targeted immunotherapy.Methods The PD-L1 targeting BiTE comprises an anti-PD-L1 single-chain variable fragment (scFv) or nanobody (NB) domain and an anti-CD3 scFv domain in a tandem repeat. …”
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