CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene by Zainab A. Bazzi, Zainab A. Bazzi, Isabella T. Tai, Isabella T. Tai

“…CDK10 has been identified as both a candidate tumor suppressor in hepatocellular carcinoma, biliary tract cancers and gastric cancer, and a candidate oncogene in colorectal cancer (CRC). …”
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Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype by Vincenzo Carafa, Lucia Altucci, Angela Nebbioso

“…In this review, we summarize current knowledge on the role of SIRTs in cancer and discuss their puzzling dual function as tumor suppressors and tumor promoters, important for the future development of novel tailored SIRT-based cancer therapies.…”
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Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State by Julie-Anne Daly, Sally-Anne Mortlock, Rosanne M. Taylor, Peter Williamson

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Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma by Francesca Chiarini, Francesca Paganelli, Tommaso Balestra, Cristina Capanni, Antonietta Fazio, Maria Cristina Manara, Lorena Landuzzi, Stefania Petrini, Camilla Evangelisti, Pier-Luigi Lollini, Alberto M. Martelli, Giovanna Lattanzi, Katia Scotlandi

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A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea by Andromeda Van Roten, Amal Zohir Abo-Zeid Barakat, Annelies Wouters, Thao Anh Tran, Stijn Mouton, Jean-Paul Noben, Luca Gentile, Karen Smeets

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Potential tumor suppressor NESG1 as an unfavorable prognosis factor in nasopharyngeal carcinoma. by Zhen Liu, Weiren Luo, Ying Zhou, Yan Zhen, Huiling Yang, Xiaoli Yu, Yanfen Ye, Xin Li, Hao Wang, Qinping Jiang, Yajie Zhang, Kaitai Yao, Weiyi Fang

“…BACKGROUND:Recently we identified nasopharyngeal epithelium specific protein 1 (NESG1) as a potential tumor suppressor in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the involvement of NESG1 in tumor progression and prognosis of human NPC. …”
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Connection between tumor suppressor BRCA1 and PTEN in damaged DNA repair by Akari eMinami, Atsuko eNakanishi, Yasunori eOgura, Yasuko eKitagishi, Satoru eMatsuda

“…Genomic instability finally induces cell death or apoptosis. The tumor suppressor PTEN is a dual-specificity phosphatase which has protein phosphatase activity and lipid phosphatase activity that antagonizes PI3K activity. …”
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SETD2, an epigenetic tumor suppressor: a focused review on GI tumor by Ming Hu, Mu Hu, Qin Zhang, Jin-ping Lai, Xiu-li Liu

“…Despite being a newly discovered tumor suppressor, SETD2 has been found to be mutated in multiple types of cancer, including gastrointestinal tumor. …”
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Protocadherin 17 Is a Tumor Suppressor and Is Frequently Methylated in Nasopharyngeal Carcinoma [Retraction] by He Y, Wang Z, Liu C, Gong Z, Li Y, Lu T, Hu G

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73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma by Kunal Baxi, Jiangfei Chen, Amanda Lipsitt, Nicole Hensch, Long Wang, Abhik Bandopadhyay, Aaron Sugalski, Andrea Gilbert, Eleanor Chen, Peter Houghton, Gail Tomlinson, Myron Ignatius

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The Interplay Between Tumor Suppressor p53 and Hypoxia Signaling Pathways in Cancer by Cen Zhang, Juan Liu, Jianming Wang, Tianliang Zhang, Dandan Xu, Wenwei Hu, Zhaohui Feng

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Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1 by Lei Li, Sen Chen, Yueming Tang, Jie Wu, Yangzhige He, Ling Qiu, Ling Qiu

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Protein adduction causes non-mutational inhibition of p53 tumor suppressor by Ravindran Caspa Gokulan, Kodisundaram Paulrasu, Jamal Azfar, Wael El-Rifai, Jianwen Que, Olivier G. Boutaud, Yuguang Ban, Zhen Gao, Monica Garcia Buitrago, Sergey I. Dikalov, Alexander I. Zaika

“…Summary: p53 is a key tumor suppressor that is frequently mutated in human tumors. …”
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The role of MiRNA‐433 in malignant tumors of digestive tract as tumor suppressor by Jie Tang, Jiawei Chen, Yongqiang Wang, Shaobo Zhou

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Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma by Fatemeh Khatami, Bagher Larijani, Ramin Heshmat, Shirzad Nasiri, Hiva Saffar, Gita Shafiee, Azam Mossafa, Seyed Mohammad Tavangar

Subjects: “…tumor suppressor genes…”
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Characterization of tumor suppressor CYLD expression in clear cell renal cell carcinoma by Dimitrios Koutsoumparis, Elena Constantinou, Dimitrios Papanikolaou, Dimitrios Karatzas, Mattheos Bobos, Paul Hadweh, Thomais Konstantinou, Eudoxia G Hatzivassiliou

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Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer. by Aaron R Thorner, Joel S Parker, Katherine A Hoadley, Charles M Perou

“…Stable RNAi knock-down of endogenous c-Myb in the MCF7 luminal breast tumor cell line increased tumorigenesis both in vitro and in vivo, suggesting a possible tumor suppressor role in luminal breast cancer. We created a mammary-derived c-Myb expression signature, comprised of both direct and indirect c-Myb target genes, and found it to be highly correlated with a published mature luminal mammary cell signature and least correlated with a mammary stem/progenitor lineage gene signature.These data describe, for the first time, a possible tumor suppressor role for the c-Myb proto-oncogene in breast cancer that has implications for the understanding of luminal tumorigenesis and for guiding treatment.…”
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Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer by Myoung-Hee Kang, Hyunji Choi, Masanobu Oshima, Jae-Ho Cheong, Seokho Kim, Jung Hoon Lee, Young Soo Park, Hueng-Sik Choi, Mi-Na Kweon, Chan-Gi Pack, Ju-Seog Lee, Gordon B. Mills, Seung-Jae Myung, Yun-Yong Park

“…Here the authors show estrogen-related receptor gamma (ESRRG) is a tumor suppressor in gastric cancer and suggest the mechanism of this tumor suppression function involves the inhibition of Wnt signaling.…”
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Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway by Shuai Yang, Yifan Guo, Xianjue Ma

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The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma by Lucia Morgado-Palacin, Jessie A. Brown, Thomas F. Martinez, Juana M. Garcia-Pedrero, Farhad Forouhar, S. Aidan Quinn, Clara Reglero, Joan Vaughan, Yasamin Hajy Heydary, Cynthia Donaldson, Sandra Rodriguez-Perales, Eva Allonca, Rocio Granda-Diaz, Agustin F. Fernandez, Mario F. Fraga, Arianna L. Kim, Jorge Santos-Juanes, David M. Owens, Juan P. Rodrigo, Alan Saghatelian, Adolfo A. Ferrando

“…Tincr loss promotes UVB-induced skin carcinogenesis in mice and deletions and mutations in human squamous cell carcinoma support a tumor suppressor role.…”
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