FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2 by Rafael Jiménez-Izquierdo, Rosario Morrugares, Lucía Suanes-Cobos, Alejandro Correa-Sáez, Martín Garrido-Rodríguez, Laura Cerero-Tejero, Omar M. Khan, Susana de la Luna, Rocío Sancho, Marco A. Calzado

“…FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. …”
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Frequent alteration of the tumor suppressor gene APC in sporadic canine colorectal tumors. by Lydia Youmans, Cynthia Taylor, Edwin Shin, Adrienne Harrell, Angela E Ellis, Bernard Séguin, Xinglai Ji, Shaying Zhao

“…To molecularly characterize canine CRC, we investigated exonic sequence mutations of adenomatous polyposis coli (APC), the best known tumor suppressor gene of human CRC, in 23 sporadic canine colorectal tumors, including 8 adenomas and 15 adenocarcinomas, via exon-resequencing analysis. …”
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The role of WT1 in breast and other cancers: oncogene or tumor suppressor gene? by P Graidist

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PAPP‐A functions as a tumor suppressor and is downregulated in renal cell carcinoma by Yanxin Lu, Shi Li, Tongyu Wang, Ximian Liao, Longyi Mao, Zesong Li

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Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion by Zhang Lihong, Qi Dongxue, Zhang Bo, Liu Xinrui, Li Wei, Jin Yuhong, Yang Hongfa

“…<p>Abstract</p> <p>Background</p> <p>ECRG4 has been shown to be a candidate tumor suppressor in several tumors, but its role in glioma remains poorly understood. …”
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A novel Golgi retention signal RPWS for tumor suppressor UBIAD1. by Xian Wang, Dangfeng Wang, Pan Jing, Yuangan Wu, Yanzhi Xia, Maorong Chen, Ling Hong

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Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation by Aziz Aiderus, Ana M. Contreras-Sandoval, Amanda L. Meshey, Justin Y. Newberg, Jerrold M. Ward, Deborah A. Swing, Neal G. Copeland, Nancy A. Jenkins, Karen M. Mann, Michael B. Mann

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DNA aptamer S11e recognizes fibrosarcoma and acts as a tumor suppressor by Yunyi Liu, Cheng Peng, Hui Zhang, Juan Li, Hailong Ou, Yang Sun, Chaoqi Wen, Dan Qi, Xiaoxiao Hu, Erxi Wu, Weihong Tan

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In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila. by Heather S Gavilan, Rima M Kulikauskas, David H Gutmann, Richard G Fehon

“…Merlin, the product of the Neurofibromatosis 2 tumor suppressor gene, has been extensively studied to understand its functions in growth control. …”
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DBC1 Functions as a Tumor Suppressor by Regulating p53 Stability by Bo Qin, Katherine Minter-Dykhouse, Jia Yu, Jun Zhang, Tongzheng Liu, Haoxing Zhang, SeungBaek Lee, JungJin Kim, Liewei Wang, Zhenkun Lou

“…It has been suggested to be either a tumor suppressor or an oncogene. Therefore, the function of DBC1 in cancer needs to be further explored. …”
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Tumor suppressor RASSF1A promoter: p53 binding and methylation. by Yihao Tian, Yu Hou, Xiang Zhou, Hanhua Cheng, Rongjia Zhou

“…Oncogenes and tumor suppressors work in concert to regulate cell growth or death, which is a pair of antagonist factors for regulation of tumorigenesis. …”
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Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma by Fatma Betul Aksoy Yasar, Fatma Betul Aksoy Yasar, Takashi Shingu, Daniel B. Zamler, Daniel B. Zamler, Daniel B. Zamler, Mohammad Fayyad Zaman, Derek Lin Chien, Qiang Zhang, Jiangong Ren, Jian Hu, Jian Hu

“…We find that Qk but not Prkn is the potent tumor suppressor in the frequently altered Ch6q region in GBM.…”
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Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma by Wei Bian, Hongfei Zhang, Miao Tang, Shaojun Zhang, Lichao Wang, Longlong Liu, Wenyao Wang

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Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene by Francesco Acquati, Lorenzo Mortara, Annarosaria De Vito, Denisa Baci, Adriana Albini, Adriana Albini, Marco Cippitelli, Roberto Taramelli, Douglas M. Noonan, Douglas M. Noonan

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MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy by Stefan Heinrichs, Lillian F Conover, Carlos E Bueso-Ramos, Outi Kilpivaara, Kristen Stevenson, Donna Neuberg, Mignon L Loh, Wen-Shu Wu, Scott J Rodig, Guillermo Garcia-Manero, Hagop M Kantarjian, A Thomas Look

“…A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. Here we show that MYBL2, a gene within the 20q CDR, is expressed at sharply reduced levels in CD34+ cells from most MDS cases (65%; n = 26), whether or not they harbor 20q abnormalities. …”
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Frequent down regulation of the tumor suppressor gene a20 in multiple myeloma. by Katharina Troppan, Sybille Hofer, Kerstin Wenzl, Markus Lassnig, Beata Pursche, Elisabeth Steinbauer, Marco Wiltgen, Barbara Zulus, Wilfried Renner, Christine Beham-Schmid, Alexander Deutsch, Peter Neumeister

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Tumor-Suppressor Function of SPARC-Like Protein 1/Hevin in Pancreatic Cancer by Irene Esposito, Hany Kayed, Shereen Keleg, Thomas Giese, E. Helene Sage, Peter Schirmacher, Helmut Friess, Jörg Kleeff

“…Its antiinvasive effects and reduced expression in metastasis indicate tumor-suppressor function.…”
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Tumor Suppressor Candidate 2 (TUSC2): Discovery, Functions, and Cancer Therapy by Austin Arrigo, Angelina T. Regua, Mariana K. Najjar, Hui-Wen Lo

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CFTR Functions as a Tumor Suppressor and Is Regulated by DNA Methylation in Colorectal Cancer by Liu C, Song C, Li J, Sun Q

“…Can Liu,1 Chao Song,2 Jiaxi Li,3 Qing Sun1,3 1Department of Pathology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People&rsquo;s Republic of China; 2Department of Pathology, Zibo Central Hospital, Zibo, Shandong Province, People&rsquo;s Republic of China; 3Department of Pathology, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, Shandong Province, People&rsquo;s Republic of ChinaCorrespondence: Qing SunDepartment of Pathology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jingshi Street, Jinan 250014, Shandong Province, People&rsquo;s Republic of ChinaTel +86-531-89269710Email sun18653130364@163.comPurpose: Cystic fibrosis transmembrane conductance regulator (CFTR) was shown to be downregulated or silenced in carcinomas and acts as a candidate tumor suppressor gene. However, the function of CFTR gene in colorectal cancer (CRC) is still unclear. …”
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Participation of tumor suppressor P53 in the expression of acute-phase protein genes by Mihailović Mirjana, Poznanović G., Dinić Svetlana, Uskoković Aleksandra, Grdović Nevena, Vidaković Melita, Arambašić Jelena, Grigorov Ilijana, Ivanović-Matić Svetlana, Martinović Vesna, Petrović M., Bogojević Desanka

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