The tumor suppressor archipelago E3 ligase is required for spermatid differentiation in Drosophila testis by Viktor Vedelek, Attila L. Kovács, Gábor Juhász, Elham Alzyoud, Rita Sinka

“…Abstract The human orthologue of the tumor suppressor protein FBW7 is encoded by the Drosophila archipelago (ago) gene. …”
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A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models by Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jianming Wang, Jun Li, Xiaohui Sun, Yiming Zhu, Zhaohui Feng, Wenwei Hu

“…Tumor suppressor p53 prevents early death due to cancer development. …”
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Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer by Kentaro Inamura

“…In lung cancer, several tumor suppressor/oncogenic microRNAs and lncRNAs function as biomarkers for metastasis and prognosis, and thus may serve as therapeutic tools. …”
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NLRX1 functions as a tumor suppressor in Pan02 pancreatic cancer cells by Margaret A. Nagai-Singer, Holly A. Morrison, Mackenzie K. Woolls, Katerina Leedy, Khan Mohammad Imran, Juselyn D. Tupik, Irving C. Allen, Irving C. Allen, Irving C. Allen

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Germinal center B-cells resist transformation by Kras independently of tumor suppressor Arf. by Chelsea D Mullins, Mack Y Su, Vishwanathan Hucthagowder, Liang Chu, Lan Lu, Shashikant Kulkarni, Deborah Novack, Ravi Vij, Michael H Tomasson

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Tumor Suppressor Function of the SEMA3B Gene in Human Lung and Renal Cancers. by Vitaly I Loginov, Alexey A Dmitriev, Vera N Senchenko, Irina V Pronina, Dmitry S Khodyrev, Anna V Kudryavtseva, George S Krasnov, Ganna V Gerashchenko, Larisa I Chashchina, Tatiana P Kazubskaya, Tatiana T Kondratieva, Michael I Lerman, Debora Angeloni, Eleonora A Braga, Vladimir I Kashuba

“…The objective of our study was to expand our knowledge of the SEMA3B gene as a tumor suppressor and the mechanisms of its inactivation. …”
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Uncovering Oncogenic Mechanisms of Tumor Suppressor Genes in Breast Cancer Multi-Omics Data by Seong Beom Cho

Subjects: “…tumor suppressor gene…”
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TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers by Hanyang Li, Hanyang Li, He Fang, Li Chang, Shuang Qiu, Xiaojun Ren, Lidong Cao, Jinda Bian, Zhenxiao Wang, Yi Guo, Jiayin Lv, Zhihui Sun, Tiejun Wang, Bingjin Li

“…Notably, TC2N has been identified as an oncogene in lung and gastric cancer but as a tumor suppressor gene in breast cancer. Recently, a large number of tumor-associated antigens (TAAs), such as heat shock proteins, alpha-fetoprotein, and carcinoembryonic antigen, have been identified in a variety of malignant tumors. …”
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Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. by Megan L Durr, Wojciech K Mydlarz, Chunbo Shao, Marianna L Zahurak, Alice Y Chuang, Mohammad O Hoque, William H Westra, Nanette J Liegeois, Joseph A Califano, David Sidransky, Patrick K Ha

“…Methylation profiling of tumor suppressor gene (TSGs) promoters is quickly becoming a powerful diagnostic tool for the early detection, prognosis, and even prediction of clinical response to treatment. …”
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Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis by Jahangir Abdi, Nasrin Rastgoo, Lihong Li, Wenming Chen, Hong Chang

“…This area is shedding new light on understanding the biologic effects of dysregulated p53 in MM pathogenesis especially drug resistance. miRNAs such as miR-125b (oncomiR) or miR-34a (tumor suppressor-miR) can be negative or positive regulators of wtp53 function, respectively, with specific effects on MM cell viability. …”
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The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice by Melanie Schoof, Gefion Dorothea Epplen, Carolin Walter, Annika Ballast, Dörthe Holdhof, Carolin Göbel, Sina Neyazi, Julian Varghese, Thomas Karl Albert, Kornelius Kerl, Ulrich Schüller

“…Abstract The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN), a member of the MYC oncogene family, are critically involved in brain development. …”
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Tumor Suppressor DAPK1 Catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices by Ruifang Qin, Shay Melamed, Bo Yang, Mayur Saxena, Michael P. Sheetz, Haguy Wolfenson

“…Here we show that death associated protein kinase 1 (DAPK1), a tumor suppressor that activates cell death, is directly linked to anoikis activation through rigidity sensing. …”
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Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma by Sudeep Banerjee, Christopher L. Corless, Markku M. Miettinen, Sangkyu Noh, Rowan Ustoy, Jessica L. Davis, Chih-Min Tang, Mayra Yebra, Adam M. Burgoyne, Jason K. Sicklick

“…Building on the role of Hh signaling in PF, PTCH1, a tumor suppressor protein, functions upstream of GLI1. Loss of PTCH1 induces GLI1 activation and downstream gene transcription. …”
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RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression by Torlakovic Emina, Pastural Elodie, Takahashi Naoto, Lakshmikuttyamma Ashakumary, Amin Hesham M, Garcia-Manero Guillermo, Voralia Michael, Czader Magdalena, DeCoteau John F, Geyer C Ronald

“…</p> <p>Conclusion</p> <p>RIZ1 is a candidate tumor suppressor gene whose expression is decreased in blast crisis. …”
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The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals by Mihaela A. Stavarache, Sergei Musatov, Marlon McGill, Mary Vernov, Michael G. Kaplitt

“…Phosphatase and Tensin homolog deleted on chromosome 10 (PTEN) is a dual lipid–protein phosphatase known primarily as a growth preventing tumor suppressor. PTEN is also expressed in neurons, and pathways modulated by PTEN can influence neuronal function. …”
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Loss of Tumor Suppressor C9orf9 Promotes Metastasis in Colorectal Cancer by Erfei Chen, Fangfang Yang, Qiqi Li, Tong Li, Danni Yao, Lichao Cao, Jin Yang

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Antagonistic effect of the tumor suppressor Menin and the HBZ protein of HTLV-1 on telomerase activity by Girard Sophie, Kuhlmann Anne-Sophie, Gazzolo Louis, Dodon Madeleine

The expression of retinoblastoma tumor suppressor protein in oral cancers and precancers: A clinicopathological study by Sunila Thomas, Anita Balan, Prabha Balaram

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Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma. by Antonia Navarro, Ping Yin, Diana Monsivais, Simon M Lin, Pan Du, Jian-Jun Wei, Serdar E Bulun

“…We selected three genes, the known tumor suppressors KLF11, DLEC1, and KRT19 and verified promoter hypermethylation, mRNA repression and protein expression using bisulfite sequencing, real-time PCR and western blot. …”
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Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation by Stephanie Kaypee, Smitha Asoka Sahadevan, Shilpa Patil, Piya Ghosh, Neeladri Sekhar Roy, Siddhartha Roy, Tapas K. Kundu

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