An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a by Serviss, J, Andrews, N, Van Den Eynden, J, Richter, F, Houtman, M, Vesterlund, M, Schwarzmueller, L, Johnsson, P, Larsson, E, Grandér, D, Pokrovskaja Tamm, K

“…The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. …”

Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans by Bishop, T, Lau, K, Epstein, A, Kim, S, Jiang, M, O'Rourke, D, Pugh, C, Gleadle, J, Taylor, MS, Hodgkin, J, Ratcliffe, P

“…The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated α subunits of hypoxia-inducible factor (HIF). …”

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. by Carr, S, Munro, S, Zalmas, L, Fedorov, O, Johansson, C, Krojer, T, Sagum, C, Bedford, M, Oppermann, U, La Thangue, N

“…The retinoblastoma tumor suppressor protein pRb is a key regulator of cell cycle progression and mediator of the DNA damage response. …”

Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing. by Masson, N, Ratcliffe, P

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. by Tacconi, E, Lai, X, Folio, C, Porru, M, Zonderland, G, Badie, S, Michl, J, Sechi, I, Rogier, M, Matía García, V, Batra, A, Rueda, O, Bouwman, P, Jonkers, J, Ryan, A, Reina-San-Martin, B, Hui, J, Tang, N, Bruna, A, Biroccio, A, Tarsounas, M

Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response. by Idit Hazan, Thomas G Hofmann, Rami I Aqeilan

“…The latter view is supported by emerging evidence showing that expression of a given CFS is associated with genome integrity and that inactivation of CFS-resident tumor suppressor genes leads to dysregulation of the DNA damage response (DDR) and increased genomic instability. …”
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Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy by M. Manirujjaman, Iwata Ozaki, Yuzo Murata, Jing Guo, Jinghe Xia, Kenichi Nishioka, Rasheda Perveen, Hirokazu Takahashi, Keizo Anzai, Sachiko Matsuhashi

“…PDCD4 (programmed cell death 4) is a tumor suppressor that plays a crucial role in multiple cellular functions, such as the control of protein synthesis and transcriptional control of some genes, the inhibition of cancer invasion and metastasis. …”
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NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation by Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, Muhammed A. Rahman, Shawn Winer, Daniel A. Winer, Catherine J. Streutker, Dana J. Philpott, Stephen E. Girardin

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SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect by Liu Yihan, Wang Xiaojing, Liu Ao, Zhang Chuanjie, Wang Haofei, Shen Yan, He Hongchao

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Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization by Lijuan Zhang, Kai Zhang, Jieyou Zhang, Jinrong Zhu, Qing Xi, Huafeng Wang, Zimu Zhang, Yingnan Cheng, Guangze Yang, Hongkun Liu, Xiangdong Guo, Dongmei Zhou, Zhenyi Xue, Yan Li, Qi Zhang, Yurong Da, Li Liu, Zhinan Yin, Zhi Yao, Rongxin Zhang

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Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer. by Takeshi Chiyomaru, Soichiro Yamamura, Shinichiro Fukuhara, Hideo Hidaka, Shahana Majid, Sharanjot Saini, Sumit Arora, Guoren Deng, Varahram Shahryari, Inik Chang, Yuichiro Tanaka, Z Laura Tabatabai, Hideki Enokida, Naohiko Seki, Masayuki Nakagawa, Rajvir Dahiya

“…In this study, we focused on tumor suppressor miRNAs regulated by genistein and investigated their function in prostate cancer (PCa) and target pathways. …”
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Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor by Tianyu He, Xiaoyun Zhang, Jianyu Hao, Shigang Ding

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Comparative Investigation of DAL-1 Tumor Suppressor Protein Expression in Cancerous and Normal Ovarian Specimens by Mehdi Nikbakht Dastjerdi, Zahra Abdolali

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A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia by Mohamed Eldeeb, Ouyang Yuan, Nicola Guzzi, Phuong Cao Thi Ngoc, Anna Konturek-Ciesla, Trine A. Kristiansen, Sowndarya Muthukumar, Jeffrey Magee, Cristian Bellodi, Joan Yuan, David Bryder

“…Functionally, overexpression of MYBBP1A phenocopies the tumor-suppressor effects of LIN28B, while its perturbation omits it. …”
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A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. by Claudia Gaspar, Patrick Franken, Lia Molenaar, Cor Breukel, Martin van der Valk, Ron Smits, Riccardo Fodde

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Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk by Juan M Vazquez, Vincent J Lynch

“…Unexpectedly, we found that tumor suppressor duplication was pervasive in Afrotherian genomes, rather than restricted to Proboscideans. …”
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Expression of Concern: Potential Tumor Suppressor NESG1 as an Unfavorable Prognosis Factor in Nasopharyngeal Carcinoma. by PLOS ONE Editors

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Identification of the Putative Tumor Suppressor Characteristics of FAM107A via Pan-Cancer Analysis by Dehua Ou, Dehua Ou, Zhiqin Zhang, Zesong Wu, Zesong Wu, Peilin Shen, Yichuan Huang, Sile She, Sifan She, Ming-en Lin

“…Family with sequence similarity 107, member A(FAM107A) was supposed as a tumor suppressor for various types of tumors. However, no pan-cancer analysis of FAM107A is available. …”
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Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer by Matthieu Lacroix, Romain Riscal, Giuseppe Arena, Laetitia Karine Linares, Laurent Le Cam

“…Background: The TP53 gene is one of the most commonly inactivated tumor suppressors in human cancers. p53 functions during cancer progression have been linked to a variety of transcriptional and non-transcriptional activities that lead to the tight control of cell proliferation, senescence, DNA repair, and cell death. …”
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DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death by Katsuhiko Itoh, Takahiro Ebata, Hiroaki Hirata, Takeru Torii, Wataru Sugimoto, Keigo Onodera, Wataru Nakajima, Ikuno Uehara, Daisuke Okuzaki, Shota Yamauchi, Yemima Budirahardja, Takahito Nishikata, Nobuyuki Tanaka, Keiko Kawauchi

“…Tumor suppressor p53 plays an integral role in DNA-damage induced apoptosis, a biological process that protects against tumor progression. …”
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