MIR22HG inhibits breast cancer progression by stabilizing LATS2 tumor suppressor by Xiaochong Deng, Danrong Ye, Kaiyao Hua, Hongming Song, Qifeng Luo, Amik Munankarmy, Diya Liu, Baian Zhou, Wenfang Zheng, Xiqian Zhou, Changle Ji, Xuehui Wang, Yunhe Yu, Lin Fang

“…Abstract The long noncoding RNA called MIR22 host gene (MIR22HG) was previously identified as a tumor suppressor in several cancers. However, the biological function of MIR22HG in breast cancer remains unknown. …”
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Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver by Aamir Salam Teeli, Kamila Łuczyńska, Effi Haque, Mohmmad Abrar Gayas, Dawid Winiarczyk, Hiroaki Taniguchi

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NRBP2 Functions as a Tumor Suppressor and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer by Zhiyu Li, Bingxiong Liu, Chenyuan Li, Si Sun, Hanpu Zhang, Shengrong Sun, Zhong Wang, Xiongjie Zhang

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Surface Plasmon Resonance Sensing of Biorecognition Interactions within the Tumor Suppressor p53 Network by Ilaria Moscetti, Salvatore Cannistraro, Anna Rita Bizzarri

“…The potentiality of SPR was exploited to sense the interactions occurring within the network of the tumor suppressor p53, which is crucial for maintaining genome integrity and whose function is inactivated, mainly by down regulation or by mutation, in the majority of human tumors. …”
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Changes in Expression of Tumor Suppressor Gene RKIP Impact How Cancers Interact with Their Complex Environment by Christopher Figy, Anna Guo, Veani Roshale Fernando, Saori Furuta, Fahd Al-Mulla, Kam C. Yeung

“…Stepwise accumulation of mutations in oncogenes and tumor suppressor genes enables cancer cells to acquire the ability to reshape the microenvironment to advance their growth and metastasis. …”
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LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer by Yichen Xu, Hua Zhang, Van Thuy Mai Nguyen, Nicos Angelopoulos, Joao Nunes, Alistair Reid, Laki Buluwela, Luca Magnani, Justin Stebbing, Georgios Giamas

“…The LMTK3/KAP1 interaction is stabilized by PP1α, which suppresses KAP1 phosphorylation specifically at LMTK3-associated chromatin regions, inducing chromatin condensation and resulting in transcriptional repression of LMTK3-bound tumor suppressor-like genes. Furthermore, LMTK3 functions at distal regions in tethering the chromatin to the nuclear periphery, resulting in H3K9me3 modification and gene silencing. …”
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Splicing profile by capture RNA-seq identifies pathogenic germline variants in tumor suppressor genes by Tyler Landrith, Bing Li, Ashley A. Cass, Blair R. Conner, Holly LaDuca, Danielle B. McKenna, Kara N. Maxwell, Susan Domchek, Nichole A. Morman, Christopher Heinlen, Deborah Wham, Cathryn Koptiuch, Jennie Vagher, Ragene Rivera, Ann Bunnell, Gayle Patel, Jennifer L. Geurts, Morgan M. Depas, Shraddha Gaonkar, Sara Pirzadeh-Miller, Rebekah Krukenberg, Meredith Seidel, Robert Pilarski, Meagan Farmer, Khateriaa Pyrtel, Kara Milliron, John Lee, Elizabeth Hoodfar, Deepika Nathan, Amanda C. Ganzak, Sitao Wu, Huy Vuong, Dong Xu, Aarani Arulmoli, Melissa Parra, Lily Hoang, Bhuvan Molparia, Michele Fennessy, Susanne Fox, Sinead Charpentier, Julia Burdette, Tina Pesaran, Jessica Profato, Brandon Smith, Ginger Haynes, Emily Dalton, Joy Rae-Radecki Crandall, Ruth Baxter, Hsiao-Mei Lu, Brigette Tippin-Davis, Aaron Elliott, Elizabeth Chao, Rachid Karam

“…Abstract Germline variants in tumor suppressor genes (TSGs) can result in RNA mis-splicing and predisposition to cancer. …”
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Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study by Cantone Laura, Rizzo Giovanna, Marinelli Barbara, Angelici Laura, Bonzini Matteo, Nordio Francesco, Tarantini Letizia, Zhang Xiao, Hou Lifang, Apostoli Pietro, Bertazzi Pier, Baccarelli Andrea

“…<p>Abstract</p> <p>Exposure to ambient air particles matter (PM) has been associated with increased risk of lung cancer. Aberrant tumor suppressor gene promoter methylation has emerged as a promising biomarker for cancers, including lung cancer. …”
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Sorting nexin-1 is a candidate tumor suppressor and potential prognostic marker in gastric cancer by Xiao-Yong Zhan, Yaqiong Zhang, Ertao Zhai, Qing-Yi Zhu, Yulong He

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Mutational hotspots in the <it>TP53 </it>gene and, possibly, other tumor suppressors evolve by positive selection by Koonin Eugene V, Babenko Vladimir N, Glazko Galina V, Rogozin Igor B

“…<p>Abstract</p> <p>Background</p> <p>The mutation spectra of the <it>TP53 </it>gene and other tumor suppressors contain multiple hotspots, i.e., sites of non-random, frequent mutation in tumors and/or the germline. …”
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LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer by Qiuhui Li, Bigang Liu, Hsueh-Ping Chao, Yibing Ji, Yue Lu, Rashid Mehmood, Collene Jeter, Taiping Chen, John R. Moore, Wenqian Li, Can Liu, Kiera Rycaj, Amanda Tracz, Jason Kirk, Tammy Calhoun-Davis, Jie Xiong, Qu Deng, Jiaoti Huang, Barbara A. Foster, Abhiram Gokhale, Xin Chen, Dean G. Tang

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The Role of the PTEN Tumor Suppressor Gene and Its Anti-Angiogenic Activity in Melanoma and Other Cancers by Jacqueline Maphutha, Danielle Twilley, Namrita Lall

“…The downregulation of the tumor suppressor, phosphatase tensin homolog (PTEN), occurs in 30–40% of human malignant melanomas, thereby elucidating the importance of the upregulation of PTEN activity. …”
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ACADL Functions as a Tumor Suppressor in Hepatocellular Carcinoma Metastasis by Inhibiting Matrix Metalloproteinase 14 by Danfeng Guo, Danfeng Guo, Danfeng Guo, Xiaodan Zhang, Xiaodan Zhang, Xiaodan Zhang, Honglei Cui, Honglei Cui, Honglei Cui, Dongsheng Yu, Dongsheng Yu, Dongsheng Yu, Huapeng Zhang, Huapeng Zhang, Huapeng Zhang, Xiaoyi Shi, Xiaoyi Shi, Xiaoyi Shi, Chun Pang, Chun Pang, Chun Pang, Jie Li, Jie Li, Jie Li, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo, Shuijun Zhang, Shuijun Zhang, Shuijun Zhang

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Immunohistochemical Expression of the Tumor Suppressor Protein p16 INK4a in Cervical Adenocarcinoma by José Eleutério Jr, Thiago Silva Lima, Maria do Perpétuo Socorro Cunha, Diane Isabelle Magno Cavalcante, Angélica Maria Holanda Silva

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Upregulation of 5′-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor by Kyle A. Cottrell, Ryan C. Chiou, Jason D. Weber

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MMP‐2 regulates Src activation via repression of the CHK/MATK tumor suppressor in osteosarcoma by Deanna V. Maybee, Christopher R. Cromwell, Basil P. Hubbard, Mohammad A. M. Ali

“…This is due to its role in suppressing on the gene and protein expression of the tumor suppressor CHK/MATK in osteosarcoma. Conclusion By targeting the MMP‐2 gene, we can potentially enhance the effectiveness of doxorubicin treatment and reduce chemoresistance in osteosarcoma.…”
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Rosiglitazone disrupts pancreatic ductal adenocarcinoma progression by activating the tumor suppressor ESE3/EHF by Hongquan Wang, Shuang Wu, Yan Wang, Bo Tang

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Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. by Shashikiran Donthamsetty, Vishakha S Bhave, Wendy M Mars, William C Bowen, Anne Orr, Meagan M Haynes, Chuanyue Wu, George K Michalopoulos

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Necroptosis-related KLRB1 was a potent tumor suppressor and immunotherapy determinant in breast cancer by Jie Xia, Xudong Zhou

“…We further examined how necroptosis-related KLRB1 functions in BRCA as a powerful tumor suppressor and regulates the activity of macrophages by in vitro validation, including CCK8, EdU, and Transwell assays. …”
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Comparative Investigation of TSLC1 Tumor Suppressor Protein Expression in Cancerous and Normal Ovarian Specimens by Mehdi Nikbakht Dastjerdi, Sedigheh Shahid-Poorfallah

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