Association Between Genetic Variant in the Promoter of Pri-miR-34b/c and Risk of Glioma by Jinghui Li, Jinghui Li, Xiaoyu Liu, Yu Qiao, Renli Qi, Shunjin Liu, Jing Guo, Yang Gui, Juanjuan Li, Hualin Yu

“…Growing evidence indicates that p53 can regulate the expression of miRNAs, particularly the miR-34 family members, which are described as potential tumor suppressors. Loss of miR-34 suppresses TP53-mediated cell death, whereas over expression of miR-34 induced apoptosis. …”
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Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes by Wing-Hang Ip, Britta Wilkens, Anastasia Solomatina, Judith Martin, Michael Melling, Paloma Hidalgo, Luca D. Bertzbach, Thomas Speiseder, Thomas Dobner

“…In this context, HAdV-C5-mediated dysregulations of cellular factors such as the tumor suppressors p53 and pRB have been intensively investigated. …”
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Use of microRNAs as Diagnostic, Prognostic, and Therapeutic Tools for Glioblastoma by David Valle-Garcia, Verónica Pérez de la Cruz, Itamar Flores, Aleli Salazar, Benjamín Pineda, Karla F. Meza-Sosa

“…Moreover, as miRNAs regulate multiple target genes and can also act as tumor suppressors and oncogenes, they are involved in the appearance, progression, and even chemoresistance of most tumors. …”
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Transcription levels and prognostic significance of the NFI family members in human cancers by Yuexian Li, Cheng Sun, Yonggang Tan, Lin Li, Heying Zhang, Yusi Liang, Juan Zeng, Huawei Zou

“…Recent study results have shown that NFI family may play a critical role in the progression of various human tumors and have been identified as key tumor suppressors and oncogenes for many cancers. However, the expression levels and distinctive prognostic values of the NFI family remain poorly explored in most cancers. …”
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Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, coh... by Ruoyang Shao, Yu Zhang, Jinping He, Fen Huang, Zhiping Fan, Kaibo Yang, Yajing Xu, Na Xu, Yi Luo, Lan Deng, Xi Zhang, Jia Chen, Mingzhe Han, Xudong Li, Sijian Yu, Hui Liu, Xinquan Liang, Xiaodan Luo, Pengcheng Shi, Zhixiang Wang, Ling Jiang, Xuan Zhou, Ren Lin, Yan Chen, Sanfang Tu, Jing Sun, Yu Wang, Qifa Liu, Li Xuan

“…Patients with mutated NPM1, DNMT3A, co-occurring NPM1/DNMT3A, “activated signaling” and “DNA methylation” genes benefited in OS from sorafenib maintenance, while those carrying CEBPA, “tumor suppressors” and “myeloid transcription factors” genes did not. …”
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Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lungResearch in context by Smruthy Sivakumar, F. Anthony San Lucas, Yasminka A. Jakubek, Tina L. McDowell, Wenhua Lang, Noah Kallsen, Shanna Peyton, Gareth E. Davies, Junya Fukuoka, Yasushi Yatabe, Jianjun Zhang, P. Andrew Futreal, Jerry Fowler, Junya Fujimoto, Erik A. Ehli, Ernest T. Hawk, Ignacio I. Wistuba, Humam Kadara, Paul Scheet

“…Among the nine AAH tissues with detected AI, seven exhibited evidence for shared chromosomal aberrations with matched LUAD specimens, including losses harboring tumor suppressors on 17p, 8p, 9p, 9q, 19p, and gains encompassing oncogenes on 8q, 12p and 1q. …”
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Cytoskeleton regulator RNA expression on cancer-associated fibroblasts is associated with prognosis and immunotherapy response in bladder cancer by Yucai Wu, Yangyang Xu, Shiming He, Yifan Li, Ninghan Feng, Jian Fan, Yanqing Gong, Xuesong Li, Liqun Zhou

“…Background: Dysregulation of long noncoding RNAs (lncRNAs) has been reported to be associated with multiple tumors where they act as tumor suppressors or accelerators. The lncRNA CYTOR was identified as an oncogene involved in many cancers, such as gastric cancer, colorectal cancer, hepatocellular carcinoma, and renal cell carcinoma. …”
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Characterization of Synonymous BRCA1:c.132C>T as a Pathogenic Variant by Jun Li, Jun Li, Jun Li, Ping Wang, Cuiyun Zhang, Cuiyun Zhang, Cuiyun Zhang, Sile Han, Han Xiao, Zhiyuan Liu, Xiaoyan Wang, Xiaoyan Wang, Xiaoyan Wang, Weiling Liu, Bing Wei, Bing Wei, Bing Wei, Jie Ma, Jie Ma, Jie Ma, Hongle Li, Yongjun Guo, Yongjun Guo, Yongjun Guo

“…Breast cancer gene 1 (BRCA1) and BRCA2 are tumor suppressors involved in DNA damage response and repair. …”
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Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I by Andrea Esposito, Alessandra Ferraresi, Amreen Salwa, Chiara Vidoni, Danny N. Dhanasekaran, Ciro Isidoro

“…Cancer cell dormancy and autophagy are interconnected at the molecular level through ARH-I (DIRAS3) and BECLIN-1, two tumor suppressors often dysregulated in ovarian cancers. …”
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The Sex Differences in Uveal Melanoma: Potential Roles of EIF1AX, Immune Response and Redox Regulation by Feng Liu-Smith, Chi-Yang Chiu, Daniel L. Johnson, Phillip Winston Miller, Evan S. Glazer, Zhaohui Wu, Matthew W. Wilson

“…Examining the 11 major oncogenes and tumor suppressors in UVM revealed that EIF1AX showed a significant sex difference in mRNA accumulation and copy number variation, with female tumors expressing higher levels of EIF1AX and exhibiting more variations in copy numbers. …”
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The Role of miRNA-221 and miRNA-34a in Non-Melanoma Skin Cancer of the Head and Neck Region by Tiberiu Tamas, Lajos Raduly, Ioana Berindan-Neagoe, Cristian Dinu, Emil Botan, Bogdan Bumbu, Adela Tamas, Sebastian Stoia, Daniel Corneliu Leucuta, Simion Bran, Florin Onisor, Grigore Băciuț, Gabriel Armencea, Mihaela Băciuț

“…Depending on the functions of the genes, miRNAs may function as oncogenes or tumor suppressors. The aim of this paper was to describe the role of miRNA-34a and miRNA-221 in head and neck NMSC. …”
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Molecular Modes of Action of an Aqueous <i>Nerium oleander</i> Extract in Cancer Cells In Vitro and In Vivo by Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth

“…Remarkably, the cellular responsiveness of odoroside H and neritaloside was not correlated with all other classical drug resistance mechanisms, i.e., ATP-binding cassette transporters (ABCB1, ABCB5, ABCC1, ABCG2), oncogenes (EGFR, RAS), tumor suppressors (TP53, WT1), and others (GSTP1, HSP90, proliferation rate), in 59 tumor cell lines of the National Cancer Institute (NCI, USA), indicating that Breastin may indeed bypass drug resistance. …”
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Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers by Jared M. Andrews, Sarah C. Pyfrom, Jennifer A. Schmidt, Olivia I. Koues, Rodney A. Kowalewski, Nicholas R. Grams, Jessica J. Sun, Leigh R. Berman, Eric J. Duncavage, Yi-Shan Lee, Amanda F. Cashen, Eugene M. Oltz, Jacqueline E. Payton

“…More striking and pervasive was the profound loss of key B-cell identity TFs, tumor suppressors and their super-enhancers, including EBF1, OCT2(POU2F2), and RUNX3. …”
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The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4A expression by Tania Lee Slatter, Janice Anne Royds, Anna ePilbrow, Antonio eAhn, Helen eMorrin, Chris eFramptom, I. Alasdair eRussell, Christine Schomisch Moravec, Wendy eSweet, W. H. Wilson eTang, Margaret Jane Currie, Noelyn Anne Hung

“…Chromosome position 9p21 encodes three-tumor suppressors p16INK4a, p14ARF, and p15INK4b, and the long non-coding RNA ANRIL (antisense noncoding RNA in the INK4 locus). …”
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Targeting histone methyltransferase G9a inhibits growth and Wnt signaling pathway by epigenetically regulating HP1α and APC2 gene expression in non-small cell lung cancer by Keqiang Zhang, Jinhui Wang, Lu Yang, Yate-Ching Yuan, Tommy R. Tong, Jun Wu, Xinwei Yun, Melissa Bonner, Rajendra Pangeni, Zheng Liu, Tiger Yuchi, Jae Y. Kim, Dan J. Raz

“…Conclusions These findings demonstrate that overexpressed G9a represents a promising therapeutic target, and targeting G9a potentially suppresses growth and Wnt signaling pathway partially through down-regulating HP1α and epigenetically restoring these tumor suppressors such as APC2 that are silenced in NSCLC.…”
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Cancer Connectors: Connexins, Gap Junctions, and Communication by Maksim Sinyuk, Maksim Sinyuk, Erin E. Mulkearns-Hubert, Ofer Reizes, Ofer Reizes, Ofer Reizes, Ofer Reizes, Justin Lathia, Justin Lathia, Justin Lathia, Justin Lathia, Justin Lathia

“…However, connexins can also serve as tumor suppressors, and therefore, a complete understanding of the roles of the connexins and GJs in physiological and pathophysiological conditions is needed before connexin targeting strategies are applied. …”
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Recovering the angiogenic/angiostatic balance in NNK-induced lung carcinoma via 12 weeks of submaximal swimming and Nigella sativa nanocapsule by Zahra Abrishami Kia, Seyede Tayebeh Sadati Bizaki, Elham Asaádi Ghareh Tapeh, Shadmehr Mirdar Harijani, Nayyereh Katal, Roya Gorji Baziary

“…Background: Carcinogen nitrosamine 4-(methyl-trosamino)−1-(3-pyridyl)−1-butanone (NNK) remarkably affects the actions of growth factors: EGFR, VEGFR-2, as well as the natural tumor suppressors: TGFβ-1 and TIMP-1. We propose that utilizing non-chemical interventions such as swimming and Nigella sativa nanocapsule play role in controlling cancer progression through direct effects on tumor-inherent factors. …”
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Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles by Chuang Li, Fang Qin, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang, Mingxiong Guo

“…Particularly, YRNA hY4-derived fragments can serve as a novel class of biomarkers, which function as tumor suppressors in NSCLC. Additionally, miR-451a and miR-122-5p may be sorted into NSCLC EVs in a selective manner.…”
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Role of SOCS and VHL Proteins in Neuronal Differentiation and Development by Hiroshi Kanno, Shutaro Matsumoto, Tetsuya Yoshizumi, Kimihiro Nakahara, Atsuhiko Kubo, Hidetoshi Murata, Taro Shuin, Hoi-Sang U

“…It has also been suggested that the inactivation of these proteins may lead to the development of nervous system malignancies and that these proteins may function as tumor suppressors. The mechanism of action of SOCS and VHL involved in neuronal differentiation and nervous system development is thought to be mediated through the inhibition of downstream signaling pathways, JAK-STAT, and hypoxia-inducible factor–vascular endothelial growth factor pathways. …”
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The Genomic Environment of <i>BRAF</i> Mutated and <i>BRAF</i>/<i>PIK3CA</i> Double Mutated Colorectal Cancers by Ioannis A. Voutsadakis

“…A high prevalence of MSI and CIMP is observed in <i>BRAF</i> mutated colorectal cancers with or without <i>PIK3CA</i> mutations. Mutations in tumor suppressors <i>FBXW7</i> and <i>ATM</i> display a higher prevalence in <i>BRAF</i> mutated cancers. …”
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