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At the double for tumor suppressor
Published 2016-07-01“…Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost.…”
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Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors
Published 2007-04-01“…<p>Abstract</p> <p>The question of whether p73 is a tumor suppressor gene, is not yet answered with full confidence. …”
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Today and tomorrow of tumor suppressor gene /
Published 2015“…A tumor suppressor gene is also known as an antioncogene. …”
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Functional Mechanisms for Human Tumor Suppressors
Published 2010-01-01“…<p>Tumor suppressors refer to a large group of molecules that are capable of controlling cell division, promoting apoptosis, and suppressing metastasis. …”
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Retinoblastoma tumor suppressor gene: An overview
Published 2012-01-01Subjects: “…Tumor suppressor gene…”
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PTEN: Tumor Suppressor and Metabolic Regulator
Published 2018-07-01“…PTEN was first discovered as a tumor suppressor with growth and survival regulatory functions. …”
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The roles of the tumor suppressor parafibromin in cancer
Published 2022-09-01Subjects: Get full text
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SIRT3: Oncogene and Tumor Suppressor in Cancer
Published 2017-07-01“…On the contrary, other studies describe SIRT3 as a tumoral suppressor, as SIRT3 could trigger cell death under stress conditions. …”
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Microbial Regulation of p53 Tumor Suppressor.
Published 2015-09-01“…p53 tumor suppressor has been identified as a protein interacting with the large T antigen produced by simian vacuolating virus 40 (SV40). …”
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Synaptopodin-2: a potential tumor suppressor
Published 2023-08-01“…In most cancers, high SYNPO2 expression is positively correlated with a good prognosis, suggesting its role as a novel tumor suppressor. Abnormal SYNPO2 expression affects autophagy generation, particularly mitophagy induced by low oxidation or viral infection, as well as chaperone-mediated autophagy triggered by microfilament damage. …”
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PML surfs into HIPPO tumor suppressor pathway
Published 2013-03-01“…Here, we discuss the role of Promyelocytic leukemia protein (PML) in functional cross-talks with the HIPPO and the p53 family tumor suppressor pathways. PML, in addition to its own anti-tumor activity, contributes to the assembly of an integrated and superior network that may be necessary for the maximization of the tumor suppressor response to diverse oncogenic insults.…”
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PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
Published 2019-07-01“…<i>PTEN</i> is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or variation in <i>PTEN</i> gene/protein levels is commonly observed in a broad spectrum of human cancers, while germline <i>PTEN</i> mutations cause inherited syndromes that lead to increased risk of tumors. …”
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