Vildagliptin increases butyrate-producing bacteria in the gut of diabetic rats. by Qian Zhang, Xinhua Xiao, Ming Li, Miao Yu, Fan Ping, Jia Zheng, Tong Wang, Xiaojing Wang

“…Emerging evidence supports a key role for the gut microbiota in metabolic diseases, including type 2 diabetes (T2D) and obesity. The dipeptidyl peptidase-4 inhibitor vildagliptin is highly efficacious in treating T2D. …”
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GLUT4 defects in adipose tissue are early signs of metabolic alterations in Alms1GT/GT, a mouse model for obesity and insulin resistance. by Francesca Favaretto, Gabriella Milan, Gayle B Collin, Jan D Marshall, Fabio Stasi, Pietro Maffei, Roberto Vettor, Jürgen K Naggert

“…Alström Syndrome, a recessive ciliopathy, caused by mutations in ALMS1, is characterized by progressive metabolic alterations such as childhood obesity, hyperinsulinemia, and type 2 diabetes. Here we investigated the role of Alms1 disruption in AT expansion and insulin responsiveness in a murine model for Alström Syndrome. …”
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Meal timing and its role in obesity and associated diseases by Beeke Peters, Beeke Peters, Janna Vahlhaus, Janna Vahlhaus, Olga Pivovarova-Ramich, Olga Pivovarova-Ramich, Olga Pivovarova-Ramich

“…Mistimed food intake, such as delayed or nighttime consumption, leads to desynchronization of the internal circadian clock and is associated with an increased risk for obesity and associated metabolic disturbances such as type 2 diabetes and cardiovascular diseases. Conversely, meal timing aligned with cellular rhythms can optimize the performance of tissues and organs. …”
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Gestational Diabetes Mellitus Among Asians – A Systematic Review From a Population Health Perspective by Ling-Jun Li, Lihua Huang, Deirdre K. Tobias, Cuilin Zhang

“…ObjectiveSince Asians are particularly vulnerable to the risk of gestational diabetes mellitus (GDM), the lifecourse health implications of which are far beyond pregnancy, we aimed to summarize the literature to understand the research gaps on current GDM research among Asians.MethodsWe systematically searched the articles in PubMed, Web of Science, Embase, and Scopus by 30 June 2021 with keywords applied on three topics, namely “GDM prevalence in Asians”, “GDM and maternal health outcomes in Asians”, and “GDM and offspring health outcomes in Asians”.ResultsWe observed that Asian women (natives and immigrants) are at the highest risk of developing GDM and subsequent progression to type 2 diabetes among all populations. Children born to GDM-complicated pregnancies had a higher risk of macrosomia and congenital anomalies (i.e. heart, kidney and urinary tract) at birth and greater adiposity later in life.ConclusionThis review summarized various determinants underlying the conversion between GDM and long-term health outcomes in Asian women, and it might shed light on efforts to prevent GDM and improve the lifecourse health in Asians from a public health perspective.Systematic Review RegistrationProspero, CRD42021286075.…”
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Frequency of increased aminotransferases levels and associated metabolic abnormalities in obese and overweight children of an elementary school in Mexico City by Judith Flores-Calderón, Rita A Gómez-Díaz, Gabriela Rodríguez-Gómez, Segundo Morán-Villota

“…Background: Elevated ALT is an indirect marker of NAFLD in patients with non-alcohol abuse and without other known causes of chronic hepatitis. Obesity, type 2 diabetes and some dyslipidemias are associated to this condition. …”
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Empagliflozin ameliorates symptoms of diabetes and renal tubular dysfunction in a rat model of diabetes with enlarged kidney (DEK). by Ayaka Domon, Kentaro Katayama, Touko Sato, Yuki Tochigi, Hiroyuki Tazaki, Hiroetsu Suzuki

“…The present study investigated the effects of a SGLT2 inhibitor, empagliflozin, on hyperglycemia in a novel rat model of non-obesity type 2 diabetes with enlarged kidney (DEK).<h4>Methods</h4>Male DEK rats with non-fasting blood glucose concentrations ≤300 mg/dl and >300 mg/dl were classified as nondiabetic and diabetic, respectively. …”
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Effect of leptin level in non insulin dependant (type 2) obese diabetic subjects by Maysaa J. Majeed, Othman G. Othman

“…Background: Determine how do obesity and type2 diabetes intertwined? and what it takes to turn an obese person into a person with diabetes. …”
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The case for action on socioeconomic differences in overweight and obesity among Australian adults: modelling the disease burden and healthcare costs by Emma Gearon, Kathryn Backholer, Anita Lal, Wilma Nusselder, Anna Peeters

“…The greatest number (proportion) of cases and deaths attributable to socioeconomic differences in BMI was observed for type 2 diabetes among women (8,602 total cases [16%], with 3,471 cases [22%] in the most disadvantaged quintile [SEIFA 1]) and all‐cause mortality among men (2027 total deaths [4%], with 815 deaths [6%] in SEIFA 1). …”
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PAK4 phosphorylates and inhibits AMPKα to control glucose uptake by Dandan Wu, Hwang Chan Yu, Hye-Na Cha, Soyoung Park, Yoonji Lee, Sun-Jung Yoon, So-Young Park, Byung-Hyun Park, Eun Ju Bae

“…In summary, our findings suggest that targeting skeletal muscle PAK4 may offer a therapeutic avenue for type 2 diabetes.…”
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Physiological Mechanisms Inherent to Diabetes Involved in the Development of Dementia: Alzheimer’s Disease by Himan Mohamed-Mohamed, Victoria García-Morales, Encarnación María Sánchez Lara, Anabel González-Acedo, Teresa Pardo-Moreno, María Isabel Tovar-Gálvez, Lucía Melguizo-Rodríguez, Juan José Ramos-Rodríguez

“…Type 2 diabetes mellitus (T2D) is a metabolic disease reaching pandemic levels worldwide. …”
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Self-reported perceptions of adults with diabetes regarding their care and health in the time of COVID-19 pandemic in a Swiss region: a cross-sectional study by Christophe Kosinski, Emilie Zuercher, Tania Carron, Julie Chevallereau, Marie-Annick Le Pogam, Chiara Storari, Anne Wojtusciszyn, Isabelle Peytremann-Bridevaux

“…RESULTS: Respondents (n = 566; 79%) had a mean age of 70 years (range: 22–94), and most had type 2 diabetes (73%). The COVID-19 pandemic did not appear to have strongly affected their care. …”
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Correlation between Insulin Resistance and Microalbuminuria Creatinine Ratio in Postmenopausal Women by Han Na, Rong Wang, Hai-Long Zheng, Xiao-Pan Chen, Lin-Yang Zheng

“…The selected research group comprised 104 postmenopausal women with type 2 diabetes who were admitted to the Department of Endocrinology in the green card center at the First Affiliated Hospital of Hainan Medical University between 2017 and 2019 inclusive. …”
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Effects of T2DM on cancer progression: pivotal precipitating factors and underlying mechanisms by Yu-Yuan Zhang, Yu-Yuan Zhang, Yong-Jiang Li, Yong-Jiang Li, Chun-Dong Xue, Chun-Dong Xue, Shen Li, Zheng-Nan Gao, Kai-Rong Qin, Kai-Rong Qin

“…Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder affecting people worldwide. …”
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Diabetic retinopathy and corneal endothelial parameters: an analytical cross-sectional study by Seyed-Ali-Akbar Mortazavi, Mohammadreza Akhlaghi, Alireza Dehghani, Mohsen Pourazizi, Mohammad Malekahmadi, Mohammadreza Fazel, Mehdi Tavakoli, Pegah Noorshargh

“…Abstract Background To investigate the possible association of different pattern of diabetic retinopathy (DR) on corneal endothelium cells in type 2 diabetes mellitus patients. Methods In this descriptive-analytical cross-sectional study, corneal endothelium parameters including endothelial cell density (ECD), average cell size (AVG), coefficient of variation in cell size (CV), and hexagonality (Hex) were evaluated by non-contact specular microscopy. …”
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The Protective Effect of Metformin on Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis by Zhen Yuan, Zhijian Heng, Yi Lu, Jia Wei, Zhejun Cai

“…BackgroundType 2 diabetes mellitus (T2DM) patients have a lower risk of abdominal aortic aneurysm (AAA) and its comorbidities, which might be associated with the usage of metformin. …”
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HDAC9 Variant Rs2107595 Modifies Susceptibility to Coronary Artery Disease and the Severity of Coronary Atherosclerosis in a Chinese Han Population. by Xue-Bin Wang, Ya-di Han, Shrestha Sabina, Ning-Hua Cui, Shuai Zhang, Ze-Jin Liu, Cong Li, Fang Zheng

“…Subgroup and multifactor dimensionality reduction analyses (MDR) further found the gene-environment interactions among SNP rs2107595, body mass index, type 2 diabetes and hyperlipidemia in CAD risk and the severity of coronary atherosclerosis. …”
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Prevalence of metabolic syndrome in scholars from Bucaramanga, Colombia: a population-based study by Camacho Paul A, Martínez María P, Cano Diana J, Rodríguez Diana C, Buitrago Adriana, Villa-Roel Cristina, Ruiz Álvaro J, Durán Álvaro E

“…<p>Abstract</p> <p>Background</p> <p>Obesity and metabolic syndrome are strongly associated with type 2 diabetes mellitus and cardiovascular diseases, thus the increasing trend in their prevalence among children and adolescents from developing countries requires a further understanding of their epidemiology and determinants.…”
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The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease by Leticia Forny-Germano, Fernanda G. De Felice, Fernanda G. De Felice, Marcelo Nunes do Nascimento Vieira

“…Altered adipokine levels underlie complications of obesity as well as the increased risk for the development of obesity-related comorbidities such as type 2 diabetes, cardiovascular and neurodegenerative diseases. …”
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Clinical characteristics of hospitalized patients with metabolic-associated fatty liver disease–related liver cancer: data from a single center, 2010–2019 by Guishuang Wang, Hong Zhao, Lei Sun, Gang Wan, Wen Xie

“…There was no significant difference in the proportions of sex, age, overweight/obesity, type 2 diabetes, and the presence of ⩾2 metabolic-related factors between the two groups. …”
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Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes. by Anke Tönjes, Mathias Fasshauer, Jürgen Kratzsch, Michael Stumvoll, Matthias Blüher

“…AIM: Altered adipokine serum concentrations early reflect impaired adipose tissue function in obese patients with type 2 diabetes (T2D). It is not entirely clear whether these adipokine alterations are already present in prediabetic states and so far there is no comprehensive adipokine panel available. …”
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