Lipid perturbation compromises UPR-mediated ER homeostasis by Ng, Benjamin Si Han

“…PC/PE disequilibrium has also been linked to metabolic diseases such as non-alcoholic fatty liver disease and type II diabetes, but its biological significance remains unclear. …”
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Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women. by Browning, L, Jebb, SA, Mishra, G, Cooke, J, O'Connell, M, Crook, M, Krebs, J

“…AIMS: C-reactive protein (CRP) is a predictor of many diseases including type II diabetes and cardiovascular disease. Fewer studies have similarly shown sialic acid (SA) to be a predictor of obesity-related diseases, but importantly SA shows less intra-individual variability than CRP and acts as an integrated marker of the activity of a number of acute-phase proteins. …”

Cohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain by Hébert, HL, Veluchamy, A, Baskozos, G, Fardo, F, Van Ryckeghem, DML, Pascal, MMV, Jones, C, Milburn, K, Pearson, ER, Crombez, G, Bennett, DLH, Meng, W, Palmer, CNA, Smith, BH

“…<br> <strong>Participants</strong> DOLORisk Dundee has been constructed by rephenotyping two pre-existing Scottish population cohorts for neuropathic pain using a standardised ‘core’ study protocol: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) (n=5236) consisting of predominantly type 2 diabetics from the Tayside region, and Generation Scotland: Scottish Family Health Study (GS:SFHS; n=20 221). …”

Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells by Amisten, S, Mohammad Al-Amily, I, Soni, A, Hawkes, R, Atanes, P, Persaud, S, Rorsman, P, Salehi, A

“…GPRC5C mRNA expression and protein level were reduced in the islets from type-2 diabetic donors. RNA sequencing in human islets revealed GPRC5C expression correlated with the expression of genes controlling apoptosis, cell survival and proliferation. …”

Studying the effect of diabetes and hyperglycaemia on brain vascular cells by Rocha, G

“…<p>Type II Diabetes Mellitus (T2DM) is a metabolic disease characterised by insulin resistance and hyperglycaemia. …”

Visceral fat and insulin resistance--causative or correlative? by Frayn, K

“…The association between abdominal fat accumulation and risk of chronic diseases, including type II diabetes and coronary heart disease, has long been recognized. …”

The interaction between ketone bodies and carbohydrate in human metabolism by Holdsworth, D

“…In overnight fasted healthy controls and type-2 diabetic participants (T2DM), KE increased insulin and lowered glucose concentrations vs. control (zero calorie) drink. …”

Starch properties and morphological differences of Oryza sativa mutants, MR219-4 and UPMTC1 by Yong, Wai Shin

“…UPMTC1 which has higher AAC may be suitable to be used as low glycemic diet for type two diabetic patients. Both MR219-4 and UPMTC1 exhibited resistant to starch disintegration towards alkali solution, suggesting both have high gelatinization temperature. …”
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Angiotensin-Converting Enzyme Genetic Polymorphism rs4343 as Risk of Diabetic Nephropathy in Jambi-Malay Population by Elfiani Elfiani, Anggelia Puspasari, Cut Wulan Arif, Citra Maharani, Zulkhair Ali, Novadian Suhaimi, Ian Effendi, Suprapti Suprapti, Nyimas Natasha Ayu Shafira

“…Background: Diabetic nephropathy (DN) is one of the frequent complications of type II diabetes mellitus (T2DM) in Jambi province. Controlling blood glucose and blood pressure does not guarantee DN prevention, since genetic factors may also contribute to this disease. …”
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Ramipril, an angiotensin-converting enzyme inhibitor, ameliorates oxidative stress, inflammation, and hepatic fibrosis in alloxan-induced diabetic rats by Shahnaz Siddiqua, Biswajit Sikder, Anayet Ullah, Farzana Akhter Sumi, Nasrin Akhter, Md Nurul Islam, Md Ashraful Alam

“…A single dose (90 mg/kg) of alloxan was given intra-peritoneally to induce type two diabetes. After the induction of diabetes, ramipril (10 mg/kg) was administered to each animal for 21 days. …”
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Prediction of insulin resistance with anthropometric measures: lessons from a large adolescent population by Wedin WK, Diaz-Gimenez L, Convit AJ

“…BMI was comparatively weak in predicting IR, suggesting that assessments that are more comprehensive and include body composition analysis could increase detection of IR during adolescence, especially among those who are lean, yet insulin-resistant.Keywords: BMI, bioelectrical impedance analysis, waist circumference, HOMA, insulin resistance, type 2 diabetes…”
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The implication of miR-200a and miR-132 expression and their correlations with NF-κB/TNF-alpha signaling in adults with diabetic nephropathy by Zienab Negeem, Adel Abdel Moneim, Basant Mahmoud, Amr E. Ahmed, Abeer M. Abd El-Hameed, Areej A. Eskandrani, Nabil A. Hasona

“…Methods: Fifty healthy controls, and 271 type 2 diabetic (T2D) patients (166 male plus 105 female) were enrolled. …”
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Towards OPtimal TIming and Method for promoting sUstained adherence to lifestyle and body weight recommendations in postMenopausal breast cancer survivors (the OPTIMUM-study): prot... by Sandra J. M. van Cappellen-van Maldegem, Floortje Mols, Nicole Horevoorts, Anja de Kruif, Laurien M. Buffart, Dounya Schoormans, Hester Trompetter, Sandra Beijer, Nicole P. M. Ezendam, Michiel de Boer, Renate Winkels, Ellen Kampman, Jantine Schuit, Lonneke van de Poll-Franse, Jacob C. Seidell, Meeke Hoedjes, the OPTIMUM research team

“…In this group, this is associated with poorer health-related quality of life and an increased risk of type II diabetes mellitus, cardiovascular disease, second primary cancers, cancer recurrences, and mortality. …”
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Eight-week aerobic training effects on Apelin-13 and insulin resistance in overweight men by Rahman Soori, Mohammad Reza Asad, Mohammad Yari, Mahsa Rastegar M.M.

“…&nbsp;According to this record, longer and higher intense exercise compare with the current study's protocol were recommended to beneficially decrease and control the incidence and catch the type II diabetes and cardiovascular diseases.…”
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Diabetic rats with high levels of endogenous dopamine do not show retinal vascular pathology by Rachael S. Allen, Rachael S. Allen, Cara T. Khayat, Andrew J. Feola, Andrew J. Feola, Andrew J. Feola, Alice S. Win, Alice S. Win, Allison R. Grubman, Allison R. Grubman, Kyle C. Chesler, Kyle C. Chesler, Li He, Li He, Jendayi A. Dixon, Timothy S. Kern, Timothy S. Kern, Timothy S. Kern, P. Michael Iuvone, P. Michael Iuvone, Peter M. Thule, Machelle T. Pardue, Machelle T. Pardue, Machelle T. Pardue

“…Previously, we examined short term (4–8 weeks) deficits in the Goto-Kakizaki (GK) rat model of Type II diabetes. Here, we investigated the long-term (1–8 months) temporal appearance of functional deficits (retinal, cognitive, and motor), retinal vascular pathology, and retinal dopamine levels in the GK rat.MethodsIn GK rats and Wistar controls, retinal neuronal function (electroretinogram), cognitive function (Y-maze), and motor function (rotarod) were measured at 1, 2, 4, 6, and 8 months of age. …”
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Sodium hydrosulfide increases glutathione synthesis in cardiac muscle cell line HL-1 under hyperglycemia and hyperlipidemia by ZHANG Weicai, LIU Siren, WANG Shangnong

“…Objective To investigate sodium hydrogen sulfide(NaHS) with function of regulating glutathione(GSH) synthesis to reduce reactive oxygen species(ROS) production in type 2 diabetic cardiomyopathy (DCM). Methods Mouse cardiomyocyte cell line HL-1 was incubated with high concentration of glucose (HG:40 mmol/L) and palmitate (Pal:500 μmol/L) as a cell model of type 2 DCM. …”
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Photoacoustic Imaging of Human Vasculature Using LED versus Laser Illumination: A Comparison Study on Tissue Phantoms and In Vivo Humans by Sumit Agrawal, Mithun Kuniyil Ajith Singh, Kerrick Johnstonbaugh, David C. Han, Colette R. Pameijer, Sri-Rajasekhar Kothapalli

“…Vascular diseases are becoming an epidemic with an increasing aging population and increases in obesity and type II diabetes. Point-of-care (POC) diagnosis and monitoring of vascular diseases is an unmet medical need. …”
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Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model by Yu‐xin Zhu, Yi Li, Yu Ma, Xiao Zhang, Xingrong Du, Jiali Gao, Nian Hui Ding, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu, Rong Li

“…This study aimed to assess the therapeutic effect of liraglutide on hind‐limb ischemia in type 2 diabetic mice and to elucidate the underlying mechanism. …”
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Implantation of Autologous Selected Renal Cells in Diabetic Chronic Kidney Disease Stages 3 and 4—Clinical Experience of a “First in Human” Study by Peter Stenvinkel, Jonas Wadström, Tim Bertram, Randal Detwiler, David Gerber, Torkel B. Brismar, Pontus Blomberg, Torbjörn Lundgren

“…Methods: We present experience from the first-in-human clinical study with SRCs. Seven male type 2 diabetic patients (63 ± 2 years of age) with chronic kidney disease stage 3 to 4 (estimated glomerular filtration rate 25 ± 2 ml/min) were recruited. …”
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Ruptured liver abscess presenting as pneumoperitoneum caused by Klebsiella pneumoniae: a case report by Thuong Pham Van, Son Vu Ngoc, Ngoc Anh Nguyen Hoang, Doan Hoang Huu, Tung Anh Dinh Duong

“…Case presentation We reported here a case with pneumoperitoneum caused by ruptured liver abscess in a 41-year-old man with a history of treated duodenal ulcer and uncontrolled type II diabetes mellitus. He had an epigastric pain associated with a high fever. …”
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