Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells by Shuyin Bao, Shuyin Bao, Xiuzhi Wang, Xiuzhi Wang, Sung Bo Cho, Yan-Ling Wu, Chengxi Wei, Shuying Han, Liming Bao, Qiong Wu, Wuliji Ao, Wuliji Ao, Ji-Xing Nan, Ji-Xing Nan

“…An oral dose of AOS (380 or 750 mg/kg) was administered to type-2 diabetic db/db mice for 8 weeks to determine whether AOS regulates glucose by the INS-R/IRS/Glut4-mediated insulin pathway. …”
Get full text

Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of <i>ACE2</i> in Diabetic Donors by Jalal Taneera, Waseem El-Huneidi, Mawieh Hamad, Abdul Khader Mohammed, Esraa Elaraby, Mahmood Yaseen Hachim

“…In this study, microarray and RNA-sequencing (RNA-seq) expression data were utilized to profile the expression pattern of <i>ACE2</i>, <i>ADAM17</i>, and <i>TMPRSS2</i> in type 2 diabetic (T2D) and non-diabetic human pancreatic islets. …”
Get full text

Genome-Wide Profiling of H3K56 Acetylation and Transcription Factor Binding Sites in Human Adipocytes by Lo, Kinyui Alice, Bauchmann, Mary K., Baumann, Amy P., Donahue, Christopher J., Thiede, Mark A., Hayes, Lisa S., Des Etages, Shelley Ann G., Fraenkel, Ernest

“…We found that while almost half of the genome shows signs of H3K56 acetylation, the highest level of H3K56 acetylation is associated with transcription factors and proteins in the adipokine signaling and Type II Diabetes pathways. In order to discover the transcription factors that recruit acetyltransferases and deacetylases to sites of H3K56 acetylation, we analyzed DNA sequences near H3K56 acetylated regions and found that the E2F recognition sequence was enriched. …”
Get full text
Get full text

Clinical resolution of periodontitis among diabetic patients under medical-dental coordinated care: A preliminary study in Kuantan by Yaacob, Munirah, Han, Tin Myo, Ismail, Razida, Sidek, Sorayah, Hari, Padmini, Aris, Mohd Aznan Md, Osman, Iskandar Firzada, Thuraiappah, Mahendran, Abdulla, Fa'iza, Sein, Than Tun, Saub, Roslan

“…The literature had reported the clinical resolution of periodontitis (CRP) in type-2 diabetic patients (T2DM-P) following non-surgical periodontal treatment (NSPT). …”

Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-CellsSummary by Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K. Pasupulati, Simon S. Evers, Ian J. Sipula, Michael Jurczak, Randy J. Seeley, Yatrik M. Shah, Sadeesh K. Ramakrishnan

“…Background &amp; Aims: Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. …”
Get full text

A Significant Association Between Rhein and Diabetic Nephropathy in Animals: A Systematic Review and Meta-Analysis by Heng-Chang Hu, Liu-Tao Zheng, Hai-Yan Yin, Yuan Tao, Xiao-Qiong Luo, Kai-Shan Wei, Li-Ping Yin

“…Subgroup analysis showed that the hypoglycemic effect of rhein on type 2 diabetic nephropathy was better than on type 1 diabetic nephropathy (P &lt; 0.05).Conclusions: These findings suggested that rhein has beneficial effects on animal models of diabetic nephropathy, and that the mechanisms are mostly involved with ameliorating levels of TGF-β1, renal fibrosis, metabolism, and oxidative stress status. …”
Get full text

Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized mice by Christian A. Unger, Ahmed K. Aladhami, Marion C. Hope, Sahar Pourhoseini, Mitzi Nagarkatti, Owen P. McGuinness, E. Angela Murphy, Kandy T. Velázquez, Reilly T. Enos

“…Abstract Epidemiological literature indicates that women are less susceptible to type II diabetes (T2D) than males. The general consensus is that estrogen is protective, whereas its deficiency in post-menopause is associated with adiposity and impaired insulin sensitivity. …”
Get full text

Consumer Reports of “Keto Flu” Associated With the Ketogenic Diet by Emmanuelle C. S. Bostock, Kenneth C. Kirkby, Bruce V. Taylor, Jason A. Hawrelak, Jason A. Hawrelak

“…KD is also self-administered, with limited evidence of efficacy, for conditions including weight loss, cognitive and memory enhancement, type II diabetes, cancer, neurological and psychiatric disorders. …”
Get full text

ACE Gene Variants Rise the Risk of Severe COVID-19 in Patients With Hypertension, Dyslipidemia or Diabetes: A Spanish Pilot Study by María Íñiguez, Patricia Pérez-Matute, Pablo Villoslada-Blanco, Emma Recio-Fernandez, Diana Ezquerro-Pérez, Jorge Alba, M. Lourdes Ferreira-Laso, José A. Oteo, José A. Oteo

“…G-carrier genotypes of both polymorphisms were also associated with higher mortality (p&lt; 0.05) and higher severity of COVID-19 in dyslipidemic (p&lt;0.05) and type 2 diabetic patients (p&lt; 0.01). The association of G alleles with disease severity was adjusted for age, sex, BMI and number of comorbidities, suggesting that both the metabolic comorbidities and the G allele act synergistically on COVID-19 outcome. …”
Get full text

Abstract 188: Rescue Left Middle Cerebral Artery Stenting With Xience Skypoint Everolimus‐Eluting Stent: Technical Report by Raman Singh, Hakeem Shakir, Shyian Jen, Uttam Verma

“…Methods Case report and review of literature Results 67‐year‐old woman with type II diabetes mellitus, hypertension, hyperlipidemia, and recent admission for transient ischemic attack (resolving right hemiparesis and mild dysnomia in the setting of severe left M1 segment stenosis with discharge on Aspirin, Clopidogrel and Atorvastatin), presented with recurrence of symptoms, and MRI brain showing left basal ganglia acute infarction. …”
Get full text

Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis by Yechen Han, Hongzhi Xie, Yongtai Liu, Peng Gao, Xufei Yang, Zhujun Shen

“…Subgroup analysis showed that metformin reduced all-cause mortality in myocardial infarction (MI) (aHR = 0.79) and heart failure (HF) patients (aHR = 0.84), the incidence of CV events in HF (aHR = 0.83) and type II diabetes mellitus (T2DM) patients (aHR = 0.83), but had no significant effect on MI (aHR = 0.87) and non-T2DM patients (aHR = 0.92). …”
Get full text

Impact of DPP4 Inhibitors in Survival of Patients With Prostate, Pancreas, and Breast Cancer by Chintan Shah, Young-Rock Hong, Rohit Bishnoi, Azka Ali, William Paul Skelton, Long H. Dang, Jinhai Huo, Nam H. Dang

“…We aim to study the impact of DPP4 inhibitors (DPP4i) in patients with prostate cancer (PRC), pancreatic cancer (PC) and breast cancer (BC).Methods: Using the SEER and Medicare linked database, we identified patients with PRC or PC or BC with coexisting type II diabetes mellitus between 2007 and 2015. Patients were classified into four groups: (1) not on either DPP4i or metformin (reference group), this group included patient that were on anti-diabetic agents other than metformin or DPP4i (2) metformin only, (3) DPP4i only, and (4) DPP4i along with metformin (combination group). …”
Get full text

Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes by Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell, David A. Copland, Karen L. Onions, Matthew J. Butler, Elizabeth J. Wasson, Michael Crompton, Raina D. Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P. Arkill, David O. Bates, Jeremy E. Turnbull, Olga V. Zubkova, Gavin I. Welsh, Denize Atan, Simon C. Satchell, Rebecca R. Foster

“…To measure the impact on barrier function, we used sodium fluorescein angiography in the eye and a glomerular albumin permeability assay in the kidney. A type 2 diabetic (T2D, db/db) mouse model was used to determine the therapeutic potential of preventing heparan sulphate damage using treatment with a novel heparanase inhibitor, OVZ/HS-1638. …”
Get full text

Report and Abstracts of the 19th Meeting of the Interuniversity Institute of Myology: Assisi, October 20-23, 2022 by Maurilio Sampaoleosi, Stefania Fulle

“…The four keynote speakers for the IIM Conference 2022 presented new insights into the role of multinucleation during muscle growth and disease, the long-range distribution of giant mRNAs in skeletal muscle, human skeletal muscle remodelling from type 2 diabetic patients and the genome integrity and cell identity in adult muscle stem cells. …”
Get full text

PS-MPs promotes the progression of inflammation and fibrosis in diabetic nephropathy through NLRP3/Caspase-1 and TGF-β1/Smad2/3 signaling pathways by Lixiang Feng, Chen Chen, Xi Xiong, Xiong Wang, Xinxin Li, Qihui Kuang, Xiao Wei, Likun Gao, Xuan Niu, Qingwen Li, Jun Yang, Lili Li, Pengcheng Luo

“…Besides, db/db mice were divided into two groups: PS-MPs group (oral administration of 0.5 µm PS-MPs) and an H2O group, and they were fed for three months. A type II diabetes model was established using db/db mice to investigate the effects of PS-MPs on body weight, blood glucose level, renal function, and renal fibrosis. …”
Get full text

Restoration of gut dysbiosis through Clostridium butyricum and magnesium possibly balance blood glucose levels: an experimental study by Hafiz Muhammad Ubaid Tayyib, Amjed Ali, Shaista Jabeen, Habib-ur-Rehman, Hafsa Kamran, Majed A. Bajaber, Muhammad Usman, Xiao Zhang

“…The findings of this study conclude that Clostridium butyricum supplementation improved blood glucose levels and intestinal bacterial load in type II diabetes mellitus.…”
Get full text

Ethnobotanical Study of Medicinal Plants Used as Anti-Obesity Remedies in the Nomad and Hunter Communities of Burkina Faso by Dramane Pare, Adama Hilou, Noufou Ouedraogo, Samson Guenne

“…This metabolic imbalance often leads to multiple pathologies (heart failure, Type II diabetes, cancers, etc.). Drugs have been developed for the treatment of these diseases; but in addition to having many side effects, locally these products are not economically accessible to the majority of the population. …”
Get full text

Combination Antiretroviral Therapy (cART) in Diabetes Exacerbates Diabetogenic Effects on Hippocampal Microstructure, Neurogenesis and Cytokine Perturbation in Male Sprague Dawley... by Jaclyn Asouzu Johnson, Robert Ndou, Ejikeme Felix Mbajiorgu

“…Therefore, the effects of cART and type two diabetes (T2D) on the hippocampal levels of cytokines, lipid peroxidation; histomorphology and neurogenesis were investigated. …”
Get full text

Acidosis láctica asociada a metformina by Maria Fernández Rodríguez, J Álvarez del Vayo, A Pascual Casado, E Zaldibar Enríquez

“…It is the drug of choice for the treatment of type II diabetes due to its efficacy and safety. It is a small molecule, whose elimination half-life is 8 to 20 hours in people with normal renal function. …”
Get full text

Toenail speciation biomarkers in arsenic‐related disease: a feasibility study for investigating the association between arsenic exposure and chronic disease by Nathan Kyle Smith, Erin Keltie, Ellen Sweeney, Swarna Weerasinghe, Kathleen MacPherson, Jong Sung Kim

“…The primary objectives of this study were to 1) establish an analytical method for arsenic speciation analysis in toenails, 2) describe preliminary arsenic speciation profiles of toenail samples from individuals with skin, lung, bladder, and kidney cancer, type II diabetes, and no known disease, and 3) determine if these speciation patterns differ between disease groups to inform the feasibility of subsequent research. …”
Get full text