25. Novel adipokine tazarotene induced gene 2 correlations with increased cardiovascular risk determined by body composition, insulin resistance, dyslipidemia and diabesity in Saud... by S.S. Habib, D. Fatani, A. Eshki, B. AlTassan, H. Helmi, S. AlSaif

“…The present study compared TIG2 levels between healthy and type 2 diabetic women matched for age and body composition. …”
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Downregulation of lncRNA EPB41L4A-AS1 Mediates Activation of MYD88-Dependent NF-κB Pathway in Diabetes-Related Inflammation by Wang Z, Liao W, Liu F, Yang T, Xie W, Liao M, Gu D, Zhang Y

“…In this study, we aimed to reveal the role and molecular mechanism of lncRNA EPB41L4A-AS1 in type 2 diabetic mellitus (T2DM)-related inflammation.Methods: To explore the relationships between the expression of EPB41L4A-AS1 and inflammatory factors in the blood of T2DM patients, we analyzed peripheral blood mononuclear cell (PBMC) expression microarrays of T2DM patients and expression microarrays of PBMC treated with lipopolysaccharide (LPS) from the GEO database. …”
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The Possible Mechanisms by which Borapetol B Stimulates Insulin Release from Rat Islets by Ezarul Faradianna, Lokman, Gu, Harvest F., Wan Nazaimoon, Wan Mohamud, M. M., Yusoff, Keh, Leong Chia, Östenson, Claes-Göran

“…This present study aims to reveal the mechanisms by which C1 stimulates insulin release in the isolated pancreatic islets of normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Isolated pancreatic islets from Wistar (W) and Goto Kakizaki (GK) rat were cultured overnight and then exposed to incubation conditions at 3.3 mM and 16.7 mM glucose. …”
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Comparación de los niveles séricos de óxido nítrico y malondialdehído en pacientes con pie diabético con y sin infección by Hernández Arteaga M, Núñez R, Godoy N, Socarras E, González Z, Chávez J, Cano C, Bermúdez VSuárez G, Suárez G

“…To compare serum NO and MDA levels in patients with infected and non-infected diabetic foot, 27 type 2 diabetics, 38 to 65 years old were studied, and divided into three groups: 8 control subjects without foot affection (A), 10 with non-infected diabetic foot (B) and 9 with infected diabetic foot (C). …”
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Targeting the DP2 receptor alleviates muscle atrophy and diet‐induced obesity in mice through oxidative myofiber transition by Huying Ning, Huiwen Ren, Yan Zhao, HaiFang Yin, Zhenji Gan, Yujun Shen, Ying Yu

“…Muscle fibre composition switch is closely associated with chronic diseases such as muscle atrophy, obesity, type II diabetes and athletic performance. Prostaglandin D2 (PGD2) is a bioactive lipid derived from arachidonic acid that aggravates muscle damage and wasting during muscle atrophy. …”
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Oxidative Stress, Inflammatory, Angiogenic, and Apoptotic molecules in Proliferative Diabetic Retinopathy and Diabetic Macular Edema Patients by Irene Andrés-Blasco, Alex Gallego-Martínez, Ximena Machado, Javier Cruz-Espinosa, Salvatore Di Lauro, Ricardo Casaroli-Marano, Víctor Alegre-Ituarte, José Fernando Arévalo, María Dolores Pinazo-Durán

“…The aim of this study is to evaluate molecules involved in oxidative stress (OS), inflammation, angiogenesis, and apoptosis, and discern which of these are more likely to be implicated in proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME) by investigating the correlation between them in the plasma (PLS) and vitreous body (VIT), as well as examining data obtained from ophthalmological examinations. Type 2 diabetic (T2DM) patients with PDR/DME (PDRG/DMEG; n = 112) and non-DM subjects as the surrogate controls (SCG n = 48) were selected according to the inclusion/exclusion criteria and programming for vitrectomy, either due to having PDR/DME or macular hole (MH)/epiretinal membrane (ERM)/rhegmatogenous retinal detachment. …”
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The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin by Vincenzo Quagliariello, Michelino De Laurentiis, Domenica Rea, Antonio Barbieri, Maria Gaia Monti, Andreina Carbone, Andrea Paccone, Lucia Altucci, Mariarosaria Conte, Maria Laura Canale, Gerardo Botti, Nicola Maurea

“…Abstract Background Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter 2, reduced the risk of hospitalization for heart failure and cardiovascular death in type 2 diabetic patients in the EMPA‐REG OUTCOME trial. …”
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Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments by Nikolay V. Goncharov, Polina I. Popova, Igor V. Kudryavtsev, Alexey S. Golovkin, Irina V. Savitskaya, Piotr P. Avdonin, Ekaterina A. Korf, Natalia G. Voitenko, Daria A. Belinskaia, Maria K. Serebryakova, Natalia V. Matveeva, Natalia O. Gerlakh, Natalia E. Anikievich, Marina A. Gubatenko, Irina A. Dobrylko, Andrey S. Trulioff, Arthur D. Aquino, Richard O. Jenkins, Pavel V. Avdonin

“…The purpose of this study was to carry out immunological and biochemical profiling of elderly people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), and subcortical ischemic vascular dementia (SIVD). …”
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<i>MTHFR</i> Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity by Dana Simona Chita, Anca Tudor, Ruxandra Christodorescu, Florina Nicoleta Buleu, Raluca Sosdean, Sanda Maria Deme, Simona Mercea, Adina Pop Moldovan, Ana Maria Pah, Any Docu Axelerad, Daniel Docu Axelerad, Simona Ruxanda Dragan

“…The <i>C677T</i> mutation in patients with NVAF was correlated with a higher incidence of cardiovascular comorbidities (hypertension HTN, heart failure (HF), dyslipidemia, type II diabetes mellitus (T2DM) with high HbA1c and increased inflammatory state). …”
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Aerobic training with moderate or high doses of vitamin D improve liver enzymes, LXRα and PGC-1α levels in rats with T2DM by Zahra Hoseini, Nasser Behpour, Rastegar Hoseini

“…Combined administration of aerobic training and vitamin D supplementation potentially improves liver enzymes in type-2 diabetic rats that were simultaneous with upregulating the levels of PGC-1α and LXRα proteins in hepatocytes. …”
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Helicobacter pylori y anticuerpos antiislotes pancreáticos en la diabetes mellitus Helicobacter pylori and islet cells antibodies in diabetes mellitus by Eduardo Cabrera Rode, Oscar Díaz Horta, Gisela Molina Matos, Claudio Tiberti, Marinela Fuentes, Pedro A. Perich Amador, Manel Puig-Domingo, Elio Vecci, Manuel Paniagua, Felipe Piñol, María del Pilar Escobar, Umberto Di Mario

“…They were compared with 101 ICA-negative patients: 20 type 2 diabetics, 20 first-degree relatives, 21 children and 40 non-diabetic adult controls to analyze if the immunolgical response to H. pylori is associated with islet cell antibodies (ICA). …”
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Retrospective analysis of the results of surgical treatment of patients with primary and postoperative ventral herniations under the conditions of morbid obesity by V. I. Piatnochka, R. D. Levchuk, I. I. Dovha

“…Diabetes was diagnosed in 21 (11.48 %), including 19 (10.38 %) patients with type II diabetes. Undifferentiated connective tissue dysplasia was diagnosed in 36 (19.46 %) patients. …”
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Phaeohyphomycotic cyst by Rashmi Joshi, Suvradeep Mitra, Mayur Parkhi, Arunanshu Behera

“…He is on medication for type II diabetes mellitus and hypertension. He underwent Whipple's surgery for periampullary carcinoma. …”
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Níveis de hemoglobina glicosilada e anomalias cardíacas em fetos de mães com diabetes mellitus Glycosylated hemoglobin levels and cardiac abnormalities in fetuses of diabetic mothe... by Ivo Behle, Paulo Zielinsky, Lucia Pellanda Zimmer, Mila Pontremoli, Juliana N. Risch

“…The difference between means of the groups with and without myocardial hypertrophy diagnosed as isolated anomaly (MCHP) was not statistically significant, when considering both type II diabetes and GDM subgroups. In conclusion, levels of HbA1c higher than 7.5% were associated with most cases of echocardiographycally diagnosed structural cardiac anomalies. …”
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Insulina, leptina y hormona de crecimiento y su relación con índice de masa corporal e índice de obesidad en adolescentes Serum Insulin, leptin and growth hormone levels are associ... by Emperatriz Molero-Conejo, Luz Marina Morales, Virginia Fernández, Xiomara Raleigh, Angel Casanova, Lissette Connell, Maria Esther Gómez, Elena Ryder, Gilberto Campos

“…We conclude that hyperinsulinemia, hyperleptinemia and low growth hormone levels, may be established as risk factors related to obesity markers, lipid alterations and insulin resistance that can lead to an early development of Type II diabetes and cardiovascular disease.…”
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Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification by Tong, Lily Victoria

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Investigation into multifunctional nanoparticles for the detection, imaging and intervention of amyloid by Xia, Yang

“…Therefore, the presence of amyloid is linked with several diseases, including Alzheimer’s disease (AD), spongiform encephalopathies and type II diabetes, which are also referred as amyloidosis. …”
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It must be my metabolism: Metabolic control of mind by Dana M Small

“…Our finding further suggests that metabolic regulation of reward circuits may differ in individuals with altered glucose metabolism, such as type II diabetes, offering a potential mechanism by which they become susceptible to weight gain.…”
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Paraplegia após revascularização cirúrgica do miocárdio: relato de caso Paraplejia después de la revascularización quirúrgica del miocardio: relato de caso Paraplegia after myocard... by Caetano Nigro Neto, Milton Patricio Chango Iza, Maria Angela Tardelli

“…The patient had controlled dyslipedemia, type II diabetes mellitus, and hypertension; history of smoking, peripheral vascular disease, and myocardial infarction 20 years ago. …”
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The impact of angiotensin converting enzyme insertion/deletion gene polymorphism on diabetic kidney disease: A debatable issue by Wen-li Zeng, Shi-kun Yang, Na Song, Fen-fen Chu

“…Conclusion: ACE I/D polymorphisms were correlated with DKD in Asian and type 2 diabetic populations. ACE D allele/DD genotype might be a risk factor, while ACE II genotype might be a protective factor for DKD. …”
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