The Role of the Unfolded Protein Response on Renal Lipogenesis in C57BL/6 Mice by Elizabeth Figueroa-Juárez, Lilia G. Noriega, Carlos Pérez-Monter, Gabriela Alemán, Rogelio Hernández-Pando, Ricardo Correa-Rotter, Victoria Ramírez, Armando R. Tovar, Iván Torre-Villalvazo, Claudia Tovar-Palacio

“…Tunicamycin-administered mice developed hyperinsulinemia, augmented lipolysis and increased circulating leptin and adiponectin. Renal unfolded protein response (UPR) gene expression markers, the lipogenic transcription factor SREBP1 and the phosphorylation of eIF2α increased 8 h after tunicamycin administration. …”
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Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR) by Gehan Botrus, Richard M. Miller, Pedro Luiz Serrano Uson Junior, Geoffrey Kannan, Haiyong Han, Daniel D. Von Hoff

Subjects: “…unfolded protein response (UPR)…”
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Endoplasmic Reticulum Stress Induces Vasodilation in Liver Vessels That Is Not Mediated by Unfolded Protein Response by Sergejs Zavadskis, Anna Shiganyan, Andrea Müllebner, Johannes Oesterreicher, Wolfgang Holnthoner, Johanna Catharina Duvigneau, Andrey V. Kozlov

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Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA. by Antony Prabhu, Bhaswati Sarcar, Soumen Kahali, Yuan Shan, Prakash Chinnaiyan

“…Rapidly growing tumors require efficient means to allow them to adapt to fluctuating microenvironments consisting of hypoxia, nutrient deprivation, and acidosis. The unfolded protein response (UPR) represents a defense mechanism allowing cells to respond to these adverse conditions. …”
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Unfolded protein response in gastric glandulocytes of rats with the pharmacological correction of type 2 diabetes by Y.G. Klys, T.R. Kerimov, S.I. Savosko, Y.S. Osadchuk, S.M. Smirnov, L.V. Natrus

“…The cellular and molecular mechanisms underlying gastrointestinal complications caused by type 2 diabetes mellitus (T2DM) may involve accumulation of misfolded proteins in the endoplasmic reticulum that disrupts protein homeostasis and activates a signaling pathway termed the unfolded protein response (UPR). The goal of the present study was to assess the state of the UPR system in gastric glandulocytes of untreated and metformin- and propionate-treated T2DM rats. …”
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A novel prognostic signature in osteosarcoma characterised from the perspective of unfolded protein response by Chengcheng Shi, Faming Zhao, Tingting Zhang, Denghui Xu, Zhuangyu Hao, Fengzhen Cui, Ji‐Hua Shi, Yang Jin, Ningning Li, Caihong Yang, Yi Zhang, Xia Sheng

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Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells by Paulina Sokołowska, Małgorzata Siatkowska, Marta Jóźwiak-Bębenista, Piotr Komorowski, Marta Koptas, Edward Kowalczyk, Anna Wiktorowska-Owczarek

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FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway by Yaqi Zhang, Yinu Wang, Guangyuan Zhao, Edward J. Tanner, Mazhar Adli, Daniela Matei

“…Our mechanistic studies highlight that FOXK2 directly regulated IRE1α (encoded by ERN1) expression, a key sensor for the unfolded protein response (UPR). Chromatin immunoprecipitation and sequencing revealed that FOXK2 bound to an intronic regulatory element of ERN1. …”
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Exercise Improves the Coordination of the Mitochondrial Unfolded Protein Response and Mitophagy in Aging Skeletal Muscle by Yan Wang, Jialin Li, Ziyi Zhang, Runzi Wang, Hai Bo, Yong Zhang

“…The mitochondrial unfolded protein response (UPRmt) and mitophagy are two mitochondrial quality control (MQC) systems that work at the molecular and organelle levels, respectively, to maintain mitochondrial homeostasis. …”
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Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE−/− Mice by Yuxiang Zhou, Xueping Wan, Kerstin Seidel, Mo Zhang, Jena B. Goodman, Francesca Seta, Naomi Hamburg, Jingyan Han

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The Unfolded Protein Response and Membrane Contact Sites: Tethering as a Matter of Life and Death? by Alexander R. van Vliet, Maria Livia Sassano, Patrizia Agostinis

“…When ER homeostasis is lost, a condition that triggers the activation of an evolutionarily conserved pathway called the unfolded protein response (UPR), the ER undergoes rapid remodeling. …”
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Cold Atmospheric Plasma Triggers Apoptosis via the Unfolded Protein Response in Melanoma Cells by Tom Zimmermann, Sebastian Staebler, R. Verena Taudte, Sumeyya Ünüvar, Sabine Grösch, Stephanie Arndt, Sigrid Karrer, Martin F. Fromm, Anja-Katrin Bosserhoff

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The Unfolded Protein Response: A Key Player in Zika Virus-Associated Congenital Microcephaly by Christian Alfano, Ivan Gladwyn-Ng, Thérèse Couderc, Thérèse Couderc, Marc Lecuit, Marc Lecuit, Marc Lecuit, Laurent Nguyen

Subjects: “…unfolded protein response…”
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PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts by Giuseppina Amodio, Ornella Moltedo, Dominga Fasano, Lucrezia Zerillo, Marco Oliveti, Paola Di Pietro, Raffaella Faraonio, Paolo Barone, Maria Teresa Pellecchia, Anna De Rosa, Giuseppe De Michele, Elena Polishchuk, Roman Polishchuk, Vincenzo Bonifati, Lucio Nitsch, Giovanna Maria Pierantoni, Maurizio Renna, Chiara Criscuolo, Simona Paladino, Paolo Remondelli

“…Interestingly, this stressful state is coupled to the activation of the PERK/eIF2α/ATF4/CHOP pathway of the Unfolded Protein Response (UPR). In addition, PARK20 fibroblasts reveal upregulation of oxidative stress markers and total ROS production with concomitant alteration of the morphology of the mitochondrial network. …”
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The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans by Caroline Beaudoin-Chabot, Lei Wang, Cenk Celik, Aishah Tul-Firdaus Abdul Khalid, Subhash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus Wen Xuan Lim, Ann Don Low, Guillaume Thibault

“…Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young animals…”
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ER Stress and the Unfolded Protein Response: Homeostatic Regulation Coordinate Plant Survival and Growth by June-Sik Kim, Keiichi Mochida, Kazuo Shinozaki

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Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases by Hyon-Seung Yi

“…The signaling network of the mitochondrial unfolded protein response (UPRmt) and mitohormesis is a retrograde signaling pathway through which mitochondria-to-nucleus communication occurs in organisms. …”
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The Unfolded Protein Response Sensor PERK Mediates Stiffness-Dependent Adaptation in Glioblastoma Cells by Mohammad Khoonkari, Dong Liang, Marina Trombetta Lima, Tjitze van der Land, Yuanke Liang, Jianwu Sun, Amalia Dolga, Marleen Kamperman, Patrick van Rijn, Frank A. E. Kruyt

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Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish by Lucie Crouzier, Morgane Denus, Elodie M. Richard, Amarande Tavernier, Camille Diez, Nicolas Cubedo, Tangui Maurice, Benjamin Delprat

“…Using qPCR to analyze the unfolded protein response genes, we observed that loss of S1R led to decreased levels of IRE1 and PERK-related effectors and increased over-expression of most of the effectors after a tunicamycin challenge. …”
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XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans by Antonopoulos, Aristotelis, Haslam, Stuart M., Dell, Anne, Dewal, Mahender, DiChiara, Andrew Stephen, Taylor, Rebecca J., Harmon, Chyleigh J., Shoulders, Matthew D.

“…Elucidating cellular mechanisms that modulate the N-linked glycome is, therefore, crucial. The unfolded protein response (UPR) is classically responsible for maintaining proteostasis in the secretory pathway by defining levels of chaperones and quality control proteins. …”
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