The Unfolded Protein Response: Neutron-Induced Therapy Autophagy as a Promising Treatment Option for Osteosarcoma by Ju Yeon Oh, Yeon-Joo Lee, Sei Sai, Tatsuya Ohno, Chang-Bae Kong, Sun Ha Lim, Eun Ho Kim

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Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress by Zhe Zhang, Lu Zhang, Li Zhou, Yunlong Lei, Yuanyuan Zhang, Canhua Huang

“…Deregulation in ER homeostasis, usually called ER stress, can provoke unfolded protein response (UPR) pathways with an aim to initially restore homeostasis by activating genes involved in protein folding and antioxidative machinery. …”
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Trends in mitochondrial unfolded protein response research from 2004 to 2022: A bibliometric analysis by Zelin Ye, Ruoning Chai, Yujie Luan, Yihang Du, Wenjing Xue, Shuqing Shi, Huaqin Wu, Yi Wei, Limei Zhang, Yuanhui Hu

Subjects: “…mitochondrial unfolded protein response…”
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The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration by Guangyan Xiong, Sajedah M Hindi, Aman K Mann, Yann S Gallot, Kyle R Bohnert, Douglas R Cavener, Scott R Whittemore, Ashok Kumar

“…Accumulation of misfolded proteins triggers endoplasmic reticulum stress that leads to unfolded protein response (UPR). The UPR is relayed to the cell through the activation of PERK, IRE1/XBP1, and ATF6. …”
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Evaluating the effects of dengue virus and iminosugar treatment on cellular unfolded protein response and redox homeostasis by Perera, N

“…This thesis focuses on two such host responses implicated in DENV pathogenesis; unfolded protein response (UPR) and oxidative stress. DENV preferentially activated the proviral and pro-inflammatory IRE1-XBP1 arm of the UPR in monocyte-derived macrophages in vitro. …”

Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells by Amoroso, F, Glass, K, Singh, R, Liberal, F, Steele, RE, Maguire, S, Tarapore, R, Allen, JE, Van Schaeybroeck, S, Butterworth, KT, Prise, K, O'Sullivan, JM, Jain, S, Waugh, DJ, Mills, IG

“…Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can lead to cell death. …”

Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication by Antoniou, A, Lenart, I, Kriston-Vizi, J, Iwawaki, T, Turmaine, M, McHugh, K, Ali, S, Blake, N, Bowness, P, Bajaj-Elliott, M, Gould, K, Nesbeth, D, Powis, S

“…OBJECTIVE:Salmonella enterica infections can lead to Reactive Arthritis (ReA), which can exhibit an association with human leucocyte antigen (HLA)-B*27:05, a molecule prone to misfolding and initiation of the unfolded protein response (UPR). This study examined how HLA-B*27:05 expression and the UPR affect the Salmonella life-cycle within epithelial cells. …”

Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review by Bolland, H, Ma, T, Ramlee, S, Ramadan, K, Hammond, E

Pathogen-induced inflammation is attenuated by the iminosugar MON-DNJ via modulation of the unfolded protein response by Sayce, AC, Martinez, FO, Tyrrell, BE, Perera, N, Hill, ML, Dwek, RA, Miller, JL, Zitzmann, N

“…Transcriptome analysis reveals the key interaction of pathogen-induced endoplasmic reticulum stress, the resulting unfolded protein response, and inflammation. Our work shows that iminosugars modulate these interactions. …”

Silence without stress by David J Young, Nicholas R Guydosh

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The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA by Rachael Di Santo, Soufiane Aboulhouda, David E Weinberg

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Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway by Anna Shishova, Ilya Dyugay, Ksenia Fominykh, Victoria Baryshnikova, Alena Dereventsova, Yuriy Turchenko, Anna A. Slavokhotova, Yury Ivin, Sergey E. Dmitriev, Anatoly Gmyl

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The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism by Manon Jaud, Céline Philippe, Loic Van Den Berghe, Christèle Ségura, Laurent Mazzolini, Stéphane Pyronnet, Henrik Laurell, Christian Touriol

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Gastrointestinal Cancer Therapeutics via Triggering Unfolded Protein Response and Endoplasmic Reticulum Stress by 2-Arylbenzofuran by Kui Zhang, Xin Hu, Jingjing Su, Dong Li, Abhimanyu Thakur, Vikramsingh Gujar, Hongjuan Cui

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The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1 by Diego Acosta-Alvear, G Elif Karagöz, Florian Fröhlich, Han Li, Tobias C Walther, Peter Walter

Subjects: “…unfolded protein response…”
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KSHV Activates Unfolded Protein Response Sensors but Suppresses Downstream Transcriptional Responses to Support Lytic Replication by Benjamin P. Johnston, Eric S. Pringle, Craig McCormick

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Mitochondrial Unfolded Protein Response Gene <i>Clpp</i> Is Required for Oocyte Function and Female Fertility by Yagmur Ergun, Aysegul Gizem Imamoglu, Mauro Cozzolino, Cem Demirkiran, Murat Basar, Akanksha Garg, Raziye Melike Yildirim, Emre Seli

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A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response by Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P. Hanger

“…Moreover, Tau35 activates ribosomal protein S6 kinase beta-1 signaling and the unfolded protein response, leading to insulin resistance in cells. …”
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Increased cellular protein modification by methylglyoxal activates endoplasmic reticulum-based sensors of the unfolded protein response by Mingzhan Xue, Zehra Irshad, Naila Rabbani, Paul J. Thornalley

Subjects: “…Unfolded protein response…”
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The unfolded protein response components IRE1α and XBP1 promote human coronavirus infection by Jessica M. Oda, Andreas B. den Hartigh, Shoen M. Jackson, Ana R. Tronco, Susan L. Fink

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