Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway by Ryosuke Isotani, Masaki Igarashi, Masaomi Miura, Kyoko Naruse, Satoshi Kuranami, Manami Katoh, Seitaro Nomura, Toshimasa Yamauchi

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Retrograde transgastric jejunostomy for nutritional management and aspiration prevention in cases with severe malignant esophageal strictures by Takeshi Yamashita, Koji Otsuka, Satoru Goto, Tomotake Ariyoshi, Kentaro Motegi, Masahiro Kohmoto, Akira Saito, Yoshihito Sato, Yutaka Kishimoto, Masahiko Murakami

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Marked Cognitive and Activities of Daily Living Improvement by Shunt Embolization in a Very Old Man with Portosystemic Encephalopathy Mimicking Alzheimer Disease: A Case Report by Soichiro Kondo, Kazufumi Takada, Taro Kojima, Kosuke Tanaka, Mitsutaka Yakabe, Eisuke Shibata, Yumi Umeda-Kamayama, Hidemasa Takao, Sumito Ogawa, Masahiro Akishita

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Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers by Denise Zujur, Kosuke Kanke, Shoko Onodera, Shoichiro Tani, Jenny Lai, Toshifumi Azuma, Xiaonan Xin, Alexander C. Lichtler, David W. Rowe, Taku Saito, Sakae Tanaka, Hideki Masaki, Hiromitsu Nakauchi, Ung-il Chung, Hironori Hojo, Shinsuke Ohba

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Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals by Toshihiko Komai, Mariko Inoue, Tomohisa Okamura, Tomohisa Okamura, Tomohisa Okamura, Kaoru Morita, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Kazuhiko Yamamoto, Kazuhiko Yamamoto, Keishi Fujio

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Comparison between microendoscopic laminectomy and open posterior decompression surgery for two-level lumbar spinal stenosis: a multicenter retrospective cohort study by Hideki Nakamoto, Junya Miyahara, Hiroyuki Nakarai, So Kato, Yuki Taniguchi, Naohiro Kawamura, Akiro Higashikawa, Yujiro Takeshita, Masayoshi Fukushima, Takashi Ono, Nobuhiro Hara, Hiroki Iwai, Sakae Tanaka, Yasushi Oshima

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Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone by Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito

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Surgical and biochemical outcomes of phosphaturic mesenchymal tumors causing tumor-induced osteomalacia in the head and neck region by Yusuke Tsuda, Yoichi Yasunaga, Masanobu Abe, Kazuto Hoshi, Nobuaki Ito, Kenji Kondo, Koichi Okajima, Liuzhe Zhang, Hajime Kato, Naoko Hidaka, Sakae Tanaka, Hiroshi Kobayashi

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Three-dimensional changes of noses after transplantation of implant-type tissue-engineered cartilage for secondary correction of cleft lip–nose patients by Kazuto Hoshi, Yuko Fujihara, Hideto Saijo, Kumiko Kurabayashi, Hideyuki Suenaga, Yukiyo Asawa, Satoru Nishizawa, Sanshiro Kanazawa, Sakura Uto, Ryoko Inaki, Mariko Matsuyama, Tomoaki Sakamoto, Makoto Watanabe, Madoka Sugiyama, Kazumichi Yonenaga, Atsuhiko Hikita, Tsuyoshi Takato

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Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis by Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki

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Comparison of phylogenetic and virulence factors between Escherichia coli isolated from biliary tract infections and uropathogenic Escherichia coli by Mahoko Ikeda, Tatsuya Kobayashi, Shu Okugawa, Fumie Fujimoto, Yuta Okada, Keita Tatsuno, Yoshimi Higurashi, Takeya Tsutsumi, Kyoji Moriya

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Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review by Masanobu Abe, Kousuke Watanabe, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Takahiro Abe, Yuko Fujihara, Yosuke Amano, Liang Zong, Cheng-Ping Wang, Emi Kubo, Ryoko Inaki, Naoya Kinoshita, Satoshi Yamashita, Daiya Takai, Toshikazu Ushijima, Takahide Nagase, Kazuto Hoshi

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Evaluation of image-enhanced endoscopic technology using advanced diagnostic endoscopy for the detection of early gastric cancer: a pilot study by Daisuke Yamaguchi, Shinya Kodashima, Mitsuhiro Fujishiro, Satoshi Ono, Keiko Niimi, Satoshi Mochizuki, Yosuke Tsuji, Itsuko Asada-Hirayama, Yoshiki Sakaguchi, Satoki Shichijo, Chihiro Minatsuki, Nobutake Yamamichi, Kazuhiko Koike

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The Role of Stereotactic Frame-Based Biopsy for Brainstem Tumors in the Era of Molecular-Based Diagnosis and Treatment Decisions by Yudai Hirano, Yuki Shinya, Toshiya Aono, Hirotaka Hasegawa, Mariko Kawashima, Masahiro Shin, Hirokazu Takami, Shunsaku Takayanagi, Motoyuki Umekawa, Masako Ikemura, Tetsuo Ushiku, Kazuki Taoka, Shota Tanaka, Nobuhito Saito

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Impact of the COVID-19 pandemic on surgical volume and outcomes in spine surgery: a multicentre retrospective study in Tokyo by Sakae Tanaka, Yuki Taniguchi, Takashi Ono, Yoshitaka Matsubayashi, So Kato, Yasushi Oshima, Nozomu Ohtomo, Naohiro Kawamura, Akiro Higashikawa, Nobuhiro Hara, Yujiro Takeshita, Masayoshi Fukushima, Seiichi Azuma

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The impact of COVID-19 on the diagnosis and treatment of HCC: analysis of a nationwide registry for advanced liver diseases (REAL) by Kazuya Okushin, Ryosuke Tateishi, Shinya Hirakawa, Hisateru Tachimori, Koji Uchino, Ryo Nakagomi, Tomoharu Yamada, Takuma Nakatsuka, Tatsuya Minami, Masaya Sato, Mitsuhiro Fujishiro, Kiyoshi Hasegawa, Yuichiro Eguchi, Tatsuya Kanto, Hitoshi Yoshiji, Namiki Izumi, Masatoshi Kudo, Kazuhiko Koike

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Cardiovascular events after the initiation of immune checkpoint inhibitors by Yuta Suzuki, Hidehiro Kaneko, Yuichi Tamura, Akira Okada, Katsuhito Fujiu, Nobuaki Michihata, Norifumi Takeda, Taisuke Jo, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro

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Human-mimetic binaural ear design and sound source direction estimation for task realization of musculoskeletal humanoids by Yusuke Omura, Kento Kawaharazuka, Yuya Nagamatsu, Yuya Koga, Manabu Nishiura, Yasunori Toshimitsu, Yuki Asano, Kei Okada, Koji Kawasaki, Masayuki Inaba

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HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation by Naohiro Kuwayama, Tomoya Kujirai, Yusuke Kishi, Rina Hirano, Kenta Echigoya, Lingyan Fang, Sugiko Watanabe, Mitsuyoshi Nakao, Yutaka Suzuki, Kei-ichiro Ishiguro, Hitoshi Kurumizaka, Yukiko Gotoh

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Corticosteroid‐triggered acute skeletal muscle loss in lipodystrophy: A case report by Takayoshi Sasako, Ken Suzuki, Sara Odawara, Hirotsugu Suwanai, Naoko Akuta, Naoto Kubota, Kohjiro Ueki, Takashi Kadowaki, Toshimasa Yamauchi

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