Genetic diversity and drug resistance among newly diagnosed and antiretroviral treatment-naive HIV-infected individuals in western Yunnan: a hot area of viral recombination in Chin... by Chen Min, Ma Yanling, Duan Song, Xing Hui, Yao Shitang, Su Yingzhen, Luo Hongbing, Yang Li, Chen Huichao, Fu Liru, Qu Aijuan, Ou Chin-Yih, Jia Manhong, Lu Lin

“…</p> <p>Results</p> <p>Among 299 <it>pol</it> sequences successfully genotyped (93.4%), subtype C accounted for 43.1% (n=129), unique recombinant forms (URFs) for 18.4% (n=55), CRF01_AE for 17.7% (n=54), B for 10.7% (n=32), CRF08_BC for 8.4% (n=25) and CRF07_BC for 1.7% (n=5). …”
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Increased Frequency of Inter-Subtype HIV-1 Recombinants Identified by Near Full-Length Virus Sequencing in Rwandan Acute Transmission Cohorts by Gisele Umviligihozo, Erick Muok, Emmanuel Nyirimihigo Gisa, Rui Xu, Dario Dilernia, Kimberley Herard, Heeyah Song, Qianhong Qin, Jean Bizimana, Paul Farmer, Jonathan Hare, Jill Gilmour, Susan Allen, Etienne Karita, Eric Hunter, Eric Hunter, Ling Yue

“…These results demonstrate the ongoing evolution and increased prevalence of recombinant and drug resistant transmitted viruses in Rwanda and highlight the importance of defining NFLG sequences to fully understand the nature of TF viruses and in particular the prevalence of unique recombinant forms (URFs) in transmission cohorts.…”
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Prevalence of resistance mutations associated with integrase inhibitors in therapy-naive HIV-positive patients in Baoding, Hebei province, China by Weiguang Fan, Xiaodong Wang, Yuchen Zhang, Juan Meng, Miaomiao Su, Xuegang Yang, Haoxi Shi, Penghui Shi, Xinli Lu

“…We identified ten genotypes, and the predominant genotype was CRF01_AE in 67 patients (51.15%), CRF07_ BC in 39 patients (29.77%), subtype B in 11 patients (8.40%), and other subtypes (CRF68_01B, 3.82%; CRF55_01B, 1.53%, CRF80_0107, 1.53%; URFs 1.53%; and CRF103_01B, CRF59_01B, and CRF65_cpx, 1.4% each). …”
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Diversity of HIV-1 genotypes and high prevalence of pretreatment drug resistance in newly diagnosed HIV-infected patients in Shanghai, China by Zhenyan Wang, Min Zhang, Renfang Zhang, Li Liu, Yinzhong Shen, Jiangrong Wang, Hongzhou Lu

“…In addition, 5% (16/317) HIV-1 strains were identified as other subtypes or CRFs/URFs (unique recombinant forms). The overall prevalence of PDR was 17.4% (55/317). …”
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Genetic characterization of HIV-1 epidemic in Anhui Province, China by Dong Zhang, Jianjun Wu, Yu Zhang, Yuelan Shen, Sheying Dai, Xiaolin Wang, Hui Xing, Jin Lin, Jingwan Han, Jingyun Li, Yizu Qin, Yongjian Liu, Lifeng Miao, Bin Su, Hanping Li, Lin Li

“…Many subtypes were identified, including CRF01_AE (226, 46.50%), CRF07_BC (151, 31.07%), subtype B (28, 5.76%), CRF08_BC (20, 4.12%), CRF55_01B (15, 3.09%), CRF68_01B (7, 1.44%), CRF67_01B (3, 0.62%), CRF57_BC (2, 0.41%), CRF59_01B (2, 0.41%), CRF79_0107 (2, 0.41%), subtype C (2, 0.41%), CRF64_BC (1, 0.21%), and circulating recombinant forms (URFs) (27, 5.55%). Four transmission subnetworks containing high transmission risk individuals (with degree ≥4) were identified based on CRF01_AE and CRF07_BC sequences, including two CRF01_AE transmission subnetworks constituted by elderly people with average ages of 67.9 and 61.5 years. …”
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Identification of a HIV-1 circulating BF1 recombinant form (CRF75_BF1) of Brazilian origin that also circulates in Southwestern Europe by Joan Bacqué, Elena Delgado, Horacio Gil, Sofía Ibarra, Sonia Benito, Isabel García-Arata, María Moreno-Lorenzo, Ester Sáez de Adana, Ester Sáez de Adana, Carmen Gómez-González, Carmen Gómez-González, Mónica Sánchez, Vanessa Montero, Michael M. Thomson

“…IntroductionThe high recombinogenic potential of HIV-1 has resulted in the generation of countless unique recombinant forms (URFs) and around 120 reported circulating recombinant forms (CRFs). …”
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Characterization of HIV-1 molecular epidemiology and transmitted drug-resistance in newly diagnosed HIV-infected patients in Sichuan, China by Chang Zhou, Shu Liang, Yiping Li, Yan Zhang, Ling Li, Li Ye, Dan Yuan, Ling Su

“…HIV-1 epidemic strains in Sichuan province: the majority of genotypes were circulating recombinant form (CRF) 07_BC (675, 52.04%), CRF01_AE (343, 26.45%), CRF08_BC (115, 8.87%), CRF85_BC (67, 5.17%), subtype B (33, 2.54%), the other genotypes only accounted for 4.93%, and unique recombinant forms (URFs) (23, 1.77%) were observed in the study, and the difference of age, ethnicity, education, occupation, region and transmission pathway of different genotypes were statistically significant. …”
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