Host Cell Receptors Implicated in the Cellular Tropism of BVDV by Shuhui Qi, Lijing Wo, Chao Sun, Juan Zhang, Quanhai Pang, Xin Yin

“…Thus, discovery of the cellular receptors involved in the entry of BVDV and other pestiviruses is significant for development of the novel intervention. The viral envelope glycoprotein E^rns and E2 are crucial determinants of the cellular tropism of BVDV. …”
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Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins. by Torben Schiffner, Jesper Pallesen, Rebecca A Russell, Jonathan Dodd, Natalia de Val, Celia C LaBranche, David Montefiori, Georgia D Tomaras, Xiaoying Shen, Scarlett L Harris, Amin E Moghaddam, Oleksandr Kalyuzhniy, Rogier W Sanders, Laura E McCoy, John P Moore, Andrew B Ward, Quentin J Sattentau

“…Inducing broad spectrum neutralizing antibodies against challenging pathogens such as HIV-1 is a major vaccine design goal, but may be hindered by conformational instability within viral envelope glycoproteins (Env). Chemical cross-linking is widely used for vaccine antigen stabilization, but how this process affects structure, antigenicity and immunogenicity is poorly understood and its use remains entirely empirical. …”
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Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus by Ruijun Zhang, David R. Martinez, Quang N. Nguyen, Justin Pollara, Trina Arifin, Christina Stolarchuk, Andrew Foulger, Josh D. Amos, Robert Parks, Jonathon E. Himes, Minyue Wang, Regina W. Edwards, Ashley M. Trama, Nathan Vandergrift, Lisa Colvin, Ken Dewar, Nikoleta Juretic, Jessica Wasserscheid, Guido Ferrari, Hua-Xin Liao, Sallie R. Permar

“…Here, Zhang et al. catalogue the immunoglobulin loci present in the genome of these animals, and experimentally study their B-cell response to the viral envelope protein.…”
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VP28 interacts with PmRab7 irrespective of its nucleotide state by Patcha Sudsat, Jiraporn Srisala, Danaya Pakotiprapha, Satita Tapaneeyakorn, Kallaya Sritunyalucksana, Siripong Thitamadee, Sitthivut Charoensutthivarakul, Ornchuma Itsathitphaisarn

“…Previous research highlighted the crucial role of the Penaeus monodon Rab7 (PmRab7) protein in WSSV entry, specifically its interaction with the viral envelope protein VP28. PmRab7 exists in two conformations: GDP-bound (inactive) and GTP-bound (active). …”
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An <i>Abies</i> Extract Containing Nonvolatile Polyphenols Shows Virucidal Activity against SARS-CoV-2 That Is Enhanced in Increased pH Conditions by Imane Maaroufi, Dulamjav Jamsransuren, Koh Hashida, Sachiko Matsuda, Haruko Ogawa, Yohei Takeda

“…Western blotting, RT-PCR, and electron microscopic analysis revealed that neutral ASE2 interacts with SARS-CoV-2 spike proteins and moderately disrupts the SARS-CoV-2 genome and viral envelope. These findings reveal the virucidal potential of ASE2.…”
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Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region. by Louis R Hollingsworth, Anne M Brown, Richard D Gandour, David R Bevan

“…One approach is designed to inhibit entry of HIV into host cells, with a target being the viral envelope glycoprotein, gp120. Polyanionic compounds have been shown to be effective in inhibiting HIV entry, with a mechanism involving electrostatic interactions with the V3 loop of gp120 being proposed. …”
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Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome by Jordan T. VanderBurgt, Jordan T. VanderBurgt, Ondre Harper, Ondre Harper, Christopher P. Garnham, Christopher P. Garnham, Susanne E. Kohalmi, Rima Menassa, Rima Menassa

“…Co-expression of the two most abundant proteins in the viral envelope, the matrix protein (M) and glycosylated protein 5 (GP5), can produce a neutralizing immune response for the virus providing a potentially effective subunit vaccine against the disease, but these proteins are difficult to express. …”
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The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes. by Maciej T Nogalski, Gary C T Chan, Emily V Stevenson, Donna K Collins-McMillen, Andrew D Yurochko

“…Furthermore, we demonstrate that the presence of the gH/gL/UL128-131 complex on the viral envelope, through its activation of the integrin/Src/paxillin pathway, is necessary for efficient HCMV internalization into monocytes and that appropriate actin and dynamin regulation is critical for this entry process. …”
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Pseudorabies Virus Glycoproteins E and B Application in Vaccine and Diagnosis Kit Development by Sara Amanuel Bude, Zengjun Lu, Zhixun Zhao, Qiang Zhang

“…<b>Background</b>: Pseudorabies virus (PRV) is a highly infectious pathogen that affects a wide range of mammals and imposes a significant economic burden on the global pig industry. The viral envelope of PRV contains several glycoproteins, including glycoprotein E (gE) and glycoprotein B (gB), which play critical roles in immune recognition, vaccine development, and diagnostic procedures. …”
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Human Immunodeficiency Virus and Heparan Sulfate: from attachment to entry inhibition by Bridgette Janine Connell, Hugues eLortat-Jacob

“…Infection starts when gp120, the viral envelope glycoprotein, binds to CD4 and to a chemokine receptor usually CCR5 or CXCR4. …”
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Structure of infective Getah virus at 2.8 Å resolution determined by cryo-electron microscopy by Aojie Wang, Feng Zhou, Congcong Liu, Dongsheng Gao, Ruxi Qi, Yiheng Yin, Sheng Liu, Yuanzhu Gao, Lutang Fu, Yinhe Xia, Yawei Xu, Chuanqing Wang, Zheng Liu

“…The cholesterol and phospholipid stabilize the hydrophobic pocket in the viral envelope membrane. The structural information will assist structure-based antiviral and vaccine screening, design, and optimization.…”
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Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia by Julie R Beegle, Nataly Lessa Magner, Stefanos Kalomoiris, Aja Harding, Ping Zhou, Catherine Nacey, Jeannine Logan White, Karen Pepper, William Gruenloh, Geralyn Annett, Jan A Nolta, Fernando A Fierro

“…Additional safety studies completed include absence of replication competent lentivirus, sterility tests, and absence of VSV-G viral envelope coding plasmid. These preclinical studies are directed toward a planned phase 1 clinical trial to treat critical limb ischemia.…”
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Structure and dynamics of membrane proteins from solid-state NMR by Lee, Myungwoon

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Solid-state NMR investigation of viral fusion glycoprotein 41 (gp41) by Morgan, Chloe A.(Chloe Anne)

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Imaging of HIV-1 envelope-induced virological synapse and signaling on synthetic lipid bilayers. by Prins, K, Vasiliver-Shamis, G, Cammer, M, Depoil, D, Dustin, M, Hioe, C

“…We take advantage of the glass-supported planar bi-layer system as a reductionist model to represent the surface of HIV-infected cells bearing the viral envelope gp120 and the cellular adhesion molecule ICAM-1. …”

The Role of Orthobunyavirus Glycoprotein Gc in the Viral Life Cycle: From Viral Entry to Egress by Han Gao, Dengshuai Zhao, Canyuan Li, Menghua Deng, Gan Li, Shengfeng Chen, Mengmeng Zhao, Limei Qin, Keshan Zhang

“…The highly glycosylated Gc protein, which has a complex conformation and forms polymers embedded in the viral envelope, plays a critical role in inducing neutralizing antibodies throughout the orthobunyavirus infection cycle from entry to egress. …”
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A Novel High-Mannose Specific Lectin from the Green Alga Halimeda renschii Exhibits a Potent Anti-Influenza Virus Activity through High-Affinity Binding to the Viral Hemagglutinin by Jinmin Mu, Makoto Hirayama, Yuichiro Sato, Kinjiro Morimoto, Kanji Hori

“…HRL40 potently inhibited the infection of influenza virus (A/H3N2/Udorn/72) into NCI-H292 cells with half-maximal effective dose (ED50) of 2.45 nM through high-affinity binding to a viral envelope hemagglutinin (KD, 3.69 × 10−11 M). HRL40 consisted of two isolectins (HRL40-1 and HRL40-2), which could be separated by reverse-phase HPLC. …”
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NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway by Shuzhi Cui, Tian Xia, Jianjin Zhao, Xiaoyu Ren, Tingtao Wu, Mireille Kameni, Xiaoju Guo, Li He, Jingao Guo, Aléria Duperray-Susini, Florence Levillayer, Jean-Marc Collard, Jin Zhong, Lifeng Pan, Frédéric Tangy, Pierre-Olivier Vidalain, Dongming Zhou, Yaming Jiu, Mathias Faure, Yu Wei

“…NDP52 forms complex with Rab9 and viral envelope proteins and links HBV to Rab9-dependent lysosomal degradation pathway. …”
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The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses by Mônika A. Coronado, Ian Gering, Marc Sevenich, Danilo S. Olivier, Mohammadamin Mastalipour, Marcos S. Amaral, Dieter Willbold, Raphael J. Eberle

“…The interaction of EGCG with the viral envelope protein and viral protease, mainly identified by computational studies, describes the interaction of these molecules with viral proteins; however, how the viral NS2B/NS3 protease interacts with epigallocatechin molecules is not yet fully deciphered. …”
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Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing by Hana Veler, Cheng Man Lun, Abdul A. Waheed, Eric O. Freed

“…These results provide novel insights into the broad antagonism of viral glycoprotein function by the cellular host innate immune response.IMPORTANCEThe surface of enveloped viruses contains viral envelope glycoproteins, an important structural component facilitating virus attachment and entry while also acting as targets for the host adaptive immune system. …”
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