Substitution of gp120 C4 region compensates for V3 loss-of-fitness mutations in HIV-1 CRF01_AE co-receptor switching by Yueyang Yu, Yi Feng, Zehua Zhou, Kang Li, Xiaoyan Hu, Lingjie Liao, Hui Xing, Yimig Shao

“…HIV-1 infection is mediated by a viral envelope subsequently binding to CD4 receptor and two main coreceptors, CCR5 (R5) for primary infection and CXCR4 (X4) in chronic infection. …”
Get full text

Are mild cleansers appropriate for hand hygiene in the COVID era? An in vitro investigation of the antiviral efficacy of different hand hygiene products by Natalie Winder, Zahra Ashraf, Sara Gohar, Nada Baalbaki, Micheal Cork, Simon Danby, Munitta Muthana

“…Therefore, new hand hygiene regimens should be implemented based on trying to encompass all viruses with varying structures, with specific emphasis on the absence of a viral envelope.…”
Get full text

The Molecular Tweezer CLR01 Inhibits Antibody-Resistant Cell-to-Cell Spread of Human Cytomegalovirus by Sina Brenner, Berenike Braun, Clarissa Read, Tatjana Weil, Paul Walther, Thomas Schrader, Jan Münch, Jens von Einem

“…Electron microscopy of extracellular virus particles indicated damage of the viral envelope by CLR01, which likely impairs the infectivity of virus particles. …”
Get full text

Measles Fusion Machinery Is Dysregulated in Neuropathogenic Variants by Eric M. Jurgens, Cyrille Mathieu, Laura M. Palermo, Diana Hardie, Branka Horvat, Anne Moscona, Matteo Porotto

“…ABSTRACT Paramyxoviruses, including the human pathogen measles virus (MV), enter host cells by fusing their viral envelope with the target cell membrane. This fusion process is driven by the concerted actions of the two viral envelope glycoproteins, the receptor binding protein (hemagglutinin [H]) and the fusion (F) protein. …”
Get full text

Immunogen design to focus the B-cell repertoire. by Sattentau, Q

“…Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens. SUMMARY: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.…”

Targeting Cell Entry of Enveloped Viruses as an Antiviral Strategy by Elodie Teissier, François Penin, Eve-Isabelle Pécheur

“…Entry inhibitors act by targeting viral and/or cellular components, through either the inhibition of protein-protein interactions within the viral envelope proteins or between viral proteins and host cell receptors, or through the inhibition of protein-lipid interactions. …”
Get full text

y Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion-associated lipid rafts by Yamanishi Koichi, Huang Honglan, Tang Huamin, Kawabata Akiko, Mori Yasuko

“…In addition, the ganglioside GM1, which is known to partition preferentially into lipid rafts, was detected in purified virions, along with viral envelope glycoproteins, gH, gL, gB, gQ1, gQ2 and gO indicating that at least one raft component was included in the viral particle during the assembly process.…”
Get full text

HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition by Sabrina E. M. Almeida, Leonardo Augusto Luvison Araújo

“…Entry of HIV-1 into a host cell is a multi-step process, with the viral envelope gp120 and gp41 acting sequentially to mediate the viral attachment, CD4 binding, coreceptor binding, and fusion of the viral and host membranes. …”
Get full text

Taking cues from convalescence to improve vaccines against hepatitis C virus by Bharath K. Sreekumar, Taha Y. Taha, Melanie Ott

“…Using pseudotyped viruses, well-characterized monoclonal antibodies, and complex modeling, the authors show that multiple exposures to antigenically related, antibody-sensitive viral envelope proteins induced potent bNAbs. This work provides valuable insight into the best strategies for developing HCV vaccines in the future that may successfully reproduce the immunity induced during natural exposures.…”
Get full text

Complete genome of a dengue virus serotype 4 strain from Amazonas, Brazil by Valdinete Alves do Nascimento, Victor Costa de Souza, Felipe Gomes Naveca

“…The use of a massive sequencing technology allowed the detection of two variable sites, one in the coding region for the viral envelope protein and the other in the nonstructural 1 coding region within viral populations.…”
Get full text

Folding and Oligomerization of the gp2b/gp3/gp4 Spike Proteins of Equine Arteritis Virus in Vitro by Aleksander Kabatek, Michael Veit

“…The glycoproteins gp2b, gp3 and gp4 form a heterotrimer in the viral envelope, which is required for cell entry of EAV. …”
Get full text

Molecular studies of the replication mechanisms of coronavirus by Wang, Jibin

“…The M protein is integrated into the viral envelope with three transmembrane domains flanked by a short amino-terminal ectodomain and a large carboxy-terminal endodomain. …”
Get full text

Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation by Agnes Musiol, Sandra Gran, Christina Ehrhardt, Stephan Ludwig, Thomas Grewal, Volker Gerke, Ursula Rescher

“…Cholesterol sequestration in the endosomal compartment impairs progeny titer and infectivity and is associated with reduced cholesterol content in the viral envelope.…”
Get full text

Novel broad spectrum virucidal molecules against enveloped viruses. by Valeria Cagno, Cristina Tintori, Andrea Civra, Roberta Cavalli, Marika Tiberi, Lorenzo Botta, Annalaura Brai, Giulio Poli, Caroline Tapparel, David Lembo, Maurizio Botta

“…Due to their selective action on enveloped viruses and to their lipid oxidation ability, we hypothesize a mechanism on the viral envelope that affects the fluidity of the lipid bilayer, thus compromising the efficiency of virus-cell fusion and preventing viral entry.…”
Get full text

Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1 by Jin Chai, Yuanheng Cai, Changxu Pang, Liguo Wang, Sean McSweeney, John Shanklin, Qun Liu

“…In this study, Liu and colleagues present structural analysis of how this phenomenon occurs between SARS-CoV-2 viral envelope protein and human PALS1. The findings provide insights in to viral-host recognition.…”
Get full text

Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L(gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like... by Chowdhury Sona, Naderi Misagh, Chouljenko Vladimir N, Walker Jason D, Kousoulas Konstantin G

“…<p>Abstract</p> <p>Background</p> <p>Herpes simplex virus type-1 (HSV-1) enters into cells via membrane fusion of the viral envelope with plasma or endosomal membranes mediated by viral glycoproteins. …”
Get full text

Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies by Maya Contreras, Jackson B. Stuart, Lisa M. Levoir, Laura Belmont, Leslie Goo

“…There are two EDE antibody subclasses (EDE1, EDE2) distinguished by their dependence on viral envelope protein N-linked glycosylation at position N153 (DENV) or N154 (ZIKV) for binding. …”
Get full text

Flow Virometry Quantification of Host Proteins on the Surface of HIV-1 Pseudovirus Particles by Jonathan Burnie, Vera A. Tang, Joshua A. Welsh, Arvin T. Persaud, Laxshaginee Thaya, Jennifer C. Jones, Christina Guzzo

“…This study demonstrates new advances in calibrated flow virometry as a tool to provide sensitive, high-throughput characterization of the viral envelope in a more efficient, quantitative manner than previously reported techniques.…”
Get full text

Removal of clinically relevant SARS-CoV-2 variants by an affinity resin containing Galanthus nivalis agglutinin. by Melanie Gooldy, Christelle M Roux, Steven P LaRosa, Nicole Spaulding, Charles J Fisher

“…The plant lectin Galanthus nivalis binds to mannose structures in the viral envelope. We hypothesized that viral binding should be unaffected by spike protein mutations. …”
Get full text

Uncovering Viral Protein-Protein Interactions and their Role in Arenavirus Life Cycle by Nora López, Maria Eugenia Loureiro, Jesica M. Levingston Macleod, Alejandra D’Antuono

“…Furthermore, current evidence suggests that binding between Z and the viral envelope glycoprotein complex is required for virion infectivity, and that Z homo-oligomerization is an essential step for particle assembly and budding. …”
Get full text