Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort) by Tangui Barré, Hélène Fontaine, Stanislas Pol, Clémence Ramier, Vincent Di Beo, Camelia Protopopescu, Fabienne Marcellin, Morgane Bureau, Marc Bourlière, Céline Dorival, Ventzislava Petrov-Sanchez, Tarik Asselah, Elisabeth Delarocque-Astagneau, Dominique Larrey, Jean-Charles Duclos-Vallée, Fabrice Carrat, Patrizia Carrieri, on behalf of the ANRS/AFEF Hepather Study Group

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Efficacy of 8- versus 12-week treatment with ledipasvir/sofosbuvir in chronic hepatitis C patients eligible for 8 week regimen in a real-world setting by Dorota Zarębska-Michaluk, Anna Piekarska, Jerzy Jaroszewicz, Jakub Klapaczyński, Marek Sitko, Magdalena Tudrujek-Zdunek, Krzysztof Tomasiewicz, Teresa Belica-Wdowik, Paweł Pabjan, Beata Lorenc, Agnieszka Czauż-Andrzejuk, Olga Tronina, Rafał Krygier, Witold Dobracki, Iwona Buczyńska, Krzysztof A. Simon, Dorota Dybowska, Waldemar Halota, Małgorzata Pawłowska, Jolanta Citko, Łukasz Laurans, Włodzimierz Mazur, Ewa Janczewska, Łukasz Socha, Zbigniew Deroń, Hanna Berak, Robert Flisiak

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Associated Bacterial Coinfections in COVID-19-Positive Patients by Eugen Radu Boia, Alexandru Romulus Huț, Alexandra Roi, Ruxandra Elena Luca, Ioana Roxana Munteanu, Ciprian Ioan Roi, Mircea Riviș, Simina Boia, Adina Octavia Duse, Dan Dumitru Vulcănescu, Florin George Horhat

“…<i>Results</i>: A total of 247 bacterial isolates were identified in the bacterial cultures in both groups. Viral hepatitis type A was more prevalent in the COVID-19-positive group (<i>p</i> = 0.026), as was the presence of oral candidiasis (<i>p</i> = 0.006). …”
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One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar by Fatiha M. Benslimane, Hebah A. Al Khatib, Ola Al-Jamal, Dana Albatesh, Sonia Boughattas, Ayeda A Ahmed, Meryem Bensaad, Shameem Younuskunju, Yasmin A. Mohamoud, Mashael Al Badr, Abdalla A. Mohamed, Reham A. El-Kahlout, Tasneem Al-Hamad, Dina Elgakhlab, Fatima H. Al-Kuwari, Chadi Saad, Andrew Jeremijenko, Abdullatif Al-Khal, Muna A. Al-Maslamani, Roberto Bertollini, Einas A. Al-Kuwari, Hamad E. Al-Romaihi, Salih Al-Marri, Mohammed Al-Thani, Radja M. Badji, Hamdi Mbarek, Yasser Al-Sarraj, Joel A. Malek, Joel A. Malek, Said I. Ismail, Laith J. Abu-Raddad, Laith J. Abu-Raddad, Laith J. Abu-Raddad, Peter V. Coyle, Asmaa A. Al Thani, Hadi M. Yassine, Hadi M. Yassine

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SARS-CoV-2 receptor ACE2 is upregulated by fatty acids in human MASH by Luis Cano, Lise Desquilles, Gevorg Ghukasyan, Gaëlle Angenard, Clémence Landreau, Anne Corlu, Bruno Clément, Bruno Turlin, Eric Le Ferrec, Caroline Aninat, Julie Massart, Orlando Musso

“…Although ACE2 mRNA was unmodified in alcoholic or viral hepatitis, it was upregulated in fibroinflammatory livers from overweight patients. …”
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Low seroprevalence of hepatitis delta virus co-infection in hepatitis B virus-infected blood donors in China: A multicenter study by Le Chang, Le Chang, Ying Yan, Ying Yan, Huimin Ji, Huimin Ji, Huizhen Sun, Huizhen Sun, Huizhen Sun, Xinyi Jiang, Xinyi Jiang, Xinyi Jiang, Zhuoqun Lu, Zhuoqun Lu, Lunan Wang, Lunan Wang, Lunan Wang, HBV-Infected Blood Donors Study Group

“…Hepatitis delta virus (HDV) coinfected with HBV causes severe viral hepatitis, however, the number of HDV infection may be underestimated. …”
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P-38 CRYPTOGENIC CHRONIC HEPATITIS: LOOKING FOR AN ETIOLOGICAL DIAGNOSIS by Guilherme Cançado Grossi Lopes, Aline Candolo Coelho Rocha, Jorge Nardelli Mateus, Patricia Zitelli Momoyo, Daniel Mazo Ferraz De Campos, Claudia Oliveira Pinto Marques De Souza, Marlone Cunha-Silva, Raquel Greca Dias, Roberta Araújo Chaves, Amanda Sacha Alustau Paulino Tolentino, Claudia Couto Alves, Roque Gabriel Rezende De Lima, Alberto Farias Queiroz, Flair José Carrilho, Mário Guimarães Pessôa

“…Using Czaja´s algorithm, diagnosis of nonalcoholic fatty liver disease could be established in 60 patients (21.3%), alpha-1-antitrypsin deficiency in 9 (3.2%), alcoholic liver disease in 7 (2.7%), autoimmune hepatitis in 5 (1.78%), hemochromatosis in 5 (1.78%), biliary-related hepatitis in 4 (1.4%), viral hepatitis in 4 (1.4%), Budd Chiari in 4 (1.4%), glycogenosis in 3 (1%), drug-induced liver injury in 2 (0.7%), and Wilson disease in 1 (0.35%). …”
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Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk by Rubén Martín-Escolano, Erick Joan Vidal-Alcántara, Javier Crespo, Pablo Ryan, Luis Miguel Real, Juan Ignacio Lazo-Álvarez, Joaquín Cabezas-González, Juan Macías, María Teresa Arias-Loste, Guillermo Cuevas, Ana Virseda-Berdices, Veronica Briz, Salvador Resino, María Ángeles Jiménez-Sousa, Amanda Fernández-Rodríguez

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Essential Fitness Repertoire of Staphylococcus aureus during Co-infection with Acinetobacter baumannii In Vivo by Gang Li, Wei Shen, Yali Gong, Ming Li, Xiaocai Rao, Qian Liu, Yanlan Yu, Jing Zhou, Keting Zhu, Mengmeng Yuan, Weilong Shang, Yi Yang, Shuguang Lu, Jing Wang, Yan Zhao

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Spleen stiffness measurement predicts decompensation and rules out high-risk oesophageal varices in primary biliary cholangitis by Cristina Rigamonti, Micol Giulia Cittone, Giulia Francesca Manfredi, Carla De Benedittis, Noemi Paggi, Francesca Baorda, Davide Di Benedetto, Rosalba Minisini, Mario Pirisi

“…Impact and implications: Spleen stiffness measurement by vibration-controlled transient elastography accurately predicts portal hypertension in patients with chronic viral hepatitis. The present study is the first to demonstrate that in primary biliary cholangitis the combination of liver stiffness and spleen stiffness measurement can significantly improve risk stratification by predicting liver decompensation. …”
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Positive Virological Outcomes of HIV-Infected Patients on Protease Inhibitor-Based Second-Line Regimen in Cambodia: The ANRS 12276 2PICAM Study by Olivier Ségéral, Olivier Ségéral, Eric Nerrienet, Eric Nerrienet, Sansothy Neth, Bruno Spire, Vohith Khol, Laurent Ferradini, Saramony Sarun, Chandara Mom, Sopheak Ngin, Charlotte Charpentier, Charlotte Charpentier, Charlotte Charpentier, Pagnaroat Men, Marion Mora, Vun Mean Chhi, Penhsun Ly, Vonthanak Saphonn

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Hepatitis B and C screening needs among different ethnic groups: A population-based study in Amsterdam, the Netherlands by Freke Zuure, Janneke Bil, Maartje Visser, Marieke Snijder, Anders Boyd, Petra Blom, Gerard Sonder, Janke Schinkel, Maria Prins

“…The proportion of first-generation migrants chronically infected with hepatitis C virus was very low among all groups studied. Keywords: Viral hepatitis, HBV, HCV, migrants, epidemiology, prevalence, population-based, HELIUS study…”
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A Comparative Study of Serum Angiogenic Biomarkers in Cirrhosis and Hepatocellular Carcinoma by Krizia Pocino, Cecilia Napodano, Mariapaola Marino, Riccardo Di Santo, Luca Miele, Nicoletta De Matthaeis, Francesca Gulli, Raffaele Saporito, Gian Ludovico Rapaccini, Gabriele Ciasca, Umberto Basile

“…A reduction of Ang-2 levels (<i>p</i> = 0.047) and of the Ang-2/Ang-1 ratio (<i>p</i> = 0.031) is observed in cirrhotic patients diagnosed with viral hepatitis after antiviral treatments. In HCC patients, Ang-1 negatively correlates with FI (ρ = −0.63, <i>p</i> = 1E−4), and PECAM-1 positively correlates with MELD (ρ = 0.44, <i>p</i> = 0.01). …”
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Quantitation of HCV RNA in liver of patients with chronic hepatitis C Quantificação do RNA-HCV no fígado de pacientes com hepatite C crônica by Ana de Lôurdes Candolo MARTINELLI, David BROWN, Allun MORRIS, Amar DHILLON, Peter DAYLEY, Geoffrey DUSHEIKO

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Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain by Zhenwu Luo, Sylvia Fitting, Catrina Robinson, Andreana Benitez, Min Li, Yongxia Wu, Xiaoyu Fu, Davide Amato, Wangbin Ning, Nicholas Funderburg, Xu Wang, Zejun Zhou, Xuezhong Yu, Amanda Wagner, Xiaomei Cong, Wanli Xu, Kendra Maas, Bethany J. Wolf, Lei Huang, Jeremy Yu, Alison Scott, Aimee Mcrae-Clark, Eric D. Hamlett, Wei Jiang

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Severe West Nile Virus Neuroinvasive Disease: Clinical Characteristics, Short- and Long-Term Outcomes by Marija Santini, Sara Haberle, Snježana Židovec-Lepej, Vladimir Savić, Marija Kusulja, Neven Papić, Klaudija Višković, Ivana Župetić, Giovanni Savini, Ljubo Barbić, Irena Tabain, Marko Kutleša, Vladimir Krajinović, Tanja Potočnik-Hunjadi, Elizabeta Dvorski, Tamara Butigan, Gordana Kolaric-Sviben, Vladimir Stevanović, Lana Gorenec, Ivana Grgić, Filip Glavač, Armin Mehmedović, Eddy Listeš, Tatjana Vilibić-Čavlek

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Implementation of anti-HDV reflex testing among HBsAg-positive individuals increases testing for hepatitis D by Adriana Palom, Ariadna Rando-Segura, Judit Vico, Beatriz Pacín, Elena Vargas, Ana Barreira-Díaz, Francisco Rodríguez-Frías, Mar Riveiro-Barciela, Rafael Esteban, Maria Buti

“…Use of reflex testing in other viral hepatitis has proven to increase detection and linking-to-care of infected patients. …”
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In vitro Activity and Heteroresistance of Omadacycline Against Clinical Staphylococcus aureus Isolates From China Reveal the Impact of Omadacycline Susceptibility by Branched-Chain... by Bing Bai, Bing Bai, Zhiwei Lin, Zhiwei Lin, Zhangya Pu, Guangjian Xu, Guangjian Xu, Fan Zhang, Fan Zhang, Zhong Chen, Zhong Chen, Xiang Sun, Jinxin Zheng, Peiyu Li, Peiyu Li, Qiwen Deng, Qiwen Deng, Zhijian Yu, Zhijian Yu

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P-10 LATIN AMERICAN REGISTRY OF CHOLANGIOCARCINOMA: CLINICAL FEATURES, MANAGEMENT AND OUTCOMES by Leonardo G. da Fonseca, Laura Izquierdo-Sanchez, Pedro H. Hashizume, Estefanía Liza Beca, Yanina Carlino, Enrique Carrera, Marco Arrese, Javier Díaz Ferrer, Domingo Balderramo, Flair J. Carrilho, Andre Boonstra, Jose D. Debes, Claudia Pinto Marques Souza de Oliveira, Jesus M. Banales

“…Most frequent risk factors were overweight/obesity (n=68;31.1%), diabetes (n=35;19.1%), NAFLD (n=14;7.7%), viral hepatitis (n=5;2.7%), cirrhosis (n=4;2.2%), gallstones (n=10;5.5%), primary sclerosing cholangitis (n=11;6%) and 21.3%(n=39) had no known-risk factor. …”
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Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion by Wenlin Ren, Xiaohui Ju, Mingli Gong, Jun Lan, Yanying Yu, Quanxin Long, Devin J. Kenney, Aoife K. O’Connell, Yu Zhang, Jin Zhong, Guocai Zhong, Florian Douam, Xinquan Wang, Ailong Huang, Rong Zhang, Qiang Ding

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