Determination of serum adenosine deaminase and xanthine oxidase activity in Kangal dogs with maternal cannibalism by N. Ercan, M. Kockaya, S. Kapancik, D. Bakir

“…Adenosine deaminase (ADA) and xanthine oxidase (XO) are important enzymes for purine metabolism. …”
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Xanthine oxidoreductase-catalyzed reactive species generation: A process in critical need of reevaluation by Nadiezhda Cantu-Medellin, Eric E. Kelley

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Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation by Evan R. DeVallance, Heidi M. Schmidt, Madison Seman, Sara E. Lewis, Katherine C. Wood, Schuyler D. Vickers, Scott A. Hahn, Murugesan Velayutham, Emily A. Hileman, Dario A. Vitturi, Roberta Leonardi, Adam C. Straub, Eric E. Kelley

Subjects: “…Xanthine oxidoreductase…”
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Xanthine oxidase, a therapeutic target of realgar for non-small cell lung cancer by Rui Guo, Xiaoyu Gong, Kongzhao Li, Zhengqi Qiu, Lina Yang, Yanbin Wan, Xinhuang Yao, Canling Long, Jiqing Xu, Kang Li, Jingyan Liu, Jia Liu

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Protective effects of resveratrol against hypoxanthine-xanthine oxidase-induced toxicity on human erythrocytes by Guang Wang, Mengmeng Zhang, Qing Zhong, Zhuogui Lei, Hui Wu, Furao Lai

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Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice by Kazuhisa Takahashi, Hiroki Mizukami, Sho Osonoi, Saori Ogasawara, Yutaro Hara, Kazuhiro Kudoh, Yuki Takeuchi, Takanori Sasaki, Makoto Daimon, Soroku Yagihashi

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Structural and functional insights into the catalytic inactivity of the major fraction of buffalo milk xanthine oxidoreductase. by Kaustubh S Gadave, Santanu Panda, Surender Singh, Shalini Kalra, Dhruba Malakar, Ashok K Mohanty, Jai K Kaushik

“…BACKGROUND: Xanthine oxidoreductase (XOR) existing in two interconvertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO), catabolises xanthine to uric acid that is further broken down to antioxidative agent allantoin. …”
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Xanthine Oxidase Inhibitors Screening, Antioxidation, and DNA Protection Properties of Geranium wilfordii Maxim by Yi Liu, Shiyong Mei, Aiping Xiao, Liangliang Liu

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Characterization of xanthine oxidase inhibitory activities of phenols from pickled radish with molecular simulation by Xiaoze Liu, Daren Wu, Jingwen Liu, Guiling Li, Zhengxiao Zhang, Chaoxiang Chen, Lingyu Zhang, Jian Li

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Insights into the Inhibitory Mechanism of Viniferifuran on Xanthine Oxidase by Multiple Spectroscopic Techniques and Molecular Docking by Yaxin Yang, Qian Chen, Shiyang Ruan, Junli Ao, Shang-Gao Liao

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Xanthine oxidoreductase inhibitor topiroxostat ameliorates podocyte injury by inhibiting the reduction of nephrin and podoplanin by Ying Zhang, Yoshiyasu Fukusumi, Mutsumi Kayaba, Takashi Nakamura, Ryusuke Sakamoto, Naoki Ashizawa, Hiroshi Kawachi

“…Background: Topiroxostat, an inhibitor of xanthine oxidoreductase (XOR) was shown to reduce urinary albumin excretion of hyperuricemic patients with chronic kidney disease. …”
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Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism by Elisa Gómez de Lope, Rebecca Ting Jiin Loo, Armin Rauschenberger, Muhammad Ali, Lukas Pavelka, Tainá M. Marques, Clarissa P. C. Gomes, Rejko Krüger, Enrico Glaab, On behalf of the NCER-PD Consortium

“…Overall, the investigations revealed significant PD-associated metabolome alterations, including pronounced changes in xanthine metabolism that are mechanistically congruent with alterations observed in independent transcriptomics data. …”
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Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension by Gustavo H. Oliveira-Paula, Lucas C. Pinheiro, Danielle A. Guimaraes, Sandra O. Conde Tella, Ana L. Furlan Blanco, Celio D. Angelis, Alan N. Schechter, Jose E. Tanus-Santos

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Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. by Bo S Kim, Leonid Serebreni, Jonathan Fallica, Omar Hamdan, Lan Wang, Laura Johnston, Todd Kolb, Mahendra Damarla, Rachel Damico, Paul M Hassoun

“…Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). …”
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Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction by Lucas C. Pinheiro, Gustavo H. Oliveira-Paula, Rafael L. Portella, Danielle A. Guimarães, Celio D. de Angelis, Jose E. Tanus-Santos

“…While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increased xanthine oxidoreductase (XOR) activity mediates PPIs-induced endothelial dysfunction (ED). …”
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Screening and Evaluation of Xanthine Oxidase Inhibitors from <i>Gnetum parvifolium</i> in China by Xiaosheng Tang, Ping Tang, Lei Ma, Liangliang Liu

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Time‐dependent changes in plasma xanthine oxidoreductase during hospitalization of acute heart failure by Hirotake Okazaki, Akihiro Shirakabe, Masato Matsushita, Yusaku Shibata, Shota Shigihara, Tomofumi Sawatani, Kenichi Tani, Kazutaka Kiuchi, Yusuke Otsuka, Takayo Murase, Takashi Nakamura, Nobuaki Kobayashi, Noritake Hata, Kuniya Asai, Wataru Shimizu

“…Abstract Aims The aim of present study is to evaluate the clinical significance of the time‐dependent changes in xanthine oxidoreductase (XOR) activity during hospitalization for acute heart failure (AHF). …”
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Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia. by Jayasri Nanduri, Damodara Reddy Vaddi, Shakil A Khan, Ning Wang, Vladislav Makerenko, Nanduri R Prabhakar

“…Reactive oxygen species (ROS) scavengers prevented HIF-2α degradation by IH and ROS mimetic decreased HIF-2α protein levels in rat pheochromocytoma PC12 cell cultures, suggesting that ROS mediate IH-induced HIF-2α degradation. IH activated xanthine oxidase (XO) by increased proteolytic conversion of xanthine dehydrogenase to XO. …”
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Xanthine Oxidase/Dehydrogenase Activity as a Source of Oxidative Stress in Prostate Cancer Tissue by Andrej Veljković, Jovan Hadži-Dokić, Dušan Sokolović, Dragoslav Bašić, Ljubinka Veličković-Janković, Marko Stojanović, Dejan Popović, Gordana Kocić

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Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I by Collazo Abal Cristina, Romero Santos Susana, González Mao Carmen, Pazos Lago Emilio C., Barros Angueira Francisco, Castiñeiras Ramos Daisy

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