Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Here we study two prototypical ruthenium-arene agents—the cytotoxic antiprimary tumour compound [(η6-p-cymene)Ru(ethylene-diamine)Cl]PF6 and the relatively non-cytotoxic antimetastasis compound [(η6-p-cymene)Ru(1,3,5-triaza-7-phosphaadamantane)Cl2]—and discover that the former targets the DNA of chromatin, while the latter preferentially forms adducts on the histone proteins. Using a novel ‘atom-to-cell’ approach, we establish the basis for the surprisingly site-selective adduct formation behaviour and distinct cellular impact of these two chemically similar anticancer agents, which suggests that the cytotoxic effects arise largely from DNA lesions, whereas the protein adducts may be linked to the other therapeutic activities. …”
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Alkaline earth complexes supported by chelating diamido ligands by Haynes, M

“…These were compared with a series of THF adducts characterised in collaboration with Prof. …”

Getting tired of your friends: the dynamics of venture capital relationships by Du, Q, Hellmann, T

“…Using US data, we find that venture capitalists dynamically adjust their relationship intensities by gradually disengaging from overly deep relationships. …”

Technology enabled interactive learning by Ong, Yu Bing

“…It should be able to sense students’ progress when going through a material and able to adjust content accordingly. This project gives insight to the implementation on how TEL can adjust content according to users’ output through branching sequence to achieve personalized learning. …”
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Systematic Studies on the Chelating Ligand Effects of Novel Borafluoronium Ions by Allen, Marissa D.

“…Further investigations into the coordination of other bisphosphine ligands, such as dppe, rac-BINAP, and Xantphos, resulted in the formation of Lewis adducts rather than the desired borafluoronium ions. …”
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Molecular recognition in protein-DNA assemblies by Davey, Curt Alexander

“…Although DNA sequence seemed to dominate site preference, histone octamer association was capable of modulating adduct formation by both inhibiting or promoting platination at certain sites. …”
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An unusual [4 + 4] cycloadduct from an o-quinodimethane : characterisation and computational studies by Mohamed Husaini Abdul Rahman, Ramabhadran, Raghunath O., Collier, Steven J., Storr, Richard C., Bates, Roderick Wayland

“…Trapping of a pyrimidinone-derived o-quinodimethane with tetraphenylcyclopentadienone gives a mixture of the [4 + 2] and formal [4 + 4] adducts. Computational studies show that the latter arises by a sequence of [4 + 2] cycloaddition, homolysis, radical recombination to a spiro-tetrahydrofuran and Claisen rearrangement under the thermolytic conditions.…”
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Linear motor control of headset position for disabled people by Leong, Melissa Sze En

“…As the intended user of the product is a disabled user, they require additional help to physically adjust the position of the VR headset on their faces should it be uncomfortable for them. …”
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Traffic managements with autonomous vehicles considering bounded rational day-to-day traffic dynamics by Guo, Zhihong

“…A general framework is developed for the flow adjustment process and dynamical control scheme which is more flexible for real implementation. …”
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GROUP III permethylindenyl-phenoxy complexes for biorenewable polymer synthesis by Hayden, JA

“…Coordination complexes of 4-coodinate PHENI* scandium monomer adducts of <em>L</em>-lactide, ϵ-caprolactone, and ω-pentadecalactone are discussed.…”

Development of sensorised tool for robotic manipulation of objects by Seetharaman, Yuvanesh

“…This report would present the design, development, and integration of a self-adjusting sensorised tool for robotic arms to enhance its gripping capabilities on objects through wrist like movement. …”
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Automated mean arterial pressure control for postoperative patients in intensive care conditions by Ma, Jie

“…The main objectives of this study is to develop and improve the automatic control system to effectively and accurately adjust the patient's arterial blood pressure.…”
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Grid-connected current source inverter with instantaneous power control by Nor Amsyar Bin Zainuddin

“…The novel power inverter aims to achieve grid-enhanced power quality and reliability through an inverter that can adjust instantly to new load demands in the grid with instantaneous increases or decreases in power. …”
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Synthesis, structural studies and ligand influence on the stability of aryl-NHC stabilised trimethylaluminium complexes by Wu, Melissa M., Gill, Arran M., Lu, Yunpeng, Laura, Falivene, Li, Yongxin, Rakesh, Ganguly, Luigi, Cavallo, Felipe, García

“…Treatment of a series of aromatic NHCs (IMes, SIMes, IPr and SIPr) with trimethylaluminium produced their corresponding Lewis acid–base adducts: IMes·AlMe3 (1), SIMes·AlMe3 (2), IPr·AlMe3 (3), and SIPr·AlMe3 (4). …”
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Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters by Yan, Lin, Han, Zhiqiang, Zhu, Bo, Yang, Caiyun, Tan, Choon-Hong, Jiang, Zhiyong

“…A series of important fluorinated adducts, with chiral quaternary carbon centres containing a fluorine atom, was achieved in good yields (up to 93%), with good to excellent enantioselectivities (up to 96% ee) and moderate diastereoselectivities (up to 4:1 dr).…”
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Heel shoe reverse engineering using SolidWorks by Hu, Han.

“…Compared with common ways using point cloud, this method is cost-effective and easy to adjust.…”
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Internationalisation and cross-cultural training in Singapore and Switzerland : between requirements and reality. by Christian Valentin Kirschner.

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Autofocusing of light for Raman imaging by Krishnamoorthi, Shalini

“…The doctors usually use manual adjustment to view or record any part of eye. Eyes are always sensitive to light and wander in all direction. …”
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A study of five derivatives markets in the Asia-Pacific Basin by Lai Ping, Lim, Yuan Yih, Sim, Maggie Yun Bee

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Hydrodynamic pattern of high-speed droplet train impingement by Junaidy Lukman

“…A function generator was used to adjust he frequency of the droplet train. Droplet diameter was adjusted by changing the pinhole. …”
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