Optimised “green solvent” extraction of long-chain menaquinones (Vitamin K2) from wet Lactococcus lactis biomass by Lee, Sze Ying, Hu, Xiao, Stuckey, David C.

“…Menaquinone (vitamin K2) is an essential fat-soluble vitamin for bone and cardiovascular health. Long-chain menaquinones are exclusively synthesised by bacteria, and Lactococcus lactis appears promising as a microbial production platform. …”
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Hydroxyapatite nanoparticles-cell interaction: new approaches to disclose the fate of membrane-bound and internalised nanoparticles by Bonany, Mar, Pérez-Berná, Ana Joaquina, Dučić, Tanja, Pereiro, Eva, Martin-Gómez, Helena, Mas-Moruno, Carlos, van Rijt, Sabine, Zhao, Zhitong, Espanol, Montserrat, Ginebra, Maria-Pau

“…Hydroxyapatite nanoparticles are popular tools in bone regeneration, but they have also been used for gene delivery and as anticancer drugs. …”
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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol by Svensson, Jonas E., Bolin, Martin, Thor, Daniel, Williams, Pete A., Brautaset, Rune, Carlsson, Marcus, Sörensson, Peder, Marlevi, David, Spin-Neto, Rubens, Probst, Monika, Hagman, Göran, Morén, Anton Forsberg, Kivipelto, Miia, Plavén-Sigray, Pontus

“…As exploratory outcomes, the study will assess change in multiple age-related pathological processes, such as periodontal inflammation, retinal degeneration, bone mineral density loss, atherosclerosis and decreased cardiac function. …”
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Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network by Leston, M, Kar, D, Forbes, A, Jamie, G, Wimalaratna, R, Jiwani, G, Ordóñez-Mena, JM, Stewart, DE, Whitaker, H, Joy, M, Lee, LYW, Hobbs, FDR, de Lusignan, S

“…Unique categorisations have been introduced, including ‘Bone Marrow Compromised’ and those dedicated to differentiating prescriptions related and unrelated to cancer. …”

Fermented bed flooring systems enhance profitability in smallholder native pig production by Sivilai, Bounlerth, Vongpaserth, Thonglai, Liang, Juan Boo, Bush, Russell

“…There were also no significant differences in growth performance (average daily gain (ADG) and feed conversion ratio (FCR)), and carcass traits, except that pigs from FB had higher hot carcass weight, dressing percentage and rib and bone weights. Native pigs kept in the FB system had significantly higher total production costs because of the cost of the bedding material, but also had four-fold higher net income return generated from the sale of the fermented floor compost. …”

Insights on the characteristics and therapeutic potential of mesenchymal stem cell-derived exosomes for mitigation of Alzheimer’s disease’s pathogenicity: a systematic review by Mohammed Yousuf Abdi, Sarah, Mustaffa Al-Bakri, Siti Sarah, Nordin, Norshariza

“…A total of 17 eligible in vivo and in vitro studies were included in this review. Bone marrow-derived stem cells (BMSCs) were the most used source for exosome isolation, even though studies on exosomes from adipose-derived stem cells (ADSCs) and human umbilical cord stem cells (HUCSCs) provide more information on the characteristics. …”

3D articulated skeleton extraction using a single consumer-grade depth camera by Lu, Xuequan, Deng, Zhigang, Luo, Jun, Chen, Wenzhi, Yeung, Sai-Kit, He, Ying

“…We then generate a skeleton involving a reasonable number of joints and bones with our skeletal structure extraction algorithm. …”
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Osteoprotegerin mediates adipogenesis in obesity by Lyu, Zipan, Chan, Yau-Tuen, Lu, Yuanjun, Lam, Tsz Fung, Wu, Xingyao, Wu, Junyu, Xu, Lin, Yang, Wei, Zhang, Cheng, Zhong, Linda Lidan, Wang, Ning

“…Osteoprotegerin (OPG), known for its role in bone metabolism regulation, emerges as a potential regulator in mediating adipogenesis during obesity onset. …”
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Metastatic pituitary tumors: an institutional case series by Yearley, Alexander G., Chalif, Eric J., Gupta, Saksham, Chalif, Joshua I., Bernstock, Joshua D., Nawabi, Noah, Arnaout, Omar, Smith, Timothy R., Reardon, David A., Laws, Edward R.

“…Common sites of metastasis included the central nervous system, liver, lung, and bone. In a pooled analysis including additional cases from the literature, treatment of metastases with chemotherapy or a combination of radiation therapy and chemotherapy significantly prolonged PFS (p = 0.02), while failing to significantly improve OS (p = 0.14). …”
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Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation by Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor, Cool, Simon M.

“…Our previous work has demonstrated that a particular affinity-selected HS (referred to henceforth as “HS3”) is capable of enhancing the osteogenic effects of bone morphogenetic protein 2 (BMP2). Here, we gamma-irradiated HS with 26 kGy of ionizing radiation to determine how this affected the structure, composition, and function. …”
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Reassessing the association: evaluation of a polyalanine deletion variant of RUNX2 in non-syndromic sagittal and metopic craniosynostosis by Walton, IS, McCann, E, Weber, A, Morton, JEV, Noons, P, Wilson, LC, Ching, RC, Cilliers, D, Johnson, D, Phipps, JM, Shears, DJ, Thomas, GPL, Wall, SA, Twigg, SRF, Wilkie, AOM

“…(Ala84_Ala89)del, occurs in humans (termed 11A allele), and a previous association study (Cuellar et al. Bone 137:115395;2020) reported that the 11A variant was significantly more frequent in non-syndromic sagittal craniosynostosis (nsSag; allele frequency [AF] = 0.156; 95% confidence interval [CI] 0.126–0.189) compared to non-syndromic metopic craniosynostosis (nsMet; AF = 0.068; 95% CI 0.045–0.098). …”

Soft tissue tumor imaging in adults: whole-body staging in sarcoma, non-malignant entities requiring special algorithms, pitfalls and special imaging aspects. Guidelines 2024 from... by Noebauer-Huhmann, I, Vanhoenacker, FM, Vilanova, JC, Tagliafico, AS, Weber, M, Lalam, RK, Grieser, T, Nikodinovska, VV, de Rooy, JWJ, Papakonstantinou, O, Mccarthy, C, Sconfienza, LM, Verstraete, K, Martel-Villagrán, J, Szomolanyi, P, Lecouvet, FE, Afonso, D, Albtoush, OM, Aringhieri, G, Arkun, R, Aström, G, Bazzocchi, A, Botchu, R, Breitenseher, M, Chaudhary, S, Mansour, RM

“…Whole-body MRI is preferred for staging bone metastasis, with [18F]FDG-PET/CT as an alternative modality in PET-avid tumors. …”

Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre by Shamsi, ZA, Paraoan, V, Kim, C, Saifuddin, SR, Cosker, TDA, Whitwell, D, Gibbons, CLMH, Stavroulias, D, DiChiara, F

“…This approach necessitates a multidisciplinary team, ideally in specialised cancer centres. The Oxford Bone and Soft Tissue Tumour Service is one such centre, and routinely treats such cancers through collaboration between orthopaedic oncology and cardiothoracic surgeons, as well as members of the wider MDT. …”

Association between feel-like temperatures and injury risk during international outdoor athletic championships: a prospective cohort study on 29 579 athlete starts during 10 champi... by Edouard, P, Dandrieux, P-E, Klöwer, MK, Junge, A, Racinais, S, Branco, P, Hollander, K, Navarro, L

“…We performed Poisson regressions with incidence rates (number of injuries per 1000 athlete starts) as outcomes and UTCI as a predictive variable adjusted for sex, for all and time-loss injuries, for different injured tissue types (ie, muscle, tendon, ligament, articular, bone and skin) and specific discipline (ie, sprints, hurdles, jumps, throws, middle distance, long distance, marathon and race walking).…”

Electromyography signal processing based on time and time-frequency representations for prosthesis application by Mahdavi, Farzaneh Akhavan

“…Skeletal muscles are attached to the bone responsible for the movements of the human body. …”
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Cytogenetic and molecular aberrations of multiple myeloma patients : a single-center study in Singapore by Ng, Yit Jun, Tan, Yu Min, See, Karen Hsu Shien, Choo, Natasha Swee Lian, Lim, Sherry Xin Er, Lim, Alvin Soon Tiong, Lim, Tse Hui, Yee, Yenny, Lau, Lai Ching, Tien, Sim Leng, Sathish, Kumar, Tan, Daryl Chen Lung

“…FISH employing standard panel probes and 1p36/1q21 and 6q21/15q22 probes was performed on diagnostic bone marrow samples. Results-Thirty-four cases (75.6%) had karyotypic abnormalities. …”
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Structure-activity relationships of photo-activated soft tissue Adhesive by Wicaksono, Gautama

“…Finally, to demonstrate potential applications, the proposed CaproGlu bioadhesive is mixed with osseointegrative additive to form a bone cement biocomposite using a model PMMA pin that allows biocomposite curing through a transparent light guide, with resulting lap shear strength up to 40 kPa. …”
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Determination of octreotide acetate as radiosensitizer in breast cancer cell lines by Alkhansa, Salih Mahmoud Abdalla

“…Ionizing radiation (IR), like X-rays and gamma rays, are used for c Cancer treatment because they can penetrate soft tissue, bone vs soft tissue. The main problem in radiotherapy is most cancer cells are radio-resistant to treatment. …”
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Carbene-based bioadhesive blended with amine, thiol, and acrylate liquid additives by Ellis, Elizabeth, Djordjevic, Ivan, Muhammad Naziruddin Bin Mohd Ali, Steele, Terry W. J.

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Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates by Lu, J

“…<p>Bisphosphonates have traditionally been used to treat bone resorptive disorders by inhibiting osteoclast activity. …”