Deep learning-enabled 3D multimodal fusion of cone-beam CT and intraoral mesh scans for clinically applicable tooth-bone reconstruction by Liu, Jiaxiang, Hao, Jin, Lin, Hangzheng, Pan, Wei, Yang, Jianfei, Feng, Yang, Wang, Gaoang, Li, Jin, Jin, Zuolin, Zhao, Zhihe, Liu, Zuozhu

“…High-fidelity three-dimensional (3D) models of tooth-bone structures are valuable for virtual dental treatment planning; however, they require integrating data from cone-beam computed tomography (CBCT) and intraoral scans (IOS) using methods that are either error-prone or time-consuming. …”
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Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone by Raimondo, Domenico, Remoli, Cristina, Astrologo, Letizia, Burla, Romina, La Torre, Mattia, Vernì, Fiammetta, Tagliafico, Enrico, Corsi, Alessandro, Del Giudice, Simona, Persichetti, Agnese, Giannicola, Giuseppe, Robey, Pamela G., Riminucci, Mara, Saggio, Isabella

“…Fibrous dysplasia (FD) of bone is a complex disease of the skeleton caused by dominant activating mutations of the GNAS locus encoding for the α subunit of the G protein-coupled receptor complex (Gsα). …”
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Quantitative analysis of bone marrow fibrosis highlights heterogeneity in myelofibrosis and augments histological assessment: an insight from a phase II clinical study of zinpentraxin alfa by Ryou, H, Sirinukunwattana, K, Wood, R, Aberdeen, A, Rittscher, J, Weinberg, OK, Hasserjian, R, Pozdnyakova, O, Peale, F, Higgins, B, Lundberg, P, Trunzer, K, Harrison, CN, Royston, D

Human Wharton's jelly mesenchymal stem cells show unique gene expression compared with bone marrow mesenchymal stem cells using single-cell RNA-sequencing by Barrett, Angela N., Fong, Chui-Yee, Subramanian, Arjunan, Liu, Wenting, Feng, Yirui, Choolani, Mahesh, Biswas, Arijit, Rajapakse, Jagath Chandana, Bongso, Ariff

“…Their broad differentiation potential, high rate of proliferation, ready availability from discarded cords, and prolonged maintenance of stemness properties in culture make them an attractive alternative source of MSCs with therapeutic value compared with human bone marrow MSCs (hBMMSCs). We aimed to characterize the differences in gene expression profiles between these two stem cell types using single-cell RNA sequencing (scRNA-Seq) to determine which pathways are involved in conferring hWJSCs with their unique properties. …”
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Analyses of human vaccine-specific circulating and bone marrow-resident B cell populations reveal benefit of delayed vaccine booster dosing with blood-stage malaria antigens by Barrett, JR, Silk, SE, Mkindi, CG, Kwiatkowska, KM, Hou, MM, Lias, AM, Kalinga, WF, Mtaka, IM, McHugh, K, Bardelli, M, Davies, H, King, LDW, Edwards, NJ, Chauhan, VS, Mukherjee, P, Rwezaula, S, Chitnis, CE, Olotu, AI, Minassian, AM, Draper, SJ, Nielsen, CM

“…Notably, a higher frequency of vaccine-specific (putatively long-lived) plasma cells was detected in the bone marrow of these delayed boosting vaccinees by ELISPOT and correlated strongly with serum IgG. …”

Contrasting effects of vasculogenic induction upon biaxial bioreactor stimulation of mesenchymal stem cells and endothelial progenitor cells cocultures in three-dimensional scaffolds under in vitro and in vivo paradigms for vascularized bone tissue engineering by Chan, Jerry Kok Yen, Liu, Yuchun, Teoh, Swee-Hin, Chong, Mark S. K., Yeow, Chen-Hua, Kamm, Roger D., Choolani, Mahesh

“…Clinical translation of bone tissue engineering approaches for fracture repair has been hampered by inadequate vascularization required for maintaining cell survival, skeletal regeneration, and remodeling. …”
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16.423J Space Biomedical Engineering & Life Support, Fall 2002 by Newman, Dava J.

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HST.523J / 2.785J / 3.97J / 20.411J Cell-Matrix Mechanics, Spring 2004 by Yannas, Ioannis, Spector, Myron

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Detection of osteoporosis using mechanical vibration by Lim, Chu Sing.

“…This report aims to investigate the feasibility of using a mechanical vibration test system as a possible in-vitro test unit for bone densitometry. The report reviews some major measurement techniques of bone densitometry and vibration analysis. …”
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The effect of secreted factors from breast tumour cells on osteogenic potential of mesenchymal cells by Toh, Gui Qin

“…As the breast cells metastasize to the bone, there are many interactions of the breast tumour cells with the bone. …”
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Optimising high porosity 3D scaffold by wet electrospinning by Ong, Su Ming

“…Recently, there has been a significant increase of bone tissue engineering research for elderly as they are more prone to bone defects and damages. …”
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Biomimetic nanocomposites to control osteogenic differentiation of human mesenchymal stem cells by Liao, Susan, Nguyen, Luong T. H., Ngiam, Michelle, Wang, Charlene, Cheng, Ziyuan, Chan, Casey K., Ramakrishna, Seeram

“…Here, the production of materials based on nano-hydroxyapatite composites in scaffolds with nanofibrous and nanoporous topographies, designed to mimic the native bone matrix for applications in bone tissue engineering, is reported. …”
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Synergistic effect of ultrasound and reinforced electrical environment by bioinspired periosteum for enhanced osteogenesis via immunomodulation of macrophage polarization through P... by Jiang, Ting, Yu, Fei, Zhou, Yuqi, Li, Ruomei, Zheng, Mengting, Jiang, Yangyang, Li, Zhenxia, Pan, Jun, Ouyang, Ningjuan

“…The periosteum plays a vital role in repairing bone defects. Researchers have demonstrated the existence of electrical potential in the periosteum and native bone, indicating that electrical signals are essential for functional bone regeneration. …”
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Deep learning approach to cervical segmentation from routine CT images by Duan, Yiming

“…This method can accu rately extract the information of bone joint location of slices and incorporate it into image features in the form of channels, which can improve the accuracy of multiple bone joint segmentation and classification. …”
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Impact of alginate encapsulation on myeloid leukemia cells. by Kyaw Htay.

“…Leukemia is a type of blood cancer characterized by a neoplastic proliferative expansion of hematopoietic stem cells, which grow in the bone marrow. Current leukemia studies using 2D culture flasks and in vivo animal models have not explained clearly yet how the interactions of cellular components in the bone marrow and their niches promote the growth of leukemic stem cells and thwart the chemotherapy. …”
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Dense/porous bioceramic composites by Hu, Yifei

“…These new types of porous materials were prepared for bone replacement and reconstruction. The pores were designed for bone ingrowth, whereas the graded pores and the dense cores were introduced for load bearing capability. …”
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Inhibition of endoplasmic reticulum stress using 4-phenyl butyrate mitigates osteoporosis in a mouse model of hindlimb suspension by Al-Daghestani, Hiba Saad Subhi

“…Osteoporosis (OP) characterized by micro-architectural deterioration of bone tissue is a common skeletal disease in the elderly and may lead to fragility fractures. …”
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3D patient specific instrumentation for high tibial osteotomy by Wong, Gina Khay Fong

“…The most time-intensive part of this project is creating the bone models as there are many alternatives to build it, with many unknown variables, like how the detection algorithm for the Hounsfield Units (HU) works, which helps to build the bone model. …”
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A Novel Approach to Open Reduction and Internal Fixation of Distal Radius Fractures Utilizing a Multi-Degree-of-Freedom Traction and Stabilization Device by Oeding, Jacob F., Bockman, Sam, Chiu, Harriet, Hua, Cheyenne, Connor, James, Slocum, Alexander

“…Open reduction and internal fixation (ORIF) is a surgical procedure performed with the objectives of restoring normal alignment and providing stability to broken bone fragments after a fracture. This procedure is increasingly used to treat fractures of the distal end of the radius. …”
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Characterisation of collagen type I/ type II composite scaffolds for osteochondral tissue engineering by Tamaddon, M

“…The goal of this thesis was to develop and characterise the layers of an osteochondral scaffold following the composition and structure of cartilage, the cartilage-bone interface and underlying bone to treat osteoarthritis or defects in bone and cartilage. …”