Effects of dehydrothermal treatment on collagen by Yeo, Sherrill Yan Ling.

“…Collagen is the most fundamental unit of the extra cellular matrix and is found in most mammal tissues such as the tendon, cartilage, bone and skin. Due to its excellent biocompatibility, collagen is often used as a matrix for cell infiltration in many tissue regenerative applications. …”
Get full text

Synthesis and application of titanium dioxide nanotube and composites by Liang, Kun

“…Two different applications were explored using TiO2 nanotube structures and its composites: bone morphogenetic protein-2 (BMP-2) delivery and photocatalytic for water purification. …”
Get full text

Ontogeny of intestinal intratumoural macrophages and their contribution in cancer regulation by Soncin, Irene

“…In contrast to their LP counterparts, the intratumoural F4/80(hi) macrophages are able to self-renew and lose the bone marrow dependency. Since their depletion via CSF1R blockade diminishes the tumour burden, our data underline the potential of these tumour-promoting intestinal macrophages as an attractive target for successful cancer immunotherapies.…”
Get full text
Get full text

Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs by Iskander, D, Psaila, B, Gerrard, G, Chaidos, A, Foong, HE, Harrington, Y, Karnik, LC, Roberts, I, de la Fuente, J, Karadimitris, A

“…By combining flow cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(-)CD36(-) bone marrow cells as EEP giving rise to BFU-E, and Lin(-)CD34(+/-)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(+)CD36(+) cells as LEP giving rise to CFU-E, in a hierarchical fashion. …”

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria by Gargiulo, L, Papaioannou, M, Sica, M, Talini, G, Chaidos, A, Richichi, B, Nikolaev, AV, Nativi, C, Layton, M, de la Fuente, J, Roberts, I, Luzzatto, L, Notaro, R, Karadimitris, A

“…The mechanism of bone marrow failure (BMF) in paroxysmal nocturnal hemoglobinuria (PNH) is not yet known. …”

A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. …”

Assessment of Radiometer Calibration With GPS Radio Occultation for the MiRaTA CubeSat Mission by Marinan, A. D., Cahoy, K. L., Bishop, R. L., Lui, S. S., Bardeen, J. R., Mulligan, T., Blackwell, W. J., Leslie, R. V., Osaretin, I. A., Shields, M.

“…The MiRaTA mission will validate new technologies in both passive microwave radiometry and GPSRO: 1) new ultracompact and low-power technology for multichannel and multiband passive microwave radiometers, 2) the application of a commercial off-the-shelf GPS receiver and custom patch antenna array technology to obtain neutral atmospheric GPSRO retrieval from a nanosatellite, and 3) a new approach to space-borne microwave radiometer calibration using adjacent GPSRO measurements. …”
Get full text

Small molecule motion within and through organic nanomaterials: an anthology by Kaser, Sam

“…AAs are noteworthy within the class of self-assembled amphiphile materials because of their unusual mechanical stability borne of strong intermolecular interactions between aramid units. …”
Get full text

Structural and functional characterisation of chikungunya virus replication complex dynamics by Tan, Yaw Bia

“…Chikungunya virus (CHIKV) is a 12 kilobase (kb) positive sense single strand RNA (+ssRNA) mosquito-borne virus. Through mosquito bites, the infected victims develop Chikungunya Fever (CHIKF) associated with symptoms like acute fever and painful polyarthritis. …”
Get full text
Get full text

Recent advancements in additively manufactured hip implant design using topology optimization technique by Noman, Abdulla All, Mohd Shamil, Shaari, Mehboob, Hassan, Abdul Hadi, Azman

“…The recent advancement of additive manufacturing (AM) offers many benefits for the medical sector, which is revolutionizing modern bone repair surgery for patients, including those with damaged hip joints. …”
Get full text

Optimisation of stamp compliance for nanoimprint lithography : an experimental and simulation investigation of deformation of Polydimethylsiloxane (PDMS) and Ultraviolet Curable Po... by Ong, Zongjue

“…This simulation is used to predict the deformation of the mold layer for nano-­‐imprint processes under variable conditions such as: 1) Different loading pressure 2) Different modulus of material 3) Different aspect ratio of structure 4) Bulging behavior with different materials For simulation to be accurate, mechanical properties of the materials are obtained by doing tensile tests on five dog-­‐bone samples of each material to acquire the engineering stress–strain curve. …”
Get full text

Electrospun composite nanofibers and their multifaceted applications by Sahay, Rahul, Kumar, Palaniswamy Suresh, Sridhar, R., Sundaramurthy, Jayaraman, Venugopal, J., Mhaisalkar, Subodh Gautam, Ramakrishna, Seeram

“…Nanofibrous materials that mimic the native extracellular matrix (ECM) and promote the adhesion of various cells are being developed as tissue-engineered scaffolds for the skin, bone, vasculature, heart, cornea, nervous system and other tissues. …”
Get full text
Get full text

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging by Jakobsen, NA, Turkalj, S, Zeng, AGX, Stoilova, B, Metzner, M, Rahmig, S, Nagree, MS, Shah, S, Moore, R, Usukhbayar, B, Angulo Salazar, M, Gafencu, G-A, Kennedy, A, Newman, S, Kendrick, BJL, Taylor, AH, Afinowi-Luitz, R, Gundle, R, Watkins, B, Wheway, K, Beazley, D, Murison, A, Aguilar-Navarro, AG, Flores-Figueroa, E, Dakin, SG, Carr, AJ, Nerlov, C, Dick, JE, Xie, SZ, Vyas, P

“…To gain insight into how CH mutations enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on human CH bone marrow (BM) samples. Most of the selective advantage of mutant cells occurs within HSCs. …”

Mycoplasma iowae infection in young Turkeys by Bradbury, Janet M., Ideris, Aini, OO, Tin Tun

“…One group was infected orally at one day of age and some birds developed bone and joint abnormalities but another group, infected via both the thoracic air sac and the foot pad, also at one day of age, developed a higher incidence of these abnormalities, which included chondrodystrophy, rotated tibia, deviated toes and, in a few cases, erosion of the articular cartilage of the hock joint. …”
Get full text

Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…To validate the selective requirement of PCBP2 in <em>TP53</em>-mutant LSC, I adopted a human bone marrow organoid model which I showed to outperform liquid culture conditions in supporting the survival and proliferation of <em>TP53</em>-sAML samples. …”

Kinematic analysis of an upper extremity stroke rehabilitation orthosis by Yang, Fang

“…This method also has some deficiencies, due to lack of the actual hand anatomy data for Singapore’s stroke patient, especially the joint angle of each finger bone, some assumptions and estimations are made. …”
Get full text

Morphological multiparameter filtration and persistent homology in mitochondrial image analysis by Chung, Yu-Min, Hu, Chuan-Shen, Sun, Emily, Tseng, Henry C.

“…Mutations in the autophagy gene Optineurin (OPTN) are associated with primary open-angle glaucoma (POAG), amyotrophic lateral sclerosis (ALS), and Paget's disease of the bone, but the pathophysiological mechanism is unclear. …”
Get full text

Development of bioactive PCL films using low temperature solvent free method by Lim, Lynette Sihui

“…In conclusion, based on the evaluation of the results, 10% MgCl2 has the potential to be developed as a bone scaffold.…”
Get full text

Molecular genetics of Dupuytren’s contracture by Aissvarya, Shankar, Ling, King-Hwa, Arumugam, Manohar, Thilakavathy, Karuppiah

Get full text

Mechanism of damnacanthal induced apoptosis in CEM-SS cell line by Gopalsamy, Banulata, Saiful Yazan, Latifah, Abdul Hamid, Hisyam

“…Leukaemia, is cancer of organs that is responsible to produce blood specifically the lymphatic system and bone marrow. Due to the harsh effects of currently used cancer drugs, damnacanthal, an anthraquinone obtained from the roots of Morinda elliptica is tested as a potential anticancer agent. …”
Get full text