An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation by Hou, Jason F, Nayeem, Md Osman Goni, Caplan, Kian A, Ruesch, Evan A, Caban-Murillo, Albit, Criado-Hidalgo, Ernesto, Ornellas, Sarah B, Williams, Brandon, Pearce, Ayeilla A, Dagdeviren, Huseyin E, Surets, Michelle, White, John A, Shapiro, Mikhail G, Wang, Fan, Ramirez, Steve, Dagdeviren, Canan

“…Ultrasound can aid in energy propagation, but transcranial ultrasound stimulation in the deep brain has limited spatial resolution caused by bone and tissue scattering. Here, we report an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal pressure of 100 kPa to modulate the activity of neurons. …”
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Microglia and CD206⁺ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease by Wu, Xiaoting, Saito, Takashi, Saido, Takaomi C., Barron, Anna M., Ruedl, Christiane

“…We used a novel inducible AD mouse model to investigate the contribution of bone marrow (BM) cells to the pool of fetal-derived brain macrophages during the development of AD. …”
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Musculoskeletal regeneration: a zebrafish perspective by Kaliya-Perumal, Arun-Kumar, Ingham, Philip William

“…Upon muscle injury, quiescent stem cells - known as satellite cells - become activated, proliferate, differentiate and fuse to form new myofibres, while bone fracture results in a phased response involving hematoma formation, inflammation, fibrocartilaginous callus formation, bony callus formation and remodelling. …”
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Capturing the fantastic voyage of monocytes through time and space by Teh, Ye Chean, Ding, Jeak Ling, Ng, Lai Guan, Chong, Shu Zhen

“…After birth, monocytes arise from bone marrow (BM)-derived HSCs and are released into the circulation upon their maturation, where they survey peripheral tissues and maintain endothelial integrity. …”
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Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method by Xu, Jinling, Khor, Khiam Aik

“…HA was prepared with 0, 1, 3 and 5 wt% silica, which are comparable to the measured silicon content of natural bone. After spray drying into micron sized powders, the silica doped HA (SiHA) powders were consolidated at 1000 C with a dwell time of 3 min using a spark plasma sintering (SPS) technique. …”
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From Sample to Answer: Innovations in sample processing and CRISPR-based diagnostics for enhanced clinical translation and field deployment by Arizti Sanz, Jon

“…We also designed and tested multiplexed diagnostic assays for the detection and differentiation of three tick-borne pathogens in clinical samples. Finally, given the inadequacy of existing sample processing methods – and their importance to nucleic acid test deployment – we developed a high throughput experimental workflow to analyze the effects of chemical reagents on diagnostic assay performance and nuclease activity in patient samples using a commercially available microfluidic platform. …”
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Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review by Ramakrishnan, Praveen, Ramprasath, Ramakrishnan, Jalaludeen, Abdulkadhar Mohamed, R., Jayakumar, Gimbun, Jolius, Balu, Ranganathan, S.B., Mohamed, T.M., Sridhar, Gunasekaran, Sivagaami Sundari, Davoodbasha, MubarakAli, Thajuddin, Nooruddin, Gnanasekaran, Lalitha, Sundaram, Thanigaivel

“…Studies concerning the medical applications of these nanofibers, such as wound healing, skin regeneration, bone tissue engineering, and neural repair, were also reviewed. …”
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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol by Svensson, Jonas E., Bolin, Martin, Thor, Daniel, Williams, Pete A., Brautaset, Rune, Carlsson, Marcus, Sörensson, Peder, Marlevi, David, Spin-Neto, Rubens, Probst, Monika, Hagman, Göran, Morén, Anton Forsberg, Kivipelto, Miia, Plavén-Sigray, Pontus

“…As exploratory outcomes, the study will assess change in multiple age-related pathological processes, such as periodontal inflammation, retinal degeneration, bone mineral density loss, atherosclerosis and decreased cardiac function. …”
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Emerging roles of downstream of kinase 3 in cell signaling by Loh, Jia Tong, Teo, Joey Kay Hui, Lim, Hong-Hwa, Lam, Kong-Peng

“…In this review, we will focus on the structure and expression profile of Dok-3 and highlight its role during signal transduction in B cells, innate cells as well as in bone and lung tissues.…”
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Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network by Leston, M, Kar, D, Forbes, A, Jamie, G, Wimalaratna, R, Jiwani, G, Ordóñez-Mena, JM, Stewart, DE, Whitaker, H, Joy, M, Lee, LYW, Hobbs, FDR, de Lusignan, S

“…Unique categorisations have been introduced, including ‘Bone Marrow Compromised’ and those dedicated to differentiating prescriptions related and unrelated to cancer. …”

Fermented bed flooring systems enhance profitability in smallholder native pig production by Sivilai, Bounlerth, Vongpaserth, Thonglai, Liang, Juan Boo, Bush, Russell

“…There were also no significant differences in growth performance (average daily gain (ADG) and feed conversion ratio (FCR)), and carcass traits, except that pigs from FB had higher hot carcass weight, dressing percentage and rib and bone weights. Native pigs kept in the FB system had significantly higher total production costs because of the cost of the bedding material, but also had four-fold higher net income return generated from the sale of the fermented floor compost. …”

Insights on the characteristics and therapeutic potential of mesenchymal stem cell-derived exosomes for mitigation of Alzheimer’s disease’s pathogenicity: a systematic review by Mohammed Yousuf Abdi, Sarah, Mustaffa Al-Bakri, Siti Sarah, Nordin, Norshariza

“…A total of 17 eligible in vivo and in vitro studies were included in this review. Bone marrow-derived stem cells (BMSCs) were the most used source for exosome isolation, even though studies on exosomes from adipose-derived stem cells (ADSCs) and human umbilical cord stem cells (HUCSCs) provide more information on the characteristics. …”

Le cinéma d’Afrique noire contemporaine: une impossible décolonisation? by Fouhba, H

“…An Africa driven by "primitivity" in the 21st century, and in which witchcraft, early marriages, excision, under-schooling of young people, non-schooling of women, juvenile delinquency, absent civil documentation (marriage and birth certificates) , water-borne diseases and insalubrity… constitute the daily lot of the populations.…”

Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…‘Rule of 5’, there has been extensive research on lead-like compounds other than those in the realm of small molecule drug-likeness. With this borne in mind Chapter 1, Antimicrobial Peptides – a New Chasm, introduces the concept of protein-protein interactions (PPIs), which could pave the way for development of promising therapeutic agents of various properties such as pacidamycin and muraymycin which are all peptide-based antibiotics that are concerned with PPIs. …”

Metastatic pituitary tumors: an institutional case series by Yearley, Alexander G., Chalif, Eric J., Gupta, Saksham, Chalif, Joshua I., Bernstock, Joshua D., Nawabi, Noah, Arnaout, Omar, Smith, Timothy R., Reardon, David A., Laws, Edward R.

“…Common sites of metastasis included the central nervous system, liver, lung, and bone. In a pooled analysis including additional cases from the literature, treatment of metastases with chemotherapy or a combination of radiation therapy and chemotherapy significantly prolonged PFS (p = 0.02), while failing to significantly improve OS (p = 0.14). …”
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Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation by Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor, Cool, Simon M.

“…Our previous work has demonstrated that a particular affinity-selected HS (referred to henceforth as “HS3”) is capable of enhancing the osteogenic effects of bone morphogenetic protein 2 (BMP2). Here, we gamma-irradiated HS with 26 kGy of ionizing radiation to determine how this affected the structure, composition, and function. …”
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Optimised “green solvent” extraction of long-chain menaquinones (Vitamin K2) from wet Lactococcus lactis biomass by Lee, Sze Ying, Hu, Xiao, Stuckey, David C.

“…Menaquinone (vitamin K2) is an essential fat-soluble vitamin for bone and cardiovascular health. Long-chain menaquinones are exclusively synthesised by bacteria, and Lactococcus lactis appears promising as a microbial production platform. …”
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Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation by Shi, Pujiang, Tan, Chiew Kei, Wu, Zhuoran, Gabriel, Jean-Christophe P., Srinivasan, Madhavi, Lee, Jong-Min, Tay, Chor Yong

“…Interestingly, compared to commercial tissue-culture treated plastics and in a competitive adipogenic and osteogenic differentiation environment, ADSCs cultured on the keyboard and light diffuser plastics favoured bone cells formation while the grating-like microstructures of the prismatic sheet promoted fat cells differentiation via the process of contact guidance. …”
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Biocompatible materials for orbital wall reconstruction - an overview by Vasile, Victor A., Istrate, Sinziana, Iancu, Raluca C., Piticescu, Roxana M., Cursaru, Laura M., Schmetterer, Leopold, Garhöfer, Gerhard, Cherecheanu, Alina Popa

“…The reconstruction materials can be divided into autografts (bone or cartilage tissue) or allografts (metals, ceramics, or plastic materials, and combinations of these materials). …”
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Reassessing the association: evaluation of a polyalanine deletion variant of RUNX2 in non-syndromic sagittal and metopic craniosynostosis by Walton, IS, McCann, E, Weber, A, Morton, JEV, Noons, P, Wilson, LC, Ching, RC, Cilliers, D, Johnson, D, Phipps, JM, Shears, DJ, Thomas, GPL, Wall, SA, Twigg, SRF, Wilkie, AOM

“…(Ala84_Ala89)del, occurs in humans (termed 11A allele), and a previous association study (Cuellar et al. Bone 137:115395;2020) reported that the 11A variant was significantly more frequent in non-syndromic sagittal craniosynostosis (nsSag; allele frequency [AF] = 0.156; 95% confidence interval [CI] 0.126–0.189) compared to non-syndromic metopic craniosynostosis (nsMet; AF = 0.068; 95% CI 0.045–0.098). …”