Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes by de Jesus, Daniel S., Mak, Tracy C. S., Wang, Yi-Fang, von Ohlen, Yorrick, Bai, Ying, Kane, Eva, Chabosseau, Pauline, Chahrour, Catherine M., Distaso, Walter, Salem, Victoria, Tomas, Alejandra, Stoffel, Markus, Rutter, Guy A., Latreille, Mathieu

“…We usedb-cell-specific miR-7 overexpressing mice (Tg7) to testthe hypothesis that loss ofb-cell identity triggered by miR-7 overexpression alters islet gene expression and islet microenvironment in diabetes.Methods:We performed bulk and single-cell RNA sequencing (RNA-seq) in islets obtained fromb-cell-specific miR-7 overexpressing mice(Tg7). …”
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ST Microelectronics – partnering for profit by Tang, Hung Kei, Gleave, Tom

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Progressive collapse assessment of prestressed concrete beams by Lin, Haoran, Luo, Da, Li, Bing

“…It is observed that the span/depth ratio alters the trend of tendon ratio and influences the change rates of other variables. …”
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Gelatin-dopamine coating for improved biocompatibility on polydimethylsiloxane substrate surfaces by Quek, Kai Yun

“…Thus, this chemical alteration can enhance the biocompatibility of PDMS, including macro and microfluidic scaled culture systems.…”
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Brain control games and applications by Darmaja, Natalia

“…Therefore, cheaper alternative Emotiv Insight headset is used to develop a simple altered version of Tetris game called Brain Tetris. …”
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Linear elastic fracture mechanics analysis of bi-material using boundary element methods by Goh, Terry Jun Jie

“…Varying the elastic modulus ratio and the angular orientation of the inclusion in the vicinity of the crack tip alters the shielding or enhancement effects on that crack tip drastically. …”
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Dynamic clustering for social networks based on evolutionary computation by Fariz Cheang Mohd Khairi

“…Dynamic network clustering requires more attention since social networks are dynamic and any minor changes to its network alters the structure entirely. Currently, most research focuses on the clustering of static social networks where the network is either a small subset of a huge network structure or the entire network structure as a whole. …”
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Neonatal antipredator tactics shape female movement patterns in large herbivores by Atmeh, K, Bonenfant, C, Gaillard, J-M, Droge, E

“…Mothers with hider offspring are unable to exploit environments where the variability of resources occurs at a broad scale, which might alter resource allocation compared with mothers with follower offspring. …”

Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes by Šimelis, K, Belle, R, Kawamura, A

“…Here, we profile 5-methylcytosine (5mC)-oxidising Ten-Eleven Translocation (TET) enzymes using MS and 1H NMR spectroscopy methods and reveal a high degree of substrate oxidation-independent 2OG turnover under a range of conditions. 2OG decarboxylase activity is substantial (>20% 2OG turned over after 1 h) in the absence of substrate, while, under substrate-saturating conditions, half of total 2OG consumption is uncoupled from substrate oxidation. 2OG kinetics are affected by substrate and non-substrate DNA oligomers, and the sequence-agnostic effects are observed in amoeboflagellate Naegleria gruberi NgTet1 and human TET2. TET inhibitors also alter uncoupled 2OG kinetics, highlighting the potential effect of 2OG dioxygenase inhibitors on the intracellular balance of 2OG/succinate.…”

Hypoxia inhibits MHC I expression and antigen presentation to escape immune surveillance by Estephan, H, Tailor, A, Parker, R, Kreamer, M, Papandreou, I, Campo, L, Easton, A, Moon, EJ, Denko, N, Ternette, N, Hammond, E, Giaccia, A

“…These data provide the molecular mechanism governing tumor immune evasion in hypoxic conditions, offering novel insights for therapeutic interventions targeting hypoxia-induced alterations in antigen presentation.…”

Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis by Singh, P, Sun, J, Cavalera, M, Al-Sharify, D, Matthes, F, Barghouth, M, Tengryd, C, Dunér, P, Persson, A, Sundius, L, Nitulescu, M, Bengtsson, E, Rattik, S, Engelbertsen, D, Orho-Melander, M, Nilsson, J, Monaco, C, Goncalves, I, Edsfeldt, A

“…Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies. …”

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis by Luo, Y, Huang, C, Howard, NC, Wang, X, Liu, Q, Li, X, Zhu, J, Amariuta, T, Asgari, S, Ishigaki, K, Calderon, R, Raman, S, Ramnarine, AK, Mayfield, JA, Moody, DB, Lecca, L, Fortune, SM, Murray, MB, Raychaudhuri, S

“…The interacting strains have altered redox states due to a thioredoxin reductase mutation. …”

Characterizing the Impact of Oligomerization on Redox Flow Cell Performance by Weiss, Trent A, Fan, Gang, Neyhouse, Bertrand J, Moore, Evan B, Furst, Ariel, Brushett, Fikile R

“…Post‐mortem analyses reveal that oligomerization does not meaningfully alter decay processes as evinced by similar capacity fade across all species. …”
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Accumulation and enhanced cycling of polyphosphate by Sargasso Sea plankton in response to low phosphorus by Martin, Patrick, Dyhrman, Sonya T., Lomas, Michael W., Poulton, Nicole J., Van Mooy, Benjamin A. S.

“…Phytoplankton alter their biochemical composition according to nutrient availability, such that their bulk elemental composition varies across oceanic provinces. …”
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Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors by Shapiguzov, Alexey, Fernie, Alisdair R., Vainonen, Julia P., Hunter, Kerri, Tossavainen, Helena, Tiwari, Arjun, Järvi, Sari, Hellman, Maarit, Aarabi, Fayezeh, Alseekh, Saleh, Wybouw, Brecht, Van Der Kelen, Katrien, Nikkanen, Lauri, Krasensky-Wrzaczek, Julia, Sipari, Nina, Keinänen, Markku, Tyystjärvi, Esa, Rintamäki, Eevi, De Rybel, Bert, Salojärvi, Jarkko, Van Breusegem, Frank, Brosché, Mikael, Permi, Perttu, Aro, Eva-Mari, Wrzaczek, Michael, Kangasjärvi, Jaakko

“…Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. …”
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Co-chairing Asia-Pacific defence diplomacy : the case ASEAN Defence Ministers’ Meeting Plus by Pitakdumrongkit, Kaewkamol, Klaisringoen, Nantasit

“…We demonstrate how the Thai and Russian co-chairs altered the bargaining dynamics to shape the outcomes regarding the ASEAN Center of Military Medicine (ACMM). …”
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Critical role for cold shock protein YB-1 in cytokinesis by Mehta, Sunali, Algie, Michael, Al-Jabry, Tariq, McKinney, Cushla, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Ma, Weini, Zhang, Jessie, Bartolec, Tara K., Masamsetti, V. Pragathi, Parker, Kim, Henderson, Luke, Gould, Maree L., Bhatia, Puja, Harfoot, Rhodri, Chircop, Megan, Kleffmann, Torsten, Cohen, Scott B., Woolley, Adele G., Cesare, Anthony J., Braithwaite, Antony

“…Using atomistic modelling we show how phosphorylation at multiple sites alters YB-1 conformation, allowing it to interact with protein partners. …”
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Observation of the interactions of silver nanoparticles (AgNPs) mediated by acid in the aquatic matrices using in-situ liquid cell transmission electron microscopy by Fernando, Ishara, Tay, Yee Yan, Karunasekera, Hasith, Zhou, Yan

“…Reducing the pH in the solution will accelerate the aggregation of AgNPs due to the alteration of the charge cloud around the NPs. Aggregates formed in this scenario were non spherical and irregular shaped and were stable under the electron beam irradiation. …”
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Cephalopod-mimetic tunable photonic coatings assembled from quasi-monodispersed reflectin protein nanoparticles by Loke, Jun Jie, Hoon, Shawn, Miserez, Ali

“…This mesmerizing color display remains unmatched in synthetic coatings and is regulated by swelling/deswelling of reflectin protein nanoparticles, which alters platelet dimensions in iridophores to control photonic patterns according to Bragg's law. …”
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Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes by McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John Campbell, Kooner, Jaspal S., Scott, William R.

“…Our results indicate DNA methylation is an important determinant of human obesity and its metabolic complications, and reveal mechanisms through which altered methylation may impact adipocyte functions.…”
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